Article
Urology & Nephrology
Yang Xu, Edouard L. Fu, Catherine M. Clase, Faizan Mazhar, Meg J. Jardine, Juan J. Carrero
Summary: In this study, it was found that glucagon-like peptide-1 receptor agonists (GLP1RA) were associated with a lower risk of kidney outcomes compared to dipeptidyl peptidase-4 inhibitors (DPP4i). The reductions in both kidney outcomes and major adverse cardiovascular events (MACE) were similar in magnitude to those reported in large cardiovascular outcome trials.
KIDNEY INTERNATIONAL
(2022)
Article
Cardiac & Cardiovascular Systems
Irene Santos-Pardo, Bo Lagerqvist, Viveca Ritsinger, Nils Witt, Anna Norhammar, Thomas Nystrom
Summary: The study found that incretin treatment did not decrease the risk of stent failure in diabetes patients undergoing PCI with DES, but was associated with a lower risk of CV death.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Aleksandra Pilszyk, Magdalena Niebrzydowska, Zuzanna Pilszyk, Magdalena Wierzchowska-Opoka, Zaneta Kimber-Trojnar
Summary: Gestational diabetes mellitus (GDM) is a metabolic disease affecting an increasing number of pregnant women worldwide. Controlling blood glucose levels is crucial to prevent complications. Current studies are investigating the use of other drug categories and have shown some success. These drugs may be used independently or as supplements to existing medications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Hiroshi Nomoto, Sho Furusawa, Akinobu Nakamura, Jun Takeuchi, So Nagai, Hiroki Yokoyama, Ichiro Sakuma, Shinji Taneda, Yoshio Kurihara, Shin Aoki, Aika Miya, Hiraku Kameda, Kyu Yong Cho, Tatsuya Atsumi, Hideaki Miyoshi
Summary: This multicentre trial aims to compare the effects of switching from a DPP-4 inhibitor to oral semaglutide on glycaemic control in patients with T2D. The study will assess the impact of oral semaglutide on HbA1c, body weight, abdominal circumference, blood pressure, and explore the relationship between improvement in metabolic parameters and patient background characteristics, side effects, and other laboratory parameters.
Article
Medicine, Research & Experimental
Cristina Bouzas, Rosario Pastor, Silvia Garcia, Margalida Monserrat-Mesquida, Miguel Angel Martinez-Gonzalez., Jordi Salas-Salvado, Dolores Corella, Albert Goday, J. Alfredo Martinez, Angel M. Alonso-Gomez, Olga Fernandez-Barcelo, Jesus Vioque, Dora Romaguera, Jose Lopez-Miranda, Ramon Estruch, Francisco J. Tinahones, Jose Lapetra, Lluis Serra-Majema, Blanca Riquelme-Gallegop, Vicente Martin-Sanchez, Xavier Pinto, Miguel Delgado-Rodriguez, Pilar Matia, Josep Vidal, Jersy-Jair Cardenas-Salas, Lidia Daimiel, Emilio Ros, Estefania Toledo, Josep M. Manzanares, Inmaculada Gonzalez-Monge, Miguel-Angel Munoz, Diego Martinez-Urbistondo, Lucas Tojal-Sierra, Carlos Munoz-Bravoaf, Salvador Miralles-Gisbert, Marian Martin, Antonio Garcia-Rios, Sara Castro-Barquero, Jose Carlos Fernandez-Garcia, Jose Manuel Santos-Lozano, F. Javier Basterra-Gortari, Liliana Gutierrez-Carrasquilla, Patricia Guillem-Saiz, Alba Satorres, Itziar Abete, Carolina Sorto-Sanchez, Javier Diez-Espino, Nancy Babio, Montse Fito, Josep A. Tur
Summary: In a one-year study involving 6881 patients with MetS, it was found that those treated with GLP-1RA and DPP-4I had better glycemic profiles, but improvements in weight and waist circumference were modest.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Medicinal
Baljit Kaur, Sombir Jaglan, Sudesh Rani, Yatin Batra, Palwinder Singh, Palwinder Vivesh
Summary: This study reports the design, synthesis, and biological studies of new anti-diabetic agents targeting DPP-4. The results show that 14 compounds display better inhibition activity against DPP-4 than the known drug Sitagliptin.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Cardiac & Cardiovascular Systems
Yi-Hsin Chan, Tze-Fan Chao, Shao-Wei Chen, Hsin-Fu Lee, Pei-Ru Li, Wei-Min Chen, Yung-Hsin Yeh, Chi-Tai Kuo, Lai-Chu See, Gregory Y. H. Lip
Summary: The study evaluated the risk of new-onset AF associated with SGLT2i, GLP-1RA, and DPP4i in patients with type 2 diabetes, and found that SGLT2i, but not GLP-1RA, was associated with a lower incidence of AF compared to DPP4i.
