Article
Multidisciplinary Sciences
Masaru Mizukoshi, Masaru Kaku, Lay Thant, Kohei Kitami, Moe Arai, Isao Saito, Katsumi Uoshima
Summary: The study revealed that periodontal ligament (PDL) cells exhibit dynamic proliferative characteristics during orthodontic tooth movement-induced tissue remodeling, with proliferative cells likely undergoing further division and contributing to tissue remodeling. Additionally, proliferating cells expressed various molecular markers, indicating the lineage plasticity of PDL cells in vivo.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Xin Gao, Fang Hong, Zhenyu Hu, Zilong Zhang, Yang Lei, Xiaoyun Li, Tao Cheng
Summary: ABC portal is a database and web portal that contains 198 single-cell transcriptomic datasets related to the development, differentiation, and disorders of blood/immune cells. It provides interactive analysis modules and customized analysis functions, facilitating the exploration and re-analysis of single-cell data by researchers and clinicians.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Cell Biology
Tomohiro Minakawa, Tetsuya Matoba, Fumiyoshi Ishidate, Takahiro K. Fujiwara, Sho Takehana, Yasuhiko Tabata, Jun K. Yamashita
Summary: The study demonstrates that neighboring cells can synchronize their differentiation stages and cellular phenotypes via extracellular vesicle (EV)-mediated cellular communication.
JOURNAL OF EXTRACELLULAR VESICLES
(2021)
Article
Biochemistry & Molecular Biology
Maria Mesuraca, Clelia Nistico, Nicola Lombardo, Giovanna Lucia Piazzetta, Nadia Lobello, Emanuela Chiarella
Summary: Killian’s (antrochoanal) polyp is a unilateral nasal polypoid lesion that mainly affects children and young adults, with unclear etiology but potentially linked to chronic inflammation, autoimmune reactions, allergies, and viral infections. The study isolated and cultured mesenchymal stem cells from surgical biopsies of patients with this condition, revealing differences in cell proliferation, migration, and differentiation potential between KNP-MSCs and HNT-MSCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biotechnology & Applied Microbiology
Xia Zhao, Daniel A. Hu, Di Wu, Fang He, Hao Wang, Linjuan Huang, Deyao Shi, Qing Liu, Na Ni, Mikhail Pakvasa, Yongtao Zhang, Kai Fu, Kevin H. Qin, Alexander J. Li, Ofir Hagag, Eric J. Wang, Maya Sabharwal, William Wagstaff, Russell R. Reid, Michael J. Lee, Jennifer Moriatis Wolf, Mostafa El Dafrawy, Kelly Hynes, Jason Strelzow, Sherwin H. Ho, Tong-Chuan He, Aravind Athiviraham
Summary: Cartilage, especially articular cartilage, is crucial for joint function and mobility, but has limited self-repair capacity. Cartilage tissue engineering (CTE) holds promise for repair, requiring effective chondrogenic factors, ample chondrogenic progenitors, and cell-friendly, biocompatible scaffold materials for success. Progress in these areas, along with advancements in 3D bio-printing, may improve clinical outcomes of cartilage repair.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Cell Biology
Remy Vu, Suoqin Jin, Peng Sun, Daniel Haensel, Quy Hoa Nguyen, Morgan Dragan, Kai Kessenbrock, Qing Nie, Xing Dai
Summary: This study used single-cell RNA sequencing to analyze the cellular and communication changes in young and aged skin wounds. It found that aged skin wounds have a more pronounced inflammatory response and higher abundance of inflammatory/glycolytic macrophages. The study also predicted differences in cell-cell communication between young and aged skin wounds.
