Review
Biochemistry & Molecular Biology
Santiago Alvarez-Argote, Caitlin C. O'Meara
Summary: Macrophages play vital roles in maintaining tissue homeostasis by clearing pathogens and have diverse functions beyond phagocytosis and immunity, such as maintaining mitochondrial function and promoting cardiac conduction. Tissue-resident macrophages in the heart adopt various functions, including clearing cell debris, reducing inflammation, promoting angiogenesis, and limiting damage extension after cardiac injury. Research on cardiac macrophages focuses on their origin, development, characterization, and function in homeostasis, regeneration, and response to injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ingrid Gomez, Virginie Robert, Paul Alayrac, Adele Arlat, Vincent Duval, Marie-Laure Renoud, Jose Vilar, Mathilde Lemitre, Jean-Sebastien Silvestre, Beatrice Cousin
Summary: Medullary and extra-medullary hematopoiesis play a significant role in regulating inflammatory cell infiltration and cardiac remodeling after acute myocardial infarction. Adipose tissue can serve as an alternative source of immune cell production and affect cardiac homeostasis. However, in the presence of diabetes, the function of immune cells derived from adipose tissue is compromised.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Pernille Heimdal Holm, Louise Hindso, Kristine Boisen Olsen, Jytte Banner
Summary: The study explores the associations between obesity, myocardial fat, visceral adipose tissue, and cardiovascular disease. It finds that myocardial fat is correlated with obesity and epicardial adipose tissue, but not with waist-hip ratio or visceral adipose tissue measures. The findings suggest that myocardial fat plays a role in cardiovascular health, particularly in the right ventricle.
Review
Cell Biology
Candice Bohaud, Rafael Contreras-Lopez, Jholy de la Cruz, Claudia Terraza-Aguirre, Mingxing Wei, Farida Djouad, Christian Jorgensen
Summary: Osteoarthritis is a multifaceted degenerative and inflammatory joint disorder, with current therapies often only providing short-term benefits without complete structural and functional reconstitution. Identifying novel therapeutic targets and strategies is crucial to achieve long-term clinical benefits for OA patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Ni Su, Yaoyao Hao, Fang Wang, Wenda Hou, Haifeng Chen, Ying Luo
Summary: This study demonstrates that cell-mediated delivery of mesenchymal stromal exosomes onto biofunctional scaffolds can induce beneficial immune cell responses in mouse skin wounds. Additionally, active adaptive T helper cell responses were found in remote immune organs, and exosome-laden scaffolds facilitated tissue repair in large skin injury models.
Article
Pharmacology & Pharmacy
B. Ozkaynak, I Sahin, E. Ozenc, C. Subasi, D. S. Oran, T. Totoz, U. S. Tetikkurt, B. Mert, A. Polat, E. Okuyan, E. Karaoz
Summary: The study demonstrated that epicardial adipose tissue-derived mesenchymal stem cells have the potential to improve cardiac function and reduce infarct size in a rabbit model of myocardial infarction. These cells could be a promising candidate for regenerative therapies in chronic heart conditions.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Cell Biology
Maria Serena Piccinno, Tiziana Petrachi, Marco Pignatti, Alba Murgia, Giulia Grisendi, Olivia Candini, Elisa Resca, Valentina Bergamini, Francesco Ganzerli, Alberto Portone, Ilenia Mastrolia, Chiara Chiavelli, Ilaria Castelli, Daniela Bernabei, Mara Tagliazucchi, Elisa Bonetti, Francesca Lolli, Giorgio De Santis, Massimo Dominici, Elena Veronesi
Summary: This study investigates the use of adipose-derived mesenchymal stromal/stem cells (AD-MSCs) in autologous fat transfer (AFT) for tissue reconstruction. The results show that AD-MSCs can improve graft persistence and reduce tissue resorption after AFT. The implanted AD-MSCs can persist and differentiate into mature adipocytes, leading to better outcomes in terms of graft weight and reduced cyst formation. This suggests a long-term protective and anti-inflammatory/proangiogenic role of AD-MSCs in autologous AFT tissue resorption.
Article
Biochemistry & Molecular Biology
Maria Kercheva, Vyacheslav Ryabov, Aleksandra Gombozhapova, Ivan Stepanov, Julia Kzhyshkowska
Summary: The aim of this study was to compare the composition of macrophages (mf) in the kidneys of patients with fatal myocardial infarction (MI) and patients without cardiovascular diseases (CVD). Kidney fragments taken during autopsy were used for analysis. The macrophage composition in the kidneys of MI patients was characterized by the predominance of CD163+ cells, while the control group showed predominance of CD163+, CD206+, and CD68+ cells. Further analysis and comparison with data from MI survivors could help determine the potential of targeting these cells for personalized therapy in postinfarction complications.