CARDIOVASCULAR DIABETOLOGY
(2022)
Review
Medicine, General & Internal
Michael Razavi, Ying-Ying Wei, Xiao-Quan Rao, Ji-Xin Zhong
Summary: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors are commonly used treatments for type 2 diabetes mellitus, but their safety has been questioned.
MILITARY MEDICAL RESEARCH
(2022)
Review
Chemistry, Medicinal
Anand-Krishna Singh, Dhananjay Yadav, Neha Sharma, Jun-O Jin
Summary: Type 2 diabetes mellitus is characterized by high blood sugar levels, and therapeutic approaches include improving insulin sensitivity and using DPP-IV inhibitors. These inhibitors improve hyperglycemia by stabilizing gut hormones such as glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptides.
Article
Endocrinology & Metabolism
Shangyu Chai, Ruya Zhang, Ye Zhang, Richard David Carr, Yiman Zheng, Swapnil Rajpathak, Linong Ji
Summary: This meta-analysis summarizes the effects of DPP4 inhibitors on glucagon levels in patients with type 2 diabetes mellitus (T2DM). The results show that DPP4 inhibitors can significantly reduce postprandial glucagon levels in T2DM patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Clinical Neurology
Xiaocui Qin, Xia Zhang, Pinyu Li, Min Wang, Li Yan, Zeqing Bao, Qili Liu
Summary: The association between different oral diabetes medications and the risk of Parkinson's disease remains unclear. While the use of sulfonylureas, DPP4 inhibitors, metformin, and glitazones show no significant link to PD risk, metformin and glitazones may still increase the risk. Limited data suggests a protective effect of glucagon-like peptide-1 agonists on the risk of PD.
FRONTIERS IN NEUROLOGY
(2021)
Article
Endocrinology & Metabolism
Mona Mashayekhi, Jessica R. Wilson, Scott Jafarian-Kerman, Hui Nian, Chang Yu, Megan M. Shuey, James M. Luther, Nancy J. Brown
Summary: Genetic variation in the gene encoding the GLP-1 receptor may affect the metabolic response to DPP-4 inhibitors. The rs6923761 variant was associated with decreased postprandial glucose excursion in individuals with type 2 diabetes and hypertension. The study suggests a potential role of GLP1R rs6923761 genotype in modulating GLP-1 signaling in response to treatment.
DIABETES OBESITY & METABOLISM
(2021)
Article
Nutrition & Dietetics
Yuki Shimizu, Hiroshi Hara, Tohru Hira
Summary: Although glucose is the most well-known nutrient to stimulate GLP-1 secretion, dietary peptides also play a significant role in stimulating GLP-1 secretion and inhibiting DPP-4 activity. Whey protein administration resulted in less degradation of GLP-1 compared to other nutrients, indicating a potential protective effect of dietary peptides on GLP-1.
BRITISH JOURNAL OF NUTRITION
(2021)
Article
Chemistry, Medicinal
Zongyang Li, Yuan Zhang, Xiangbao Meng, Min Li, Weiwei Cao, Junshan Yang, Xudong Xu, Wenlan Liu, Weiping Li, Qian Cai, Sicen Wang, Guoxu Ma, Zhiheng Liu, Guodong Huang
Summary: The DPP-4 inhibitor Gramcyclin A enhances GLP-1 signaling and shows protective effects against Alzheimer's disease by reversing cognitive decline, reducing abnormal deposits in the brain, suppressing neuroinflammation, and increasing glucose uptake in the brain.
