Article
Cell Biology
Gabriel Borges-Velez, Juan A. Arroyo, Yadira M. Cantres-Rosario, Ana Rodriguez de Jesus, Abiel Roche-Lima, Julio Rosado-Philippi, Lester J. Rosario-Rodriguez, Maria S. Correa-Rivas, Maribel Campos-Rivera, Loyda M. Melendez
Summary: This study investigates the expression and activation pathways of CSTB, RAGE, and AXL receptors in ZIKV-infected placental tissues. The results suggest decreased expression of CSTB, RAGE, and AXL, as well as upregulation of caspase 1 and heat shock protein 27. These findings provide potential targets for modulation of ZIKV infection in the placenta.
Review
Immunology
Georgia Fakonti, Paschalia Pantazi, Vladimir Bokun, Beth Holder
Summary: Placental macrophages, also known as Hofbauer cells, play a crucial role in responding to placental infection and protecting the developing fetus. Studies show that these cells can be infected by various pathogens, leading to hyperplasia, and they respond to infection by altering their transcriptional, translational, and secretion profiles. The outcomes of infection vary across gestation and may be influenced by pre-existing immunity, although clinical information in studies is often lacking.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Anatomy & Morphology
Zdenek Tauber, Tereza Foltynkova, Katerina Cizkova
Summary: The study revealed significant changes in the number and morphology of Hofbauer cells in placenta with chorioamnionitis compared to normal placenta, with cells appearing unevenly distributed, present in higher numbers, larger, and more elongated.
ANATOMIA HISTOLOGIA EMBRYOLOGIA
(2021)
Article
Entomology
Rebecca A. Zimler, Barry W. Alto
Summary: This study evaluates the vertical transmission capacity of Aedes aegypti and Ae. albopictus mosquitoes in Florida for Zika virus (ZIKV). The results show low rates of vertical transmission in both species, with Ae. aegypti (1.1-3.2%) and Ae. albopictus (0-0.3%). However, both invasive Stegomyia mosquitoes were capable of vertically transmitting ZIKV under laboratory conditions, and approximately 5% of female progeny of Ae. aegypti were capable of transmitting Zika virus upon first bite.
Article
Immunology
Awadalkareem Adam, Camila R. Fontes-Garfias, Vanessa V. Sarathy, Yang Liu, Huanle Luo, Emily Davis, Wenqian Li, Antonio E. Muruato, Binbin Wang, Renat Ahatov, Yoseph Mahmoud, Chao Shan, Samantha R. Osman, Steven G. Widen, Alan D. T. Barrett, Pei-Yong Shi, Tian Wang
Summary: The study generated a stable and attenuated ZIKV mutant, ZE4B-36, with combined mutations in E glycosylation and NS4B P36, showing significant reduction in neuroinvasiveness and neurovirulence, as well as low infectivity in mosquitoes. The mutant induced strong immune responses in mice and protected against ZIKV-induced diseases and vertical transmission, suggesting it as a candidate live attenuated vaccine with increased safety and strong immunogenicity for ZIKV prevention and control.
Article
Mathematical & Computational Biology
Hai-Feng Huo, Tian Fu, Hong Xiang
Summary: A new transmission model of Zika virus is established, considering three transmission routes: mosquito bites, sexual transmission, and vertical transmission. The basic reproduction number R0 is derived, and it has been proven that the disease-free equilibrium is globally stable when R0 < 1. Optimal control and mitigation methods for Zika virus transmission are deduced and explored. The MCMC method is used to estimate parameters, and the reasons for discrepancies between actual infection cases and simulated data are discussed. Different strategies for controlling the spread of Zika virus are simulated and studied, with a combination of mosquito control strategies and internal human control strategies being the most effective in reducing the risk of infection.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2023)
Article
Developmental Biology
Laina Freyer, Yvan Lallemand, Pascal Dardenne, Alina Sommer, Anne Biton, Elisa Gomez Perdiguero
Summary: In this study, the researchers used flow cytometry and genetic labeling techniques to analyze the characteristics of placenta macrophages in mice. They identified fetal-derived HBCs and placenta-associated maternal macrophages and traced the ontogeny of HBCs. The findings suggest that HBCs originate from yolk sac-derived erythro-myeloid progenitors and may play an important role in fetoplacental vascular development and/or remodeling. The researchers also discovered that HBCs are dependent on the transcription factor Pu.1 and its loss-of-function affects the morphology of the placenta labyrinth.
