Article
Chemistry, Physical
David O. Obada, Semiyou A. Osseni, Haziz Sina, Kazeem A. Salami, Ayodeji N. Oyedeji, David Dodoo-Arhin, Naresh D. Bansod, Stefan Csaki, Abdulazeez Y. Atta, Opeoluwa O. Fasanya, Adetunji R. Sowunmi, Laminu S. Kuburi, Muhammad Dauda, Johnson K. Abifarin, Emmanuel T. Dauda
Summary: In this study, hydroxyapatite microparticles from animal bones were synthesized and reinforced with beneficiated kaolin for the first time using the sol-gel route to improve the mechano-biological properties of the bioceramic materials. Sintering at different temperatures resulted in the formation of dominant hydroxyapatite phase, with the reinforced samples showing improved compressive strengths. In-vitro experiments confirmed the degradability and compatibility of the scaffolds, with sample K-HAp 900 also exhibiting inhibitory potentials for bacterial strain E. Coli.
APPLIED CLAY SCIENCE
(2021)
Article
Engineering, Manufacturing
Quyang Liu, Tian Li, Soo Wah Gan, Soon Yee Chang, Ching Chiuan Yen, Wei Zhai
Summary: In this study, hierarchical porous hydroxyapatite (hpHA) scaffolds with high porosity and superior mechanical properties were fabricated using 3D printing of emulsion inks. The scaffolds exhibited improved cell attachment and proliferation, indicating their potential for bone tissue engineering applications. The reported method of 3D printing emulsion inks is a promising strategy for the fabrication of highly porous scaffolds.
ADDITIVE MANUFACTURING
(2023)
Article
Chemistry, Applied
Amitava Bhattacharyya, Hyeong-wook Ham, JiAe Sonh, Marla Gunbayar, R. Jeffy, R. Nagarajan, Mst Rita Khatun, Insup Noh
Summary: Controlled in situ 3D bioprinting of hydrogel without toxic crosslinker is achieved using an advanced pen-type extruder, allowing for tissue regeneration by distributing reinforcing agent during fabrication of large area and complex tissue engineering scaffolds. The addition of kaolin to the alginate-chitosan bioink improves mechanical properties and printability, while also promoting uniform cell growth and proliferation throughout the bioprinted gel matrix. The advanced pen-type extruder ensures better mixing effectiveness and suitability for in vitro tissue regeneration.
CARBOHYDRATE POLYMERS
(2023)
Review
Engineering, Biomedical
Mohammad Mirkhalaf, Yinghui Men, Rui Wang, Young No, Hala Zreiqat
Summary: 3D printed bone scaffolds have the potential to replace autografts and allografts due to their ability to customize the scaffolds' properties and the unlimited supply. Progress has been made in 3D printing bone grafts, but challenges remain in replicating the mechanical and biological functions of native bones. This review outlines the recent progress and challenges in engineering synthetic bone scaffolds and provides suggestions for overcoming these challenges.
ACTA BIOMATERIALIA
(2023)
Article
Nanoscience & Nanotechnology
Thiago Domingues Stocco, Mayara Cristina Moreira Silva, Marcus Alexandre Finzi Corat, Gabriely Goncalves Lima, Anderson Oliveira Lobo
Summary: This study presents a new biofabrication strategy for developing biomimetic meniscus scaffolds. The use of bioprinted cell-laden hydrogel reinforced by aligned nanofiber sheets improved the structural integrity, shape fidelity, and mechanical properties of the scaffolds. Importantly, the introduction of nanofiber mats did not negatively affect cell viability. This bioengineering approach offers a promising strategy for tissue engineering of the knee meniscus.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Chen Cui, Huai-Ling Gao, Ze-Yu Wang, Shao-Meng Wen, Lin-Jun Wang, Xiwen Fan, Xinglong Gong, Shu-Hong Yu
Summary: Additive manufacturing (AM) is the key to creating a wide variety of 3D structures with unique and programmable functionalities. A new AM strategy has been reported to create 3D microarchitectures at the macroscopic level through controlled desiccation of preprinted hydrogel scaffolds followed by infilling objective components. This method has the capability to fabricate functional and complex 3D architectures with micron-level resolution from different material systems.