Article
Biochemistry & Molecular Biology
Julia Hesse, Wiebke Groterath, Christoph Owenier, Julia Steinhausen, Zhaoping Ding, Bodo Steckel, Constantin Czekelius, Christina Alter, Aseel Marzoq, Juergen Schrader
Summary: This study identified A(2B)R-mediated HIF-1 alpha induction as a novel aspect in the HIF-1 alpha-adenosine crosstalk, which modulates EpiSC activity and can potentially enhance HIF-1 alpha-mediated cardioprotection.
Review
Cardiac & Cardiovascular Systems
Andrea Lorenzo Poggi, Benedicte Gaborit, Thomas Hellmut Schindler, Luca Liberale, Fabrizio Montecucco, Federico Carbone
Summary: Obesity is a heterogeneous condition that may have a closer link with cardiovascular disease burden and atrial fibrillation. Dysfunction of epicardial adipose tissue (EAT) due to ectopic fat deposition is associated with atrial remodelling and may play a significant role in the development and recurrence of atrial fibrillation. This study provides an updated understanding of the relationship between dysfunctional EAT, LA remodelling, and atrial fibrillation onset and recurrence.
Article
Immunology
Omar K. Yaghi, Bola S. Hanna, P. Kent Langston, Daniel A. Michelson, Teshika Jayewickreme, Miguel Marin-Rodero, Christophe Benoist, Diane Mathis
Summary: Research has shown that muscle mesenchymal stromal cells respond rapidly to acute injury by expressing an early-responder subtype with a notable array of immune-related transcripts, inducing inflammation and promoting tissue regeneration. These early-responder cells play a critical role in coordinating immune responses and driving regenerative mechanisms following muscle injury.
Article
Cardiac & Cardiovascular Systems
Hanjay Wang, Terrence Pong, Oluwatomisin O. Obafemi, Haley J. Lucian, Joy Aparicio-Valenzuela, Nicholas A. Tran, Danielle M. Mullis, Stefan Elde, Yuko Tada, Sam W. Baker, Caroline Y. Wang, Kevin J. Cyr, Michael J. Paulsen, Yuanjia Zhu, Anson M. Lee, Y. Joseph Woo
Summary: Newborn piglets are capable of natural heart regeneration after myocardial infarction (MI) on the first day of birth, but this ability is lost by the seventh day. A study using magnetic resonance imaging and mapping arrays found that the epicardial conduction dynamics are well preserved in the naturally regenerated myocardium.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Iokfai Cheang, Xu Zhu, Xin Yue, Yuan Tang, Yujie Gao, Xinyi Lu, Shi Shi, Shengen Liao, Wenming Yao, Yanli Zhou, Haifeng Zhang, Yinsu Zhu, Yi Xu, Xinli Li
Summary: The purpose of this study was to investigate the prognostic values of ventricle epicardial fat volume (EFV) in patients with chronic heart failure (CHF) using cardiac magnetic resonance. A total of 516 CHF patients were recruited, and 136 (26.4%) of them experienced major adverse cardiovascular events (MACE) within a median follow-up of 24 months. The study found that EFV was significantly associated with MACE and showed promising predictive ability for MACE at different time points.
Article
Biochemistry & Molecular Biology
Shaowei Kang, Bin Wang, Yanan Xie, Xu Cao, Mei Wang
Summary: M1 and M2 macrophages are crucial for cardiac healing post-MI, with M1 macrophages playing a critical role in promoting remodeling through activation of the EMT pathway.
Review
Biochemistry & Molecular Biology
Giusi Alberti, Eleonora Russo, Simona Corrao, Rita Anzalone, Peter Kruzliak, Vitale Miceli, Pier Giulio Conaldi, Francesca Di Gaudio, Giampiero La Rocca
Summary: Extracellular vesicles (EVs) are one of the main mechanisms of communication between cells and the surrounding tissue or at distance. Recent studies have revealed the molecular composition and clinical indications of EVs derived from adult mesenchymal stromal cells (MSCs). These EVs maintain some of the properties of their parent cells and have important implications for cell-free therapies.
Article
Medicine, General & Internal
Anat Berkovitch, Alexey Naimushin, Nir Shlomo, Shlomi Matetzky, Roy Beigel, Michael Naroditsky, Elad Asher, Eli Rozen, Ilan Goldenberg, Robert Klempfner, Ronen Goldkorn
Summary: The study found that intermediate zone troponin elevation is an independent risk factor associated with adverse outcomes. Patients with an initial value in this range should be closely monitored and aggressively managed.
