Review
Cell Biology
Mykyta Malkov, Chee Teik Lee, Cormac T. Taylor
Summary: Hypoxia and inflammation frequently co-occur in inflammatory diseases, with pro-inflammatory cytokines such as TNF-alpha and IL-1 beta directly impacting HIF signaling pathways. Multi-level crosstalk between inflammatory and hypoxic signaling pathways plays a crucial role in shaping the degree of inflammation at hypoxic sites.
Article
Biochemistry & Molecular Biology
Zhe Yang, Tengling Li, Jianzhong Xian, Jia Chen, Yin Huang, Qin Zhang, Xiufang Lin, Hongyun Lu, Yubi Lin
Summary: This study found that SGLT2i attenuated cardiac dysfunction and adverse remodeling in ACM by suppressing cardiac fibrosis and inflammation via reverting the HIF-2 alpha signaling pathway. This suggests that SGLT2i is a novel and available therapy for ACM.
Article
Neurosciences
Huifei Hao, Yuxuan Hou, Aicheng Li, Li Niu, Shaolan Li, Bingqiang He, Xingyuan Zhang, Honghua Song, Rixin Cai, Yue Zhou, Chun Yao, Yongjun Wang, Yingjie Wang
Summary: SCI-induced activation of HIF-1a promotes MIF production from astrocytes, which may be beneficial for clinical treatment of neuroinflammation.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Maciej Jaskiewicz, Adrianna Moszynska, Jaroslaw Kroliczewski, Aleksandra Cabaj, Sylwia Bartoszewska, Agata Charzynska, Magda Gebert, Michal Dabrowski, James F. Collawn, Rafal Bartoszewski
Summary: HIF is a transcription factor that activates the adaptive hypoxic response during low oxygen levels. HIF-1 and HIF-2 mediate this response in a sequential manner, but their transcriptional profiles differ and the transition between them is not well understood.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Adiza Abass, Tokuju Okano, Kotchakorn Boonyaleka, Ryo Kinoshita-Daitoku, Shoji Yamaoka, Hiroshi Ashida, Toshihiko Suzuki
Summary: The study revealed that under hypoxic conditions, Helicobacter pylori can trigger enhanced host immune responses, with HIF-1 alpha playing a crucial role in the process.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Pharmacology & Pharmacy
Xinguo Jiang, Wen Tian, Dongeon Kim, Alexander S. McQuiston, Ryan Vinh, Stanley G. Rockson, Gregg L. Semenza, Mark R. Nicolls
Summary: Lymphedema is a chronic inflammatory disorder with incomplete understanding of its pathology and lack of approved pharmacological therapy. Studying hypoxia-regulated pathways in lymphedema may lead to new treatment approaches.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Yang Yu, Jian He, Wenhui Liu, Zhimin Li, Shaoping Weng, Jianguo He, Changjun Guo
Summary: This study investigated the characterization of PHD2 gene from mandarin fish and its role in the HIF-1 signaling pathway. The results showed that overexpression of scPHD2 could inhibit the HIF-1 signaling pathway and promote the degradation of scHIF-1a. This study enhances our understanding of the molecular mechanisms underlying hypoxia adaptation in teleost fish.
Review
Biochemistry & Molecular Biology
Thuy-Hang Nguyen, Stephanie Conotte, Alexandra Belayew, Anne-Emilie Decleves, Alexandre Legrand, Alexandra Tassin
Summary: Muscular dystrophies are genetic degenerative muscle disorders characterized by muscle wasting, often accompanied by respiratory impairments and hypoxemia. Hypoxic stress activates compensatory mechanisms, with HIF-1α playing a key role. Alterations in HIF-1α in muscle may impact the pathophysiology of muscular dystrophies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Cell Biology
Narges Moasefi, Mehdi Fouladi, Amir Hossein Norooznezhad, Reza Yarani, Adibeh Rahmani, Kamran Mansouri
Summary: The COVID-19 pandemic remains a global challenge, with inflammation and cytokine storm being key factors in the pathogenesis of the disease. HIF-1α activation following hypoxia-induced ARDS plays a crucial role in cytokine storm progression. Utilizing PFCs as a co-treatment to reduce hypoxemia and affect NF kappa B pathway shows promise in mitigating COVID-19 ARDS, warranting further research evaluation.
INFLAMMATION RESEARCH
(2021)
Article
Immunology
Ju-Won Jang, Sojin Park, Eun-Yi Moon
Summary: B cells may be regulated by crosstalk between HIF-1 alpha and Nrf2 through ROS-mediated Syk activation, where HIF-1 alpha levels might control Nrf2 levels and vice versa, possibly associated with Syk phosphorylation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Immunology
Tineke Vanderhaeghen, Rudi Beyaert, Claude Libert
Summary: Glucocorticoid-induced and hypoxia-induced transcriptional responses play crucial roles in maintaining tissue homeostasis and regulating cellular stress and inflammatory responses. Cells respond rapidly to hypoxia to prevent metabolic shutdown and death through hypoxia inducible factors (HIFs). The crosstalk between the glucocorticoid receptor (GR) and HIFs has been investigated, and the therapeutic effects of GCs on HIF-mediated diseases have been discussed.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yu-Kun Jie, Jian-Jun Jiang, Hong-Ling Ma, Chang -Hong Cheng, Guang-Xin Liu, Si-Gang Fan, Juan Feng, Zhi-Xun Guo
Summary: In this study, a novel PHD2 gene, SpPHD2, was cloned and identified in the mud crab Scylla paramamosain. The mRNA expression of SpPHD2 was widely distributed across all examined tissues, and the protein was mainly localized in the cytoplasm. Silencing SpPHD2 in vivo upregulated SpHIF-1 alpha and downstream genes, while overexpression of SpPHD2 in vitro dose-dependently reduced SpHIF-1 alpha transcriptional activity, indicating the crucial role of SpPHD2 in regulating SpHIF-1 alpha.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hao Cai, Zhenzhong Bai, Ri-Li Ge
Summary: The study revealed that hypoxia exposure can promote the development of NASH by upregulating HIF-2 alpha, further activating NF-kappa B, exacerbating fibrosis and inflammation, providing a new approach for the treatment of NASH.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Oncology
Leah Davis, Matthias Recktenwald, Evan Hutt, Schuyler Fuller, Madison Briggs, Arnav Goel, Nichole Daringer
Summary: Hypoxia, or inadequate oxygen supply, is a characteristic of the tumor microenvironment and is associated with a poor prognosis and resistance to therapy. HIF-alpha, specifically the HIF-1 alpha and HIF-2 alpha subunits, play a crucial role in mediating the transcription of important proteins involved in tumor progression. While HIF-1 alpha has been extensively studied, the role of HIF-2 alpha is often overlooked. HIF-2 alpha can enhance the aggressive behavior of tumors, promoting metastasis, tissue remodeling, angiogenesis, and the upregulation of cancer stem cell factors. This review highlights the structure, function, hypoxic response, and roles of HIF-2 alpha in cancer progression, as well as discussing current therapeutic strategies and future directions.
Review
Biochemistry & Molecular Biology
Alina Mihaela Stanigut, Camelia Pana, Manuela Enciu, Mariana Deacu, Bogdan Cimpineanu, Liliana Ana Tuta
Summary: Research has found that hypoxia response and hypoxia-inducible factors play critical roles in the pathogenesis of diabetic nephropathy, and HIF stabilizers are considered as novel therapeutic agents for treating anemia in CKD patients and relieving oxidative stress in renal tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