ADVANCED MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Baoshuai Bai, Junxiang Hao, Mengjie Hou, Tao Wang, Xiaodi Wu, Yanhan Liu, Yiyang Wang, Chengxiang Dai, Yujie Hua, Guangyu Ji, Guangdong Zhou
Summary: This study successfully prepared a bone biomimetic scaffold with controllable 3D morphology, appropriate mechanical properties, good biocompatibility and biodegradability, porous structure suitable for cell loading, and a biomimetic osteogenic inorganic salt (OIS) microenvironment. The addition of the OIS in the scaffold promoted ectopic bone regeneration and successfully repaired dual long rib defects.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Baoshuai Bai, Junxiang Hao, Mengjie Hou, Tao Wang, Xiaodi Wu, Yanhan Liu, Yiyang Wang, Chengxiang Dai, Yujie Hua, Guangyu Ji, Guangdong Zhou
Summary: This study successfully prepared a reliable bone biomimetic scaffold with good performance, which substantially promoted bone regeneration by activating osteogenic and angiogenic signaling pathways, and successfully repaired large-scale bone defects.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Physical
Degeng Xia, Yue Hu, Ning Ma, Li Zhang, Yi Zheng, Tianci Lin, Jian Qi, Quan Jin
Summary: The nano-hydroxyapatite and polycaprolactone composite scaffold has excellent biological activity and mechanical properties, but lacks multidimensional voids required for cell infiltration and growth. In this study, polyethylene glycol was introduced into the composite scaffold to improve its hydrophilicity, porosity, and degradation rate, resulting in a rich multilevel pore structure. This modified scaffold shows potential in bone tissue engineering.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2024)
Review
Pharmacology & Pharmacy
Amber F. MacDonald, Meaghan E. Harley-Troxell, Steven D. Newby, Madhu S. Dhar
Summary: This article summarizes the application of graphene-based materials in tissue engineering, with a focus on bone tissue engineering. It discusses the need for developing 3D graphene scaffolds and introduces the current manufacturing techniques and limitations.
Article
Chemistry, Multidisciplinary
Martina M. De Santis, Hani N. Alsafadi, Sinem Tas, Deniz A. Bolukbas, Sujeethkumar Prithiviraj, Iran A. N. Da Silva, Margareta Mittendorfer, Chiharu Ota, John Stegmayr, Fatima Daoud, Melanie Koenigshoff, Karl Sward, Jeffery A. Wood, Manlio Tassieri, Paul E. Bourgine, Sandra Lindstedt, Sofie Mohlin, Darcy E. Wagner
Summary: The study introduces a hybrid bioink composed of alginate and rECM for 3D bioprinting, showing promising printing properties and biological inductive capabilities for generating human tissue.
ADVANCED MATERIALS
(2021)
Article
Engineering, Biomedical
Hongshi Ma, Chen Yang, Zhenjiang Ma, Xiaoyue Wei, Muhammad Rizwan Younis, Hanbo Wang, Wentao Li, Zhiyong Wang, Wenhao Wang, Yongxiang Luo, Peng Huang, Jinwu Wang
Summary: This study utilizes bioinspired calcium silicate nanowires and alginate composite hydrogels as building blocks to construct multiscale hierarchical bioactive scaffolds, and successfully promotes tissue regeneration from tendon to bone.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Polymer Science
Evangelos Daskalakis, Boyang Huang, Cian Vyas, Anil Ahmet Acar, Ali Fallah, Glen Cooper, Andrew Weightman, Bahattin Koc, Gordon Blunn, Paulo Bartolo
Summary: This study proposes a method for preparing polycaprolactone/bioglass scaffolds with pore size gradient by investigating the coupled effect between material composition and scaffold architecture. The results show that the addition of bioglass improves the mechanical properties and biological performance of the scaffolds.
