Article
Biochemistry & Molecular Biology
Mark Stewart, Timothy Morello, Richard Kollmar, Rena Orman
Summary: With the increasing average human lifespan, the impact of neurodegenerative diseases on individuals and communities has grown, leading to the exploration of animal models such as the long-lived Seba's short-tailed fruit bat, Carollia perspicillata, for research on brain aging and neurodegeneration. This bat species shows anatomical similarities to primate and human hippocampal formation, offering unique advantages for studying these conditions through captive colony studies.
Article
Andrology
Mehmet Ozbek, Feyzullah Beyaz, Emel Ergun, Levent Ergun, Harun Karaca, Ahmet Cabir, Yahy Abood Kareem Alesawi
Summary: This study investigates the expression of calcium-binding proteins and neural cell markers in the rat testis and epididymis during postnatal development. The results show that these proteins have differential expression patterns in different stages and may play important roles in reproductive physiology.
Article
Veterinary Sciences
Miguel Merchan Jr, Rafael Covenas, Ignacio Plaza, Jose Alfonso Abecia, Carlos Palacios
Summary: In this study, the anatomy of nuclei involved in seasonal fertility regulation (SFR) in ewes was analyzed. The analysis included morphometric and qualitative analysis of various nuclei in the brain, as well as data collection on calcium-binding proteins and cell phenotypes. Glial architecture was also assessed. The results provided guidelines for microdissecting the nuclei involved in SFR.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Anatomy & Morphology
Timothy Morello, Richard Kollmar, Abdessamad Ramzaoui, Mark Stewart, Rena Orman
Summary: This study investigated the distribution of calcium-binding proteins in the claustrum and dorsal endopiriform nucleus of the fruit bat. The results showed that the claustrum is more complex than previously thought, with at least four distinct subregions within its shell. Different calcium-binding proteins label different types of neurons in both the claustrum and dorsal endopiriform nucleus, and there are significant differences in inhibitory connectivity between subregions.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Clinical Neurology
Laura A. Smith, Daniel Erskine, Alasdair Blain, Robert W. Taylor, Robert McFarland, Nichola Z. Lax
Summary: In this study, the researchers investigated the neuropathological changes in Alpers' syndrome patients and identified severe loss of parvalbumin-positive interneurons, as well as impaired mitochondrial oxidative phosphorylation. The higher abundance of parvalbumin-positive interneurons in the occipital cortex provides insights into the etiology of occipital-predominant epilepsy in Alpers' syndrome. These findings have important implications for the development of preclinical models and therapeutics for Alpers' syndrome.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2022)
Article
Physiology
Martin Salaj, Filip Barinka, Hana Kubova, Rastislav Druga
Summary: The study aimed to describe the interneuronal population expressing calcium binding proteins calretinin (CR) and parvalbumin (PV) in the perirhinal (PRC) and retrosplenial (RSC) cortex of rats. The results showed that PRC has higher absolute and relative densities of CR+ and PV+ neurons compared to RSC, with a higher CR:PV ratio in RSC similar to the neocortex.
