Review
Biochemistry & Molecular Biology
Panagiotis Tsioufis, Panagiotis Theofilis, Konstantinos Tsioufis, Dimitris Tousoulis
Summary: Coronary atherosclerosis is a chronic disease involving inflammation, endothelial dysfunction, and lipoprotein dysregulation. Inflammatory cytokines, such as interleukins, tumor necrosis factor-alpha, and chemokines, play a role in the development and progression of coronary artery disease. Targeting these cytokines with drugs like IL-1 beta and colchicine has shown promise in reducing cardiovascular risk. Other cytokine-targeted treatments are being explored, but more research is needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Ali Rafiei, Reza Ahmadi, Shakiba Kazemian, Tina Rahimzadeh-Fallah, Mina Mohammad-Rezaei, Fatemeh Azadegan-Dehkordi, Samira Sanami, Yousef Mirzaei, Farzad Aghaei, Nader Bagheri
Summary: Coronary artery disease (CAD) is a major cause of death worldwide. Recent evidence suggests that inflammation plays a crucial role in the progression of atherosclerosis. This study aimed to compare serum levels of interleukin-37 (IL-37) in CAD patients and controls, and investigate its correlation with oxidative stress, cholesterol homeostasis, and inflammation. The results showed that CAD patients had significantly lower levels of IL-37 compared to controls, and IL-37 was significantly increased in men with CAD compared to women with CAD. IL-37 was also inversely correlated with various inflammatory markers and oxidative stress, and positively correlated with antioxidant power.
JOURNAL OF INVESTIGATIVE MEDICINE
(2022)
Article
Medicine, General & Internal
Xiaoying Kang, Tong Jiao, Haiyang Wang, John Pernow, Karin Wirdefeldt
Summary: This study evaluated the repurposing potential of TNF inhibitors for coronary artery disease (CAD) and ischemic stroke (IS) using drug-target Mendelian randomization design. The findings suggest that TNF/TNFR1 blockade does not have a protective effect on CAD or IS. Further research is needed to explore potential strategies to counteract the detrimental effects of circulating TNF on CAD and IS.
Article
Veterinary Sciences
Carol G. Chitko-McKown, Gary L. Bennett, Larry A. Kuehn, Keith D. DeDonder, Michael D. Apley, Gregory P. Harhay, Michael L. Clawson, Aspen M. Workman, Bradley J. White, Robert L. Larson, Sarah F. Capik, Brian V. Lubbers
Summary: The study found no significant differences in cytokine and HPT profiles between animals receiving metaphylaxis and saline-treated controls over time, with differences mainly observed between animals with BRDC and those that remained healthy. The origin of the sale barn tended to affect TNF-alpha concentration, and differences for all analytes changed over days, associated with the state of origin and treatment method. The Treatment by Day by Case interaction was significant for HPT.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Medicine, General & Internal
Afrouz Behboudi, Tilia Thelander, Duygu Yazici, Yeliz Celik, Tulay Yucel-Lindberg, Erik Thunstrom, Yuksel Peker
Summary: Obstructive sleep apnea is common in patients with coronary artery disease, and the TNF-alpha-308A allele appears to modulate circulatory TNF-alpha levels and mitigate excessive daytime sleepiness in this population.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Yeliz Celik, Yueksel Peker, Tuelay Yucel-Lindberg, Tilia Thelander, Afrouz Behboudi
Summary: This study examined the effect of TNF-alpha (-308G/A) gene polymorphism on circulating TNF-alpha levels after continuous positive airway pressure (CPAP) therapy in coronary artery disease (CAD) patients with obstructive sleep apnea (OSA). The results suggest that individuals with the TNF-alpha A allele have a smaller response to CPAP treatment regarding the decline in circulating TNF-alpha levels.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Helene Kolstad Skovdahl, Shreya Gopalakrishnan, Tarjei Dahl Svendsen, Atle van Beelen Granlund, Ingunn Bakke, Zekarias G. Ginbot, Silje Thorsvik, Arnar Flatberg, Bjornar Sporsheim, Jenny Ostrop, Tom Eirik Mollnes, Arne Kristian Sandvik, Torunn Bruland
