Article
Acoustics
I. Dhaifalah, E. Magalova, D. Studnykova, J. Havalova, E. Slintakova, H. Cuckle
Summary: This study assesses the performance and impact of first-trimester preterm pre-eclampsia screening in a single center. The results show a high detection rate but further evaluation is needed to determine the impact on the condition.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Acoustics
V. GIORGIONE, O. QUINTERO MENDEZ, A. PINAS, W. ANSLEY, B. THILAGANATHAN
Summary: Preterm birth (PTB) is a major public health issue worldwide, and this study aimed to investigate whether there is a shared uteroplacental etiology in PTB subtypes during the first trimester of pregnancy. The analysis found that factors used to predict preterm PE risk could also be used to predict PTB at < 33 weeks, suggesting a shared etiological pathway for preterm births.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Medicine, General & Internal
Zagorka Milovanovic, Dejan Filimonovic, Ivan Soldatovic, Natasa Karadzov Orlic
Summary: This study assessed the clinical utility of subclinical hypothyroidism (SCH) marker, elevated thyroid-stimulating hormone (TSH), and thyroid antibodies in predicting gestational diabetes mellitus (GDM). The results showed a positive correlation between increased TSH levels and the presence of thyroid antibodies with the risk of GDM. Patient age, TSH 4 IU/mL, and anti TPO Ab > 35 IU/mL were identified as significant predictors of GDM, improving the screening performance in the first trimester of pregnancy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Anna Meroni, Margaret Mascherpa, Monica Minopoli, Benjamin Lambton, Rawan Elkalaawy, Alexander Frick, Basky Thilaganathan
Summary: Routine mid-gestational uterine artery Doppler can modify the risk for preterm pre-eclampsia after first-trimester combined pre-eclampsia screening. Women at low risk in the first trimester but with high mid-gestational uterine artery Doppler resistance had a higher prevalence of preterm pre-eclampsia. This suggests that pregnancy care should not be de-escalated for women at high risk in the first trimester with low mid-gestational uterine artery Doppler resistance, and escalation of care may be justified for women at low risk but with high mid-gestational uterine artery Doppler resistance.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Medicine, General & Internal
Olga Buerger, Tania Elger, Antonia Varthaliti, Argyro Syngelaki, Alan Wright, Kypros H. Nicolaides
Summary: In this study, we found that maternal characteristics and medical history can be used to predict the risk of Gestational Diabetes Mellitus (GDM), with a higher risk in twin pregnancies. Factors such as maternal age, weight, family history, racial background, and conception method all influence the risk of GDM.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Cecilia Legare, Veronique Desgagne, Kathrine Thibeault, Frederique White, Andree-Anne Clement, Cedrik Poirier, Zhong Cheng Luo, Michelle S. Scott, Pierre-Etienne Jacques, Patrice Perron, Renee Guerin, Marie-France Hivert, Luigi Bouchard
Summary: The study aims to identify and predict plasmatic miRNAs associated with and predictive of GDM during the first trimester of pregnancy. Next-generation sequencing was used to quantify miRNA in discovery and replication cohorts. Seventeen miRNAs were identified as being associated with GDM development in both cohorts, and certain miRNAs showed slightly better prediction performance than classic GDM risk factors. Combining miRNAs and classic risk factors further improved the prediction values.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Cihan Cetin, Nur Dokuzeylul Gungor, Melike Yavuz
Summary: HbA1c shows promise as a biomarker for screening GDM during the first trimester of pregnancy, with a cut-off value of 5.33%, sensitivity of 71.9%, and specificity of 82.8%. Pregnant women with ft-HbA1c levels above the prediabetes limit are at increased risk of developing GDM.