Article
Nanoscience & Nanotechnology
Xuanwen Xu, Yi Zhou, Kai Zheng, Xinyu Li, Lu Li, Yan Xu
Summary: Periodontitis is a chronic inflammatory disease that affects people worldwide and has an uncertain prognosis with surgical treatment. In this study, a three-dimensional scaffold made of electrospun polycaprolactone/gelatin fibrous membranes was developed to overcome the challenges of periodontal treatment. The scaffold showed good properties and promoted adhesion and proliferation of human periodontal ligament stem cells. In vivo experiments confirmed that the scaffold could guide cellular orientation and potentially facilitate periodontal regeneration.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Abudureheman Maihemuti, Han Zhang, Xiang Lin, Yangyufan Wang, Zhihong Xu, Dagan Zhang, Qing Jiang
Summary: In this study, a three-dimensional printed porous multilayer scaffold made of cold-water fish skin gelatin was developed for osteoarticular cartilage regeneration. The scaffold mimics the structure of native cartilage, allowing chondrocytes to adhere, proliferate, and communicate, as well as transport nutrients and prevent further joint damage. Moreover, the gelatin scaffolds were found to be nonimmunogenic, nontoxic, and biodegradable. Implanting the scaffold into rat cartilage defects resulted in satisfactory repair outcomes in an animal model. Therefore, cold-water fish skin gelatin scaffolds have promising applications in regenerative medicine.
BIOACTIVE MATERIALS
(2023)
Article
Mathematics, Interdisciplinary Applications
Jinshuai Bai, Timon Rabczuk, Ashish Gupta, Laith Alzubaidi, Yuantong Gu
Summary: In this paper, a modified loss function called LSWR loss function is proposed for the Physics-Informed Neural Network (PINN) in computational solid mechanics. Through testing and comparison in 2D and 3D problems, the effectiveness, robustness, and accuracy of the PINN based on the LSWR loss function in predicting displacement and stress fields are demonstrated.
COMPUTATIONAL MECHANICS
(2023)
Article
Food Science & Technology
M. Imran H. Khan, Duval Longa, Shyam S. Sablani, YuanTong Gu
Summary: This study proposes a machine learning-based model to characterize the micromechanical properties of plant-based food materials. By developing an artificial neural network model and optimizing it, the elastic modulus, stiffness, and hardness of plant-based food materials can be accurately predicted. The model has the potential to be used for characterizing the micromechanical properties of similar food products.
FOOD AND BIOPROCESS TECHNOLOGY
(2023)
Article
Engineering, Mechanical
Zilin Li, Huajiang Ouyang, Yuantong Gu, Saulo Martelli, Shiyu Yang, Hongtao Wei, Wei Wang, Ron-Han Wei
Summary: This study proposes a new mix-level time iteration scheme for simulating non-smooth/discontinuous systems with elastic contact and friction. It provides a generic and effective approach for different systems with the same contact features. Through detailed dynamic analysis of a 10-DoF system with two sliders, interesting findings regarding mode-coupling instability, non-smoothness, and the influences of contact states on vibration frequency and non-stationary vibration range are reported.
NONLINEAR DYNAMICS
(2023)
Article
Mechanics
Mohammad S. Islam, Md. Mizanur Rahman, Puchanee Larpruenrudee, Akbar Arsalanloo, Hamidreza Mortazavy Beni, Md. Ariful Islam, YuanTong Gu, Emilie Sauret
Summary: This study focuses on the analysis of microplastic transport and deposition in the upper lung airways. The findings reveal that the shape and size of microplastics, as well as the morphology of the airways, significantly influence the flow fields and deposition patterns. The research provides valuable insights into the understanding of microplastic transport in airways and can contribute to future therapeutics development.
Article
Mechanics
Jiachen Zhao, Zhongzheng Wang, Yuantong Gu, Emilie Sauret
Summary: A hybrid numerical model based on the lattice Boltzmann method and finite difference method is developed to investigate the control of viscous fingering using electrohydrodynamics. The effects of electric field strength and direction, as well as fluid properties, on viscous fingering are studied extensively. It is found that a horizontal electric field can either promote or suppress viscous fingering, depending on the permittivity ratio and conductivity ratio. A phase diagram is established to characterize the interfacial morphologies under different electric field orientations and fluid properties.
Article
Medicine, General & Internal
Ali H. Al-Timemy, Laith Alzubaidi, Zahraa M. Mosa, Hazem Abdelmotaal, Nebras H. Ghaeb, Alexandru Lavric, Rossen M. Hazarbassanov, Hidenori Takahashi, Yuantong Gu, Siamak Yousefi
Summary: In this study, a deep learning model is proposed to accurately and robustly detect early clinical keratoconus (KCN). By extracting features from three different corneal maps using Xception and InceptionResNetV2 deep learning architectures, and then fusing the features, subclinical forms of KCN can be detected with high accuracy. The model achieved an AUC of 0.99 and an accuracy range of 97-100% in distinguishing normal eyes from eyes with subclinical and established KCN. The model was further validated on an independent dataset with an AUC of 0.91-0.92 and an accuracy range of 88-92%. This model is a step toward improving the detection of clinical and subclinical forms of KCN.
