Article
Clinical Neurology
Matthew Weightman, Neeraj Lalji, Chin-Hsuan Sophie Lin, Joseph M. Galea, Ned Jenkinson, R. Chris Miall
Summary: Brief bursts of anodal stimulation to the cerebellum during a visuomotor adaptation task were found to enhance motor adaptation significantly better than standard TDCS. Short duration, event related, anodal TDCS targeting the cerebellum enhances motor adaptation compared to the standard model.
Article
Neurosciences
Yun R. Lien, Yi-Cheng Lin, Shang-Hua N. Lin, Ching-Po Lin, Li-Hung Chang
Summary: The study found that repetitive transcranial magnetic stimulation (rTMS) has frequency-dependent modulatory effects on visuomotor accuracy, enhancing it in the high-frequency group and disrupting it in the low-frequency group. However, rTMS did not significantly affect visuomotor stability. This suggests that visuomotor accuracy and stability are controlled by different neural mechanisms and highlights the potential for training strategies based on cerebellar neuromodulation.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Tingting Zhang, Bingqi Guo, Zhentao Zuo, Xiaojing Long, Shimin Hu, Siran Li, Xin Su, Yuping Wang, Chunyan Liu
Summary: This study aimed to evaluate the modulatory effects of transcranial focus ultrasound stimulation (tFUS) on human motor cortex excitability and explore the mechanism of neurotransmitter-related intracortical circuitry and plasticity. The results showed that tFUS can significantly increase M1 excitability, decrease intracortical inhibition, and change the concentration of GABA and Glx in the brain. These findings provide new insights into how tFUS can modulate cortical excitability and plasticity.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Taisei Sugiyama, Keita Nakae, Jun Izawa
Summary: This study investigates the noninvasive modulation of motor adaptation in humans. The results show that transcranial magnetic stimulation can increase adaptation and the direction of modulation is specific to the targeted area. Additionally, the study demonstrates the feasibility of using PMd as a target region for neuromodulation to understand human motor adaptation and improve motor rehabilitation.
Article
Multidisciplinary Sciences
Jin Seung Choung, Sohom Bhattacharjee, Jeong Pyo Son, Jong Moon Kim, Dong Sik Cho, Choon Sik Cho, MinYoung Kim
Summary: Repetitive transcranial magnetic stimulation (rTMS) is being explored as a new treatment technique for brain lesions, but the effects in animals cannot directly represent the effects in humans due to differences in size and mechanistic characteristics. This study aimed to develop a mouse rTMS device to simulate clinical application. The magnetic field intensity generated by the mouse coil was lower than that by the human coil, and the predicted simulation values matched the measured intensity in vivo. Further research using miniaturized rTMS devices for mice should be conducted to make the findings more relevant to humans.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Asher Geffen, Nicholas Bland, Martin V. Sale
Summary: The study investigated the effects of slow oscillatory (SO) tACS on motor cortical excitability and found that tACS had a facilitatory effect on motor cortical excitability that outlasted stimulation. However, there was no evidence supporting entrainment of endogenous oscillations as the underlying mechanism.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Maximilian Lenz, Amelie Eichler, Andreas Vlachos
Summary: Inflammation affects neuronal plasticity, and inflammation-induced alterations in synaptic plasticity are associated with the development of neuropsychiatric symptoms. Current diagnostic and intervention strategies are limited in restoring inflammation-induced deficits in synaptic plasticity.
Article
Clinical Neurology
Lipeng Ning, Yogesh Rathi, Tracy Barbour, Nikos Makris, Joan A. Camprodon
Summary: This study utilized novel dMRI analysis to investigate microstructural changes related to rTMS treatment response in 21 MDD patients, finding that rTMS significantly affected the white matter microstructure in the anterior-medial prefrontal fiber bundles, while changes in lateral prefrontal tracts were correlated with treatment response. Further research with larger datasets is needed to fully understand the impact of rTMS on structural connectivity in MDD patients.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Neurosciences
Giulia Paparella, Martina De Riggi, Antonio Cannavacciuolo, Donato Colella, Davide Costa, Daniele Birreci, Massimiliano Passaretti, Luca Angelini, Andrea Guerra, Alfredo Berardelli, Matteo Bologna
Summary: Through a study involving 33 healthy subjects, it was found that unilateral motor practice leads to improved performance of both the trained and untrained contralateral limbs. The transfer of this skill is asymmetric and relates to the modulation of specific inhibitory interhemispheric connections.
Article
Neurosciences
Cecilia Neige, Florent Lebon, Catherine Mercier, Jeremie Gaveau, Charalambos Papaxanthis, Celia Ruffino
Summary: Pain interferes with the motor imagery process, preventing the enhancement of corticospinal excitability and use-dependent plasticity.
Article
Biochemistry & Molecular Biology
Kevin Pacheco-Barrios, Danielle Carolina Pimenta, Anne Victorio Pessotto, Felipe Fregni
Summary: The clinical correlates of transcranial magnetic stimulation (TMS) measures, such as resting motor threshold (MT), motor-evoked potential (MEP), short intracortical inhibition (SICI), and intracortical facilitation (ICF), in fibromyalgia syndrome (FMS) patients were investigated. It was found that SICI was associated with sleepiness, comorbidities, disease duration, and anxiety, while ICF showed a positive correlation with pain levels and a negative correlation with body mass index (BMI). These findings suggest that SICI and ICF metrics may serve as potential phenotyping biomarkers in FMS.
