Article
Virology
Florence Hugues, Ignacio Cabezas, Mutien Garigliany, Felipe Rivas, Tomas Casanova, Eddy E. Gonzalez, Oliberto Sanchez, Raul Castillo, Natalie C. Parra, Oscar Inostroza-Michael, Lucila Moreno, Cristian E. Hernandez, Jorge R. Toledo
Summary: This study investigated the subgenotypes of BVDV circulating in cattle samples from the Aysen region, southern Chile. Phylogenetic analysis revealed distinct strains of BVDV not previously reported in the country. These findings highlight the importance of ongoing analysis of viral phylogeny and updating vaccines for the cattle breeding area.
Article
Microbiology
Ningning Yang, Jiangwei Zhang, Mingguo Xu, Jihai Yi, Zhen Wang, Yong Wang, Chuangfu Chen
Summary: This study successfully developed BVDV VLPs using an insect baculovirus expression vector system, obtaining VLPs of high purity. Mice immunized with VLPs showed higher levels of BVDV-neutralizing antibodies compared to the control group, and had significantly lower viral loads in various organs compared to the control group in a subsequent challenge. These findings suggest that VLPs are a promising candidate vaccine for BVDV.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Virology
Shollie M. M. Falkenberg, Rohana P. P. Dassanayake, Lauren Crawford, Kaitlyn Sarlo Davila, Paola Boggiatto
Summary: This study evaluated the impact of vaccinating with live or killed antigens and re-vaccinating with the reciprocal. The results showed that vaccinating with live vaccine followed by killed vaccine can enhance virus neutralizing antibody levels and increase the activity of immune cells, which is critical for optimizing protective immune responses.
Article
Veterinary Sciences
Anwar A. G. Al-Kubati, Mahmoud Kandeel, Jamal Hussen, Maged Gomaa Hemida, Abdullah I. A. Al-Mubarak
Summary: This study compared the protein antigenicity and pathogenicity of different BVDV genotypes and sub-genotypes using computational methods. Differences were identified between them, and the possibility of developing novel diagnostic assays and vaccines against BVDV was suggested.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Immunology
Gilles Meyer, Mickael Combes, Angelique Teillaud, Celine Pouget, Marie-Anne Bethune, Herve Cassard
Summary: Border Disease (BD) in sheep is characterized by various symptoms, and control measures include eliminating persistently infected lambs and vaccination. However, vaccines for Bovine Viral Diarrhea Virus (BVDV) may not be effective against BDV infection in sheep, as evidenced by a study showing limited protection against fetal infection.
Article
Virology
Yusuke Goto, Gakuji Yaegashi, Kazuhiro Fukunari, Tohru Suzuki
Summary: Bovine viral diarrhea virus (BVDV) is a viral pathogen that causes serious issues in the cattle industry, with persistently infected cattle serving as sources of transmission. Acutely infected cattle generally recover, but there is a lack of information on the clinical characteristics. More data is needed for accurate diagnosis.
Article
Agriculture, Dairy & Animal Science
Xiaomei Yue, Wilma Steeneveld, Mariska van der Voort, Gerdien van Schaik, Johannes C. M. Vernooij, Linda van Duijn, Anouk M. B. Veldhuis, Henk Hogeveen
Summary: The study focused on the impact of introducing bovine viral diarrhea virus (BVDV) on milk production in dairy herds. Results showed that the reduction in milk yield was most significant in the first year after the introduction of BVDV, with relatively small effects in subsequent years. This study provides valuable insights for dairy farmers and policymakers on the quantitative effects of BVDV on milk production in a control program.
JOURNAL OF DAIRY SCIENCE
(2021)
Review
Veterinary Sciences
Ninnet Gomez-Romero, Julia F. Ridpath, Francisco Javier Basurto-Alcantara, Antonio Verdugo-Rodriguez
Summary: Bovine viral diarrhea (BVD) is a globally-distributed infectious disease caused by bovine Pestiviruses, affecting cattle and other ruminant populations. The disease leads to economic losses in the cattle industry due to its wide range of clinical manifestations. In Mexico, studies have shown varying seroprevalence rates of BVDV, with at least four subgenotypes circulating in animal populations in the country.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Review
Immunology
Feng Pang, Qinqin Long, Min Wei
Summary: This article provides an overview of how bovine viral diarrhea virus (BVDV) evades the host's immune response through various immune evasion strategies, thereby promoting the virus's survival and replication. Understanding BVDV's immune evasion strategies can enhance our knowledge of its pathogenesis and contribute to the development of more effective prevention, control, and eradication measures.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Microbiology
Ben M. Hause, Angela Pillatzki, Travis Clement, Tom Bragg, Julia Ridpath, Christopher C. L. Chase
Summary: Bovine viral diarrhea viruses (BVDV) are important pathogens of cattle, but can also infect a wide range of domestic and wild ruminants, including American bison. This study found that BVDV can persistently infect bison and may have synergistic effects with bovine bosavirus co-infection. These results have implications for BVDV control and eradication programs.
VETERINARY MICROBIOLOGY
(2021)
Article
Veterinary Sciences
Jose Rivas, Alesia Hasanaj, Caroline Deblon, Philippe Gisbert, Mutien-Marie Garigliany
Summary: This study aimed to determine the genetic diversity of BVDV strains currently circulating in France. By sampling and analyzing genetic sequences, the research found a higher genetic diversity of BVDV genotypes in France, including known genotypes and several new genotypes.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Virology
Yingying Ma, Yanyan Han, Yuan Li, Wenlu Fan, Xin Yao, Xinning Huang, Mei Wang, Sheng Jiang, Jinghua Zhao, Xinyuan Qiao, Houhui Song, Yigang Xu
Summary: Bovine viral diarrhea virus (BVDV), an important pathogen of cattle, causes extensive economic losses in the cattle industry worldwide. The molecular interactions between BVDV and its host are complex. In this study, researchers explored the role of DHCR24-mediated cholesterol synthesis in regulating BVDV replication. They found that increased DHCR24 induced by BVDV infection promotes cholesterol production and plays a significant role in viral replication.
JOURNAL OF VIROLOGY
(2022)
Review
Veterinary Sciences
Nai-Chao Diao, Zi-Yang Chen, Jun-Feng Shi, Qi Wang, Chen-Yan Sheng, Bao-Yi Ma, Yang Yang, Yu-Han Sun, Kun Shi, Rui Du
Summary: This systematic review and meta-analysis analyzed the global prevalence of BVDV in sheep and goat populations, finding that prevalence is higher in middle-income countries than in high-income countries. There were no significant differences in prevalence rates by species of BVDV, sampling year, and test species.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Veterinary Sciences
Ninnet Gomez-Romero, Carlos F. Arias, Antonio Verdugo-Rodriguez, Susana Lopez, Luis Fernando Valenzuela-Moreno, Carlos Cedillo-Pelaez, Francisco Javier Basurto-Alcantara
Summary: Bovine viral diarrhea virus (BVDV) is a significant viral pathogen in ruminants, causing a wide range of clinical manifestations and economic losses in the beef and dairy industries. Traditional vaccines have limitations, leading to research on subunit vaccines as a viable alternative for BVDV protection.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Virology
Guanghui Yang, Jialu Zhang, Shenghua Wang, Jun Wang, Jing Wang, Yaohong Zhu, Jiufeng Wang
Summary: Gypenoside exhibits high anti-BVDV activity by interfering with viral attachment and internalization, subsequently inducing apoptosis of infected cells, contributing to the development of novel prophylactic and therapeutic strategies against BVDV infection.