Structure-Function Relationships of the Neisserial EptA Enzyme Responsible for Phosphoethanolamine Decoration of Lipid A: Rationale for Drug Targeting

ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Soluble immune effector molecules [II]: agents targeting interleukins, immunoglobulins and complement factors)

(2018) K.L. Winthrop et al.   CLINICAL MICROBIOLOGY AND INFECTION

Genetic characterisation of Neisseria gonorrhoeae resistant to both ceftriaxone and azithromycin

(2018) David M Whiley et al.   LANCET INFECTIOUS DISEASES

Neisseria gonorrhoeae host adaptation and pathogenesis

(2018) Sarah Jane Quillin et al.   NATURE REVIEWS MICROBIOLOGY

Intravaginal Administration of Interleukin 12 during Genital Gonococcal Infection in Mice Induces Immunity to Heterologous Strains of Neisseria gonorrhoeae

(2018) Yingru Liu et al.   mSphere

Meningococcal disease in the Middle East and Africa: Findings and updates from the Global Meningococcal Initiative

(2017) Ray Borrow et al.   JOURNAL OF INFECTION

Effectiveness of a group B outer membrane vesicle meningococcal vaccine against gonorrhoea in New Zealand: a retrospective case-control study

(2017) Helen Petousis-Harris et al.   LANCET

Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance

(2017) Seth W. Dickey et al.   NATURE REVIEWS DRUG DISCOVERY

Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding

(2017) Anandhi Anandan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological Targeting of the Host–Pathogen Interaction: Alternatives to Classical Antibiotics to Combat Drug-Resistant Superbugs

(2017) Jason Munguia et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Asplenic Patient: Post-Insult Immunocompetence, Infection, and Vaccination

(2017) Brandon Dionne et al.   Surgical Infections

MCR-1 Inhibition with Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Restores Sensitivity to Polymyxin in Escherichia coli

(2017) Seth M. Daly et al.   mBio

Biological Functions of the Secretome of Neisseria meningitidis

(2017) Jan Tommassen et al.   Frontiers in Cellular and Infection Microbiology

The Global Meningococcal Initiative: global epidemiology, the impact of vaccines on meningococcal disease and the importance of herd protection

(2016) Ray Borrow et al.   Expert Review of Vaccines

Utilizing complement evasion strategies to design complement-based antibacterial immunotherapeutics: Lessons from the pathogenic Neisseriae

(2016) Sanjay Ram et al.   IMMUNOBIOLOGY

Meningococcal disease during the Hajj and Umrah mass gatherings

(2016) Saber Yezli et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Failure of Dual Antimicrobial Therapy in Treatment of Gonorrhea

(2016) Helen Fifer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Meningococcal B vaccination: real-world experience and future perspectives

(2016) Parvanè Kuhdari et al.   Pathogens and Global Health

Dissemination and Mechanism for the MCR-1 Colistin Resistance

(2016) Rongsui Gao et al.   PLoS Pathogens

Antimicrobial peptide resistance in Neisseria meningitidis

(2015) Yih-Ling Tzeng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The lipooligosaccharide-modifying enzyme LptA enhances gonococcal defence against human neutrophils

(2015) Jonathan W. Handing et al.   CELLULAR MICROBIOLOGY

Neisseria meningitidis: pathogenesis and immunity

(2015) Mariagrazia Pizza et al.   CURRENT OPINION IN MICROBIOLOGY

Lipooligosaccharide Structures of Invasive and Carrier Isolates ofNeisseria meningitidisAre Correlated with Pathogenicity and Carriage

(2015) Constance M. John et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphoethanolamine Modification of Neisseria gonorrhoeae Lipid A Reduces Autophagy Flux in Macrophages

(2015) Susu M. Zughaier et al.   PLoS One

Global Estimates of the Prevalence and Incidence of Four Curable Sexually Transmitted Infections in 2012 Based on Systematic Review and Global Reporting

(2015) Lori Newman et al.   PLoS One

Phase-Variable Expression oflptAModulates the Resistance of Neisseria gonorrhoeae to Cationic Antimicrobial Peptides

(2014) Justin L. Kandler et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antimicrobial Resistance in Neisseria gonorrhoeae in the 21st Century: Past, Evolution, and Future

(2014) M. Unemo et al.   CLINICAL MICROBIOLOGY REVIEWS

Phosphoethanolamine Decoration of Neisseria gonorrhoeae Lipid A Plays a Dual Immunostimulatory and Protective Role during Experimental Genital Tract Infection

(2014) M. Packiam et al.   INFECTION AND IMMUNITY

The Role of Oxidoreductases in Determining the Function of the Neisserial Lipid A Phosphoethanolamine Transferase Required for Resistance to Polymyxin

