Engineered bacteriophage lysins as novel anti-infectives

Art-175 Is a Highly Efficient Antibacterial against Multidrug-Resistant Strains and Persisters of Pseudomonas aeruginosa

(2014) Yves Briers et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Intravitreal Injection of the Chimeric Phage Endolysin Ply187 Protects Mice from Staphylococcus aureus Endophthalmitis

(2014) Pawan Kumar Singh et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Engineered Endolysin-Based "Artilysins" To Combat Multidrug-Resistant Gram-Negative Pathogens

(2014) Y. Briers et al.   mBio

Construction of a chimeric lysin Ply187N-V12C with extended lytic activity against staphylococci and streptococci

(2014) Qiuhua Dong et al.   Microbial Biotechnology

Novel Chimeric Lysin with High-Level Antimicrobial Activity against Methicillin-Resistant Staphylococcus aureus In Vitro andIn Vivo

(2013) Hang Yang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Novel Bacteriophage Lysin with Broad Lytic Activity Protects against Mixed Infection by Streptococcus pyogenes and Methicillin-Resistant Staphylococcus aureus

(2013) Daniel B. Gilmer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antibacterial Bioagents Based on Principles of Bacteriophage Biology: An Overview

(2013) B. M. Knoll et al.   CLINICAL INFECTIOUS DISEASES

Chimeric Ply187 endolysin killsStaphylococcus aureusmore effectively than the parental enzyme

(2013) Jinzhe Mao et al.   FEMS MICROBIOLOGY LETTERS

Combination Therapy With Lysin CF-301 and Antibiotic Is Superior to Antibiotic Alone for Treating Methicillin-Resistant Staphylococcus aureus–Induced Murine Bacteremia

(2013) Raymond Schuch et al.   JOURNAL OF INFECTIOUS DISEASES

Lysins: the arrival of pathogen-directed anti-infectives

(2013) M. Pastagia et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Efficacy of anti-staphylococcal protein P128 for the treatment of canine pyoderma: potential applications

(2013) Raghu Patil Junjappa et al.   VETERINARY RESEARCH COMMUNICATIONS

Existence of Separate Domains in Lysin PlyG for Recognizing Bacillus anthracis Spores and Vegetative Cells

(2012) Hang Yang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Chimeric Phage Lysins Act Synergistically with Lysostaphin To Kill Mastitis-Causing Staphylococcus aureus in Murine Mammary Glands

(2012) Mathias Schmelcher et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Antistaphylococcal activity of bacteriophage derived chimeric protein P128

(2012) Aradhana A Vipra et al.   BMC MICROBIOLOGY

Wall Teichoic Acids Restrict Access of Bacteriophage Endolysin Ply118, Ply511, and PlyP40 Cell Wall Binding Domains to the Listeria monocytogenes Peptidoglycan

(2012) Marcel R. Eugster et al.   JOURNAL OF BACTERIOLOGY

Novel Chimerical Endolysins with Broad Antimicrobial Activity Against Methicillin-Resistant Staphylococcus aureus

(2012) Sofia Fernandes et al.   Microbial Drug Resistance

Structural engineering of a phage lysin that targets Gram-negative pathogens

(2012) P. Lukacik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

X-ray crystal structure of the streptococcal specific phage lysin PlyC

(2012) S. McGowan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacteriophage endolysins as a response to emerging foodborne pathogens

(2012) Hugo Oliveira et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

In VitroActivity against Staphylococcus aureus of a Novel Antimicrobial Agent, PRF-119, a Recombinant Chimeric Bacteriophage Endolysin

(2011) Evgeny A. Idelevich et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The cell wall binding domain of Listeria bacteriophage endolysin PlyP35 recognizes terminal GlcNAc residues in cell wall teichoic acid

(2011) Marcel R. Eugster et al.   MOLECULAR MICROBIOLOGY

Domain shuffling and module engineering of Listeria phage endolysins for enhanced lytic activity and binding affinity

(2011) Mathias Schmelcher et al.   Microbial Biotechnology

Synergism between a Novel Chimeric Lysin and Oxacillin Protects against Infection by Methicillin-Resistant Staphylococcus aureus

(2010) A. Daniel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Novel Chimeric Lysin Shows Superiority to Mupirocin for Skin Decolonization of Methicillin-Resistant and -SensitiveStaphylococcus aureusStrains

(2010) Mina Pastagia et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Rapid Multiplex Detection and Differentiation of Listeria Cells by Use of Fluorescent Phage Endolysin Cell Wall Binding Domains

(2010) M. Schmelcher et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Food applications of bacterial cell wall hydrolases

(2010) Lien Callewaert et al.   CURRENT OPINION IN BIOTECHNOLOGY

Bacteriophage endolysins: A novel anti-infective to control Gram-positive pathogens

(2010) Vincent A. Fischetti   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Systemic use of the endolysin Cpl-1 rescues mice with fatal pneumococcal pneumonia*

(2009) Martin Witzenrath et al.   CRITICAL CARE MEDICINE

Cathelicidin peptide SMAP-29: comprehensive review of its properties and potential as a novel class of antibiotics

(2009) Raymond M. Dawson et al.   DRUG DEVELOPMENT RESEARCH

Differentially conserved staphylococcal SH3b_5 cell wall binding domains confer increased staphylolytic and streptolytic activity to a streptococcal prophage endolysin domain

(2009) Stephen C. Becker et al.   GENE

Phage Lysin LysK Can Be Truncated to Its CHAP Domain and Retain Lytic Activity against Live Antibiotic-Resistant Staphylococci

(2008) M. Horgan et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Bacteriophage lysins as effective antibacterials

(2008) Vincent A Fischetti   CURRENT OPINION IN MICROBIOLOGY

Analysis of outer membrane permeability ofPseudomonas aeruginosaand bactericidal activity of endolysins KZ144 and EL188 under high hydrostatic pressure

(2008) Yves Briers et al.   FEMS MICROBIOLOGY LETTERS

LambdaSa2 prophage endolysin requires Cpl-7-binding domains and amidase-5 domain for antimicrobial lysis of streptococci

(2008) David M. Donovan et al.   FEMS MICROBIOLOGY LETTERS

Lytic activity of the recombinant staphylococcal bacteriophage ΦH5 endolysin active against Staphylococcus aureus in milk

(2008) José María Obeso et al.   INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

Antimicrobial activity of a chimeric enzybiotic towards Staphylococcus aureus

(2008) Salim Manoharadas et al.   JOURNAL OF BIOTECHNOLOGY

Phage Lytic Enzyme Cpl‐1 for Antibacterial Therapy in Experimental Pneumococcal Meningitis

(2008) Denis Grandgirard et al.   JOURNAL OF INFECTIOUS DISEASES