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Berta Serrano, Erika Bonacina, Carlota Rodo, Pablo Garcia-Manau, Maria Angeles Sanchez-Duran, Maria Pancorbo, Cristina Forcada, Maria Teresa Murcia, Ana Perestelo, Mireia Armengol-Alsina, Manel Mendoza, Elena Carreras
Summary: This study compared the predictive accuracy of the Gaussian algorithm and the FMF algorithm for early-onset pre-eclampsia (PE) and small for gestational age (SGA). The results showed that these two algorithms had similar performances for most outcomes and marker combinations. However, the Gaussian algorithm had significant differences in predicting early-onset PE in certain combinations.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Diane Nzelu, Tom Palmer, Daniel Stott, Pranav Pandya, Raffaele Napolitano, Davide Casagrandi, Christina Ammari, Sara Hillman
Summary: This study investigates the cost-effectiveness of first trimester pre-eclampsia screening using the FMF algorithm and targeted aspirin prophylaxis compared with standard care. The results show that screening using the FMF algorithm can lead to cost savings and improved QALY values.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Monica Minopoli, Laure Noel, Anna Meroni, Margaret Mascherpa, Alex Frick, Basky Thilaganathan
Summary: The objective of this study is to evaluate the positive predictive value (PPV) of first-trimester combined PE screening for various placenta-mediated adverse pregnancy outcomes. The findings suggest that women at high risk for preterm PE are also at increased risk for other adverse outcomes such as PTB, SGA birth, and stillbirth. Therefore, it is recommended to implement higher surveillance and interventions to mitigate these risks.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
G. P. Guy, K. Leslie, D. Diaz Gomez, K. Forenc, E. Buck, A. Khalil, B. Thilaganathan
Summary: The study evaluates the clinical effectiveness of implementing a first-trimester combined pre-eclampsia screening program in a public healthcare setting. The results show a significant reduction in screen-positive rate, increased aspirin use, and effective identification of preterm pre-eclampsia.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Peripheral Vascular Disease
Nir Melamed, Nanette Okun, Tianhua Huang, Elad Mei-Dan, Amir Aviram, Melinda Allen, Kasim E. Abdulaziz, Sarah D. McDonald, Beth Murray-Davis, Joel G. Ray, Jon Barrett, John Kingdom, Howard Berger
Summary: Unlike second-trimester AFP, elevated first-trimester AFP is not an independent risk factor for placenta-mediated complications.
Article
Obstetrics & Gynecology
Manel Mendoza, Berta Serrano, Erika Bonacina, Sira Capote, Pablo Garcia-Manau, Laia Regincos, Maria Teresa Murcia, Lidia Barberan, Marta Miguez, Elena Carreras
Summary: This study showed that early prediction of both pre-eclampsia and SGA is feasible using a Gaussian algorithm. The algorithm identified a significant percentage of early and preterm SGA cases, providing a simplified approach for clinical practice.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Review
Obstetrics & Gynecology
Seneesh Kumar Vikraman, Rinshi Abid Elayedatt
Summary: Pre-eclampsia screening plays an important role in reducing complications during pregnancy, and it can be effectively achieved by measuring various indicators and early intervention with aspirin.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Acoustics
G. P. Guy, K. Leslie, D. Diaz Gomez, K. Forenc, E. Buck, A. Bhide, B. Thilaganathan
Summary: This retrospective cohort study evaluated the impact of a first-trimester combined screening program for pre-eclampsia using the FMF algorithm. The results showed a significant reduction in the rate of term small-for-gestational age (SGA) birth below the 10th percentile, but no effect on SGA birth below the 5th or 3rd percentile.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Anna Collins, Annie Jacob, Esther Moss
Summary: This article reviews the current evidence on minimally-invasive surgery in high-risk endometrial cancer patients and identifies areas that require further research.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
Editorial Material
Obstetrics & Gynecology
Thomas D'Hooghe
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
Editorial Material
Obstetrics & Gynecology
Thomas M. D'Hooghe
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
Article
Obstetrics & Gynecology
Lina Youssef, Lea Testa, Francesca Crovetto, Fatima Crispi
Summary: Preeclampsia is a pregnancy-specific disease with an unknown precise cause. Multi-omics approaches have been used to study the molecular mechanisms of preeclampsia, and various genetic variants, altered gene expressions, potential biomarkers, and metabolic changes have been identified. Microbiomics studies have also found dysbiosis in the microbiota of pregnant women with preeclampsia. Further research is needed to integrate and translate these findings into clinical practice.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)