Article
Dermatology
Seoungwoo Shin, Jeesun Lee, So Hyun Yoon, Deokhoon Park, Jae Sung Hwang, Eunsun Jung
Summary: Methyl gallate demonstrated anti-glycation and antioxidant potential, validated in a human skin ex-vivo model. It did not cause skin irritation and can be used as an active ingredient in cosmetics.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
D. Recabarren-Leiva, C. F. Burgos, B. Hernandez, F. J. Garcia-Garcia, R. Castro, L. Guzman, E. Fuentes, I Palomo, M. Alarcon
Summary: The study revealed that RAGE expression is higher and more inducible in platelets from elderly individuals, indicating its potential significance in cardiovascular disease treatment for the elderly.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Editorial Material
Plant Sciences
Priya Gambhir, Arun Kumar Sharma, Rahul Kumar
Summary: DJ-1D has the potential to repair glycation of molecules in plants.
TRENDS IN PLANT SCIENCE
(2023)
Review
Cell Biology
Andrea Heinz
Summary: This review provides an overview of the role and aging process of elastic fibers in the human lifespan, discussing various factors causing damage to elastic fibers and genetic or acquired pathologies related to the structure and function of elastic fibers and microfibrils, predominantly in the cardiorespiratory system and skin.
AGEING RESEARCH REVIEWS
(2021)
Article
Nutrition & Dietetics
Kim Maasen, Simone J. P. M. Eussen, Jean L. J. M. Scheijen, Carla J. H. van der Kallen, Pieter C. Dagnelie, Antoon Opperhuizen, Coen D. A. Stehouwer, Marleen M. J. van Greevenbroek, Casper G. Schalkwijk
Summary: The study aimed to investigate the association of dietary dicarbonyl intake with plasma dicarbonyl concentrations and skin AGEs in a population-based study. The findings revealed that higher intake of dietary MGO and GO was positively associated with corresponding plasma concentrations, while intake of 3-DG showed no significant association. These results suggest potential dietary absorption of MGO and GO, highlighting the importance of further research on the biological implications of dietary absorption of these compounds.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Endocrinology & Metabolism
Sarah C. Shuck, Peter Achenbach, Bart O. Roep, John S. Termini, Carlos Hernandez-Castillo, Christiane Winkler, Andreas Weiss, Anette-Gabriele Ziegler
Summary: The study found that serum levels of MG-AGEs were associated with the rate of progression to stage 3 type 1 diabetes, with lower levels increasing the risk of progression. This provides a potential new clinical biomarker for determining the rate of disease progression and points to contributing metabolic pathways.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jeremy Boizot, Melaine Minville-Walz, Dieter Peter Reinhardt, Marielle Bouschbacher, Pascal Sommer, Dominique Sigaudo-Roussel, Romain Debret
Summary: Most chronic wounds are affected by hypoxia, but studies about wound healing are usually conducted under normal oxygen conditions. This study found that hypoxia inhibits the synthesis of elastic fibers and specifically affects the expression of fibrillin-2 and lysyl oxidase.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Der-Yen Lee, Yu-Chin Lin, Geen-Dong Chang
Summary: MG is a reactive glycation metabolite that can induce dicarbonyl stress, and its production in cells is influenced by carbohydrate metabolism. The glyoxalase system consisting of GlxI and GlxII is crucial for converting MG into nontoxic metabolites. Insulin stimulation leads to the accumulation of MG and S-d-lactoylglutathione in cells, which can be efficiently removed by metformin. Metformin affects the glyoxalase system by controlling the redox state and may help maintain cellular MG homeostasis.
Article
Plant Sciences
Thavaree Thilavech, Marisa Marnpae, Kittana Makynen, Sirichai Adisakwattana
Summary: The study found that Brassica vegetable extract (BVE) showed strong antioxidant and antiglycation activities, which may help protect against the effects of protein glycation and oxidation.
PLANT FOODS FOR HUMAN NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Eduardo Fuentes-Lemus, Juan S. Reyes, Camilo Lopez-Alarcon, Michael J. Davies
Summary: This study explores the effect of crowding on protein glycation using high concentrations of proteins and alpha-oxoaldehyde metabolites. The results show that crowding modulates the extent of transferrin cross-links formation and the modification pathways in albumin and transferrin. Arginine is the most susceptible residue for modification, and crowding does not affect the extent of arginine and lysine loss, but the modification sites differ under dilute and crowded conditions.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Junwei Chen, Yuna Lin, Wanjin Xing, Xingchen Zhang, Huan Xu, Wei Wang, Kaiyan Lou
Summary: A turn-on fluorescent probe ANC-DCP-1 based on anthracenecarboximide-guanidine was reported for the selective detection of glyoxals under weak acidic conditions. This probe has great potential in studying relative GOS levels in weak acidic biological fluids for diabetic diagnosis and prognosis, and has also found application in the food industry for determining the unique manuka factor (UMF) scale in Manuka honey.
Article
Agriculture, Multidisciplinary
Mengting Ni, Xin Song, Junhui Pan, Deming Gong, Guowen Zhang
Summary: Vitexin was found to exhibit strong antiglycation effects by protecting protein structure, trapping MGO, and altering glycation sites, thereby reducing the glycation degree and forming only one vitexin-mono-MGO adduct. This study provides valuable information for the development of vitexin as a potential antiglycation agent.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemical Research Methods
I. M. Atzeni, S. C. van de Zande, J. Westra, J. Zwerver, A. J. Smit, D. J. Mulder
Summary: Studies have shown that skin autofluorescence (SAF) is a useful marker of disease processes associated with oxidative stress. It predicts the development of cardiovascular events in patients with diabetes, renal or cardiovascular disease, and also predicts diabetes, cardiovascular disease, and mortality in the general population. However, there are factors that may limit the reliability of the SAF measurement in individual subjects, including endogenous and exogenous factors that may influence SAF levels.
Article
Chemistry, Medicinal
Jae-Min Lim, Hee Joon Yoo, Kwang-Won Lee
Summary: High molecular weight fucoidan from brown seaweeds has been found to protect intestinal integrity and prevent dysfunction caused by methylglyoxal-derived hydroimidazolone-1. It reduces reactive oxygen species generation, improves monolayer integrity, inhibits tight junction marker expression, and prevents receptor for AGEs-mediated intestinal damage.
Article
Cell Biology
Paola Schildhauer, Philipp Selke, Christian Scheller, Christian Strauss, Ruediger Horstkorte, Sandra Leisz, Maximilian Scheer
Summary: This study investigated the effects of MGO on GBM cell lines and glioma cell lines, as well as primary human astrocytes. The results showed that MGO caused glycation, accumulation of advanced glycation end-products, and decreased cell viability in all cell lines. Physiological concentrations of MGO increased invasiveness in GBM cell lines and decreased invasiveness in hA. Glycation also had differential effects on ECM components involved in invasion progress. These findings highlight the importance of further research on preventing glycation as a potential therapeutic strategy against glioma and GBM.