Summary: Treatment of inflammatory bowel disease (IBD) is challenging due to the limited efficacy of available drugs, highlighting the need for biomarkers and assays to predict drug effect. The intestinal epithelium plays a crucial role in disease pathogenesis and offers a promising target for IBD treatments. Lowering oxygen concentration can better mimic the in vivo physiological environment of colonic epithelial cells and enhance the translational value of intestinal organoids in drug testing.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Ana Carolina Matias Dinelly Pinto, Rodolfo de Melo Nunes, Igor Albuquerque Nogueira, Bernhard Fischer, Rudolf Lucas, Virginia Claudia Carneiro Girao-Carmona, Vivian Louise Soares de Oliveira, Flavio Almeida Amaral, Georg Schett, Francisco Airton Castro Rocha
Summary: TNF inhibitors are commonly used for the treatment of arthropathies like rheumatoid arthritis (RA), but not all patients achieve remission and there is a risk of infection. This study found that the lectin-like domain of TNF has anti-inflammatory effects and can mitigate the development of immune-mediated arthritis in mice.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Olga M. Koper-Lenkiewicz, Kinga Sutkowska, Natalia Wawrusiewicz-Kurylonek, Ewa Kowalewska, Joanna Matowicka-Karna
Summary: Studies have shown that the relationship between SNPs in proinflammatory cytokines genes and susceptibility to developing RA is inconclusive and varies among different ethnic populations. These polymorphisms also have an impact on clinicopathological features of RA and patients' response to treatment. Further research on larger cohorts and diverse populations is needed to elucidate the role of these SNPs in RA patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Psychiatry
Maria Skibinska, Aleksandra Rajewska-Rager, Monika Dmitrzak-Weglarz, Pawel Kapelski, Natalia Lepczynska, Mariusz Kaczmarek, Joanna Pawlak
Summary: Bipolar disorder is a disabling psychiatric illness that often begins with a depressed mood episode. Currently, there is a lack of diagnostic tools or biomarkers to predict the conversion from major depressive disorder to bipolar disorder. This study aimed to find biomarkers for diagnosis conversion in young patients with mood disorders. The researchers found correlations between cytokine levels and symptom severity and defense mechanisms, but no predictors of diagnosis conversion were discovered.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Ana Paula Anzolin, Jacson Gabriel Feiten, Giovana Bristot, Gabriela Maria Pereira Possebon, Marcelo Pio de Almeida Fleck, Marco Antonio Caldieraro, Marcia Kauer-Sant'Anna
Summary: Early-onset major depressive disorder (MDD) is associated with changes in systemic inflammatory markers, specifically higher levels of TNFα and IL-1β. IL-6 levels are also higher in the early-onset group, while IL-10 levels are higher in the late-onset group. Imbalance in inflammatory markers may contribute to the severity and progression pattern of depressive disorders.
PSYCHIATRY RESEARCH
(2022)
Article
Allergy
Shakiba Kazemian, Reza Ahmadi, Ali Rafiei, Fatemeh Azadegan-Dehkordi, Arsalan Khaledifar, Meghdad Abdollahpour-Alitappeh, Nader Bagheri
Summary: This study found higher serum levels of IL-36 in patients with coronary artery disease (CAD) and their association with the serum levels of tumor necrosis factor (TNF)-alpha, IL-6, and IL-32. The high levels of IL-36 may play a key role in the pathogenesis of CAD.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2022)
Article
Oncology
Paula Roberta Aguiar Pastrez, Ana Margarida Barbosa, Vania Sammartino Mariano, Rhafaela Lima Causin, Antonio Gil Castro, Egidio Torrado, Adhemar Longatto-Filho
Summary: Esophageal squamous cell carcinoma (ESCC) is a rapidly progressing cancer with high mortality rates. In this study, we investigated the levels of inflammatory cytokines in ESCC patients and healthy individuals. We found increased levels of IL-1 beta, IL-6, IL-8, and IL-10 in ESCC patients. Among these cytokines, IL-8 was identified as an independent prognostic factor for ESCC. Additionally, patients with low IL-6, IL-8, TNM I/II, or those who underwent surgery had a higher overall survival rate. Our findings suggest IL-8 as a potential biomarker for ESCC.
