Article
Medical Laboratory Technology
Nicole Mueller, Stefanie T. Rothkegel, Nicolas Boerter, Kavita Sumaria, Johannes Breuer, Noa J. Freudenthal
Summary: The study indicates the potential of urinary NT-proBNP in discriminating between complex and simple CHD, while the changes in plasma NT-proBNP can predict the duration of postoperative non-invasive ventilation.
CLINICA CHIMICA ACTA
(2021)
Review
Chemistry, Analytical
Olga A. Goryacheva, Tatiana D. Ponomaryova, Daniil D. Drozd, Alina A. Kokorina, Tatiana Yu Rusanova, Pradyumna K. Mishra, Irina Yu Goryacheva
Summary: Rapid assessment of biomarker levels in patients is an effective approach in the diagnosis and treatment of heart failure. BNP and NT-proBNP, as biomarkers of HF, have a high negative predictive value and are particularly useful in excluding HF as a cause of non-specific symptoms.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Bader Alsuwailem, Abdelrahman Zamzam, Muzammil H. Syed, Elisa Greco, Mark Wheatcroft, Charles de Mestral, Mohammed Al-Omran, John Harlock, John Eikelboom, Krishna K. Singh, Rawand Abdin, Mohammad Qadura
Summary: In this study, NT-proBNP levels were found to be significantly higher in patients with peripheral arterial disease (PAD) compared to non-PAD controls, even after adjusting for various factors. Elevated levels of NT-proBNP were observed in PAD patients regardless of prior history of congestive heart failure, coronary artery disease, diabetes, or hypercholesterolemia. Additionally, a negative correlation was found between NT-proBNP levels and the ankle-brachial index in these patients.
Article
Cardiac & Cardiovascular Systems
Jonas Palm, Stefan Holdenrieder, Georg Hoffmann, Jurgen Hoerer, Ruibing Shi, Frank Klawonn, Peter Ewert
Summary: This study evaluated the prognostic power of ztog-proBNP for major adverse cardiovascular events (MACE) throughout childhood in patients with congenital heart diseases (CHD). The results showed that high zlog-proBNP values were strongly associated with adverse events, and ztog-proBNP was the best predictor for MACE, surpassing absolute NT-proBNP values. The study suggests that zlog-proBNP could play a pivotal role in the future management of children with heart diseases.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Zuoan Qin, Yaoyao Du, Quan Zhou, Xuelin Lu, Li Luo, Zhixiang Zhang, Ning Guo, Liangqing Ge
Summary: This study aimed to investigate the relationship between NT-proBNP levels and the occurrence of short-term MACEs in patients with STEMI who underwent emergency PCI. The results showed a positive correlation between NT-proBNP levels and MACE, especially when NT-proBNP was >11.66.
CARDIOLOGY RESEARCH AND PRACTICE
(2021)
Article
Medical Laboratory Technology
Meraj Neyazi, Jan P. Bremer, Marius S. Knorr, Stefan Gross, Jan Brederecke, Nils Schweingruber, Dora Csengeri, Benedikt Schrage, Martin Bahls, Nele Friedrich, Tanja Zeller, Stephan Felix, Stefan Blankenberg, Marcus Doerr, Marcus Vollmer, Renate B. Schnabel
Summary: This study developed a deep learning model to predict serum levels of NT-proBNP from ECG, aiming to reliably identify individuals at risk for cardiovascular disease (CVD). Validation studies conducted in population-based cohorts demonstrated that the model has high diagnostic and predictive value for heart failure (HF) and other major CVD, making it a valuable tool for identifying high-risk individuals.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Stefanie Hendricks, Iryna Dykun, Bastian Balcer, Matthias Totzeck, Tienush Rassaf, Amir A. Mahabadi
Summary: This study conducted a meta-analysis to investigate the value of BNP/NT-proBNP levels as predictors of long-term prognosis in cohorts with and without heart failure. The results showed that BNP/NT-proBNP levels are predictors for adverse long-term outcome in both patients with and without known heart failure. Further research is necessary to establish appropriate thresholds, especially in non-heart failure cohorts.
Article
Cardiac & Cardiovascular Systems
Claire Sweeney, Rebabonye B. Pharithi, Brian Kerr, Cristin Ryan, Fiona Ryan, Libhan Collins, Carmel Halley, Matt Barrett, Chris J. Watson, Kenneth McDonald, Mark Ledwidge
Summary: Guidelines support the use of BNP and NT-proBNP for risk stratification in heart failure prevention programs. However, a study in a Caucasian population did not find routine simultaneous measurement of both BNP and NT-proBNP to be warranted for predicting HF or LVD.
Article
Cardiac & Cardiovascular Systems
Claire Sweeney, Rebabonye B. Pharithi, Brian Kerr, Cristin Ryan, Fiona Ryan, Libhan Collins, Carmel Halley, Matt Barrett, Chris J. Watson, Kenneth McDonald, Mark Ledwidge
Summary: The study found that the NT-proBNP/BNP ratio was inversely associated with the future development of heart failure and left ventricular dysfunction risk. However, the study does not support routine simultaneous measurement of BNP and NT-proBNP in heart failure prevention programs among European, Caucasian patients.