(2014) Susannah Piek et al.   PLoS One

Neisseria gonorrhoeaephagosomes delay fusion with primary granules to enhance bacterial survival inside human neutrophils

(2013) M. Brittany Johnson et al.   CELLULAR MICROBIOLOGY

Genetic susceptibility to meningococcal infection

(2013) Adam P Dale et al.   Expert Review of Anti-Infective Therapy

The Structure of the Neisserial Lipooligosaccharide Phosphoethanolamine Transferase A (LptA) Required for Resistance to Polymyxin

(2013) Christopher Wanty et al.   JOURNAL OF MOLECULAR BIOLOGY

Unbiased Proteomics Analysis Demonstrates Significant Variability in Mucosal Immune Factor Expression Depending on the Site and Method of Collection

(2013) Kenzie M. Birse et al.   PLoS One

Neisseria gonorrhoeae-derived heptose elicits an innate immune response and drives HIV-1 expression

(2013) R. J. Malott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vaccine research for gonococcal infections: where are we?

(2013) Ann E Jerse et al.   SEXUALLY TRANSMITTED INFECTIONS

Lipid A's Structure Mediates Neisseria gonorrhoeae Fitness during Experimental Infection of Mice and Men

(2013) M. M. Hobbs et al.   mBio

Meningococcal disease and the complement system

(2013) Lisa A Lewis et al.   Virulence

Antibodies and Their Receptors: Different Potential Roles in Mucosal Defense

(2013) Rachel E. Horton et al.   Frontiers in Immunology

Cloning, expression, purification and crystallization of an endotoxin-biosynthesis enzyme fromNeisseria meningitidis

(2012) Anandhi Anandan et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Phosphoethanolamine Residues on the Lipid A Moiety of Neisseria gonorrhoeae Lipooligosaccharide Modulate Binding of Complement Inhibitors and Resistance to Complement Killing

(2012) Lisa A. Lewis et al.   INFECTION AND IMMUNITY

Lack of Lipid A Pyrophosphorylation and FunctionallptAReduces Inflammation by Neisseria Commensals

(2012) Constance M. John et al.   INFECTION AND IMMUNITY

The Emerging Threat of Untreatable Gonococcal Infection

(2012) Gail A. Bolan et al.   NEW ENGLAND JOURNAL OF MEDICINE

A comparison of the endotoxin biosynthesis and protein oxidation pathways in the biogenesis of the outer membrane of Escherichia coli and Neisseria meningitidis

(2012) Susannah Piek et al.   Frontiers in Cellular and Infection Microbiology

Is Neisseria gonorrhoeae Initiating a Future Era of Untreatable Gonorrhea?: Detailed Characterization of the First Strain with High-Level Resistance to Ceftriaxone

(2011) Makoto Ohnishi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Human Airway Epithelial Cell Responses to Neisseria lactamica and Purified Porin via Toll-Like Receptor 2-Dependent Signaling

(2010) X. Liu et al.   INFECTION AND IMMUNITY

Phosphoryl Moieties of Lipid A from Neisseria meningitidis and N. gonorrhoeae Lipooligosaccharides Play an Important Role in Activation of Both MyD88- and TRIF-Dependent TLR4-MD-2 Signaling Pathways

(2010) M. Liu et al.   JOURNAL OF IMMUNOLOGY

Structure and Function of the Oxidoreductase DsbA1 from Neisseria meningitidis

(2009) Julian P. Vivian et al.   JOURNAL OF MOLECULAR BIOLOGY

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Modification of Lipooligosaccharide with Phosphoethanolamine by LptA in Neisseria meningitidis Enhances Meningococcal Adhesion to Human Endothelial and Epithelial Cells

(2008) H. Takahashi et al.   INFECTION AND IMMUNITY

Phosphoethanolamine Substitution of Lipid A and Resistance of Neisseria gonorrhoeae to Cationic Antimicrobial Peptides and Complement-Mediated Killing by Normal Human Serum

(2008) L. A. Lewis et al.   INFECTION AND IMMUNITY

Structural and Biochemical Characterization of the Oxidoreductase NmDsbA3 fromNeisseria meningitidis

(2008) Julian P. Vivian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduced DNA binding and uptake in the absence of DsbA1 and DsbA2 of Neisseria meningitidis due to inefficient folding of the outer-membrane secretin PilQ

(2008) S. Sinha et al.   MICROBIOLOGY-SGM

The role of complement in gonococcal infection of cervical epithelia

(2008) Jennifer L. Edwards   VACCINE