Article
Microbiology
Stephanea L. Sotcheff, John Yun-Chung Chen, Nathan Elrod, Jun Cao, Elizabeth Jaworski, Muge N. Kuyumcu-Martinez, Pei-Yong Shi, Andrew L. Routh
Summary: By analyzing the response of human placental cells to Zika virus (ZIKV) infection, this study revealed that ZIKV infection affects host cell gene expression and alternative polyadenylation, resulting in upregulation of pathways related to RNA processing and immune response. These findings are important for understanding the infection mechanism and disease progression of ZIKV.
Review
Microbiology
Laiza Vianna Arruda, Natalia Gedeao Salomao, Felipe de Andrade Vieira Alves, Kissila Rabelo
Summary: Zika virus is a vector-borne virus that can cause severe complications in pregnant women and newborns. Although there have been studies on the susceptibility of placenta cells to infection, the understanding of innate immune response is still limited.
Article
Mathematics, Interdisciplinary Applications
Abdoulaye Sow, Cherif Diallo, Hocine Cherifi
Summary: The main objective of this study is to determine the relative importance of different factors contributing to Zika transmission and develop a mathematical model to answer questions about the impact of sexual and vertical transmission on disease dynamics. Neglecting sexual transmission underestimates the proportion of infected population and slows down disease spreading, while vertical transmission in mosquitoes has a negligible effect. The sensitivity analysis identifies adult mosquito death rate, sting rate, transmission probability from mosquitoes to humans, and transmission probability from humans to mosquitoes as the most sensitive parameters in driving disease dynamics.
Article
Pharmacology & Pharmacy
Qin Hui Li, Kenneth Kim, Sujan Shresta
Summary: Seven years after the onset of the Zika virus epidemic, longitudinal studies have shown that children infected in utero without severe birth defects exhibit motor skill deficits at up to 3 years of age. The long-term health and socioeconomic impacts of fetal Zika virus infection seem inevitable. In the absence of vaccines or antivirals, small animal models of Zika virus transmission are essential to test antiviral strategies and understand the mechanisms of immunity at the maternal-fetal interface. The review discusses the current state of Zika virus transplacental transmission models, highlights key unanswered questions, and sets goals for the next generation of mouse models.
ANTIVIRAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jiahui Ding, Paulomi Aldo, Cai M. Roberts, Paul Stabach, Hong Liu, Yuan You, Xuemin Qiu, Jiwon Jeong, Anthony Maxwell, Brett Lindenbach, Demetrios Braddock, Aihua Liao, Gil Mor
Summary: The study identified ISG20 as a key component in controlling Zika virus infection and successfully developed a recombinant ISG20-Fc protein that could potentially serve as an antiviral treatment option for high-risk populations, especially pregnant women.
Article
Cell Biology
Diego Kafer, Agostina Marquez, Fatima Merech, Vanesa Hauk, Daniel Paparini, Rosanna Ramhorst, Claudia Perez Leiros, Cybele Garcia, Daiana Vota
Summary: In the last 15 years, Zika virus has caused multiple outbreaks in various regions, with increasing severity of clinical presentation in neonates. This study focused on investigating the metabolic changes in trophoblast cells and the role of vasoactive intestinal peptide (VIP) in limiting ZIKV infection during early pregnancy.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Microbiology
Siavash Azari, Lauren J. Johnson, Amy Webb, Sophia M. Kozlowski, Xiaoli Zhang, Kara Rood, Amal Amer, Stephanie Seveau
Summary: Pregnant women are highly susceptible to infection by Listeria monocytogenes, which can lead to severe pregnancy complications. Hofbauer cells (HBCs) within the placenta play a crucial role in protecting the fetus from infection, even though they can be permissive to the replication and spread of the pathogen. Upon infection, HBCs may transition to a pro-inflammatory state while still maintaining tolerogenic factors that prevent maternal anti-fetal adaptive immunity.
