Article
Cell Biology
Chathurika Henpita, Rajesh Vyas, Chastity L. Healy, Tra L. Kieu, Aditi U. Gurkar, Matthew J. Yousefzadeh, Yuxiang Cui, Aiping Lu, Luise A. Angelini, Ryan D. O'Kelly, Sara J. McGowan, Sanjay Chandrasekhar, Rebecca R. Vanderpool, Danielle Hennessy-Wack, Mark A. Ross, Timothy N. Bachman, Charles McTiernan, Smitha P. S. Pillai, Warren Ladiges, Mitra Lavasani, Johnny Huard, Donna Beer-Stolz, Claudette M. St. Croix, Simon C. Watkins, Paul D. Robbins, Ana L. Mora, Eric E. Kelley, Yinsheng Wang, Timothy D. O'Connell, Laura J. Niedernhofer
Summary: Cardiomyopathy is a progressive disease of the myocardium leading to impaired contractility. This study shows that endogenous genotoxic stress contributes to the development of cardiomyopathy by activating the p53 pathway and increasing oxidative stress, leading to cardiac myocyte apoptosis, dilated cardiomyopathy, and sudden death.
Article
Cardiac & Cardiovascular Systems
Brent Gudenkauf, Michael R. Goetsch, Rachit M. Vakil, Oscar Cingolani, Luigi Adamo
Summary: An increasing body of evidence suggests that inflammation may play a crucial role in the development of Takotsubo stress cardiomyopathy. In this case report, a patient initially improved but later experienced a systemic inflammatory response and rapidly deteriorated into obstructive shock. The case highlights the potential close connection between systemic inflammatory response and Takotsubo stress cardiomyopathy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Giacomo Tini, Luca Arcari, Matteo Sclafani, Paolo Spallarossa, Giovanni Camastra, Allegra Battistoni, Camillo Autore, Massimo Volpe, Beatrice Musumeci, Pietro Ameri, Luca Cacciotti
Summary: Patients with both takotsubo syndrome (TTS) and cancer have a higher mortality rate compared to cancer patients without TTS. However, TTS does not worsen the prognosis of cancer patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Albert Topf, Moritz Mirna, Nina Bacher, Vera Paar, Lukas J. Motloch, Bernhard Ohnewein, Robert Larbig, Janine Grueninger, Uta C. Hoppe, Michael Lichtenauer, Rudin Pistulli
Summary: Among patients with diagnosed cardiomyopathy, the differentiation between Takotsubo cardiomyopathy (TTC) and ischemic cardiomyopathy (ICMP) or dilated cardiomyopathy (DCMP) can be challenging. Biomarkers such as sST-2 may play a crucial role in predicting and distinguishing these conditions.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Adrija Hajra, Aaqib Malik, Dhrubajyoti Bandyopadhyay, Akshay Goel, Ameesh Isath, Rahul Gupta, Suraj Krishnan, Devesh Rai, Chayakrit Krittanawong, Salim S. Virani, Gregg C. Fonarow, Carl J. Lavie
Summary: This study analyzed the in-hospital outcomes of patients with stress cardiomyopathy and concurrent COVID-19 infection. The results showed that patients with COVID-19 had a significantly higher incidence of complications and mortality compared to those without COVID-19. Moreover, female patients were less likely to have COVID-19 infection and patients with COVID-19 were more likely to have other health issues.