Review
Biochemistry & Molecular Biology
Bong-Woo Lee, Su-Jin Moon
Summary: Psoriatic arthritis (PsA) is a chronic inflammatory disease that affects individuals with psoriasis, arthritis, and enthesitis. Inflammatory cytokines, such as TNF-α, IL-23, and IL-17, play a crucial role in the onset and progression of PsA by attracting inflammatory cells to the joint tissues and causing cartilage and bone deterioration. Blocking these cytokines has shown significant clinical benefits, and further research is being conducted to explore other potential therapeutic targets for PsA treatment. This review discusses the current understanding of the role of inflammatory cytokines in PsA pathogenesis and the clinical implications of targeting these cytokines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Jing Zhang, Haobo Weng, Qiongfei Pei, Penghui Yang, Wentao Fan, Ruixi Liu, Qijian Yi
Summary: In Kawasaki disease (KD) patients, serum TL1A levels are significantly higher in the acute phase compared to controls, with a more substantial increase in KD patients with coronary artery aneurysms (CAA). TL1A levels are positively correlated with the duration of fever and the time point of IVIG treatment and white blood cell count, while negatively correlated with red blood cell count, hemoglobin, and albumin levels. TL1A may play a role in KD-associated vasculitis and the development of CAAs.
CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Article
Mathematical & Computational Biology
Arezoo Orooji, Toktam Sahranavard, Mohammad-Taghi Shakeri, Mohammad Tajfard, Seyed Ehsan Saffari
Summary: This paper investigates the risk factors of the number of vessels with obstructive coronary artery disease and proposes a novel statistical model. The study finds significant associations between BMI, gender, and the count of obstructive vessels. The proposed model demonstrates better goodness-of-fit compared to conventional regression models.
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
(2022)
Review
Pathology
Amir Abbas Hamidi, Malihe Zangoue, Daniel Kashani, Amir Sadra Zangouei, Hamid Reza Rahimi, Mohammad Reza Abbaszadegan, Meysam Moghbeli
Summary: Cancer is a major global health challenge, and early detection of tumors is crucial for reducing mortality rates. MicroRNAs, particularly miR-217, play key roles in cell regulation and can serve as non-invasive diagnostic markers in cancer patients. miR-217 functions by regulating transcription factors and targeting important signaling pathways in various cancers, making it a promising therapeutic target in cancer therapy.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2022)
Article
Marine & Freshwater Biology
Parichehr Hanachi, Mehdi Khoshnamvand, Tony R. Walker, Amir Hossein Hamidian
Summary: The presence of natural organic matter (NOM), modeled by humic acid (HA), can mitigate the acute toxicity of amino-functionalized polystyrene nanoplastics (PS-NH2) to green microalga Chlorella vulgaris, reducing cellular aggregation and cell size reduction. Higher concentrations of HA are more effective in reducing the toxicity of PS-NH2. The formation of cellular aggregates under the influence of PS-NH2 is likely related to the electrostatic attraction between the positively charged surfaces of the particles and the negatively charged polysaccharide walls of C. vulgaris.
AQUATIC TOXICOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Sara Saffar Soflaei, Maryam Saberi-Karimian, Mojtaba Baktashian, Mohammad Tajfard, Hedieh Alimi, Maryam Tayefi, Mohsen Moohebati, Mahmoud Ebrahimi, Negin Kosari, Mashallah Dehghani, Habibollah Esmaily, Seyed Mohammad Hashemi, Gordon A. Ferns, Mansoor Salehi, Alireza Pasdar, Majid Ghayour-Mobarhan
Summary: This study found that the levels of pro-inflammatory and anti-inflammatory cytokines and growth factors were higher in patients with coronary artery disease (CAD) 12 months after stent implantation. However, the level of high-sensitive C-reactive protein (hs-CRP) decreased in these patients, suggesting that drug treatment may play a positive role in attenuating inflammation in CAD patients.
Article
Biochemistry & Molecular Biology
Mostafa Dastani, Hamid Reza Rahimi, Vahid Reza Askari, Mahmoud Reza Jaafari, Lida Jarahi, Asal Yadollahi, Vafa Baradaran Rahimi
Summary: Nano-curcumin has a significant impact on cardiovascular risk factors in type 2 diabetic patients, reducing inflammation marker hs-CRP and lipoprotein levels, and potentially preventing atherosclerosis progression and cardiovascular events.