PHYSIOLOGICAL RESEARCH
(2021)
Article
Clinical Neurology
Cheng-Ta Li, Chi-Hung Juan, Hui-Ching Lin, Chih-Ming Cheng, Hui-Ting Wu, Bang-Hung Yang, Shih-Jen Tsai, Tung-Ping Su, Paul B. Fitzgerald
Summary: This study is the first to reveal the underlying molecular mechanisms of the fronto-limbic circuit in individuals with major depressive disorder and demonstrates the differential modulation of neurotransmitter systems by rTMS and iTBS.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Neurosciences
Dubravka Aleksic, Joko Poleksic, Gorana Agatonovic, Vuk Djulejic, Maja Vulovic, Miljana Aksic, Gebhard Reiss, Mohammad I. K. Hamad, Igor Jakovcevski, Milan Aksic
Summary: There is increasing evidence linking traumatic experiences during early development to later psychopathology. In this study, researchers examined the effects of maternal deprivation on GABAergic interneurons in the amygdala and nucleus accumbens of 9-day-old rats. The results showed that early stress leads to changes in the number and morphology of these inhibitory interneurons, providing further understanding of the impact of maternal deprivation on brain development.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Saptarsi Mitra, Sumela Basu, Omprakash Singh, Abhinav Srivastava, Praful S. Singru
Summary: This study investigated the characteristics of calcium-binding proteins (CBPs) in the ventral tegmental area (VTA) and substantia nigra (SN) of zebra finches. The expression levels of Calbindin and Calretinin mRNA were found to be higher, and the distribution of CBPs varied in different regions. These findings suggest that CBPs may play a crucial role in the heterogeneity and activity regulation of midbrain dopamine neurons in zebra finches.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Lennart Seizer, Sadegh Rahimi, Sandra Santos-Sierra, Meinrad Drexel
Summary: Toll-like receptors (TLR) are important components of the innate immune system in mammals. This study found that TLR8 expression in the hippocampus of mice is region-specific and particularly high in GABAergic interneurons, suggesting a possible association with vulnerability to temporal lobe epilepsy in humans.
Article
Neurosciences
Natalia Merkulyeva, Aleksandr Mikhalkin, Anna Kostareva, Tatyana Vavilova
Summary: This study focused on the postnatal development of perigeniculate neurons and found different neuronal subpopulations in kittens and adult cats. These subpopulations showed differences in morphology and neurochemical characteristics, which may have implications for the development of thalamocortical processing.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Article
Neurosciences
Sandra U. Okoro, Roman U. Goz, Brigdet W. Njeri, Madhumita Harish, Catherine F. Ruff, Sarah E. Ross, Charles Gerfen, Bryan M. Hooks
Summary: This research demonstrates the relationship between synaptic connections and activation patterns of neurons in the motor cortex (M1) of the brain. Inputs from sensory cortex and thalamus target different types of M1 interneurons in a specific manner. In the regulation of M1 output, different types of neurons are activated in a specific way and circuit.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Timothy Morello, Richard Kollmar, Mark Stewart, Rena Orman
Summary: The retrosplenial cortex (RSC) is a brain region involved in crucial cognitive functions and commonly affected in neurodegenerative diseases. This study identified distinct distributions and marker proteins in subregions of RSC, suggesting the potential of using bat RSC as a model for studying age-related neurodegeneration.
Article
Anatomy & Morphology
James T. McKenna, Chun Yang, Thomas Bellio, Marissa B. Anderson-Chernishof, Mackenzie C. Gamble, Abigail Hulverson, John G. McCoy, Stuart Winston, Erik Hodges, Fumi Katsuki, James M. McNally, Radhika Basheer, Ritchie E. Brown
Summary: The study examines the distribution and function of BF glutamatergic neurons expressing vGluT2, revealing a dual role in promoting wakefulness and avoidance behavior.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Clinical Neurology
Barbara Puhahn-Schmeiser, Kathrin Leicht, Florian Gessler, Thomas M. Freiman
Summary: The study compared resected hippocampal specimens from patients with hippocampal sclerosis to controls with only mild sclerosis, finding that sprouted mossy fibers in epileptic hippocampi not only activate excitatory granule cells, but also connect to inhibitory parvalbuminergic interneurons. Despite neuronal death in hippocampal sclerosis, the axonal plexus of inhibitory parvalbuminergic interneurons surrounding the granule cells is preserved. Connections between sprouted mossy fibers and inhibitory axon terminals were quantified, showing that inhibitory terminals significantly outnumber excitatory mossy fiber terminals.