Article
Surgery
Sophie L. van Veldhuisen, Gijs van Woerden, Martin E. W. Hemels, Yves G. C. J. America, Rudolf A. de Boer, Michiel Rienstra, Dirk J. van Veldhuisen, Eric J. Hazebroek
Summary: Elevated NT-proBNP levels are present in 23% of patients aged 50 years and older undergoing bariatric surgery, indicating a potential risk for cardiovascular complications.
SURGERY FOR OBESITY AND RELATED DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Man Wang, Wen Su, Hui Chen, Hongwei Li
Summary: This study aimed to examine the joint association of diabetes status and NT-proBNP with subsequent risk of MACCEs and all-cause mortality in patients with NSTE-ACS. The study found that diabetes and higher levels of NT-proBNP were independently associated with the risk of MACCEs and all-cause mortality, and the highest risks were observed in patients with diabetes and NT-proBNP ≥336 pg/ml.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Aliza Hussain, Wensheng Sun, Anita Deswal, James A. de Lemos, John W. McEvoy, Ron C. Hoogeveen, Kunihiro Matsushita, David Aguilar, Biykem Bozkurt, Salim S. Virani, Amil M. Shah, Elizabeth Selvin, Chiadi Ndumule, Christie M. Ballantyne, Vijay Nambi
Summary: Elevated NT-proBNP is independently associated with increased CVD risk and can help identify individuals at higher risk, especially in those with stage 1 hypertension but elevated NT-proBNP levels.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Chin-Shern Lau, Ya Li Liang, Soon Kieng Phua, Gillian Murtagh, Imo E. Hoefer, Ron H. Stokwielder, Milica Kosevich, Jennifer Yen, Jaganathan Sickan, Christos Varounis, Tar-Choon Aw
Summary: This study evaluated the performance of the Abbott NT-proBNP assay compared to the Roche NT-proBNP immunoassay at two sites. Precision, linearity, and sensitivity studies were conducted, and a regression analysis was performed. The results showed excellent agreement between the two assays, with slight bias in the Roche assay. The age groups recommended for acute heart failure diagnosis by ESC/AHA were also applicable to the Abbott assay.
Article
Pharmacology & Pharmacy
Yan Duan, Meimei Yu, Yan Xu
Summary: The purpose of this study was to assess the effect of sacubitril-valsartan on chronic heart failure (CHF). The results showed that sacubitril-valsartan treatment led to lower levels of serum NT-proBNP and NT-proBNP/BNP, as well as higher levels of LVEF and 6-MWT, compared with conventional treatment. Sacubitril-valsartan had a better therapeutic effect and reduced the readmission rate for heart failure.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2023)
Article
Medical Laboratory Technology
Ling Li, Alexander G. Semenov, Evgeniya E. Feygina, Chenchen Yang, Nan Wang, Chao Chen, Xinghai Hu, Xiaoqin Ni, Zhenlu Zhang
Summary: The study compared the diagnostic accuracy of two NT-proBNP assays and found that the clinical value of total NT-proBNP for HF diagnosis was similar to the non-glycosylated subfraction of NT-proBNP. The lower percentage of non-glycosylated NT-proBNP to total NT-proBNP in non-HF patients suggests that total NT-proBNP might be more sensitive in individuals without current or prior symptoms of HF.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Sandeep A. Saha, Alexis L. Beatty, Rakesh K. Mishra, Mary A. Whooley, Nelson B. Schiller
AMERICAN JOURNAL OF CARDIOLOGY
(2015)
Article
Cardiac & Cardiovascular Systems
Kristoff A. Olson, Alexis L. Beatty, Bettina Heidecker, Mathilda C. Regan, Edward N. Brody, Trudi Foreman, Shintaro Kato, Robert E. Mehler, Britta S. Singer, Kristian Hveem, Havard Dalen, David G. Sterling, Richard M. Lawn, Nelson B. Schiller, Stephen A. Williams, Mary A. Whooley, Peter Ganz
EUROPEAN HEART JOURNAL
(2015)
Article
Cardiac & Cardiovascular Systems
Alexis L. Beatty, Ivy A. Ku, Kirsten Bibbins-Domingo, Robert H. Christenson, Christopher R. DeFilippi, Peter Ganz, Joachim H. Ix, Donald Lloyd-Jones, Torbjorn Omland, Marc S. Sabatine, Nelson B. Schiller, Michael G. Shlipak, Hicham Skali, Madoka Takeuchi, Eric Vittinghoff, Mary A. Whooley
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2015)
Review
Cardiac & Cardiovascular Systems
Linda G. Park, Alexis Beatty, Zoey Stafford, Mary A. Whooley
PROGRESS IN CARDIOVASCULAR DISEASES
(2016)
Article
Cardiac & Cardiovascular Systems
Alexis L. Beatty, Steven M. Bradley, Charles Maynard, James M. McCabe
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2017)
Article
Cardiac & Cardiovascular Systems
Alexis L. Beatty, Michael Truong, David W. Schopfer, Hui Shen, Justin M. Bachmann, Mary A. Whooley
Article
Cardiac & Cardiovascular Systems
Alexis L. Beatty, Jacob A. Doll, David W. Schopfer, Charles Maynard, Mary E. Plomondon, Hui Shen, Mary A. Whooley