PHYTOTHERAPY RESEARCH
(2022)
Article
Endocrinology & Metabolism
Shiau Chin Chong, Norlela Sukor, Sarah Anne Robert, Kim Fong Ng, Nor Azmi Kamaruddin
Summary: This study assessed the impact of endogenous GLP-1 levels on the treatment response to DPP-IV inhibitors in individuals with prediabetes and T2D. The results showed that linagliptin significantly reduced HbA1c and glucose levels in individuals with high GLP-1 levels. This suggests that endogenous GLP-1 levels play an important role in determining the efficacy of DPP-IV inhibitors.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Letter
Anesthesiology
Abinaya Ramakrishnan, Cynthia Zheng, Manuel L. Fontes, Frederic W. Lombard, Austin A. Woolard, Yaping Shi, Matthew S. Shotwell, Frederic T. Billings, Mias Pretorius, Jonathan P. Wanderer, Rushikesh Vyas, Tarek S. Absi, Ashish S. Shah, Miklos D. Kertai
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2021)
Article
Anesthesiology
Frederic T. Billings, Marcos G. Lopez, Andrew D. Shaw
Summary: The purpose of this study is to present clinical updates, current research findings, and consensus statements relevant to the care of the acute kidney injury (AKI) patient. Acute kidney injury is a common and debilitating complication of surgery and critical illness. New serum and urine biomarkers may provide earlier evidence of AKI, but their clinical utility remains limited.
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2021)
Article
Biochemistry & Molecular Biology
Loren E. Smith, Derek K. Smith, Patricia G. Yancey, Valentina Kon, Alan T. Remaley, Frederic T. Billings, MacRae F. Linton
Summary: The study found that higher preoperative HDL-P concentration is associated with less AKI, indicating lower oxidative damage. Changes in HDL-P concentrations during surgery are also associated with AKI.
JOURNAL OF LIPID RESEARCH
(2021)
Article
Anesthesiology
Stephen Bruehl, Ginger Milne, Jonathan Schildcrout, Yaping Shi, Sara Anderson, Andrew Shinar, Gregory Polkowski, Puneet Mishra, Frederic T. Billings
Summary: This study examined the relationship between the dysfunctional chronic pain (Dysfunctional CP) phenotype and elevated oxidative stress (OS). The results showed that higher levels of OS were associated with more severe pain, widespread pain, greater depressive symptoms and pain catastrophizing, higher pain interference, and lower function.
Review
Anesthesiology
Ke Peng, David R. McIlroy, Bruce A. Bollen, Frederic T. Billings, Alexander Zarbock, Wanda M. Popescu, Amanda A. Fox, Linda Shore-Lesserson, Shaofeng Zhou, Mariya A. Geube, Fuhai Ji, Meena Bhatia, Nanette M. Schwann, Andrew D. Shaw, Hong Liu
Summary: Cardiac surgery-associated acute kidney injury (CS-AKI) is common and associated with increased morbidity and mortality. The evidence for several potential renoprotective strategies is currently rated as moderate, low, or very low. Based on the available evidence, goal-directed oxygen delivery on cardiopulmonary bypass (CPB) and the KDIGO bundle of care may prevent CS-AKI in high-risk patients, while vasopressin may reduce CS-AKI in vasoplegic shock patients. The decision to use a restrictive or liberal strategy for perioperative red cell transfusion should not be based on renal protection concerns.
ANESTHESIA AND ANALGESIA
(2022)
Article
Clinical Neurology
Stephen Bruehl, Frederic T. Billings, Sara Anderson, Gregory Polkowski, Andrew Shinar, Jonathan Schildcrout, Yaping Shi, Ginger Milne, Anthony Dematteo, Puneet Mishra, R. Norman Harden
Summary: This study evaluated the preoperative predictors of complex regional pain syndrome (CRPS) outcomes following total knee arthroplasty (TKA) at 6 months. The findings suggest that central sensitization and inflammatory mechanisms play a role in CRPS risk after tissue trauma.
