Review
Critical Care Medicine
Abdelaziz Farhat, Ryan Ruiyang Ling, Christopher L. Jenks, Wynne Hsing Poon, Isabelle Xiaorui Yang, Xilong Li, Yulun Liu, Cindy Darnell-Bowens, Kollengode Ramanathan, Ravi R. Thiagarajan, Lakshmi Raman
Summary: The study revealed a rapid expansion in the use of extracorporeal cardiopulmonary resuscitation in pediatric patients, with an overall survival rate of 46% and a 30% rate of favorable neurologic outcomes.
CRITICAL CARE MEDICINE
(2021)
Article
Critical Care Medicine
Amanda V. O'Halloran, Anne Grossestreuer, Lakshman E. Balaji, Catherine J. Ross, Mathias W. Holmberg, Michael E. Donnino, Monica E. Kleinman
Summary: This study aims to describe in-hospital cardiac arrest (IHCA) in adults admitted to pediatric services. The findings suggest that survival outcomes of adults with IHCA in pediatric services are not associated with age, and further research is needed to understand resuscitation in this population.
PEDIATRIC CRITICAL CARE MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Gene Y. Y. Ong, Zhao Jin Chen, Dana E. E. Niles, Vijay Srinivasan, Anita I. I. Sen, Sophie Skellett, Takanari Ikeyama, Jimena del Castillo, Robert A. A. Berg, Vinay M. M. Nadkarni
Summary: Current guidelines recommend chest compressions of one-third anterior-posterior diameter (APD) during pediatric cardiac arrest. This study found poor concordance between measured one-third APD and absolute age-specific chest compression depth targets, particularly for infants. Further research is needed to validate current pediatric chest compression depth targets for better outcomes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Health Care Sciences & Services
Tak Kyu Oh, You Hwan Jo, In-Ae Song
Summary: The rate of in-hospital cardiopulmonary resuscitation and cost of care have significantly increased in South Korea since 2010, while the 6-month and 1-year rates of survival post in-hospital resuscitation remain low.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Pediatrics
Francesca Sperotto, Addison Gearhart, Aparna Hoskote, Peta M. A. Alexander, Jessica A. Barreto, Victoria Habet, Eleonore Valencia, Ravi R. Thiagarajan
Summary: Children with cardiac disease are at a higher risk of cardiac arrest, with limited knowledge on resuscitation strategies based on physiology. This review aims to summarize the current recommendations, highlight knowledge gaps, and emphasize the need for further research to improve care and outcomes for this high-risk population. Factors associated with cardiac arrest and mortality include younger age, lower weight, genetic syndrome, and factors related to resources and institutional characteristics.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Critical Care Medicine
Ryan W. Morgan, Adam S. Himebauch, Heather Griffis, William O. Quarshie, Timothy Yeung, Todd J. Kilbaugh, Alexis A. Topjian, Danielle Traynor, Vinay M. Nadkarni, Robert A. Berg, Akira Nishisaki, Robert M. Sutton
Summary: This study aimed to determine the prevalence of pulmonary hypertension (PH) among children with in-hospital cardiac arrest (IHCA) and its relation to survival. Results showed that children with pre-existing documented PH were less likely to survive to hospital discharge compared to those without PH.
Article
Critical Care Medicine
Ryan Morgan, Robert S. Berg, Ron M. Reeder, Todd Carpenter, Deborah M. Franzon, Aisha Frazier, Kathryn Graham, Kathleen P. Meert, Vinay Nadkarni, Maryam Naim, Bradley Tilford, Heather Wolfe, Andrew R. Yates, Robert F. Sutton
Summary: The change in diastolic blood pressure (DBP) following epinephrine administration during pediatric CPR was found to be associated with return of spontaneous circulation (ROSC) in responders, but not in non-responders.
Article
Critical Care Medicine
Robert A. A. Berg, Ryan W. W. Morgan, Ron W. W. Reeder, Tageldin Ahmed, Michael J. J. Bell, Robert Bishop, Matthew Bochkoris, Candice Burns, Joseph A. A. Carcillo, Todd C. C. Carpenter, J. Michael Dean, J. Wesley Diddle, Myke Federman, Richard Fernandez, Ericka L. L. Fink, Deborah Franzon, Aisha H. H. Frazier, Stuart H. H. Friess, Kathryn Graham, Mark Hall, David A. A. Hehir, Christopher M. M. Horvat, Leanna L. L. Huard, Tensing Maa, Arushi Manga, Patrick S. S. McQuillen, Kathleen L. L. Meert, Peter M. M. Mourani, Vinay M. M. Nadkarni, Maryam Y. Y. Naim, Daniel Notterman, Chella A. A. Palmer, Murray M. M. Pollack, Anil Sapru, Carleen Schneiter, Matthew P. P. Sharron, Neeraj Srivastava, Sarah Tabbutt, Bradley Tilford, Shirley Viteri, David Wessel, Heather A. A. Wolfe, Andrew R. R. Yates, Athena F. F. Zuppa, Robert M. M. Sutton
Summary: Arterial diastolic blood pressure (DBP) greater than 25 mm Hg in infants and greater than 30 mm Hg in children greater than 1 year old during CPR is associated with survival to hospital discharge, as validated by a multicenter prospective observational study.
