Article
Biochemistry & Molecular Biology
Magdalena Kowalowka, Grzegorz Kosewski, Daniel Lipinski, Juliusz Przyslawski
Summary: This study found that the LCT gene polymorphism, VDR gene polymorphisms, and diet and nutritional status can affect the prevalence of vitamin D and calcium deficiency in young adults. The study was conducted on a group of 63 individuals, with 21 individuals having primary adult lactase deficiency and 42 individuals without lactose intolerance. The CC genotype of the LCT gene polymorphism was associated with significantly lower milk and dairy product consumption, as well as lower levels of vitamin D and calcium.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Emily Sonestedt, Yan Borne, Elisabet Wirfaelt, Ulrika Ericson
Summary: The study found that consumption above 1,000 g/day of non-fermented milk was associated with higher mortality rates, while fermented milk and cheese intake were associated with lower mortality. Additionally, the composition differences in dairy products are important, and should be separately examined in relation to health and disease.
FRONTIERS IN NUTRITION
(2021)
Article
Genetics & Heredity
Mulata Haile Nega, Derbew Fikadu Berhe, Vera Ribeiro
Summary: This study assessed the genotype and allele frequencies of a gene variant related to statin-induced myopathy in individuals from Colombia, Mozambique, and Portugal. The CC genotype was less frequent, but relatively higher in Colombians and Portuguese populations, which may have implications for the risk and benefit variability of statin use in these populations.
BMC MEDICAL GENOMICS
(2023)
Article
Endocrinology & Metabolism
Shelley M. Vanderhout, Charles D. G. Keown-Stoneman, Catherine S. Birken, Deborah L. O'Connor, Kevin E. Thorpe, Jonathon L. Maguire
Summary: This study found that compared to reduced fat (0.1-2%) milk, consumption of whole milk was associated with lower zBMI and lower risk of overweight and obesity.
INTERNATIONAL JOURNAL OF OBESITY
(2021)
Review
Medicine, General & Internal
Guanglu Che, Fang Liu, Li Chang, Yongmei Jiang
Summary: The study found no significant association between IL-10 -819C/T, -592A/C polymorphisms and the risk of preeclampsia, but did show a significant association with preeclampsia susceptibility in Asian and Caucasian populations.
Article
Agriculture, Dairy & Animal Science
Philip Alex, Raji Kanakkaparambil, Radhika Gopalakrishnan, Chitra Ramasamy, Aravindakshan Thazhathuveettil
Summary: This study aimed to detect the c.546 + 179170A > T transversion in intron 2 of the IGF1R gene in Attappady Black and Malabari goat breeds and examine its association with growth and milk production traits. T-ARMS-PCR was used for SNP identification and all three genotypes were found in both breeds. The polymorphism was significantly linked with growth traits but had no effect on milk production. Therefore, this SNP could be used as a molecular marker in the selection of meat-producing goat breeds.
ANIMAL BIOTECHNOLOGY
(2023)
Article
Genetics & Heredity
Boran Gao, Can Yang, Jin Liu, Xiang Zhou
Summary: The new computational method GECKO improves the accuracy of estimating genetic and environmental covariances in GWAS, revealing shared genetic and environmental structures between traits and aiding in the investigation of causal relationships. Compared to traditional methods, GECKO provides more accurate estimates and identifies significant genetic and environmental covariances, demonstrating a twofold power gain in analyzing trait pairs.
Article
Cell Biology
Marcin Kosmalski, Izabela Szymczak-Pajor, Jozef Drzewoski, Agnieszka Sliwinska
Summary: This study investigated the association between CAT levels and -262 C/T polymorphism in the promoter of CAT (rs1001179) with NAFLD. The results showed that CAT levels were decreased in NAFLD patients and the CT genotype and T allele of -262 C/T CAT polymorphism may elevate the risk of NAFLD.
