☆ 4.6 Article

Associations Between Body Mass Index and Development of Metabolic Disorders in Fertile Women-A Nationwide Cohort Study

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2014)

Journal

JOURNAL OF THE AMERICAN HEART ASSOCIATION

Volume 3, Issue 2, Pages -

Publisher

WILEY

DOI: 10.1161/JAHA.113.000672

Keywords

body mass index; diabetes; hypercholesterolemia; hypertension; women

Funding

University of Copenhagen, Denmark

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Abstract

Background-Metabolic disorders are relatively uncommon in young women, but may increase with obesity. The associations between body mass index (BMI) and risks of diabetes, hypertension, and dyslipidemia in apparently healthy, young women have been insufficiently investigated, and are the aims of this study. Methods and Results-Women giving birth during the years 2004-2009, with no history of cardiovascular disease, renal insufficiency, pregnancy-associated metabolic disorders, diabetes, hypertension, or dyslipidemia were identified in nationwide registers. Women were categorized as underweight (BMI<18.5 kg/m(2)), normal weight (BMI=18.5 to <25 kg/m2), overweight (BMI=25 to <30 kg/m2), obese-I (BMI=30 to <35 kg/m2), obese-II (BMI=35 to <40 kg/m2), and obese-III (BMI=40 kg/m2). We assessed risks by Poisson regression models (adjusted for age, calendar year; reference=normal weight). The cohort comprised 252 472 women with a median age of 30.4 years (IQR=27.2; 33.7) and a median follow-up of 5.5 years (IQR=3.9; 6.8). In total, 2029 women developed diabetes, 3133 women developed hypertension, and 1549 women developed dyslipidemia. Rate ratios (RRs) of diabetes were: 0.84 (95% confidence interval [CI]=0.62 to 1.14) for underweight, 2.63 (CI=2.36 to 2.93) for overweight, 4.83 (CI=4.27 to 5.47) for obese grade-I, 7.17 (CI=6.10 to 8.48) for obese grade-II, and 6.93 (CI=5.47 to 8.79) for obese grade-III women. For hypertension, corresponding RRs were 0.86 (CI=0.69 to 1.09), 1.82 (CI=1.67 to 1.98), 2.81 (CI=2.52 to 3.13), 3.92 (CI=3.36 to 4.56), and 5.69 (CI=4.71 to 6.89), and for dyslipidemia, RRs were 1.18 (CI=0.85 to 1.65), 2.01 (CI=1.75 to 2.31), 3.11 (CI=2.61 to 3.70), 4.64 (CI=3.66 to 5.87), and 3.72 (CI=2.53 to 5.48). Cusions-In this nationwide study of fertile, apparently healthy women, pre-pregnancy BMI was strongly associated with an increased risk of diabetes, hypertension, and dyslipidemia within 5.5 years following childbirth.

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Body composition of the upper limb associated with hypertension, hypercholesterolemia, and diabetes

Qianjin Qi, Kui Sun, Ying Rong, Zhaoping Li, Yixia Wu, Di Zhang, Shuaihua Song, Haoran Wang, Li Feng

Summary: This study investigated the association between segmental body composition and metabolic diseases, specifically hypertension, hypercholesterolemia, and diabetes, in U.S. adults. The results showed that increased upper limb lean body mass was associated with a lower risk of these metabolic diseases, while increased upper limb fat mass was associated with an increased risk. Significant differences were also found between genders.

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