PROGRESS IN CARDIOVASCULAR DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Feng Dong, Liya Yin, Hamayak Sisakian, Tatevik Hakobyan, Lacey S. Jeong, Hirva Joshi, Ellianna Hoff, Selena Chandler, Geetika Srivastava, Abdur Rahman Jabir, Kelly Kimball, Yeong-Renn Chen, Chwen-Lih Chen, Patrick T. Kang, Parisa Shabani, Lindsay Shockling, Thomas Pucci, Karlina Kegecik, Christopher Kolz, Zhenyu Jia, William M. Chilian, Vahagn Ohanyan
Summary: This study found that coronary microvascular dysfunction plays a key role in the development of Takotsubo syndrome, and abnormalities in flow regulation between the left ventricular apex and base contribute to ventricular dysfunction. Normalization of blood flow between these two regions restores ventricular function.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Jordi Sans-Rosello, Estefania Fernandez-Peregrina, Albert Duran-Cambra, Jose Carreras-Mora, Alessandro Sionis, Jesus Alvarez-Garcia, Hector M. Garcia-Garcia
Summary: This study aimed to investigate whether the degree and extent of impaired microvascular resistance (MR) in Takotsubo syndrome (TTS) patients were associated with 1-year prognosis. The results showed that higher values of NH-IMRangio and the presence of 3 coronary arteries with increased MR were independent predictors of major adverse cardiac events (MACE) in TTS patients during 1-year follow-up.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Medicine, General & Internal
Yuko Fukuda, Yoshitaka Kawa, Akiko Nonaka, Hideyuki Shiotani
Summary: This case highlights the potential risk of osimertinib in causing Takotsubo cardiomyopathy, and serves as a reminder for caution when prescribing this medication.
CLINICAL CASE REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Danielle J. Beetler, Katelyn A. Bruno, Damian N. Di Florio, Erika J. Douglass, Swikriti Shrestha, Carsten Tschoepe, Madeleine W. Cunningham, Jan Krejci, Julie Bienertova-Vasku, Sabine Pankuweit, Dennis M. McNamara, Eun-Seok Jeon, Sophie van Linthout, Lori A. Blauwet, Leslie T. Cooper, DeLisa Fairweather
Summary: This study aimed to investigate the sex and age differences in soluble ST2 (sST2) levels for various cardiovascular diseases (CVDs). Using ELISA kit, sST2 levels were measured in patients with myocarditis, cardiomyopathy, coronary artery disease (CAD), myocardial infarct (MI), and congestive heart failure (CHF) and compared to controls without CVDs. The results showed that myocarditis occurred in younger patients around the age of 40, while other CVDs were more common in individuals around the age of 60. There were significant differences in sST2 levels between sexes in myocarditis and cardiomyopathy, but not in other CVDs.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Geriatrics & Gerontology
Monica Li, Christopher N. Nguyen, Olga Toleva, Puja K. Mehta
Summary: Takotsubo syndrome is an acute heart failure syndrome associated with increased cardiovascular morbidity and mortality. It predominantly affects women, especially post-menopausal women, but the reasons for this are unclear. Timely diagnosis through cardiac imaging is crucial for management of this condition. The syndrome can lead to life-threatening complications.
Article
Cardiac & Cardiovascular Systems
Sofia Schino, Andrea Bezzeccheri, Alessandro Russo, Michela Bonanni, Joseph Cosma, Giuseppe Sangiorgi, Gaetano Chiricolo, Eugenio Martuscelli, Francesco Santoro, Enrica Giuliana Mariano
Summary: Takotsubo syndrome is an acute, transient episode of left ventricular dysfunction that occurs predominantly in postmenopausal women following significant physical or emotional stress. It can be diagnosed based on clinical symptoms and the absence of coronary artery disease on angiography. Despite being transient, complications occur in almost half of the patients and the mortality rate is significant. It can also lead to permanent myocardial damage.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Panpan Xia, Yan Zhang, Yumin Sun, Jun Wang
Summary: This case is a representative case of TTS caused by hypoglycemia. Due to the self-limiting nature of TTS, diagnoses can be missed among hypoglycemic patients. Thus, echocardiography is required for patients with hypoglycemia to ensure an accurate TTS diagnosis in the emergency department.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cell Biology
Yuanxiu Song, Hongxia Li, Shuhong Ma, Min Zhu, Wen-Jing Lu, Feng Lan, Ming Cui
Summary: Alcoholic cardiomyopathy (ACM) is a myocardial injury caused by long-term heavy drinking. This study used human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to establish an in vitro model of ACM and found that AngII and AT1R play a role in alcohol-induced myocardial damage through oxidative stress. The mechanism may involve the regulation of NOX.