Article
Anthropology
Amanda L. Thompson
Summary: This study evaluates the applicability of a standard for healthy child growth, discusses the perspectives of global health, human biology, and parents on growth variability, and highlights the differences in views of normal growth across different contexts. Results show considerable variability in child growth across backgrounds, indicating that no single framework can serve as a model for healthy growth. Both biomedicine and parents base their care decisions on perceptions of normal, healthy growth, emphasizing the importance of the comparative framework used for medical treatment and feeding practices.
AMERICAN JOURNAL OF HUMAN BIOLOGY
(2021)
Review
Endocrinology & Metabolism
Ha Young Yoon, Min Hye Lee, Yubin Song, Jeong Yee, Gonjin Song, Hye Sun Gwak
Summary: The CC or CT genotype of ABCA1 69C>T polymorphism is associated with an increased risk of type 2 diabetes mellitus, with C allele carriers in the Asian population showing a higher risk compared to those with the TT genotype.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiao-feng Wang, Dong-li Liu, Li Geng
Summary: Through the analysis of numerous studies, we found that the PSCA rs2294008 (C/T) polymorphism is associated with an increased risk of cancer, especially gastric and bladder cancers. Additionally, this polymorphism results in a decreased expression level of PSCA in gastric cancer patients.
GENETIC TESTING AND MOLECULAR BIOMARKERS
(2023)
Article
Chemistry, Applied
Junjun Qing, Cheng Peng, Hongbing Chen, Haixing Li, Xiaohua Liu
Summary: The study aimed to investigate the impact of fermentation conditions on c9,t11-conjugated linoleic acid (CLA) synthesis by Lactobacillus casei, as well as its effects on whey syneresis, water holding capacity (WHC), and texture characteristics of set yogurt. The addition of 0.1% linoleic acid (LA) decreased whey syneresis by about 30%. UV-Vis absorption spectroscopy, 3D fluorescence spectroscopy, and CD spectroscopy revealed the interaction between LA and casein (CS), fi-lactoglobulin (fi-Lg), and bovine serum albumin (BSA). LA changed the microenvironment and polarity around amino acids, as well as the conformation of the three milk proteins. Scanning electron microscope (SEM) analysis showed that the addition of LA resulted in a more uniform and compact microstructure of the set yogurt, suggesting that LA can promote the crosslink of milk proteins, which may explain the reduction in whey syneresis.
Article
Multidisciplinary Sciences
Beatrice M. Muriuki, Catherine S. Forconi, Peter O. Oluoch, Jeffrey A. Bailey, Anita Ghansah, Ann M. Moormann, John M. Ong'echa
Summary: The study revealed that individuals with more activating KIR genes are more susceptible to endemic Burkitt lymphoma, and certain KIR polymorphisms are associated with increased EBV levels and disease susceptibility.
SCIENTIFIC REPORTS
(2021)
Article
Genetics & Heredity
Recai Aci, Gulay Ciftci, Serbulent Yigit, Ozlem Sezer, Adem Keskin
Summary: This study investigated the relationship between biochemical parameters and circadian rhythm hormones with Clock 3111 T/C and Period3 VNTR gene polymorphisms in infertile women. The results showed a significant difference in the frequency of Period3 DD (Per3(4/4)) genotype between the groups, and the Clock protein level was higher in the infertile group. These findings provide a basis for future research.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Tobias Peitz, Birte Moehlendick, Winfried Siffert, Falko Markus Heinemann, Andreas Kribben, Ute Eisenberger, Justa Friebus-Kardash
Summary: This study investigated the effect of the GNB3 c.825C>T polymorphism on cardiovascular events among renal allograft recipients posttransplant. The results showed that recipients with the TT genotype had a higher risk of death due to acute cardiovascular events and lower survival rates for myocardial infarction and acute peripheral artery occlusive disease. However, the homozygous GNB3 T allele only exerted a significant effect on the risk of myocardial infarction and acute peripheral artery occlusive disease in the presence of additional nonheritable risk factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)