Article
Microbiology
Nicole Brimer, Scott Vande Pol
Summary: This study reveals that the enhanced competitiveness of HPV16-infected cells is primarily due to the expression of the E6 oncoprotein, rather than the E7 or E5 oncoproteins. E6 can induce a super-competitor phenotype, which has important implications for understanding the mechanism of cell competition.
Article
Oncology
Henrike Reder, Steffen Wagner, Nora Wuerdemann, Christine Langer, Sarah Sandmann, Andreas Braeuninger, Martin Dugas, Stefan Gattenloehner, Claus Wittekindt, Jens Peter Klussmann
Summary: Patients with HPV-positive and HPV-negative oropharyngeal squamous cell carcinoma have significantly different overall survival rates, but those with HPV+OPSCC who develop local/distant recurrence show a mutation pattern similar to HPV-OPSCC, impacting disease severity. Despite similar overall mutation counts, specific mutations rather than the number of mutations may be important for disease progression.
Article
Oncology
Shreya P. P. Ramkumar, Matthew C. C. Simpson, Eric Adjei Boakye, Aleksandr R. R. Bukatko, Jastin L. L. Antisdel, Sean T. T. Massa, Nosayaba Osazuwa-Peters
Summary: This study aimed to assess the independent prognostic role of human papillomavirus (HPV) status in sinonasal cancer. The results showed that HPV16/18-positive sinonasal cancer had a higher survival rate compared to HPV-negative cases, while other high-risk and low-risk HPV subtypes had similar survival rates to HPV-negative disease. Therefore, HPV status may be an important independent prognostic factor in sinonasal cancer.
Article
Multidisciplinary Sciences
Leslye Samano-Hernandez, Y. Garfias, Humberto Gonzalez-Marquez, L. A. Corazon-Martinez, V. M. Bautista-de Lucio
Summary: Pterygium is a common ophthalmology pathology characterized by the overgrowth of fibrovascular tissue from the conjunctiva over the cornea. The pathogenesis of pterygium is still debated, with theories including genetic instability, cellular proliferation, inflammatory influence, and viral infection. In this study, HPV DNA presence in pterygium samples was identified, with HPV-11 and HPV-18 genotypes being the most common. The expression of HPV-L1 capsid protein suggests viral integration into the cellular genome.
Article
Ophthalmology
Ingvild Ramberg, Filipe Garrett Vieira, Peter Bjerre Toft, Christian von Buchwald, Mikkel Funding, Finn Cilius Nielsen, Steffen Heegaard
Summary: The study has identified two potentially distinct distributions of somatic mutations in conjunctival SCC based on HPV status, indicating the significant role of HPV in carcinogenesis in certain cases.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Otorhinolaryngology
Usha Patel, Neha Mittal, Swapnil U. Rane, Asawari Patil, Poonam Gera, Sadhana Kannan, Amit Joshi, Vanita Noronha, Vijay M. Patil, Kumar Prabhash, Manoj B. Mahimkar
Summary: HPV-positive HNSCC showed distinct molecular profiles compared to HPV-negative and p16-positive HNSCC, with lower membrane expression of EGFR, pEGFRY1068, pEGFRY1173, CD44, CD44v6, and CD98hc in HPV-positive tumors. The expression of HIF1 alpha, CA9, ALDH1A1, and SOX2 was not significantly associated with HPV status. Clinical outcomes and biomarker expression levels were similar between HPV-negative and p16-positive HNSCC.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Microbiology
Paula Iglesias, Celine Tendobi, Silvia Carlos, Maria D. Lozano, David Barquin, Luis Chiva, Gabriel Reina
Summary: This study provides important insights into the circulating HPV16 variants in Kinshasa and the potential association between LCR mutations and malignancy, as well as between L1 mutations and vaccine efficacy.
Article
Virology
Cremildo Maueia, Alltalents Murahwa, Alice Manjate, Soren Andersson, Jahit Sacarlal, Darlene Kenga, Tufaria Mussa, Anna-Lise Williamson
Summary: This study demonstrates a high prevalence of HPV infection in women from Maputo, Mozambique, with HIV-positive women having the highest HPV prevalence and being more susceptible to multiple HPV types. High-risk genotypes were the most commonly found.
