Article
Cardiac & Cardiovascular Systems
Gyu Chul Oh, Taehoon Ko, Jin-Hyu Kim, Min Ho Lee, Sae Won Choi, Ye Seul Bae, Kyung Hwan Kim, Hae-Young Lee
Summary: This study proposed a novel method to estimate LDL-C using machine learning, which showed better correlation with directly measured LDL-C compared to conventional methods, especially at high TG levels. Machine learning algorithms were superior in estimating LDL-C compared with the conventional Friedewald or the more contemporary Martin equations, suggesting their potential use in electronic health records.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Letter
Pediatrics
Yiyi Zhang, Jessica G. Woo, Elaine M. Urbina, David R. Jacobs, Andrew E. Moran, Sarah D. de Ferranti
Summary: This cohort study seeks to characterize the longitudinal trajectories of low-density lipoprotein among children in the United States as they age.
Article
Pharmacology & Pharmacy
Enchen Zhou, Zhuang Li, Hiroyuki Nakashima, Ahlam Choukoud, Sander Kooijman, Jimmy F. P. Berbee, Patrick C. N. Rensen, Yanan Wang
Summary: Accelerating lipolytic processing of VLDL by brown fat activation can further lower (V)LDL levels and reduce the risk of atherosclerosis.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yun Cheng, Xiao-Zhuo Kang, Pearl Chan, Pak-Hin Hinson Cheung, Tao Cheng, Zi-wei Ye, Chi-Ping Chan, Cheng-Han Yu, Dong-Yan Jin
Summary: The study revealed that FACI protein interacts with the AP2 complex and facilitates LDL endocytosis. Overexpression of FACI enhances LDL uptake, while depletion of FACI impairs endocytosis.
CELL AND BIOSCIENCE
(2023)
Article
Health Care Sciences & Services
Yong Huo, Beijian Chen, Qiufang Lian, Shuqing Wang, Lu Liu, Di Lu, Yanling Qu, Guanzhong Zheng, Lipeng Li, Yuan Ji, Guotian Yin, Wenjun Huang, Ying Xie, Xinchun Yang, Xiufang Gao, Pei An, Fengtai Xue, Haoyu Li, Huan Deng, Li Li, Lijuan Pei, Lei Qian
Summary: This study evaluated the long-term efficacy and safety of tafolecimab in Chinese non-FH patients. The results showed that tafolecimab significantly reduced LDL-C levels and also decreased non-HDL-C, apolipoprotein B, and lipoprotein(a) levels. The lipid-lowering effect of tafolecimab was superior to placebo in the treatment groups of 450 mg Q4W and 600 mg Q6W.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Article
Cardiac & Cardiovascular Systems
Hayato Tada, Hirofumi Okada, Atsushi Nohara, Ryuji Toh, Amane Harada, Katsuhiro Murakami, Takuya Iino, Manabu Nagao, Tatsuro Ishida, Ken-ichi Hirata, Masayuki Takamura, Masa-aki Kawashiri
Summary: The function of high-density lipoprotein (HDL) is more important than the HDL cholesterol (HDL-C) level in predicting the risk of coronary artery disease (CAD). A study on patients with familial hypercholesterolemia (FH) found that serum cholesterol uptake capacity (CUC) levels were significantly lower in patients with CAD compared to those without CAD. The study also showed that CUC levels were negatively correlated with the carotid plaque score and were independently associated with CAD, while HDL-C was not.
CIRCULATION JOURNAL
(2023)
Article
Medicine, General & Internal
Jamal S. Rana, Salim S. Virani, Howard H. Moffet, Jennifer Y. Liu, Landis A. Coghlan, Jitesh Vasadia, Christie M. Ballantyne, Andrew J. Karter
Summary: The study aimed to evaluate the association between outpatient LDL-C testing and subsequent statin adherence and intensification in patients after an ASCVD event. The results showed that LDL-C testing was associated with improved statin adherence and higher rates of treatment intensification.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Nutrition & Dietetics
Ewa Wieczorek, Agnieszka Cwiklinska, Agnieszka Kuchta, Barbara Kortas-Stempak, Anna Gliwinska, Maciej Jankowski
Summary: This study aimed to evaluate the impact of hypercholesterolemia and hypertriglyceridemia on the efficiency of lipoprotein lipase-mediated VLDL-triglyceride lipolysis, as well as the role of HDL in this process. The results showed that VLDL from patients with hypercholesterolemia and hypertriglyceridemia are more resistant to lipolysis, with HDL helping to enhance the efficiency of lipolysis in these groups.
