Review
Immunology
Mariam Oladejo, Yvonne Paterson, Laurence M. Wood
Summary: Tumor immunotherapy promises to improve patient survival, with Listeria-based vaccines emerging as a promising treatment. Clinical trials have shown Listeria-based vaccines to be effective in activating anti-tumor immunity and eradicating tumors.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Qing He, Hua Gao, Dejiang Tan, Heng Zhang, Jun-zhi Wang
Summary: mRNA vaccines are well-tolerated by patients and offer flexibility in the choice of encoded molecules. The approval of the first mRNA-based COVID-19 vaccine by the FDA in 2021 has sparked enthusiasm for mRNA vaccine research and development. mRNA cancer vaccines have become a hot topic and have undergone rapid development in recent years.
ACTA PHARMACEUTICA SINICA B
(2022)
Review
Immunology
Ting Huang, Li Liu, Zheng Lv, Kelei Zhao, Qiong Yi, Jing Zhang
Summary: Lung cancer is a major cause of patient deaths globally, and despite advancements in tumor immunotherapy, the 5-year survival rate for lung cancer patients remains low. The development of effective vaccines for lung cancer is crucial, and DNA vaccines are considered a promising strategy to activate the immune system against lung cancer due to their ability to induce both humoral and cellular immune responses.
Review
Pharmacology & Pharmacy
Neftali Ortega Alarcon, Maddy Jaramillo, Heidi M. Mansour, Bo Sun
Summary: This review summarizes the current progress of therapeutic subunit vaccines for cancer immunotherapy, including the classification of tumor antigens and the bioinformatic approaches for identifying tumor neoantigens. The targeting adjuvants based on pattern recognition receptors (PRRs) and their delivery platforms are extensively discussed, emphasizing the importance of the interplay between multiple adjuvants and their combined delivery in cancer immunotherapy.
Review
Oncology
Jian Liu, Minyang Fu, Manni Wang, Dandan Wan, Yuquan Wei, Xiawei Wei
Summary: Research on tumor immunotherapy has made significant progress, and cancer vaccines have emerged as a promising therapeutic strategy. Cancer vaccines stimulate anti-tumor immunity with tumor antigens, potentially overcoming immune suppression and inducing both humoral and cellular immunity. This review introduces the working mechanism of cancer vaccines, summarizes different development platforms, and highlights their clinical research progress, with a focus on clinical application and therapeutic efficacy.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Immunology
Fatemeh Zahedipour, Khadijeh Jamialahmadi, Parvin Zamani, Mahmoud Reza Jaafari
Summary: Peptide vaccines have shown potential in cancer immunotherapy by targeting tumor antigens and activating the immune system, but their efficacy is still a major challenge. This review discusses the current status and strategies to improve the efficacy of peptide vaccines, including the use of novel adjuvants, neoantigens, nano-delivery systems, and combination therapies. Personalized cancer vaccines, multivalent peptides, conjugated peptides, fusion proteins, and self-assembled peptides are also highlighted as ways to enhance the immunogenicity of peptide vaccines. Combining peptide vaccines with other immunotherapeutic approaches and developing personalized vaccines can significantly improve their efficacy and clinical outcomes for cancer patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Rong Yang, Shanshan Zhou, Qibing Zhou
Summary: In vitro cancer cells treated with a new potent ICD inducer, NAP, followed by UVA irradiation, were effective tumor immunotherapy when combined with CpG adjuvant, leading to enhanced survival and activation of T cells in tumors.
JOURNAL OF ADVANCED RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Beata Biri-Kovacs, Zoltan Banoczi, Anitha Tummalapally, Ildiko Szabo
Summary: Skin cancer is the most common type of cancer, with melanoma being a leading cause of skin cancer deaths. Recent advancements in understanding melanoma tumorigenesis and its interaction with the immune system have led to the development of new therapeutic strategies. Peptide-based vaccines, which target tumor antigens and activate immune responses, have shown promise in treating advanced melanoma. However, the immunogenicity of peptide antigens can be enhanced through synthetic modifications, adjuvants, and delivery systems. This review summarizes the various chemical approaches for developing effective peptide-based vaccines for immunotherapy in advanced melanoma.
Article
Oncology
David Reparaz, Marta Ruiz, Diana Llopiz, Leyre Silva, Enric Vercher, Belen Aparicio, Josune Egea, Ibon Tamayo-Uria, Sandra Hervas-Stubbs, Jorge Garcia-Balduz, Carla Castro, Mercedes Inarrairaegui, Maria Tagliamonte, Angela Mauriello, Beatrice Cavalluzzo, Luigi Buonaguro, Charlotte Rohrer, Kathrin Heim, Catrin Tauber, Maike Hofmann, Robert Thimme, Bruno Sangro, Pablo Sarobe
Summary: Immunogenic neoantigens with potential applicability for future combinatorial therapeutic strategies may be generated in hepatocellular carcinoma tumors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Immunology
Mariam Oladejo, Hong-My Nguyen, Ashok Silwal, Britney Reese, Wyatt Paulishak, Maciej M. M. Markiewski, Laurence M. M. Wood
Summary: This study demonstrates the therapeutic efficacy of a Listeria-based vaccine targeting both RCC tumor cells and the tumor-associated vasculature in mouse models of RCC. The vaccine not only reduces primary tumor growth but also enhances anti-tumor immunity and remodels the tumor microenvironment. The efficacy of the vaccine relies on CD8(+) T cells and the antigenic expression of CD105 by RCC tumor cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Si-Yuan Zhu, Ke-Da Yu
Summary: Breast cancer is the most commonly diagnosed cancer worldwide, with relapse and metastasis posing significant challenges. Innovative therapeutic strategies, such as cancer vaccines, are needed to address these challenges. Although current results have been disappointing, recent studies suggest the potential of combining vaccines with other treatments for breast cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Yuan Yuan, Fan Gao, Ying Chang, Qiu Zhao, Xingxing He
Summary: High-frequency mutations in tumor genomes can be utilized to develop tumor vaccines. With advancements in genomics, intelligent algorithms and tumor immunology, it is now possible to target genetic alterations in tumor cells and select vaccine targets efficiently. The application of mRNA in tumor vaccines was initially limited, but the development of mRNA vaccines against SARS-COV-2 has allowed for rapid and cost-effective preparation of tumor mRNA vaccines with good stability and efficiency. This review systematically summarizes the classification and characteristics of tumor antigens, methods for screening neoantigens, vaccine preparation strategies, clinical trial advances, and the main challenges in mRNA tumor vaccine development.