Article
Biochemical Research Methods
Jiang Qian, Yadi Wang, Xueling Li, Junhong Lu
Summary: The stem cell microenvironment is crucial for regulating cell proliferation and differentiation. This study utilizes synchrotron radiation-based Fourier transform infrared microspectroscopy to examine the combined effects of physical and chemical factors on stem cell differentiation at the single-cell level. The results demonstrate the distinct effects of low-concentration lithium and Wnt5a on human mesenchymal stem cells in a polyvinyl alcohol (PVA) hydrogel, highlighting the important role of niche signals in the Wnt pathway. These findings emphasize the significance of the microenvironment in chemical-induced effects on stem cell differentiation and provide a label-free, noninvasive method to identify niche function in stem cell biology.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Cell Biology
Huey-Shan Hung, Yi-Chin Yang, Chih-Hsuan Chang, Kai-Bo Chang, Chiung-Chyi Shen, Chien-Lun Tang, Szu-Yuan Liu, Chung-Hsin Lee, Chun-Ming Yen, Meng-Yin Yang
Summary: The study demonstrates that the composite material of chitosan and gold nanoparticles can enhance the neural differentiation of mesenchymal stem cells and has the potential as a biosafe nanomaterial for neural tissue engineering.
Article
Chemistry, Multidisciplinary
Deogil Kim, Byung-Hyun Cha, Jinsung Ahn, Yoshie Arai, Bogyu Choi, Soo-Hong Lee
Summary: Understanding the biophysical relationships between stem cells and applied biomaterials is crucial in controlling stem cell functions. This study highlights the significant role of 3D microenvironment, particularly methacrylated hyaluronic acid (HA) hydrogel, in improving cellular reprogramming into iPSCs. The incorporation of cues from the 3D microenvironment accelerates the reprogramming process, offering potential advantages for translational applications.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Multidisciplinary Sciences
Mohammad Faujul Kabir, Adam L. Karami, Ricardo Cruz-Acuna, Alena Klochkova, Reshu Saxena, Anbin Mu, Mary Grace Murray, Jasmine Cruz, Annie D. Fuller, Margarette H. Clevenger, Kumaraswamy Naidu Chitrala, Yinfei Tan, Kelsey Keith, Jozef Madzo, Hugh Huang, Jaroslav Jelinek, Tatiana Karakasheva, Kathryn E. Hamilton, Amanda B. Muir, Marie-Pier Tetreault, Kelly A. Whelan
Summary: This study uses single cell RNA sequencing to analyze 44,679 murine esophageal epithelial cells, identifying 11 distinct cell populations and studying their pathway alterations along the basal-superficial axis and within each population. The study also reveals the impact of aging on esophageal epithelial cell populations and their association with mitochondrial dysfunction. By comparing single cell transcriptomic profiles of 3D murine organoids, human esophageal biopsies, and murine esophageal epithelium, a working model of cell fate determination in the murine esophageal epithelium is developed. These findings provide a comprehensive molecular perspective on the cellular heterogeneity of murine esophageal epithelium in the context of homeostasis and aging.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Sajjad Shirazi, Chun-Chieh Huang, Miya Kang, Yu Lu, Sriram Ravindran, Lyndon F. Cooper
Summary: The study found that modulation of miRNA biosynthesis and regulation can influence osteoblastic differentiation of human mesenchymal stem cells (hMSCs).
SCIENTIFIC REPORTS
(2021)
Review
Cell Biology
Jennifer Steens, Diana Klein
Summary: Stem cells have the unique ability to self-renew and differentiate into specialized cells. Adult stem cells exhibit limited differentiation capabilities determined by their tissue of origin. HOX genes, as master regulators of cell identity and fate, play a role in embryogenesis and maintaining positional identity. Understanding the regulation of HOX genes in stem cells may lead to advancements in regenerative medicine.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Qian Sun, Fang Pei, Man Zhang, Bo Zhang, Ying Jin, Zhihe Zhao, Qiang Wei
Summary: This study focuses on understanding the role of the curved structure in the extracellular matrix (ECM) network in regulating stem cell mechanotransduction. The fabrication of a curved nanofiber network promotes cell bridge formation, leading to cell lineage commitment towards osteogenic differentiation.