Article
Anesthesiology
Stephen Bruehl, Ginger Milne, Jonathan Schildcrout, Yaping Shi, Sara Anderson, Andrew Shinar, Gregory Polkowski, Puneet Mishra, Frederic T. Billings
Summary: Total knee arthroplasty (TKA) is effective for pain reduction in most patients, but 15% or more report unsatisfactory long-term pain outcomes. Elevated perioperative oxidative stress (OS) seems to exert small but significant adverse effects on long-term post-TKA pain outcomes, although this OS seems unrelated to ischemic reperfusion (IR) injury associated with extended tourniquet use.
Article
Medicine, General & Internal
Edward Tang Qian, Cheryl L. Gatto, Olga Amusina, Mary Lynn Dear, William Hiser, Reagan Buie, Sunil Kripalani, Frank E. Harrell, Robert E. Freundlich, Yue Gao, Wu Gong, Cassandra Hennessy, Jillann Grooms, Megan Mattingly, Shashi K. Bellam, Jessica Burke, Arwa Zakaria, Eduard E. Vasilevskis, Frederic T. Billings, Jill M. Pulley, Gordon R. Bernard, Christopher J. Lindsell, Todd W. Rice
Summary: Awake prone positioning does not provide clinical benefit for COVID-19 patients with hypoxemia who have not received mechanical ventilation. There is even evidence suggesting potential harm from the awake prone positioning intervention.
JAMA INTERNAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Wei Chen, Justin P. Van Beusecum, Liang Xiao, David M. Patrick, Mingfang Ao, Shilin Zhao, Marcos G. Lopez, Frederic T. Billings, Cristina Cavinato, Alexander W. Caulk, Jay D. Humphrey, David G. Harrison
Summary: In this study, brief episodes of hypertension in mice led to chronic aortic remodeling and renal dysfunction. The inflammatory response in the aorta and kidneys was mediated by GAS6/Axl signaling and could be improved with Axl blockade.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Critical Care Medicine
Eric H. Mace, Melissa J. Kimlinger, Tom J. No, Sergey Dikalov, Cassandra Hennessy, Matthew S. Shotwell, Frederic T. Billings, Marcos G. Lopez
Summary: Hyperoxia impairs endothelium-dependent and endothelium-independent vasodilation, but has no effect on the response to heme-independent soluble guanylyl cyclase activation. It increases vascular superoxide production.
Article
Medicine, General & Internal
David R. McIlroy, Matthew S. Shotwell, Marcos G. Lopez, Michelle T. Vaughn, Joanna S. Olsen, Cassandra Hennessy, Jonathan P. Wanderer, Matthew S. Semler, Todd W. Rice, Sachin Kheterpal, Frederic T. Billings
Summary: This study examines the association between supraphysiological oxygen administration during surgery and postoperative kidney, heart, and lung injury. The results indicate that increased oxygen exposure is associated with a higher risk of acute kidney injury, myocardial injury, and lung injury.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Editorial Material
Medicine, General & Internal
David R. McIlroy, Frederic T. Billings
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Meeting Abstract
Anesthesiology
Frederic T. Billings, David R. McIlroy, Matthew S. Shotwell, Marcos Lopez, Shelley Housey, Jonathan Wanderer, Matthew Semler, Hannah M. Wunsch, Sachin Kheterpal
ANESTHESIA AND ANALGESIA
(2022)
Meeting Abstract
Clinical Neurology
Stephen Bruehl, Frederic T. Billings, Sara Anderson, Gregory Polkowski, Andrew Shinar, Jonathan Schildcrout, Yaping Shi, Ginger Milne, Anthony Dematteo, Puneet Mishra, R. Norman
Article
Anesthesiology
Xinyu Yan, Jeff Goldsmith, Sumit Mohan, Zachary A. Turnbull, Robert E. Freundlich, Frederic T. Billings, Ravi P. Kiran, Guohua Li, Minjae Kim
Summary: This study evaluated the performance of machine learning algorithms in predicting 30-day mortality in intra-abdominal surgery patients. The results showed that excellent discrimination can be achieved using only preoperative variables, and the addition of intraoperative data did not improve the model performance.
ANESTHESIA AND ANALGESIA
(2022)