Article
Computer Science, Theory & Methods
Laith Alzubaidi, Jinshuai Bai, Aiman Al-Sabaawi, Jose Santamaria, A. S. Albahri, Bashar Sami Nayyef Al-dabbagh, Mohammed. A. A. Fadhel, Mohamed Manoufali, Jinglan Zhang, Ali. H. H. Al-Timemy, Ye Duan, Amjed Abdullah, Laith Farhan, Yi Lu, Ashish Gupta, Felix Albu, Amin Abbosh, Yuantong Gu
Summary: Data scarcity is a major challenge in training deep learning models due to the need for a large amount of labeled data. Manual labeling is costly and time-consuming, and many applications lack sufficient data for training. This paper presents a comprehensive overview of state-of-the-art techniques to address the issue of data scarcity in deep learning and provides recommendations for data acquisition and ensuring the trustworthiness of training datasets.
JOURNAL OF BIG DATA
(2023)
Article
Chemistry, Physical
Chengkai Li, Haifei Zhan, Jiachen Zhao, Jinshuai Bai, Liangzhi Kou, Yuantong Gu
Summary: This study systematically investigated the sliding behaviors of one-dimensional carbon nanotubes in a polymer matrix through atomistic simulations. The functionalized nanotubes showed significantly enhanced interfacial shear strengths due to the strong mechanical interlocking effect. However, excess volume within the functionalized bundle structure weakened the non-bonded interaction. Covalent cross-linking allowed the simultaneous pulling out of surrounding nanotubes while extracting the central nanotube, attributed to filler-filler and filler-matrix interactions. The findings have implications for fiber design and high-performance polymer nanocomposites with one-dimensional nanomaterials.
Article
Nanoscience & Nanotechnology
Runze Sun, Chicheng Ma, Bader Al-Anzi, Emilie Sauret, Yuantong Gu, Zirui Li
Summary: Electroosmotic flow (EOF) is a common phenomenon in microfluidic systems. The study compared the electrochemistry (EC) model, which takes into account electrode reactions and water dissociation, with the traditional electrokinetic (EK) model. The EC model showed that electrode reactions significantly reduce the EOF velocity and cause changes in pH and ion concentration within the microchannel. The results provide valuable insights for manipulating fluid flow and molecular transport in microfluidic systems.
MICROFLUIDICS AND NANOFLUIDICS
(2023)
Article
Oncology
Zaenab Alammar, Laith Alzubaidi, Jinglan Zhang, Yuefeng Li, Waail Lafta, Yuantong Gu
Summary: This paper presents a new technique of enhancing medical image diagnosis through transfer learning. The approach utilizes pre-training deep learning models on similar medical images and refining them with a small set of annotated medical images. The proposed transfer learning approach showed excellent results in classification tasks and demonstrated adaptability in CT cases. It overcomes the limitations of limited labelled images and improves the performance of medical image classification algorithms.
Article
Chemistry, Multidisciplinary
Anastasiia Tukova, Yihan Nie, Mohammad Tavakkoli Yaraki, Ngoc Thanh Tran, Jiaqiu Wang, Alison Rodger, Yuantong Gu, Yuling Wang
Summary: Gold nanoparticles (AuNPs) undergo changes upon contact with biological media, leading to the formation of protein corona (PC) around the particles. Understanding the mechanisms and functions of PC formation is important for utilizing its benefits and avoiding drawbacks. This study investigates the differences in PC formation on spherical and anisotropic AuNPs, revealing that protein does not fully cover the surface of anisotropic nanoparticles, providing potential binding sites for analytes while stabilizing the AuNPs.
Article
Engineering, Electrical & Electronic
Minghao Liu, Lei Zhang, Junxian Liu, Tsz Lok Wan, Aijun Du, Yuantong Gu, Liangzhi Kou
Summary: Controlling magnetism via electric fields instead of magnetic fields has long been envisioned as a revolutionary technology, but it faces challenges of volatility, high energy cost, and low storage density. In this work, effective approaches to achieve magnetic control in bilayer NiI2 are developed through electrostatic doping and polarization field. The interlayer antiferromagnetic to ferromagnetic transition has been observed when the critical electron doping concentration reaches 0.625%. The critical concentration of magnetic transition can be reduced or increased depending on the polarization direction on the ferroelectric substrate of Sc2CO2.