INTERNAL AND EMERGENCY MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Magdalena Skalnikova, Katerina Stano Kozubik, Jakub Trizuljak, Zuzana Vrzalova, Lenka Radova, Kamila Reblova, Radka Holbova, Terezia Kurucova, Hana Svozilova, Jiri Stika, Ivona Blahakova, Barbara Dvorackova, Marie Prudkova, Olga Stehlikova, Michal Smida, Leos Kren, Petr Smejkal, Sarka Pospisilova, Michael Doubek
Summary: Bernard-Soulier syndrome (BSS) is a rare inherited disorder characterized by large platelets, low platelet count, and prolonged bleeding time. This study identifies a likely pathogenic variant causing monoallelic BSS and provides insight into the clinical presentation and phenotype of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Tal Y. Samuel, Tal Hasin, Israel Gotsman, Tanya Weitzman, Fanny Ben Ivgi, Ziv Dadon, Elad Asher, Offer Amir, Michael Glikson, Ronny Alcalai, David Leibowitz
Summary: This study examined the effect of CoQ10 supplementation on diastolic function in elderly patients with HFpEF. The results showed that treatment with CoQ10 did not significantly affect echocardiographic indices of diastolic function and serum NT-proBNP levels in these patients.
Article
Cardiac & Cardiovascular Systems
Lior Lupu, Louay Taha, Rivka Farkash, Feras Bayya, Mohammad Karmi, Yoed Steinmetz, Fauzi Fadi Shaheen, Nimrod Perel, Kamal Hamayel, Nir Levi, Tommer Maller, Hani Karameh, Gavriel Lichewitz, Dov Gavish, Nurit Algur, Michael Glikson, Elad Asher
Summary: This study suggests that HbA1c levels are associated with prognosis in patients admitted to the ICCU, with prediabetes patients having the highest risk for mortality rates.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Lior Lupu, Louay Taha, Ariel Banai, Hezzy Shmueli, Ariel Borohovitz, Shlomi Matetzky, Mustafa Gabarin, Mony Shuvy, Roy Beigel, Katia Orvin, Sa'ar Minha, Yacov Shacham, Shmuel Banai, Michael Glikson, Elad Asher
Summary: Based on a nationwide survey in Israel, this study found that adherence to the European Society of Cardiology guidelines for immediate and early PCI in NSTEMI patients was inadequate, with patients who postponed coronary angiography being older and having more comorbidities.
CLINICAL CARDIOLOGY
(2022)
Article
Health Care Sciences & Services
Elad Asher, Alexander Fardman, Hezzy Shmueli, Katia Orvin, Daniel Oren, Natalia Kofman, Jameel Mohsen, Gassan Moady, Louay Taha, Ronen Rubinshtein, Osherov Azriel, Roi Efraim, Dabbah Saleem, Philippe Taieb, Eyal Ben-assa, Tal Cohen, Robert Klempfner, Amir Orlev, Roy Beigel, Amit Segev, Shlomi Matetzky
Summary: Contrary to previous reports, admission rates of NSTEMI remained stable during the COVID-19 era in Israel. Despite longer time from symptom onset to hospital admission, the time from hospital admission to reperfusion therapy was similar, and in-hospital and 30-day mortality rates were also similar.
INTERNATIONAL JOURNAL FOR QUALITY IN HEALTH CARE
(2022)
Review
Medicine, General & Internal
Sharon Bruoha, Chaim Yosefy, Louay Taha, Danny Dvir, Mony Shuvy, Rami Jubeh, Shemy Carasso, Michael Glikson, Elad Asher
Summary: Cardiogenic shock complicating acute myocardial infarction is a complex clinical condition with poor prognosis. Early target vessel revascularization is the most effective treatment, but mortality remains high. Temporary circulatory support devices aim to enhance cardiac unloading and improve organ perfusion, but there is a lack of quality evidence to guide device selection and management, highlighting the importance of multidisciplinary expert care.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Nimrod Perel, Elad Asher, Luoay Taha, Nir Levy, Yoed Steinmetz, Hani Karameh, Mohammad Karmi, Tomer Maller, Emanuel Harari, Danny Dvir, Michael Glikson, Shemy Carasso, Mony Shuvy
Summary: This study evaluated the effectiveness of urgent valve intervention using transcatheter edge-to-edge repair procedures in patients with cardiogenic shock. Results showed that this intervention was associated with higher 30-day and 6-month survival rates.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Gil Marcus, Natalia Kofman, Shiri L. Maymon, Elad Asher, Dan Loberman, David Pereg, Shmuel Fuchs, Sa'ar Minha
Summary: This study investigates the association between marital status and outcomes in patients with heart failure. The results show that there is no independent association between marital status and outcomes in patients admitted for acute decompensated heart failure. Efforts for improving outcomes should focus on other traditional risk factors.