Article
Biochemical Research Methods
Zahra Gharari, Parichehr Hanachi, Tony R. Walker
Summary: Scutellaria multicaulis stem extract was used to synthesize silver nanoparticles (Sm-AgNPs) which exhibited optimal shape, size, and stability for drug use. These Sm-AgNPs showed higher antioxidant activity and effective anticancer properties against MDA-MB231 cells, indicating their potential as new antitumor agents for breast cancer treatment.
ANALYTICAL BIOCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Zahra Gharari, Parichehr Hanachi, Hanie Sadeghinia, Tony R. Walker
Summary: This study synthesized silver nanoparticles using C. intybus leaf-derived callus extract and evaluated their antibacterial, antioxidant, and anticancer activities. The results showed that these silver nanoparticles exhibited significant cytotoxicity against breast cancer cells and inhibitory effects on cell proliferation. Additionally, they demonstrated strong antibacterial and antioxidant activities.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Physical
Parichehr Hanachi, Zahra Gharari, Hanie Sadeghinia, Tony R. Walker
Summary: In this study, silver nanoparticles (Hp-AgNPs) were synthesized using stem extract of Persian hogweed and their phytochemical contents, antioxidant, and anti-proliferative activities were evaluated. The biosynthesized Hp-AgNPs showed high antioxidant activity and inhibited the growth of human breast cancer cells.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Immunology
Maryam Shayani Rad, Mohsen Moohebati, Seyed Ahmad Mohajeri
Summary: This study investigated the effects of celery seed extract as a supplement on anxiety and depression in hypertensive patients. The results showed that celery can significantly reduce symptoms of anxiety and depression, as well as lower blood pressure.
INFLAMMOPHARMACOLOGY
(2023)
Review
Biology
Amir Sadra Zangouei, Malihe Zangoue, Negin Taghehchian, Alireza Zangooie, Hamid Reza Rahimi, Ehsan Saburi, Mahya Sadat Alavi, Meysam Moghbeli
Summary: Cell cycle plays a crucial role in tumor progression, and molecular pathways targeting cell cycle progression are of great interest in cancer research. Long non-coding RNAs (LncRNAs) have been identified as potential non-invasive markers for the early detection of breast cancer due to their stability in body fluids. In this review, we summarize the reported LncRNAs involved in cell cycle regulation in breast cancer, with a focus on their impact on the G1/S transition through the CCND1/CDK4-6 complex. This review provides insights into the potential of cell cycle-related LncRNAs as efficient markers for early breast cancer detection.
BIOLOGICAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Parastoo Golpour, Mohammad Tajfard, Majid Ghayour-Mobarhan, Mohsen Moohebati, Ali Taghipour, Habibollah Esmaily, Sara Sabbaghian Tousi
Summary: This study compared the application of Random Forest (RF) and Artificial Neural Network (ANN) in diagnosing Coronary Artery Disease (CAD). The results showed that both methods could predict the outcome of coronary angiography by considering multiple features, and identified several important predictive factors.
INTERNATIONAL CARDIOVASCULAR RESEARCH JOURNAL
(2022)
Article
Clinical Neurology
Mina Erfani, Farah Ashrafzadeh, Hamid Reza Rahimi, Seyed Ali Ebrahimi, Keivan Kalali, Mehran Beiraghi Toosi, Elnaz Faraji Rad
Summary: A double-blinded randomized clinical trial was conducted on 22 pediatric patients with intractable epilepsy, showing that nanomicelle curcumin significantly reduced the number of seizures.
IRANIAN JOURNAL OF CHILD NEUROLOGY
(2022)
Review
Genetics & Heredity
Mohammad Reza Abbaszadegan, Majid Mojarrad, Hamid Reza Rahimi, Meysam Moghbeli
Summary: Non-coding RNAs are found to be the main factors involved in gastric cancer tumorigenesis among the Iranian population, highlighting the need for an efficient and general panel of molecular markers for early detection.
EGYPTIAN JOURNAL OF MEDICAL HUMAN GENETICS
(2022)
Article
Medicine, Research & Experimental
Hamid Reza Rahimi, Mohammad Reza Abbaszadegan, Meysam Moghbeli
Summary: Cancer is a major global health challenge, and late diagnosis in advanced stages of the disease is a leading cause of cancer-related mortality. Non-invasive diagnostic methods are needed for early detection of tumors. MiR-96, a stable circulating miRNA, plays important roles in tumor progression and metastasis, and can serve as an efficient non-invasive tumor marker.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2022)