ACS APPLIED ELECTRONIC MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Dongyu Bai, Yihan Nie, Jing Shang, Junxian Liu, Minghao Liu, Yang Yang, Haifei Zhan, Liangzhi Kou, Yuantong Gu
Summary: In this study, the effects of strain on ferroelectric domains in an In2Se3 monolayer were investigated using density functional theory and deep learning molecular dynamics simulations. The results show that bending, rippling, and bubbling can create localized ferroelectric domains with varying sizes, and the switching dynamics depend on the magnitude of curvature and temperature.
Article
Engineering, Multidisciplinary
Zeng Lin, Fawang Liu, Junchao Wu, Dongdong Wang, Yuantong Gu
Summary: In this work, a meshfree technique is used to analyze the time-Caputo and space-Laplacian fractional diffusion equations in three dimensions. The proposed method employs the stabilized conforming nodal integration and lumped mass matrix techniques to increase computational efficiency. The spatial discretization is achieved using a three-dimensional reproducing kernel particle method. Numerical examples demonstrate the accuracy and effectiveness of the proposed method.
ENGINEERING ANALYSIS WITH BOUNDARY ELEMENTS
(2023)
Article
Engineering, Multidisciplinary
Hyogu Jeong, Chanaka Batuwatta-Gamage, Jinshuai Bai, Yi Min Xie, Charith Rathnayaka, Ying Zhou, Yuantong Gu
Summary: Physics-Informed Neural Networks (PINNs) have gained attention in the field of topology optimization. This paper proposes a novel framework, CPINNTO, which integrates two distinct PINNs to achieve complete machine-learning-based topology optimization. The research findings indicate that CPINNTO can achieve optimal topologies without labeled data nor FEA, and it demonstrates stability and favorable compliance values in various topology optimization applications.
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
(2023)
Article
Materials Science, Biomaterials
Izabela Stupka, Artur P. Biela, Bernard Piette, Agnieszka Kowalczyk, Karolina Majsterkiewicz, Kinga Borzecka-Solarz, Antonina Naskalska, Jonathan G. Heddle
Summary: Artificial protein cages, such as TRAP-cages, have potential applications in vaccines and drug delivery. TRAP-cages have the ability to control the disassembly conditions by modifying the interface between their building blocks. By using TRAP rings with different numbers of monomers, it is possible to predict the formation of other cages.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Guo Zhang, Yu Wang, Hua Qiu, Lei Lu
Summary: This study presents a one-pot synthesis method for flower-like AMPs@EAMP particles by combining antimicrobial peptides with ellagic acid, offering enlarged surface area, excellent biocompatibility, and broad-spectrum antibacterial activity. In vivo studies indicate their potential for tissue repair and immune barrier reconstruction.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Jiamei Zhang, Lingshuang Wang, Cheng Xu, Yingui Cao, Shengsheng Liu, Rui L. Reis, Subhas C. Kundu, Xiao Yang, Bo Xiao, Lian Duan
Summary: Pluronic F127 modified silk fibroin film with different types of antibacterial agents could accelerate wound recovery by promoting fibroblast adhesion, eradicating bacteria, and facilitating angiogenesis and re-epithelialization.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Yinsheng Liu, Mingyue Wang, Yinfei Hui, Lei Sun, Yanrui Hao, Henlong Ren, Hao Guo, Wu Yang
Summary: In this study, a rare-earth hybrid luminescent material was developed for the detection of a biomarker for anthrax. The material showed excellent selectivity and high sensitivity, allowing for the determination of the biomarker in saliva and urine. Additionally, a convenient point-of-care testing method using fluorescent test paper and a smartphone was established for the initial diagnosis of anthrax.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Review
Materials Science, Biomaterials
Wenshuai Yang, Jingsi Chen, Ziqian Zhao, Meng Wu, Lu Gong, Yimei Sun, Charley Huang, Bin Yan, Hongbo Zeng
Summary: Injectable hydrogels with shear-thinning and/or in situ formation properties offer distinct advantages in bioengineering applications, as they can be directly delivered to target sites, possess self-healing abilities, and simplify the implantation process.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