Review
Virology
Nicole N. Haese, Victoria H. J. Roberts, Athena Chen, Daniel N. Streblow, Terry K. Morgan, Alec J. Hirsch
Summary: The outbreak of Zika virus in Brazil and South/Central America in 2015-2016 has significantly decreased, but the virus still remains prevalent in tropical and sub-tropical regions. Zika virus infection is strongly associated with severe birth defects in pregnant women. Research using nonhuman primates has been crucial in understanding the pathogenesis of Zika virus and its effects on fetal development.
Article
Immunology
Daiane Cristine Martins Ronchi, Mineia Alessandra Scaranello Malaquias, Patricia Zadorosnei Rebutini, Leticia Arianne Panini do Carmo, Plinio Cezar Neto, Emily Scaranello Marini, Amanda Prokopenko, Seigo Nagashima, Camila Zanluca, Claudia Nunes Duarte dos Santos, Lucia de Noronha
Summary: The study found that placental morphometric changes were more pronounced in the ZIKV group compared to the healthy control group, with increased area, knots, sprouts, and CD163+ Hofbauer cells. The morphometric abnormalities in the HIV group were similar to those in the ZIKV group, but some parameters in the ZIKV group were more significantly different than the HIV group.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Betina Soares dos Reis, Felipe Cintra Staub, Andrea Koishi, Camila Zanluca, Claudia Nunes Duarte dos Santos, Thelma L. Skare, Barbara Stadler Kahlow
Summary: The study found that fractionated dose of yellow fever vaccine is effective and safe in rheumatoid arthritis patients, with no clinical infection symptoms observed in the patients.
CLINICAL RHEUMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Seigo Nagashima, Anderson Azevedo Dutra, Mayara Pezzini Arantes, Rafaela Chiuco Zeni, Carolline Konzen Klein, Flavia Centenaro de Oliveira, Giulia Werner Piper, Isadora Drews Brenny, Marcos Roberto Curcio Pereira, Rebecca Benicio Stocco, Ana Paula Camargo Martins, Eduardo Morais de Castro, Caroline Busatta Vaz de Paula, Andrea Novaes Moreno Amaral, Cleber Machado-Souza, Cristina Pellegrino Baena, Lucia Noronha
Summary: Mast cells have significant involvement in inflammatory and vascular hyperpermeability events in COVID-19 patients. The activation of MCs is associated with disease severity, and therapy targeting MC activation/degranulation may prevent worsening of prognosis and improve outcomes for patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Health Care Sciences & Services
Thais Almeida, Werner Schroth, Jeanine Nardin, Thomas E. Murdter, Stefan Winter, Solane Picolotto, Reiner Hoppe, Jenifer Kogin, Elisa Gaio, Angela Dasenbrock, Raquel Cristina Skrsypcsak, Lucia de Noronha, Matthias Schwab, Hiltrud Brauch, Jose Claudio Casali-da-Rocha
Summary: This study investigated the association between the active tamoxifen metabolite (Z)-endoxifen and event-free survival in early-stage breast cancer patients, and found that lower levels of (Z)-endoxifen were associated with shorter survival.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Virology
Aline Cristina Zanchettin, Leonardo Vinicius Barbosa, Anderson Azevedo Dutra, Daniele Margarita Marani Pra, Marcos Roberto Curcio Pereira, Rebecca Benicio Stocco, Ana Paula Camargo Martins, Caroline Busatta Vaz de Paula, Seigo Nagashima, Lucia de Noronha, Cleber Machado-Souza
Summary: This study analyzed lung tissue samples from COVID-19, H1N1, and control groups and found that perforin expression was higher in COVID-19 patients, CD8+ expression was higher in the H1N1 group, and CD57+ expression was higher in the control group. In addition, two genes related to the cytolytic pathway showed associations, and PRF1 rs350947132 was associated with increased immune tissue expression for perforin in the COVID-19 group. The genotype approach can help identify more susceptible patients.