Article
Cardiac & Cardiovascular Systems
Douglas G. Johns, Louis-Charles Campeau, Puja Banka, An Bautmans, Tjerk Bueters, Elisabetta Bianchi, Danila Branca, Paul G. Bulger, Inne Crevecoeur, Fa-Xiang Ding, Robert M. Garbaccio, Erik D. Guetschow, Yan Guo, Sookhee N. Ha, Jennifer M. Johnston, Hubert Josien, Eunkyung A. Kauh, Kenneth A. Koeplinger, Jeffrey T. Kuethe, Eseng Lai, Christine L. Lanning, Anita Y. H. Lee, Li Li, Anilkumar G. Nair, Edward A. O'Neill, S. Aubrey Stoch, David A. Thaisrivongs, Thomas J. Tucker, Petr Vachal, Kristien van Dyck, Frederic P. Vanhoutte, Bram Volckaert, Dennis G. Wolford, Andy Xu, Tian Zhao, Dan Zhou, Susan Zhou, Xiaohong Zhu, Hratch J. Zokian, Abbas M. Walji, Harold B. Wood
Summary: Through structure-based drug design and novel synthetic chemistry, an oral PCSK9 inhibitor MK-0616 was developed and validated in clinical trials for its effectiveness in lowering cholesterol.
Article
Pharmacology & Pharmacy
Robert C. Block, Matthew Bang, Amy Peterson, Nathan D. Wong, Dean G. Karalis
Summary: Cardiologists are more likely to recognize and treat HeFH patients compared to primary care physicians, but both specialties do not adequately recognize or treat HeFH. There is a need for enhanced education and training, greater access to lipid specialists, and reduced barriers for PCSK9 inhibitor use.
JOURNAL OF CLINICAL LIPIDOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rui Gao, Kaixin Du, Jinhua Liang, Yi Xia, Jiazhu Wu, Yue Li, Bihui Pan, Li Wang, Jianyong Li, Wei Xu
Summary: This study aims to evaluate the prognostic value of cholesterol levels in CLL and develop a prognostic nomogram that incorporates lipid metabolism. The results showed that lower cholesterol levels at diagnosis were associated with worse prognosis, and post-therapeutic elevation of cholesterol levels correlated with better survival. Therefore, cholesterol profiles can be used as a cheap and readily accessible tool for predicting prognosis in CLL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Haochang Hu, Tian Shu, Jun Ma, Ruoyu Chen, Jian Wang, Shuangshuang Wang, Shaoyi Lin, Xiaomin Chen
Summary: The study investigated genetic mutations in familial hypercholesterolemia patients, revealing elevated LDLC levels in the proband and his daughter, as well as two LDLR missense mutations in the family. Bioinformatic analysis suggested pathogenicity of the mutations, and in vitro experiments indicated the mutations could cause dysfunction in LDLR uptake.
FRONTIERS IN GENETICS
(2021)
Review
Medicine, General & Internal
Chen Gurevitz, Eitan Auriel, Avishay Elis, Ran Kornowski
Summary: Excessive levels of LDL-C are a risk factor for atherosclerosis, but low LDL-C levels are associated with intracerebral hemorrhage. Individualized therapy should be considered for patients with high risk of ICH when aggressive LDL reduction is being considered.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Food Science & Technology
Seyedeh-Masomeh Derakhshandeh-Rishehri, Saeed Ghobadi, Masoumeh Akhlaghi, Shiva Faghih
Summary: Calcium supplement intake is associated with a significant reduction in low density lipoprotein cholesterol level, especially in individuals without dyslipidemia, higher calcium intakes, and longer period of consumption.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Medical Laboratory Technology
Na Xu, Deshan Yuan, Yi Yao, Lin Jiang, Jingjing Xu, Xiaofang Tang, Ying Song, Lijian Gao, Jue Chen, Lei Song, Xueyan Zhao, Jilin Chen, Yuejin Yang, Bo Xu, Runlin Gao, Jinqing Yuan
Summary: This study investigated the relationship between increased Lp(a) and long-term outcomes in patients undergoing PCI, as well as the influence of different LDL-C concentrations. The results showed that increased Lp(a) was associated with an increased risk of poor prognosis, but this association varied depending on the LDL-C concentration.