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2018)
Article
Critical Care Medicine
Kathleen E. Kearney, Charles Maynard, Bryn Smith, Thomas D. Rea, Alexis Beatty, James M. McCabe
Article
Cardiac & Cardiovascular Systems
Randal J. Thomas, Alexis L. Beatty, Theresa M. Beckie, LaPrincess C. Brewer, Todd M. Brown, Daniel E. Forman, Barry A. Franklin, Steven J. Keteyian, Dalane W. Kitzman, Judith G. Regensteiner, Bonnie K. Sanderson, Mary A. Whooley
Article
Medicine, General & Internal
Marco V. Perez, Kenneth W. Mahaffey, Haley Hedlin, John S. Rumsfeld, Ariadna Garcia, Todd Ferris, Vidhya Balasubramanian, Andrea M. Russo, Amol Rajmane, Lauren Cheung, Grace Hung, Justin Lee, Peter Kowey, Nisha Talati, Divya Nag, Santosh E. Gummidipundi, Alexis Beatty, Mellanie True Hills, Sumbul Desai, Christopher B. Granger, Manisha Desai, Mintu P. Turakhia
NEW ENGLAND JOURNAL OF MEDICINE
(2019)
Article
Health Care Sciences & Services
Alexis L. Beatty, Noah D. Peyser, Xochitl E. Butcher, Thomas W. Carton, Jeffrey E. Olgin, Mark J. Pletcher, Gregory M. Marcus
Summary: The COVID-19 Citizen Science study is a longitudinal cohort study aiming to generate knowledge about COVID-19. As of February 2021, over 50,000 participants have enrolled with an average completion rate of surveys in the past 4 weeks of 59%. This study demonstrates important advances in digital clinical studies and highlights the future of clinical research through continued innovation in digital methods.
JMIR RESEARCH PROTOCOLS
(2021)
Article
Cardiac & Cardiovascular Systems
Alexis L. Beatty, Todd M. Brown, Mollie Corbett, Dean Diersing, Steven J. Keteyian, Ana Mola, Haley Stolp, Hilary K. Wall, Laurence S. Sperling
Summary: This article discusses the proceedings of the Million Hearts Cardiac Rehabilitation Think Tank in October 2020, focusing on new care models and trends in cardiac rehabilitation. Amid the COVID-19 public health emergency, virtual cardiac rehabilitation has gained traction, but its permanency remains uncertain. The new models must address disparities in a fair manner and strategies for implementation should include safety, exercise prescription, monitoring, and education.
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2021)
Article
Cardiac & Cardiovascular Systems
Merilyn S. Varghese, Alexis L. Beatty, Yang Song, Jiaman Xu, Laurence S. Sperling, Gregg C. Fonarow, Steven J. Keteyian, Kevin W. McConeghy, Joanne Penko, Robert W. Yeh, Jose F. Figueroa, Wen-Chih Wu, Dhruv S. Kazi
Summary: This study investigated the impact of the COVID-19 pandemic on participation in and availability of cardiac rehabilitation (CR). The results showed that the declaration of a national emergency led to a sharp decline in CR participation, although it gradually recovered afterwards but remained lower than pre-pandemic levels. The decline in CR participation was most prominent among dual Medicare and Medicaid enrollees and patients residing in rural areas or socially vulnerable communities. Additionally, there was a closure of CR centers, which disproportionately affected rural and low-income patients and the most socially vulnerable communities. Therefore, there is an urgent need for innovative financing and delivery methods to equitably enhance CR participation among Medicare beneficiaries.
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2022)
Article
Oncology
Elizabeth Y. Wang, Hala T. Borno, Samuel L. Washington III, Terence Friedlander, Sylvia Zhang, Evelin Trejo, Erin L. Van Blarigan, June M. Chan, Salma Shariff-Marco, Alexis L. Beatty, Stacey A. Kenfield
Summary: Understanding the preferences, attitudes, and health behaviors related to diet and lifestyle among a diverse group of prostate cancer patients is crucial for informing mHealth interventions and promoting health equity. This study provides qualitative findings from web-based focus groups with patients on androgen deprivation therapy, highlighting recommendations for future mHealth intervention design and implementation.
Article
Cardiac & Cardiovascular Systems
Alexis L. Beatty, Theresa M. Beckie, John Dodson, Carly M. Goldstein, Joel W. Hughes, William E. Kraus, Seth S. Martin, Thomas P. Olson, Quinn R. Pack, Haley Stolp, Randal J. Thomas, Wen-Chih Wu, Barry A. Franklin
Summary: Cardiac rehabilitation (CR) is a beneficial but underused program for people with cardiovascular disease (CVD). The emergence of new virtual and remote delivery models has the potential to improve access to and participation in CR. Important research priorities include including diverse populations, enhancing equitable delivery, identifying populations that benefit most from virtual and remote CR, and comparing outcomes between traditional and virtual CR.