CLINICAL CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Hani Karameh, Sharon Bruoha, Louay Taha, Meir Tabi, Rivka Farkash, Mohammad Karmi, Kamal Hamayel, Nimrod Perel, Yoed Steinmetz, David Marmor, Mohammed Manassra, Tomer Maller, Rafael Hitter, Itshak Amsalem, Michael Glikson, Elad Asher
Summary: This study aimed to assess the mortality rate and outcomes of patients treated with blood transfusion (BT) in a modern intensive cardiac care unit (ICCU). The study found that BT was associated with higher mortality rates in both the short and long term. Further consideration is needed to improve the strategy of BT administration in ICCU patients and develop guidelines for high-risk patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Stefano Cacciatore, Luigi Spadafora, Marco Bernardi, Mattia Galli, Matteo Betti, Francesco Perone, Giulia Nicolaio, Emanuele Marzetti, Anna Maria Martone, Francesco Landi, Elad Asher, Maciej Banach, Olivier Hanon, Giuseppe Biondi-Zoccai, Pierre Sabouret, C. Noel Bairey Merz
Summary: Coronary artery disease is a common condition in older adults but managing it is challenging due to the complexity of patient characteristics including frailty burden, comorbidities, and body composition abnormalities. The aim of this narrative review is to emphasize the importance of assessing frailty in guiding therapeutic decision-making and tailoring coronary artery disease management to the specific needs of older adults, taking into account age-related changes and potential drug interactions. The review also discusses gaps in evidence and offers perspectives on optimizing coronary artery disease management in older adults.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Elad Asher, Hani Karameh, Hamed Nassar, Chaim Yosefy, David Marmor, Nimrod Perel, Louay Taha, Meir Tabi, Omri Braver, Mony Shuvy, Yonit Wiener-Well, Michael Glikson, Sharon Bruoha
Summary: Administering vasopressors via a peripheral venous catheter is a safe and effective alternative for managing cardiogenic shock patients, with shorter treatment duration and similar rates of phlebitis and extravasation compared to central venous catheters. However, bleeding rate is lower in the peripheral venous catheter group.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Haijiang Dai, Arsalan Abu Much, Elad Maor, Elad Asher, Arwa Younis, Yawen Xu, Yao Lu, Xinyao Liu, Jingxian Shu, Nicola Luigi Bragazzi
Summary: This study aimed to estimate the burden and risk factors for ischaemic heart disease (IHD) in 195 countries and territories from 1990 to 2017. The results showed that IHD remains a major public health challenge worldwide, with variations in burden and temporal trends across different geographical locations. High blood pressure, high cholesterol, high blood sugar, smoking, and obesity were identified as the main risk factors for IHD deaths.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2022)
Article
Cardiac & Cardiovascular Systems
Nir Levi, Ziv Dadon, Yoed Steinmetz, Nimrod Perel, Amir Orlev, Elad Asher, Rami Jubeh, Rivka Farkash, Shmuel Gottlieb, Yaron Almagor, Danny Dvir, Michael Glikson, Rafael Wolff
Summary: Approximately 20% of STEMI patients have angiographically significant non-IRA CAD. Older age, male gender, and diabetes mellitus are independent predictors for non-IRA CAD, while smoking and family history of CAD predict IRA-only CAD. The presence of non-IRA CAD is associated with higher long-term all-cause mortality rates.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Hematology
Moshe Rav Acha, Louay Taha, Anna Turyan, Rivka Farkash, Feras Bayya, Mohammad Karmi, Yoed Steinmetz, Fauzi Fadi Shaheen, Nimrod Perel, Kamal Hamayel, Nir Levi, Hani Karameh, Ariella Tvito, Michael Glikson, Elad Asher
Summary: This study aimed to investigate the prognostic impact of D-dimer in intensive coronary care unit (ICCU) patients. The results showed that high D-dimer levels were associated with older age, more comorbidities, diverse admission diagnoses, and higher mortality rate. Therefore, D-dimer levels can serve as an independent poor prognostic factor in ICCU patients.
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2022)