BIOMARKER RESEARCH
(2023)
Article
Engineering, Biomedical
Ping Ji, Xin-Chen Deng, Xiao-Kang Jin, Shi-Man Zhang, Jia-Wei Wang, Jun Feng, Wei-Hai Chen, Xian-Zheng Zhang
Summary: A tumor-specific nanovaccine, named FCM@4RM, is designed to deliver tumor antigens and adjuvants to antigen-presenting cells and modulate the immune microenvironment for strong antitumor immunity. This nanovaccine shows high targeting capabilities towards tumors developed from 4T1 cells, providing a paradigm for developing nanovaccines that systematically regulate multiple immune-related processes for optimal antitumor immunotherapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yao Liu, Yiping Lu, Bo Ning, Xiaomin Su, Binru Yang, Haiqing Dong, Bo Yin, Zhiqing Pang, Shun Shen
Summary: In this study, an immunotherapy system based on red blood cell membrane encapsulated Listeria monacytagenes (Lmo@RBC) was developed to address the limitations of Lmo as a cancer vaccine. Lmo@RBC showed low systemic inflammatory response and enhanced accumulation in tumors, resulting in a strong and durable anti-tumor immune response with excellent therapeutic effects.
Article
Immunology
Giuditta Guerrini, Antonio Vivi, Sabrina Gioria, Jessica Ponti, Davide Magri, Arnd Hoeveler, Donata Medaglini, Luigi Calzolai
Summary: Physicochemical properties of adjuvant-protein antigen complexes impact vaccine efficacy and safety, and a multi-staged characterization strategy has been developed for accurate assessment of nanoaluminum-ovalbumin complex, which can be adapted for various adjuvant-protein antigen combinations to control quality and improve immunological outcomes of vaccines.
Article
Oncology
Nicola J. Mason, Josephine S. Gnanandarajah, Julie B. Engiles, Falon Gray, Danielle Laughlin, Anita Gaurnier-Hausser, Anu Wallecha, Margie Huebner, Yvonne Paterson
CLINICAL CANCER RESEARCH
(2016)
Article
Immunology
Maciej M. Markiewski, Surya Kumari Vadrevu, Sharad K. Sharma, Navin Kumar Chintala, Shanawaz Ghouse, Jun-Hung Cho, David P. Fairlie, Yvonne Paterson, Aristotelis Astrinidis, Magdalena Karbowniczek
JOURNAL OF IMMUNOLOGY
(2017)
Article
Oncology
Laurence M. Wood, Zhen-Kun Pan, Matthew M. Seavey, Geetha Muthukumaran, Yvonne Paterson
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2012)
Article
Immunology
Anu Wallecha, Laurence Wood, Zhen-Kun Pan, Paulo C. Maciag, Vafa Shahabi, Yvonne Paterson
CLINICAL AND VACCINE IMMUNOLOGY
(2013)
Article
Immunology
Cac T. Bui, Lisa M. Shollenberger, Yvonne Paterson, Donald A. Harn
CLINICAL AND VACCINE IMMUNOLOGY
(2014)
Article
Immunology
Cac T. Bui, Lisa M. Shollenberger, Yvonne Paterson, Donald A. Harn
CLINICAL AND VACCINE IMMUNOLOGY
(2015)
Review
Immunology
John Rothman, Yvonne Paterson
EXPERT REVIEW OF VACCINES
(2013)
Article
Immunology
Lisa M. Shollenberger, Cac T. Bui, Yvonne Paterson, Lindsay Nyhoff, Donald A. Harn
Article
Immunology
Lisa M. Shollenberger, Cac Bui, Yvonne Paterson, Kelsey Allen, Donald Harn
Article
Cell & Tissue Engineering
Yasmin Z. Paterson, Nicola Rash, Elaine R. Garvican, Romain Paillot, Deborah J. Guest
STEM CELL RESEARCH & THERAPY
(2014)
Article
Oncology
Patrick D. Guirnalda, Yvonne Paterson
Article
Oncology
Patrick Guirnalda, Laurence Wood, Radhika Goenka, Joel Crespo, Yvonne Paterson
Article
Immunology
Shanawaz M. Ghouse, Surya K. Vadrevu, Sasikanth Manne, Britney Reese, Jalpa Patel, Bhaumik Patel, Ashok Silwal, Niraj Lodhi, Yvonne Paterson, Sanjay K. Srivastava, Magdalena Karbowniczek, Maciej M. Markiewski
JOURNAL OF IMMUNOLOGY
(2020)
Article
Immunology
K. G. Hernandez-Flores, A. L. Calderon-Garciduenas, G. Mellado-Sanchez, R. Ruiz-Ramos, L. A. Sanchez-Vargas, P. Thomas-Dupont, I. Y. Izaguirre-Hernandez, J. Tellez-Sosa, J. Martinez-Barnetche, L. Wood, Y. Paterson, L. Cedillo-Barron, O. Lopez-Franco, H. Vivanco-Cid
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2017)