Article
Biology
Katia Martins Foltz, Aloysio Enck Neto, Julio Cesar Francisco, Rossana Baggio Simeoni, Anna Flavia Ribeiro dos Santos Miggiolaro, Thatyanne Gradowski do Nascimento, Bassam Felipe Mogharbel, Katherine Athayde Teixeira de Carvalho, Jose Rocha Faria-Neto, Lucia de Noronha, Luiz Cesar Guarita-Souza
Summary: This study aimed to evaluate the capacity of decellularized Wharton's jelly (WJ) as a scaffold in tracheal tissue regeneration in rabbits. The results showed that the scaffold was suitable as a heterologous implant and did not cause rejection or material extrusion. However, it did not provide histopathological benefits in tracheal tissue regeneration.
Article
Biology
Maiara Carolina Perussolo, Bassam Felipe Mogharbel, Claudia Sayuri Sacaki, Dilcele Silva Moreira Dziedzic, Seigo Nagashima, Leanderson Franco de Meira, Luiz Cesar Guarita-Souza, Lucia de Noronha, Katherine Athayde Teixeira de Carvalho
Summary: This study analyzed the relationships between histopathological and clinical score findings in EAE models of MS. The results showed that the doses of 250 ng and 350 ng of PTX were the most effective in inducing demyelination lesions in the brain and spinal cord.
Article
Biochemistry & Molecular Biology
Lucas Baena Carstens, Raissa Campos D'amico, Karen Fernandes de Moura, Eduardo Morais de Castro, Flavia Centenaro, Giovanna Silva Barbosa, Guilherme Vieira Cavalcante da Silva, Isadora Brenny, Julio Cesar Honorio D'Agostini, Elisa Carolina Hlatchuk, Sabrina Pissette de Lima, Ana Paula Camargo Martins, Marina De Castro Deus, Carolline Konzen Klein, Ana Paula Kubaski Benevides, Seigo Nagashima, Cleber Machado-Souza, Ricardo A. Pinho, Cristina Pellegrino Baena, Lucia de Noronha
Summary: The activation of the inflammasome complex is significantly increased in COVID-19 patients, indicating its involvement in the pathogenesis of the disease. Additionally, levels of cell pyroptosis and inflammasome-derived cytokines are greatly elevated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Marta Giovanetti, Svetoslav Nanev Slavov, Vagner Fonseca, Eduan Wilkinson, Houriiyah Tegally, Jose Salvatore Leister Patane, Vincent Louis Viala, Emmanuel James San, Evandra Strazza Rodrigues, Elaine Vieira Santos, Flavia Aburjaile, Joilson Xavier, Hegger Fritsch, Talita Emile Ribeiro Adelino, Felicidade Pereira, Arabela Leal, Felipe Campos De Melo Iani, Glauco De Carvalho Pereira, Cynthia Vazquez, Gladys Mercedes Estigarribia Sanabria, Elaine Cristina De Oliveira, Luiz Demarchi, Julio Croda, Rafael Dos Santos Bezerra, Loyze Paola Oliveira De Lima, Antonio Jorge Martins, Claudia Renata Dos Santos Barros, Elaine Cristina Marqueze, Jardelina De Souza Todao Bernardino, Debora Botequio Moretti, Ricardo Augusto Brassaloti, Raquel De Lello Rocha Campos Cassano, Pilar Drummond Sampaio Correa Mariani, Joao Paulo Kitajima, Bibiana Santos, Rodrigo Proto-Siqueira, Vlademir Vicente Cantarelli, Stephane Tosta, Vanessa Brandao Nardy, Luciana Reboredo De Oliveira Da Silva, Marcela Kelly Astete Gomez, Jaqueline Gomes Lima, Adriana Aparecida Ribeiro, Natalia Rocha Guimaraes, Luiz Takao Watanabe, Luana Barbosa Da Silva, Raquel Da Silva Ferreira, Mara Patricia F. Da Penha, Maria Jose Ortega, Andrea Gomez De La Fuente, Shirley Villalba, Juan Torales, Maria Liz Gamarra, Carolina