CLINICA CHIMICA ACTA
(2023)
Article
Cardiac & Cardiovascular Systems
Dong-Hyuk Park, Seon Young Goo, Sung Hyun Hong, Ji-hee Min, Ji Yong Byeon, Mi-Kyung Lee, Hae Dong Lee, Byoung Wook Ahn, Heejin Kimm, Sun Ha Jee, Dong Hoon Lee, Yong-ho Lee, Eun Seok Kang, Justin Y. Jeon
Summary: This study aimed to investigate the association between resting heart rate (RHR) and the prevalence of undiagnosed diabetes. The results showed that participants with higher RHR had a significantly higher prevalence of undiagnosed diabetes, and this association was stronger among younger and leaner individuals. Therefore, RHR can be used as an indicator to identify and prevent undiagnosed diabetes.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Endocrinology & Metabolism
Minyoung Lee, Yongin Cho, Yong-ho Lee, Eun Seok Kang, Bong-soo Cha, Byung-Wan Lee
Summary: This study investigated the clinical relevance of ketone bodies in newly diagnosed type 2 diabetes patients. The results showed that patients with higher initial serum β-hydroxybutyrate (BHB) levels had greater improvement in glycemic control after 6 months of anti-diabetic treatment, as indicated by lower HbA1c levels and better blood sugar control.
DIABETES & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Yong-ho Lee, Doo-Man Kim, Jae Myung Yu, Kyung Mook Choi, Sin Gon Kim, Kang Seo Park, Hyun-Shik Son, Choon Hee Chung, Kyu Jeung Ahn, Soon Hee Lee, Ki-Ho Song, Su Kyoung Kwon, Hyeong Kyu Park, Kyu Chang Won, Hak Chul Jang
Summary: This study compared the effects of anagliptin 100 mg BID versus sitagliptin 100 mg QD on managing glycaemic variability and found that the anagliptin BID regimen was superior in blood glucose control after dinner, as indicated by MAGE and TIR, but was equivalent to the QD regimen in terms of HbA1c and FPG.
DIABETES OBESITY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Yong-Joon Lee, Jae Young Cho, Seng Chan You, Yong-Ho Lee, Kyeong Ho Yun, Yun-Hyeong Cho, Won-Yong Shin, Sang Wook Im, Woong Chol Kang, Yongwhi Park, Sung Yoon Lee, Seung-Jun Lee, Sung-Jin Hong, Chul-Min Ahn, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Jung-Sun Kim
Summary: This study evaluated the effect of moderate-intensity statin with ezetimibe combination therapy versus high-intensity statin monotherapy among patients with diabetes mellitus and atherosclerotic cardiovascular disease. The study found that the combination therapy had similar outcomes in terms of cardiovascular events compared to the monotherapy, but had a higher rate of intolerance-related discontinuation or dose reduction. However, the combination therapy was more effective in achieving lower LDL cholesterol levels.
EUROPEAN HEART JOURNAL
(2023)
Article
Endocrinology & Metabolism
Sejeong Lee, Jaehyun Bae, Doo Ri Jo, Minyoung Lee, Yong-ho Lee, Eun Seok Kang, Bong-Soo Cha, Byung-Wan Lee
Summary: In newly diagnosed type 2 diabetes patients, intact ketogenesis may be associated with a decreased risk of metabolic-associated fatty liver disease (MAFLD).