Article
Developmental Biology
Diana V. Castillo-Padilla, Klaus Funke
DEVELOPMENTAL NEUROBIOLOGY
(2016)
Review
Clinical Neurology
T. Schmidt-Wilcke, E. Fuchs, K. Funke, A. Vlachos, F. Mueller-Dahlhaus, N. A. J. Puts, R. E. Harris, R. A. E. Edden
Article
Biology
Bingshuo Li, Juha P. Virtanen, Axel Oeltermann, Cornelius schwarz, Martin A. Giese, Ulf Ziemann, Alia Benali
Article
Clinical Neurology
Danny Jazmati, Ute Neubacher, Klaus Funke
Article
Biochemistry & Molecular Biology
Ravit Hadar, Rebecca Winter, Henriette Edemann-Callesen, Franziska Wieske, Bettina Habelt, Niranjan Khadka, Viktoria Felgel-Farnholz, Elizabeth Barroeta-Hlusicka, Janine Reis, Cristian Alexandru Tatarau, Klaus Funke, Brita Fritsch, Nadine Bernhardt, Marom Bikson, Michael A. Nitsche, Christine Winter
MOLECULAR PSYCHIATRY
(2020)
Article
Neurosciences
Ellen Kloosterboer, Klaus Funke
JOURNAL OF PHYSIOLOGY-LONDON
(2019)
Article
Clinical Neurology
Elisabeth Petrasch-Parwez, Andreas Schoebel, Alia Benali, Zahra Moinfar, Eckart Foerster, Martin Bruene, Georg Juckel
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2020)
Article
Developmental Biology
Jeyanthan Charles James, Klaus Funke
DEVELOPMENTAL NEUROBIOLOGY
(2020)
Article
Neurosciences
Benjamin Lippmann, Gleb Barmashenko, Klaus Funke
Summary: Aberrant neuronal network activity, particularly within the limbic networks, is implicated in cognitive deficits in neuropsychiatric diseases like schizophrenia. Deep brain stimulation and repetitive transcranial magnetic stimulation have shown acute normalization effects on the oscillatory activity patterns in rat models, suggesting potential therapeutic implications in the long term.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Nadine Rittweger, Tanja Ishorst, Gleb Barmashenko, Verena Aliane, Christine Winter, Klaus Funke
Summary: rTMS, especially iTBS, showed positive effects on sensory processing and learning in rats with MIA-related schizophrenia model. While there were improvements in sensory gating and novel object recognition, there were no significant changes in anxiety, anhedonia, and depression symptoms.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Correction
Clinical Neurology
Elisabeth Petrasch-Parwez, Andreas Schoebel, Alia Benali, Zahra Moinfar, Eckart Foerster, Martin Bruene, Georg Juckel
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Review
Clinical Neurology
Hartwig R. Siebner, Klaus Funke, Aman S. Aberra, Andrea Antal, Sven Bestmann, Robert Chen, Joseph Classen, Marco Davare, Vincenzo Di Lazzaro, Peter T. Fox, Mark Hallett, Anke N. Karabanov, Janine Kesselheim, Mikkel M. Beck, Giacomo Koch, David Liebetanz, Sabine Meunier, Carlo Miniussi, Walter Paulus, Angel Peterchev, Traian Popa, Michael C. Ridding, Axel Thielscher, Ulf Ziemann, John C. Rothwell, Yoshikazu Ugawa
Summary: Transcranial (electro)magnetic stimulation (TMS) is a non-invasive method used to induce neural activity in the human brain. TMS generates a time-varying electric field in the brain, affecting cortical neurons and their action potentials. TMS primarily targets the axonal terminals in the cortical gyri, with additional stimulation of myelinated axon bends in the juxtacortical white matter. The response to TMS influences both local neuronal populations and connected networks in the target area, as well as causing stimulation in the peripheral nervous system. The interpretation of TMS effects requires caution, and understanding its underlying mechanisms is crucial for its scientific and therapeutic advancements.
CLINICAL NEUROPHYSIOLOGY
(2022)
Review
Cell Biology
Friederike Pfeiffer, Alia Benali
NEURAL REGENERATION RESEARCH
(2020)
Article
Clinical Neurology
G. Cirillo, G. Di Pino, F. Capone, F. Ranieri, L. Florio, V. Todisco, G. Tedeschi, K. Funke, V. Di Lazzaro
Article
Neurosciences
Kathrin Hoppenrath, Wolfgang Haertig, Klaus Funke
FRONTIERS IN NEURAL CIRCUITS
(2016)