CELL DEATH DISCOVERY
(2022)
Article
Cardiac & Cardiovascular Systems
Ju Yan, Mahesutihan Madina, Changjiang Deng, Qianru Yuan, Shixiong Cao, Xiang Xie, Yitong Ma
Summary: Takotsubo syndrome is a group of clinical syndromes characterized by emotional or somatic stimulation and chest pain as the main symptoms, with generally good prognosis and few serious complications.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Veterinary Sciences
Marine Roche-Catholy, Dominique Paepe, Mathias Devreese, Bart J. G. Broeckx, Frederique Woehrle, Marc Schneider, Andrea Garcia de Salazar Alcala, Arnaut Hellemans, Pascale Smets
Summary: This study assessed the pharmacokinetic and pharmacodynamic parameters of torasemide in healthy cats, demonstrating that a single dose leads to significant increase in diuresis and activation of the renin-angiotensin-aldosterone system. Clinically, a once daily dosing of 0.27 mg/kg may be appropriate.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Kashvi Gupta, Ioannis Mastoris, Andrew J. Sauer
HEART FAILURE CLINICS
(2024)
Review
Cardiac & Cardiovascular Systems
Alexander L. Wallner, Salvatore Savona, Rami Kahwash
HEART FAILURE CLINICS
(2024)
Article
Cardiac & Cardiovascular Systems
Muhammad Shahzeb Khan, Anousheh Awais Paracha, Jan Biegus, Rafael de la Espriella, Julio Nunez, Carlos G. Santos-Gallego, Dmitry Yaranov, Marat Fudim
Summary: The increase of preload in heart failure can lead to excessive intracardiac pressures. The reduction of preload can be achieved through pharmacological and nonpharmacological interventions, with nonpharmacological interventions aiming to reduce blood inflow or increase splanchnic vascular blood pooling.
HEART FAILURE CLINICS
(2024)
Article
Cardiac & Cardiovascular Systems
Parin J. Patel, Asim S. Ahmed
HEART FAILURE CLINICS
(2024)
Article
Cardiac & Cardiovascular Systems
Husam M. Salah, Claudia Baratto, Dmitry M. Yaranov, Karl-Philipp Rommel, Satyanarayana Achanta, Sergio Caravita, Vinay Kumar Reddy Vasanthu, Marat Fudim
HEART FAILURE CLINICS
(2024)
Article
Cardiac & Cardiovascular Systems
Gregory R. Jackson, Abhinav Singh
HEART FAILURE CLINICS
(2024)
Review
Cardiac & Cardiovascular Systems
Ronald D. Bass, Joseph Phillips, Jorge Sanz Sanchez, Priti Shah, Stephen Sum, Ron Waksman, Hector M. Garcia-Garcia
Summary: NIRS-derived LCBI is an effective measurement for identifying vulnerable patients and plaques at risk of future adverse events. Patients with an elevated LCBI have higher odds of enduring a future adverse event.
HEART FAILURE CLINICS
(2024)
Article
Cardiac & Cardiovascular Systems
Adam Bland, Eunice Chuah, William Meere, Thomas J. Ford
Summary: CMD is a challenging condition to manage due to its heterogenous pathophysiology, presentation, and response to therapy. Although awareness of CMD is improving, there is a lack of randomized trials for therapy. Invasive assessment of the coronary microcirculation can improve patient-centered outcomes. Beta-blockers are the cornerstone of therapy for CMD angina, and non-pharmacological interventions play a central role in management. Further research is needed to assess the impact of traditional and novel pharmacological therapies on symptoms and clinical events in different CMD endotypes.
HEART FAILURE CLINICS
(2024)