CRITICAL CARE MEDICINE
(2023)
Review
Neurosciences
Marlena Ornowska, Andrew Wormsbecker, Gary Andolfatto, Tim S. Leung, Idan Khan, George Medvedev
Summary: Review of literature on the use of ketamine as a neuroprotective agent following cardiac arrest. No clinical trials were identified, so a scoping review was conducted instead of a systematic review. Ketamine functions as an NMDA antagonist, and preclinical models indicate its efficacy in neuroprotection. Clinical studies in other conditions also support its use in improving neurological outcomes. Future research should explore the potential of ketamine as a clinical intervention in post-cardiac arrest scenarios.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Cardiac & Cardiovascular Systems
Sebastian Wolfrum, Kevin Roedl, Alexia Hanebutte, Rudiger Pfeifer, Volkhard Kurowski, Reimer Riessen, Anne Daubmann, Stephan Braune, Gerold Soffker, Eric Bibiza-Freiwald, Karl Wegscheider, Heribert Schunkert, Holger Thiele, Stefan Kluge
Summary: This study found that hypothermic temperature control after IHCA did not improve survival nor functional outcome. The study may have been underpowered to detect clinically important differences between hypothermic temperature control and normothermia.
Article
Critical Care Medicine
Ryan W. Morgan, Heather A. Wolfe, Ron W. Reeder, Jessica S. Alvey, Aisha H. Frazier, Stuart H. Friess, Tensing Maa, Patrick S. McQuillen, Kathleen L. Meert, Vinay M. Nadkarni, Matthew P. Sharron, Ashley Siems, Andrew R. Yates, Tageldin Ahmed, Michael J. Bell, Robert Bishop, Matthew Bochkoris, Candice Burns, Joseph A. Carcillo, Todd C. Carpenter, J. Michael Dean, J. Wesley Diddle, Myke Federman, Richard Fernandez, Ericka L. Fink, Deborah Franzon, Mark Hall, David Hehir, Christopher M. Horvat, Leanna L. Huard, Arushi Manga, Peter M. Mourani, Maryam Y. Naim, Daniel Notterman, Murray M. Pollack, Anil Sapru, Carleen Schneiter, Nerraj Srivastava, Sarah Tabbutt, Bradley Tilford, Shirley Viteri, David Wessel, Athena F. Zuppa, Robert A. Berg, Robert M. Sutton
Summary: Using the ICU-RESUS dataset, this study found that compared to the previous year, the first year of the COVID-19 pandemic in pediatric in-hospital cardiac arrest was associated with greater worsening of functional status and higher odds of new functional morbidity among survivors.
PEDIATRIC CRITICAL CARE MEDICINE
(2022)
Article
Immunology
Niels Moeslund, Zhang Long Zhang, Lars Bo Ilkjaer, Pia Ryhammer, Christine Cramer, Johan Palmfeldt, Michael Pedersen, Michiel Elardus Erasmus, Steven Tsui, Hans Eiskjaer
Summary: This study investigated the effects of high oxygenation (HOX) and low oxygenation (LOX) on donor heart function. The results showed that the HOX group had improved right ventricular function, while the left ventricular function remained stable at baseline levels. Hemodynamic function was similar between the two groups. The LOX group exhibited more myocardial damage and poorer contractile performance.
Article
Critical Care Medicine
Ryan W. Morgan, Heather A. Wolfe, Ron W. Reeder, Jessica S. Alvey, Aisha H. Frazier, Stuart H. Friess, Tensing Maa, Patrick S. McQuillen, Kathleen L. Meert, Vinay M. Nadkarni, Matthew P. Sharron, Ashley Siems, Andrew R. Yates, Tageldin Ahmed, Michael J. Bell, Robert Bishop, Matthew Bochkoris, Candice Burns, Joseph A. Carcillo, Todd C. Carpenter, J. Michael Dean, J. Wesley Diddle, Myke Federman, Richard Fernandez, Ericka L. Fink, Deborah Franzon, Mark Hall, David Hehir, Christopher M. Horvat, Leanna L. Huard, Arushi Manga, Peter M. Mourani, Maryam Y. Naim, Daniel Notterman, Murray M. Pollack, Anil Sapru, Carleen Schneiter, Nerraj Srivastava, Sarah Tabbutt, Bradley Tilford, Shirley Viteri, David Wessel, Athena F. Zuppa, Robert A. Berg, Robert M. Sutton
Summary: This study found that pediatric in-hospital cardiac arrest (IHCA) during the first year of the COVID-19 pandemic was associated with greater worsening of functional status and higher odds of new functional morbidity among survivors, compared to the year prior.
PEDIATRIC CRITICAL CARE MEDICINE
(2022)
Article
Critical Care Medicine
Tak Kyu Oh, You Hwan Jo, In-Ae Song
Summary: This study investigated the association between physician turnover and survival outcomes after in-hospital cardiopulmonary resuscitation (ICPR) in South Korea and did not find a significant association.
Article
Critical Care Medicine
Laura A. Ortmann, Ron W. Reeder, Tia T. Raymond, Marissa A. Brunetti, Adam Himebauch, Rupal Bhakta, Jessica Kempka, Shauna di Bari, Javier J. Lasa
Summary: This retrospective study aimed to describe the distribution of epinephrine dosing using time-stamped data and evaluate the impact of dosing strategy on survival after ECPR in children. The study found that survivors received fewer doses of epinephrine compared to non-survivors after the first 10 minutes of CPR. However, there was no statistical difference in survival based on dosing strategy, questioning the assumption of even dosing distribution in ECPR analysis.