Aquino, Gloria Patricia Martinez Figueredo, Wellington Santos Fava, Ana Rita C. Motta-Castro, James Venturini, Sandra Maria Do Vale Leone De Oliveira, Crhistinne Cavalheiro Maymone Goncalves, Maria Do Carmo Debur Rossa, Guilherme Nardi Becker, Mayra Presibella Giacomini, Nelson Quallio Marques, Irina Nastassja Riediger, Sonia Raboni, Gabriela Mattoso, Allan D. Cataneo, Camila Zanluca, Claudia N. Duarte Dos Santos, Patricia Akemi Assato, Felipe Allan Da Silva Da Costa, Mirele Daiana Poleti, Jessika Cristina Chagas Lesbon, Elisangela Chicaroni Mattos, Cecilia Artico Banho, Livia Sacchetto, Marilia Mazzi Moraes, Rejane Maria Tommasini Grotto, Jayme A. Souza-Neto, Mauricio Lacerda Nogueira, Heidge Fukumasu, Luiz Lehmann Coutinho, Rodrigo Tocantins Calado, Raul Machado Neto, Ana Maria Bispo De Filippis, Rivaldo Venancio Da Cunha, Carla Freitas, Cassio Roberto Leonel Peterka, Cassia De Fatima Rangel Fernandes, Wildo Navegantes, Rodrigo Fabiano Do Carmo Said, Carlos F. Campelo De A. E. Melo, Maria Almiron, Jose Lourenco, Tulio De Oliveira, Edward C. Holmes, Ricardo Haddad, Sandra Coccuzzo Sampaio, Maria Carolina Elias, Simone Kashima, Luiz Carlos Junior De Alcantara, Dimas Tadeu Covas
Summary: The COVID-19 pandemic in Brazil is assessed using phylogenetic and phylogeographic analysis. Multiple viral lineages were found to be circulating in Brazil with links to importations from Europe. Large local transmission clusters were detected within the country, and variants of concern and variants under monitoring emerged and spread both within and outside Brazil. Genomic surveillance in Brazil enabled real-time assessment of the spread of emerging SARS-CoV-2 variants.
NATURE MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Leonardo Vinicius Barbosa, Daniele Margarita Marani Pra, Seigo Nagashima, Marcos Roberto Curcio Pereira, Rebecca Benicio Stocco, Francys de Luca Fernandes da Silva, Milena Rueda Cruz, Djessyka Dallagassa, Thiago Joao Stupak, George Willian Xavier da Rosa Gotz, Georgia Garofani Nasimoto, Luiz Augusto Fanhani Cracco, Isabela Busto Silva, Karen Fernandes de Moura, Marina de Castro Deus, Ana Paula Camargo Martins, Beatriz Akemi Kondo Van Spitzenbergen, Andrea Novais Moreno Amaral, Caroline Busatta Vaz de Paula, Cleber Machado-Souza, Lucia de Noronha
Summary: The COVID-19 pandemic has caused widespread morbidity and mortality, with a fine balance between protective immune responses and pathological reactions. This study evaluated tissue biomarker expression in patients who died of COVID-19 and found differences compared to patients who died of H1N1, suggesting a poor cellular response in COVID-19 patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Carina Z. Segato-Vendrameto, Camila Zanluca, Amanda Z. Zucoloto, Tiago H. Zaninelli, Mariana M. Bertozzi, Telma Saraiva-Santos, Camila R. Ferraz, Larissa Staurengo-Ferrari, Stephanie Badaro-Garcia, Marilia F. Manchope, Amanda M. Dionisio, Felipe A. Pinho-Ribeiro, Sergio M. Borghi, Ana Luiza Pamplona Mosimann, Rubia Casagrande, Juliano Bordignon, Victor Fattori, Claudia N. Duarte dos Santos, Waldiceu A. Verri
Summary: This article investigates therapeutic strategies against Chikungunya virus, finding that inhibiting viral proteins and using recombinant antibodies can alleviate virus-induced pain symptoms.
