Article
Cardiac & Cardiovascular Systems
Michael L. O'Byrne, Andrew C. Glatz, Yuan-shung Huang, Michael S. Kelleman, Christopher J. Petit, Athar M. Qureshi, Shabana Shahanavaz, George T. Nicholson, Shawn Batlivala, Jeffery J. Meadows, Jeffrey D. Zampi, Mark A. Law, Jennifer C. Romano, Christopher E. Mascio, Paul J. Chai, Shiraz Maskatia, Ivor B. Asztalos, Asaad Beshish, Joelle Pettus, Amy L. Pajk, Steven J. Healan, Lindsay F. Eilers, Taylor Merritt, Courtney E. McCracken, Bryan H. Goldstein
Summary: This study compares the economic costs of primary repair (PR) and staged repair (SR) in neonates with symptomatic tetralogy of Fallot (sTOF). The results show that PR is associated with lower total costs, cost per day alive, and department-level costs compared to SR.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Review
Pediatrics
Owen Hammett, Michael J. Griksaitis
Summary: "Tetralogy of Fallot (ToF) is a common cyanotic heart defect that requires care from pediatric intensive care teams throughout the different stages of management."
FRONTIERS IN PEDIATRICS
(2023)
Article
Anesthesiology
Kwannapas Saengsin, Francesca Sperotto, Minmin Lu, Julia Garcia Mancebo, Elizabeth Sacco, Manasee Godsay, James A. DiNardo, John N. Kheir
Summary: The use of milrinone within the first 72 hours following TOF repair is associated with more frequent administration of volume, a slower recovery of heart rate, and lower blood pressure, but is not associated with improved cardiac output.
ANESTHESIA AND ANALGESIA
(2023)
Article
Medicine, General & Internal
Christopher DeZorzi, Anais Marenco, Anne Marie Valente
Summary: Tricuspid regurgitation is a significant finding in patients who have undergone repair for tetralogy of Fallot, and it can have primary or secondary causes. Moderate or severe tricuspid regurgitation is associated with a higher occurrence of atrial tachyarrhythmias in these patients. The optimal timing for tricuspid valve intervention during pulmonary valve replacement in repaired tetralogy of Fallot patients remains uncertain.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Johanna Persson, Albert Gyllencreutz Castellheim, Mikael Dellborg, Kok Wai Giang, Christina Karazisi, Araz Rawshani, Zacharias Mandalenakis
Summary: A study in Sweden found that there has been a significant improvement in survival among pediatric patients with tetralogy of Fallot (TOF) who underwent surgery from 1970 to 2017, indicating the effectiveness of surgical correction. However, the mortality rate in this group is still higher compared to the general population, highlighting the need for further investigation into predictors of outcomes.
Review
Anesthesiology
Jianwen Li, Xiwen Wang, Wengui Liu, Shihong Wen, Xueping Li
Summary: This systematic review and meta-analysis aimed to examine the effectiveness of remote ischemia preconditioning (RIPreC) in reducing the duration of mechanical ventilation and intensive care unit (ICU) length of stay after pediatric cardiac surgery. The results showed that RIPreC did not reduce the duration of mechanical ventilation but reduced the ICU length of stay. However, in children not exposed to propofol, both mechanical ventilation duration and ICU length of stay were reduced by RIPreC.
BMC ANESTHESIOLOGY
(2023)
Article
Engineering, Biomedical
Alessia Di Nardo, Leslie Louvelle, David A. Romero, Matthew Doyle, Thomas L. Forbes, Cristina H. Amon
Summary: Tetralogy of Fallot (ToF), a congenital heart disease, can be alleviated through surgical application of a biocompatible vessel patch. This study used computational simulations to compare the mechanical performance of four patch materials at different stenosis locations. Biological patch materials showed higher stress levels compared to synthetic patch materials, regardless of stenosis location or patient anatomy.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Medical Laboratory Technology
Wei Wang, Hao Cui, Gao Ran, Chuhao Du, Xiao Chen, Shuo Dong, Siyuan Huang, Jun Yan, Junmin Chu, Jiangping Song
Summary: This study investigated the plasma metabolic profiles to identify key metabolites for early diagnosis of Tetralogy of Fallot (TOF), a common congenital heart disease. The researchers found significant metabolic differences between TOF patients and normal controls, specifically in nicotinamide and purine metabolism pathways. The study suggests that plasma FAD could serve as a highly valuable biomarker for differentiating TOF from normal. These findings contribute to the development of reliable biomarkers and improving early screening for TOF.