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Sun Ok Song, Eugene Han, Kang Ju Son, Bong-Soo Cha, Byung-Wan Lee
Summary: This study investigates whether mortality trends have changed in individuals with type 2 diabetes and kidney transplantation (KT), and found that the age at death of KT recipients has been increasing. The age at KT was higher in patients with type 2 diabetes and was the main contributor to the age at death in KT recipients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Hye Jin Chun, Eun Ran Kim, Minyoung Lee, Da Hyun Choi, Soo Hyun Kim, Eugene Shin, Jin-Hong Kim, Jin Won Cho, Dai Hoon Han, Bong-Soo Cha, Yong-ho Lee
Summary: The aim of this study was to investigate the mechanism by which SGLT2 inhibitors reduce steatosis in NASH patients. The results showed that SGLT2 expression and O-GlcNAcylation were increased in the livers of NASH patients. In vitro and in vivo experiments demonstrated that SGLT2 inhibitor treatment reduced hepatocellular glucose uptake and promoted autophagy, leading to alleviation of lipid accumulation, inflammation, and fibrosis in NASH.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Medicine, General & Internal
Sunghwan Lee, Seul Lee, Sunhee Jo, Kyung-Ah Kim, Yu Jin Yang, Jung Joo Lee, Eunsung Kim, Yongjung Park, Taeyoung Kyong, Jeong-Ho Kim
Summary: Serum creatinine levels can overestimate renal function in elderly patients with sarcopenia. This study examined calf circumference (CC) as a potential indicator to test for cystatin C instead of creatinine in elderly inpatients. The results showed a positive correlation between CC and the eGFRcys/eGFRcr ratio in both sexes, suggesting that CC could be a cost-effective screening tool for detecting hidden renal impairment in elderly male patients using cystatin C as an add-on test.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Jisook Yim, Nak-Hoon Son, Taeyoung Kyong, Yongjung Park, Jeong-Ho Kim
Summary: This study analyzed the effects of age and sex on the relationship between muscle mass and serum creatinine levels. The results showed a significant negative correlation between serum creatinine levels and age in males, but not in females. This suggests that the decline in muscle mass has a more significant impact on serum creatinine levels in older males.
Article
Multidisciplinary Sciences
Seul Ki Kim, Le Trung Tran, Cherl NamKoong, Hyung Jin Choi, Hye Jin Chun, Yong-ho Lee, MyungHyun Cheon, ChiHye Chung, Junmo Hwang, Hyun-Ho Lim, Dong Min Shin, Yun-Hee Choi, Ki Woo Kim
Summary: The mitochondrial-derived peptide SHLP2 plays a crucial role in energy homeostasis by activating hypothalamic neurons and binding to CXCR7. It protects against obesity and improves insulin sensitivity in mice fed a high-fat diet.
NATURE COMMUNICATIONS
(2023)
Article
Endocrinology & Metabolism
Yong-Joon Lee, Sang-Hyup Lee, Seng Chan You, Yong-ho Lee, Seung-Jun Lee, Sung-Jin Hong, Chul-Min Ahn, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Jung-Sun Kim
Summary: The study evaluated the safety and efficacy of a moderate-intensity statin with ezetimibe combination therapy versus high-intensity statin monotherapy in patients with metabolic syndrome (MetS) and atherosclerotic cardiovascular disease. The combination therapy showed comparable cardiovascular benefits with lower drug intolerance and low-density lipoprotein cholesterol levels compared to monotherapy, but no significant difference in new-onset diabetes.
DIABETES OBESITY & METABOLISM
(2023)
Article
Multidisciplinary Sciences
Seul Ki Kim, Le Trung Tran, Cherl NamKoong, Hyung Jin Choi, Hye Jin Chun, Yong-ho Lee, MyungHyun Cheon, ChiHye Chung, Junmo Hwang, Hyun-Ho Lim, Dong Min Shin, Yun-Hee Choi, Ki Woo Kim
Summary: Small humanin-like peptide 2 (SHLP2), a mitochondrial-derived peptide, plays a crucial role in energy homeostasis. The study demonstrates that SHLP2 can protect mice from high-fat diet-induced obesity and improve insulin sensitivity. It activates pro-opiomelanocortin (POMC) neurons in the hypothalamus, which suppresses food intake and promotes thermogenesis. The researchers also discover that SHLP2 binds to and activates chemokine receptor 7 (CXCR7).
NATURE COMMUNICATIONS
(2023)