Article
Multidisciplinary Sciences
Joilson Xavier, Luiz Carlos Junior Alcantara, Vagner Fonseca, Mauricio Lima, Emerson Castro, Hegger Fritsch, Carla Oliveira, Natalia Guimaraes, Talita Adelino, Mariane Evaristo, Evandra S. Rodrigues, Elaine Vieira Santos, Debora de La-Roque, Laise de Moraes, Stephane Tosta, Adelino Neto, Alexander Rosewell, Ana Flavia Mendonca, Anderson Leite, Andreza Vasconcelos, Arabela L. Silva de Mello, Bergson Vasconcelos, Camila A. Montalbano, Camila Zanluca, Carla Freitas, Carlos F. C. de Albuquerque, Claudia Nunes Duarte dos Santos, Cleiton S. Santos, Cliomar Alves dos Santos, Crhistinne C. Maymone Goncalves, Dalane Teixeira, Daniel F. L. Neto, Diego Cabral, Elaine C. de Oliveira, Ethel L. Noia Maciel, Felicidade Mota Pereira, Felipe Iani, Fernanda P. de Carvalho, Gabriela Andrade, Gabriela Bezerra, Gislene G. de Castro Lichs, Glauco Carvalho Pereira, Haline Barroso, Helena Cristina Ferreira Franz, Hivylla Ferreira, Iago Gomes, Irina N. Riediger, Isabela Rodrigues, Isadora C. de Siqueira, Jacilane Silva, Jairo Mendez Rico, Jaqueline Lima, Jayra Abrantes, Jean Phellipe M. do Nascimento, Judith N. Wasserheit, Julia Pastor, Jurandy J. F. de Magalhes, Kleber Giovanni Luz, Lidio G. Lima Neto, Livia C. V. Frutuoso, Luana Barbosa da Silva, Ludmila Sena, Luis Arthur F. de Sousa, Luiz Augusto Pereira, Luiz Demarchi, Magaly C. B. Camara, Marcela G. Astete, Maria Almiron, Maricelia Lima, Marina C. S. Umaki Zardin, Mayra M. Presibella, Melissa B. Falco, Michael Gale, Naishe Freire, Nelson Marques, Noely F. O. de Moura, Pedro E. Almeida Da Silva, Peter Rabinowitz, Rivaldo V. da Cunha, Karen S. Trinta, Rodrigo F. do Carmo Said, Rodrigo Kato, Rodrigo Stabeli, Ronaldo de Jesus, Roselene Hans Santos, Simone Kashima, Svetoslav N. Slavov, Tamires Andrade, Themis Rocha, Thiago Carneiro, Vanessa Nardy, Vinicius da Silva, Walterlene G. Carvalho, Wesley C. Van Voorhis, Wildo N. Araujo, Ana M. B. de Filippis, Marta Giovanetti
Summary: The emergence and reemergence of mosquito-borne diseases in Brazil have serious impacts on public health. The rapid dissemination of the chikungunya virus across the country has raised concerns. Genomic surveillance activities have led to the generation of chikungunya virus genomes from different Brazilian states, providing valuable data for understanding the dispersal dynamics and genetic diversity of the virus in Brazil.