The application of genetics approaches to the study of exceptional longevity in humans: potential and limitations

Genetic Signatures of Exceptional Longevity in Humans

(2012) Paola Sebastiani et al.   PLoS One

Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited

(2011) Joris Deelen et al.   AGING CELL

Diet and Atherosclerosis in Apolipoprotein E-Deficient Mice

(2011) Katsumi IMAIZUMI   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

AMPK and autophagy get connected

(2011) D Grahame Hardie   EMBO JOURNAL

A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals

(2011) Almut Nebel et al.   MECHANISMS OF AGEING AND DEVELOPMENT

ELOVL6 Genetic Variation Is Related to Insulin Sensitivity: A New Candidate Gene in Energy Metabolism

(2011) Sonsoles Morcillo et al.   PLoS One

Association Study on Long-Living Individuals from Southern Italy Identifies rs10491334 in the CAMKIV Gene That Regulates Survival Proteins

(2011) Alberto Malovini et al.   REJUVENATION RESEARCH

Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans

(2011) J. Guevara-Aguirre et al.   Science Translational Medicine

Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data

(2010) Mette Soerensen et al.   AGING CELL

Relation of High Heart Rate Variability to Healthy Longevity

(2010) Usman Zulfiqar et al.   AMERICAN JOURNAL OF CARDIOLOGY

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

High-Density Genomewide Linkage Analysis of Exceptional Human Longevity Identifies Multiple Novel Loci

(2010) Steven E. Boyden et al.   PLoS One

Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity

(2009) Ludmila Pawlikowska et al.   AGING CELL

The relationship of autonomic imbalance, heart rate variability and cardiovascular disease risk factors

(2009) Julian F. Thayer et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Disruption of the Ang II type 1 receptor promotes longevity in mice

(2009) Ariela Benigni et al.   JOURNAL OF CLINICAL INVESTIGATION

RNA Editing Genes Associated with Extreme Old Age in Humans and with Lifespan in C. elegans

(2009) Paola Sebastiani et al.   PLoS One

Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis

(2009) J. E. Landers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association ofFOXO3Avariation with human longevity confirmed in German centenarians

(2009) Friederike Flachsbart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of the FOXO3A Locus with Extreme Longevity in a Southern Italian Centenarian Study

(2009) Chiara Viviani Anselmi et al.   REJUVENATION RESEARCH

Disentangling the Roles of Disability and Morbidity in Survival to Exceptional Old Age

(2008) Dellara F. Terry et al.   ARCHIVES OF INTERNAL MEDICINE

Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism

(2008) Haiming Cao et al.   CELL

FOXO3A genotype is strongly associated with human longevity

(2008) B. J. Willcox et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Mapping in Human Disease

(2008) D. Altshuler et al.   SCIENCE

Calcium/calmodulin-dependent kinase IV in immune and inflammatory responses: novel routes for an ancient traveller

(2008) Luigi Racioppi et al.   TRENDS IN IMMUNOLOGY

Fatty Acid Profile of Erythrocyte Membranes As Possible Biomarker of Longevity

(2007) Annibale A. Puca et al.   REJUVENATION RESEARCH