CLINICA CHIMICA ACTA
(2023)
Review
Physiology
Nouf J. Althali, Kathryn E. Hentges
Summary: Congenital heart defects refer to structural abnormalities of the heart or blood vessels present at birth, affecting approximately 1% of newborns worldwide. Tetralogy of Fallot is the most common cyanotic congenital heart abnormality, accounting for 5-10% of all congenital cardiac defects. While some cases of TOF are associated with known diseases or chromosomal abnormalities, the majority are non-syndromic and have unknown causes.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Nikesh Arya, Silvia Schievano, Massimo Caputo, Andrew M. Taylor, Giovanni Biglino
Summary: This study investigated the impact of pulmonary regurgitation (PR) on left ventricular ventriculo-arterial (VA) coupling in patients with repaired tetralogy of Fallot (ToF). The results suggested that increasing severity of PR leads to a decrease in the forward compression wave (FCW) peak in aortic wave intensity, due to interactions between the right and left ventricles. By utilizing cardiovascular magnetic resonance (CMR)-derived wave-intensity analysis, this study provided a non-invasive comparison between patients with different degrees of PR. The findings indicated that any level of PR resulted in a significant reduction in the FCW peak.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Bryan H. Goldstein, Christopher J. Petit, Athar M. Qureshi, Courtney E. McCracken, Michael S. Kelleman, George T. Nicholson, Mark A. Law, Jeffery J. Meadows, Jeffrey D. Zampi, Shabana Shahanavaz, Christopher E. Mascio, Paul J. Chai, Jennifer C. Romano, Sarosh P. Batlivala, Shiraz A. Maskatia, Ivor B. Asztalos, Alicia M. Kamsheh, Steven J. Healan, Justin D. Smith, R. Allen Ligon, Joelle A. Pettus, Sarina Juma, James E. B. Raulston, Krissie M. Hock, Amy L. Pajk, Lindsay F. Eilers, Hala Q. Khan, Taylor C. Merritt, Matthew Canter, Stephan Juergensen, Fatuma-Ayaan Rinderknecht, Holly Bauser-Heaton, Andrew C. Glatz
Summary: In this multicenter comparison of staged repair (SR) and primary repair (PR) for neonates with symptomatic tetralogy of Fallot (sTOF), early mortality and neonatal morbidity were lower in the SR group, while cumulative morbidity and reinterventions favored the PR group, suggesting potential benefits to each strategy.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Giorgio Spiniello, Giancarlo Scognamiglio, Assunta Merola, Michela Palma, Flavia Fusco, Berardo Sarubbi
Summary: Additional digital content is available in the text.
JOURNAL OF CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Jouke P. Bokma, Tal Geva, Lynn A. Sleeper, Ji Hae Lee, Minmin Lu, Tehila Sompolinsky, Sonya V. Babu-Narayan, Rachel M. Wald, Barbara J. M. Mulder, Anne Marie Valente
Summary: The study aimed to determine whether pulmonary valve replacement (PVR) is associated with improved survival and freedom from sustained ventricular tachycardia (VT) in patients with repaired tetralogy of Fallot (rTOF). The results showed that patients who received PVR had a lower risk of death or sustained VT compared to those who did not receive PVR.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Psychology, Clinical
Wan-Fu Hsu, Wu-Chien Chien, Chi-Hsiang Chung, Pi-Chang Lee, Der-Shiun Wang, Shao-Wei Huang, Hsin-An Chang, Yu-Chen Kao, Sung-Sen Yang, Nian-Sheng Tzeng
Summary: A study using a nationwide database in Taiwan found that patients with Tetralogy of Fallot (TOF) have nearly a 3-fold higher risk of developing psychiatric disorders, including anxiety, depression, bipolar, and sleep disorders, compared to the general population. Continued mental health screening and surveillance are recommended for TOF patients.