Article
Chemistry, Multidisciplinary
Zhirong Liu, Mingjun Cai, Xiaodi Zhang, Xin Yu, Shu Wang, Xingyi Wan, Zhong Lin Wang, Linlin Li
Summary: The study designs a smart piezoelectric scaffold by modulating dynamic mechanical forces in the cell microenvironment, enabling on-demand electrical stimulation without adverse effects on cell spreading and adhesion from early electrical stimulation.
ADVANCED MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Patricia Torres-Barrera, Dafne Moreno-Lorenzana, Jose Antonio Alvarado-Moreno, Elena Garcia-Ruiz, Cesar Lagunas, Hector Mayani, Antonieta Chavez-Gonzalez
Summary: The bone marrow microenvironment in chronic myeloid leukemia plays a role in regulating the proliferation and quiescence of stem and progenitor cells. A co-culture model of primitive CML cells and endothelial colony forming cells has been used to study this interaction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jamal Majidpoor, Keywan Mortezaee, Zahra Khezri, Fardin Fathi, Alireza Zali, Homayoon Bana Derakhshan, Mehdi Ghasemzadeh Bariki, Mohammad Taghi Joghataie, Reza Shirazi, Fatemeh Moradi
Summary: The study shows that NLRP3 inflammasome activity in spinal cord injury is not influenced by segment, but the effect of hormonal therapy on inflammasome activity varies in different segments. Melatonin or E2 can provide beneficial effects on inflammation caused by spinal cord injury in different thoracic segments.
CELL BIOCHEMISTRY AND FUNCTION
(2021)
Article
Endocrinology & Metabolism
Reza Sardar, Zahra Zandieh, Zeinab Namjoo, Mansoureh Soleimani, Reza Shirazi, Javad Hami
Summary: BDNF shows significant gender differences and left-right asymmetries in the developing rat hippocampus, potentially influencing the gender and laterality differences in the development, structure, and function of the hippocampus.
METABOLIC BRAIN DISEASE
(2021)
Review
Cell & Tissue Engineering
Rano Zhankina, Neda Baghban, Manarbek Askarov, Dana Saipiyeva, Almaz Ibragimov, Bakhyt Kadirova, Arezoo Khoradmehr, Iraj Nabipour, Reza Shirazi, Ulanbek Zhanbyrbekuly, Amin Tamadon
Summary: Stem cells, especially MSCs, have shown potential in treating reproductive diseases like NOA by differentiating into germ cells and even inducing spermatogenesis in infertile animal models. Despite these promising results, clinical trials on MSC therapy for NOA in men have not yet been completed.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell Biology
Mohammad Amin Keshvari, Alireza Afshar, Sajad Daneshi, Arezoo Khoradmehr, Mandana Baghban, Mahdi Muhaddesi, Pouya Behrouzi, Mohammad Reza Miri, Hossein Azari, Iraj Nabipour, Reza Shirazi, Mehdi Mahmudpour, Amin Tamadon
Summary: An automatic decellularization device was developed to perfuse and decellularize male rats' kidneys using SLES and SDS, comparing their efficacy in kidney decellularization and post-transplantation angiogenesis. SLES showed better preservation of extracellular matrix and was the preferred solvent for kidney decellularization.
CELL AND TISSUE RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Reza Sardar, Javad Hami, Mansoureh Soleimani, Mohammad-Taghi Joghataei, Reza Shirazi, Fereshteh Golab, Zeinab Namjoo, Zahra Zandieh
Summary: Maternal diabetes during pregnancy affects the development of offspring's hippocampus, with insulin treatment improving the expression of BDNF and preventing alterations in developing hippocampus.