Article
Genetics & Heredity
Verena M. M. Merk, Leonie Grob, Achim Fleischmann, Thomas Brunner
Summary: The need for new options in lung cancer treatment requires understanding the tumor microenvironment and its interaction with the immune system. This study shows that lung tumors can synthesize steroid hormones, which inhibit immune responses and contribute to tumor development and treatment resistance. The release of immunoregulatory hormones by lung tumors potentially leads to immune evasion and treatment resistance.
GENES AND IMMUNITY
(2023)
Review
Biology
Julio C. Osorio, Felipe Candia-Escobar, Alejandro H. Corvalan, Gloria M. Calaf, Francisco Aguayo
Summary: High-risk human papillomaviruses (HR-HPVs) may be involved in the development of lung cancer, regardless of smoking status, but their role in lung cancer remains controversial. Further research is needed to clarify the role of HR-HPVs in lung cancer.
Article
Virology
Nathan R. Fons, Rhonda C. Kines, Cynthia D. Thompson, Patricia M. Day, Douglas R. Lowy, John T. Schiller
Summary: Heparan sulfate proteoglycans (HSPGs) have been identified as primary attachment factors for human papillomaviruses (HPVs) prior to infection. In vitro experiments show that HPV binding to HSPGs strongly depends on the surrounding experimental conditions, including the concentration of fetal bovine serum (FBS). High concentrations of FBS obstruct the cell surface HSPGs and consequently, HPV particles utilize 6O-sulfated chondroitin sulfate proteoglycans (CSPGs) as initial binding receptors. The findings also suggest a possible role for CSPGs in active wound healing environments. These unexpected findings indicate the significance of serum/platelet factors in HPV binding and identify CSPGs as alternative cell attachment receptors for HPV.
JOURNAL OF VIROLOGY
(2022)
Article
Engineering, Environmental
Luis Fernando Amato-Lourenco, Regiani Carvalho-Oliveira, Gabriel Ribeiro Junior, Luciana dos Santos Galvao, Romulo Augusto Ando, Thais Mauad
Summary: This study confirmed the presence of microplastics in human lung tissues, with polyethylene and polypropylene being the most frequently detected polymers. The potential adverse effects of these microplastics on the respiratory system following inhalation are still unknown, but further research is needed to understand the heterogeneous characteristics of these contaminants.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Review
Immunology
Zheng Quan Toh, Chau Quang, Joseph A. Tooma, Suzanne M. Garland, Kim Mulholland, Paul V. Licciardi
Summary: Australian researchers have played a significant role in the field of vaccinology, particularly in relation to pneumococcal vaccines and HPV vaccines, aiming to enhance access to these vaccines in low- and lower-middle-income countries. The outcomes of these research programs have had significant global health impacts, emphasizing the importance of these vaccines in preventing pneumococcal disease and HPV-associated diseases.
Article
Virology
Ting Li, Zhiping Yang, Chunlin Zhang, Sutong Wang, Bing Mei
Summary: In central China, HPV-16 E6 and E7 genes exhibit multiple variations, and a nucleotide variation (A647G, N29S) is significantly associated with a higher risk of cervical cancer. Variations in the E6 gene affect multiple B-cell epitopes, while variations in the E7 gene have minimal impact on B-cell epitopes. These variation data have important implications for HR-HPV prevention and vaccine development.
Article
Clinical Neurology
Yura Ahn, Young Jun Choi, Yu Sub Sung, Josef Pfeuffer, Chong Hyun Suh, Sae Rom Chung, Jung Hwan Baek, Jeong Hyun Lee
Summary: PCASL imaging showed differences in perfusion parameters based on HPV status in patients with OPSCC, with HPV-positive patients exhibiting significantly lower standard deviation and 95th percentile values of tumor blood flow. The standard deviation of tumor blood flow was found to be the best predictive parameter, with leave-one-out cross-validation showing good accuracy, sensitivity, and specificity.