Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 2, Issue 39, Pages 6749-6757Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4tb00956h
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Funding
- Fundamental Research Funds for the Central Universities [200-1244951]
- State Forestry Administration 948 Project of China [2014-4-35]
- Beijing Municipal Natural Science Foundation of China [2142024]
- National Natural Science Foundation of China [20976179]
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Cellulose based carriers have the potential for sustained release of drugs, which can protect drugs and deliver them to the target site. Herein, BA-loaded cellulose-graft-poly(L-lactic acid) nanoparticles (CE-g-PLLA/BA NPs) were fabricated by employing cellulose (CE) and poly(L-lactic acid) (PLLA) as materials and betulinic acid (BA) as a model drug. Both drug-free and BA-loaded nanoparticles were spherical in shape with a uniform size of 100-170 nm. The release of BA from CE-g-PLLA/BA NPs was relatively slow. In vitro cytotoxicity studies with A549 and LLC cell lines suggested that CE-g-PLLA/BA NPs were slightly superior to BA in antitumor activity and CE-g-PLLA NPs were non-toxic. The antitumor effect of the CE-g-PLLA/BA NPs in a mouse tumor xenograft model exhibited much better tumor inhibition efficacy and fewer side effects than that of BA, strongly supporting their use as efficient carriers for anti-cancer therapy.
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