JOURNAL OF CHEMICAL NEUROANATOMY
(2021)
Correction
Endocrinology & Metabolism
Reza Sardar, Zahra Zandieh, Zeinab Namjoo, Mansoureh Soleimani, Reza Shirazi, Javad Hami
METABOLIC BRAIN DISEASE
(2021)
Editorial Material
Microbiology
Amin Tamadon, Nader Tanideh, Reza Shirazi
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Cell & Tissue Engineering
Mohammad Reza Kouchakian, Neda Baghban, Seyedeh Farzaneh Moniri, Mandana Baghban, Shabnam Bakhshalizadeh, Vahid Najafzadeh, Zahra Safaei, Safoura Izanlou, Arezoo Khoradmehr, Iraj Nabipour, Reza Shirazi, Amin Tamadon
Summary: Mesenchymal stromal cells (MSCs) hold great potential for treating autoimmune, inflammatory, and degenerative diseases. Despite extensive research on the application of MSCs, a low percentage of studies are related to clinical trials.
STEM CELLS INTERNATIONAL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Neda Hajihassani, Navid Mohammadi, Ahmad Karimi Kelayeh, Shima Aalaei
Summary: The present study compared the effect of post space preparation time on the apical seal of two different sealers. The results showed that the apical microleakage in the AH+ sealer group with delayed post-space preparation was significantly less than all the other groups over time.
Article
Biology
Marzieh Beigom Khezri, Abbas Akrami, Matina Majdi, Bijan Gahandideh, Navid Mohammadi
Summary: This study evaluated the effects of cryotherapy on pain scores and satisfaction levels of cataract surgery patients. The results showed that cryotherapy reduced pain scores during surgery and provided better operating conditions for surgeons.
BMC RESEARCH NOTES
(2022)
Review
Chemistry, Medicinal
Afshin Zare, Safoura Izanloo, Sajed Khaledi, Mussin Nadiar Maratovich, Asset Askerovich Kaliyev, Nurgul Abdullayevna Abenova, Farhad Rahmanifar, Mahdi Mahdipour, Shabnam Bakhshalizadeh, Reza Shirazi, Nader Tanideh, Amin Tamadon
Summary: Sea cucumber is a marine-derived source for discovering anti-lung cancer compounds. Triterpene glucosides were found to be the most frequently identified compounds with anti-cancer properties in sea cucumbers. Among them, Intercedenside C, Scabraside A, and Scabraside B showed the highest affinity for apoptotic receptors in lung cancer cells.
Article
Infectious Diseases
Nurgul Ablakimova, Gaziza A. Smagulova, Svetlana Rachina, Aigul Z. Mussina, Afshin Zare, Nadiar M. Mussin, Asset A. Kaliyev, Reza Shirazi, Nader Tanideh, Amin Tamadon
Summary: This study conducts a bibliometric analysis of research on antimicrobial resistance (AMR) among pneumonia pathogens from 2013 to 2023. The findings reveal an increase in research output and emphasize the importance of collaborative studies. The analysis also identifies key journals, leading countries and institutions, as well as common microorganisms. It underscores the significance of knowledge dissemination and evidence-based interventions in addressing this public health challenge.
Article
Dentistry, Oral Surgery & Medicine
Neda Hajihassani, Soolmaz Heidari, Mohammad Ghanati, Navid Mohammadi
Summary: This study compared the fracture resistance of teeth using a bioceramic sealer and an epoxy resin-based sealer. The results showed that SureSeal Root sealer was more effective in improving fracture resistance compared to AH Plus sealer.
Article
Urology & Nephrology
Sepideh Hajian, Mohammad Taheri, Navid Mohammadi
Summary: This study found that intravenous vitamin C can reduce serum ferritin levels in hemodialysis patients, making it a potential adjunct treatment for anemia in patients with kidney failure.
IRANIAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Immunology
Morteza Habibi, Hana Sanandaji, Seyed Hooshyar Mojabi, Farahnaz Mohammadkhaniha, Navid Mohammadi, Marzieh Mohammadhoseini
Summary: This study demonstrates that oral probiotics can reduce hospitalization days and decrease the risk of readmission for neonatal jaundice.
IMMUNOPATHOLOGIA PERSA
(2022)