JOURNAL OF CLINICAL PSYCHIATRY
(2021)
Article
Cardiac & Cardiovascular Systems
Eva Havers-Borgersen, Jawad H. Butt, Morten Smerup, Gunnar H. Gislason, Christian Torp-Pedersen, Mathis Groning, Michael Rahbek Schmidt, Lars Sondergaard, Lars Kober, Emil L. Fosbol
Summary: Patients with tetralogy of Fallot (ToF) are at increased risk of infective endocarditis (IE), particularly those who undergo pulmonary valve replacement (PVR). Limited data exist on the long-term risk of IE, but the study confirms an association between PVR and increased incidence of IE.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Cardiac & Cardiovascular Systems
Jerome Soquet, David J. Barron, Yves d'Udekem
ANNALS OF THORACIC SURGERY
(2019)
Article
Cardiac & Cardiovascular Systems
Matthew S. Yong, Michael Z. L. Zhu, Douglas Bell, Nelson Alphonso, Johann Brink, Yves d'Udekem, Igor E. Konstantinov
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2019)
Editorial Material
Cardiac & Cardiovascular Systems
Julia S. Donald, FraserR. O. Wallace, Yves d'Udekem, Igore. Konstantinov
HEART LUNG AND CIRCULATION
(2019)
Article
Cardiac & Cardiovascular Systems
Chin L. Poh, David S. Celermajer, Leeanne E. Grigg, Jonathan M. Kalman, Mark A. McGuire, Thomas L. Gentles, Dorothy J. Radford, Andrew Bullock, Patrick J. S. Disney, David Winlaw, Karin du Plessis, Yves d'Udekem
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2019)
Article
Oncology
Chantal Attard, Joanna Huang, Fiona Newall, Paul Monagle, Yves d'Udekem, Vera Ignjatovic
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Emily Moroney, Diana Zannino, Rachael Cordina, Thomas Gentles, Yves d'Udekem, Dominica Zentner
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Tyson A. Fricke, Samantha Donaldson, James R. Schneider, Samuel Menahem, Yves d'Udekem, Christian P. Brizard, Igor E. Konstantinov
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2020)
Article
Cardiac & Cardiovascular Systems
Michael Daley, Karin du Plessis, Dianna Zannino, Tim Hornung, Patrick Disney, Rachael Cordina, Leeanne Grigg, Dorothy J. Radford, Andrew Bullock, Yves d'Udekem
Article
Cardiac & Cardiovascular Systems
Cristina Villa del Campo, Norman Y. Liaw, Mala Gunadasa-Rohling, Moritz Matthaei, Luca Braga, Tahnee Kennedy, Gabriela Salinas, Niels Voigt, Mauro Giacca, Wolfram-Hubertus Zimmermann, Paul Richard Riley
Summary: Researchers investigated the signaling of epicardial EVs to promote cardiomyocyte proliferation in infarcted mouse hearts and a human myocardial injury model. Deep RNA-sequencing revealed conserved miRs in exosomes derived from mouse and human epicardium, and the combination of these miRs replicated the therapeutic effects of promoting cardiomyocyte proliferation.
CARDIOVASCULAR RESEARCH
(2022)
Article
Nanoscience & Nanotechnology
Naim Kittana, Mohyeddin Assali, Wolfram-Hubertus Zimmermann, Norman Liaw, Gabriela Leao Santos, Abdul Rehman, Susanne Lutz
Summary: The study showed that reinforcement of ECT using C-MWCNT can enhance the biophysical properties of the tissue, including increased stiffness, reduced contraction, improved elasticity and extensibility, as well as higher resilience and toughness compared to control tissues.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Tarek Alsaied, Rahul H. Rathod, Jamil A. Aboulhosn, Werner Budts, Jeffrey B. Anderson, Helmut Baumgartner, David W. Brown, Rachael Cordina, Yves D'udekem, Salil Ginde, David J. Goldberg, Bryan H. Goldstein, Adam M. Lubert, Erwin Oechslin, Alexander R. Opotowsky, Jack Rychik, Kurt R. Schumacher, Anne Marie Valente, Gail Wright, Gruschen R. Veldtman
Summary: This study reached a consensus among experts using the Delphi methodology to establish unified definitions for morbidities seen after the Fontan palliation, aiming to standardize research and clinical practices in this field.
Article
Cardiac & Cardiovascular Systems
Yaroslav Ivanov, Edward Buratto, Phillip Naimo, Adrienne Lui, Thomas Hu, Yves D'Udekem, Christian P. Brizard, Igor E. Konstantinov
Summary: The incidence of LVOTO after AVSD repair is low, but the recurrence rate is high. Standard subaortic resection does not always provide definitive relief for LVOTO. Survival after LVOTO reoperation is excellent.
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Alyssia Venna, Yves d'Udekem
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Soichiro Henmi, Yasin Essa, Mahmut Ozturk, Aybala Tongut, Manan Desai, Can Yerebakan, Yves d'Udekem
Summary: This study retrospectively evaluated the outcomes of cardiovascular surgery in very low birth weight patients. The study found that the occurrence of postoperative intracerebral hemorrhage was significantly higher in low birth weight patients compared to slightly higher weight patients. The early and late mortality rates were also higher in the low birth weight group. Early surgery was acceptable for simple lesions, while delayed surgery may provide better long-term outcomes for complex lesions.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Biochemical Research Methods
Malte Tiburcy, Tim Meyer, Norman Y. Liaw, Wolfram-Hubertus Zimmermann