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Marta Giovanetti, Francesco Pinotti, Camila Zanluca, Vagner Fonseca, Taishi Nakase, Andrea C. Koishi, Marcel Tscha, Guilherme Soares, Gisiane Gruber Dorl, Antonio Ernesto M. L. Marques, Renato Sousa, Talita Emile Ribeiro Adelino, Joilson Xavier, Carla de Oliveira, Sandro Patroca, Natalia Rocha Guimaraes, Hegger Fritsch, Maria Angelica Mares-Guia, Flavia Levy, Pedro Henrique Passos, Vinicius Leme da Silva, Luiz Augusto Pereira, Ana Flavia Mendonca, Isabel Luana de Macedo, Davi Emanuel Ribeiro de Sousa, Gabriela Rodrigues de Toledo Costa, Marcio Botelho de Castro, Miguel de Souza Andrade, Filipe Vieira Santos de Abreu, Fabricio Souza Campos, Felipe Campos de Melo Iani, Maira Alves Pereira, Karina Ribeiro Leite Jardim Cavalcante, Andre Ricardo Ribas de Freitas, Carlos Frederico Campelo de Albuquerque, Eduardo Marques Macario, Marlei Pickler Debiasi dos Anjos, Rosane Campanher Ramos, Aline Alves Scarpellini Campos, Adriano Pinter, Marcia Chame, Livia Abdalla, Irina Nastassja Riediger, Servio Pontes Ribeiro, Ana I. Bento, Tulio de Oliveira, Carla Freitas, Noely Fabiana Oliveira de Moura, Allison Fabri, Cintia Damasceno dos Santos Rodrigues, Carolina Cardoso Dos Santos, Marco Antonio Barreto de Almeida, Edmilson dos Santos, Jader Cardoso, Douglas Adriano Augusto, Eduardo Krempser, Luis Filipe Mucci, Renata Rispoli Gatti, Sabrina Fernandes Cardoso, Joao Augusto Brancher Fuck, Maria Goretti David Lopes, Ivana Lucia Belmonte, Gabriela Mayoral Pedroso da Silva, Maiane Regina Ferreira Soares, Marilia de Melo Santos de Castilhos, Joseana Cardoso Silva, Alceu Bisetto Junior, Emanuelle Gemin Pouzato, Laurina Setsuko Tanabe, Daniele Akemi Arita, Ricardo Matsuo, Josiane dos Santos Raymundo, Paula Cristina Linder Silva, Ana Santana Araujo Ferreira Silva, Sandra Samila, Glauco Carvalho, Rodrigo Stabeli, Wildo Navegantes, Luciano Andrade Moreira, Alvaro Gil A. Ferreira, Guilherme Garcia Pinheiro, Bruno Tardelli Diniz Nunes, Daniele Barbosa de Almeida Medeiros, Ana Cecilia Ribeiro Cruz, Rivaldo Venancio da Cunha, Wes Van Voorhis, Ana Maria Bispo de Filippis, Maria Almiron, Edward C. Holmes, Daniel Garkauskas Ramos, Alessandro Romano, Jose Lourenco, Luiz Carlos Junior Alcantara, Claudia Nunes Duarte dos Santos
Summary: This study reconstructed the transmission history of yellow fever virus (YFV) in Brazil using phylogenetic and epidemiological models. The results showed the circulation of three distinct lineages and provided evidence of a known spatial corridor for virus transmission. The study highlights the importance of combining genomics with eco-epidemiology for infectious disease surveillance and control.
Article
Health Care Sciences & Services
Ana Paula Dergham, Caroline Busatta Vaz de Paula, Seigo Nagashima, Marcia Olandoski, Lucia de Noronha, Vanessa Santos Sotomaior
Summary: Assessment of immunotherapeutic markers in paraffin-embedded samples of advanced serous ovarian carcinoma is feasible and may provide prognostic information.
JOURNAL OF PERSONALIZED MEDICINE
(2023)