Article
Multidisciplinary Sciences
P. O. Boucher, R. A. Ozdemir, D. Momi, M. J. Burke, A. Jannati, P. J. Fried, A. Pascual-Leone, M. M. Shafi, Emiliano Santarnecchi
Summary: In this study, the effects of continuous TBS and intermittent TBS protocols on corticospinal excitability were compared over time, with results showing varying effects on motor evoked potentials. However, these effects were generally diminished in repeat visits. The findings challenge the efficacy and reliability of TBS protocols, highlighting the need to consider sham effects when evaluating TBS outcomes.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Adriano H. Moffa, Tjeerd W. Boonstra, Ashley Wang, Donel Martin, Colleen Loo, Stevan Nikolin
Summary: Theta burst stimulation (TBS) is a new form of non-invasive transcranial magnetic stimulation (TMS) that can modulate cortical excitability. This study investigated the neuromodulatory effects of TBS on the dorsolateral prefrontal cortex (DLPFC) using EEG, ECG, and MRI recordings. The findings provide foundational knowledge for future research on the application of TBS.
Article
Clinical Neurology
Mohd Faizal Mohd Zulkifly, Ornela Merkohitaj, Juergen Brockmoeller, Walter Paulus
Summary: The study investigated the impact of caffeine on brain plasticity and found that it increased motor cortex excitability in caffeine-naive subjects, enhanced PAS 25 effects, and affected alertness and motor evoked potentials under light deprivation. Time of day had no effect on tACS-induced plasticity in caffeine consumers.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Carolin Balloff, Iris-Katharina Penner, Meng Ma, Iason Georgiades, Lina Scala, Nina Troullinakis, Jonas Graf, David Kremer, Orhan Aktas, Hans-Peter Hartung, Sven Gunther Meuth, Alfons Schnitzler, Stefan Jun Groiss, Philipp Albrecht
Summary: This study investigated the association between cortical plasticity and cognitive performance in multiple sclerosis (MS) patients. The results showed that cortical plasticity correlated with cognitive performance and clinical disability in MS patients. Interestingly, the overall MS patient cohort did not exhibit reduced plasticity compared to healthy controls.
Review
Dentistry, Oral Surgery & Medicine
Taihiko Yamaguchi, Saki Mikami, Masana Maeda, Taishi Saito, Toshinori Nakajima, Wataru Yachida, Akihito Gotouda
Summary: This article reviews the current state of portable/wearable EMG devices for assessment of bruxism. The results show that ultra-miniaturized wearable EMG devices with performance equivalent to conventional devices have been developed and used during sleep and in the daytime, with a high level of diagnostic accuracy for sleep bruxism. However, a definite cut-off value for awake bruxism has not been established.
CRANIO-THE JOURNAL OF CRANIOMANDIBULAR & SLEEP PRACTICE
(2023)
Review
Sport Sciences
Lukas Moesgaard, Mikkel Malling Beck, Lasse Christiansen, Per Aagaard, Jesper Lundbye-Jensen
Summary: Based on the analysis of 35 studies, it was found that when volume is equated, periodized resistance training has a greater effect on maximal strength compared to non-periodized resistance training, while the effect on muscle hypertrophy is not significant. Additionally, undulating periodization training leads to greater improvements in maximal strength compared to linear periodization training. However, these effects are mainly observed in trained individuals, with minimal impact on untrained individuals. Periodization of volume and intensity does not seem to significantly affect muscle hypertrophy.
Letter
Biotechnology & Applied Microbiology
Jens Nielsen, Markus J. Herrgard, Bobby Soni
NATURE BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Olena P. Ishchuka, Ivan Domenzain, Benjamin J. Sanchez, Facundo Muniz-Paredes, Jose L. Martinez, Jens Nielsen, Dina Petranovic
Summary: Heme synthesis can be increased by modifying certain genes, leading to higher production of heme proteins. This study identified 84 gene targets through computational simulations, of which 40 were confirmed to enhance heme production in experiments. Not only genes directly involved in heme biosynthesis, but also genes related to glycolysis, glycine, and succinyl-coenzyme A metabolism were found to affect heme production.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Feiran Li, Yu Chen, Mihail Anton, Jens Nielsen
Summary: Enzyme parameters are crucial for understanding, modeling, and engineering cells. Experimental measurements only cover a small portion of enzyme-compound pairs, and even less in non-model organisms. Artificial intelligence techniques have accelerated the exploration of enzyme properties by predicting them in a high-throughput manner. GotEnzymes is a comprehensive database that provides predicted enzyme parameters using AI approaches, allowing for interactive web exploration and programmatic access.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Neurosciences
Malene Norup, Jonas Rud Bjorndal, August Lomholt Nielsen, Patrick Wiegel, Jesper Lundbye-Jensen
Summary: This study investigated the effects of dynamic motor practice and isometric motor practice on force control and position control, as well as the effects on corticospinal excitability. The results showed that dynamic motor practice significantly improved movement accuracy in position control and led to increased corticospinal excitability.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Biochemical Research Methods
Le Yuan, Hongzhong Lu, Feiran Li, Jens Nielsen, Eduard J. Kerkhoven
Summary: In this study, a computational toolbox called HGTphyloDetect was developed, which combines high-throughput analysis with phylogenetic inference to accurately identify horizontal gene transfer (HGT) events and illustrate the transmission pathway among evolutionarily distant or closely related species. The HGTphyloDetect toolbox is user-friendly, capable of detecting HGT events with high efficiency and low false discovery rate.
BRIEFINGS IN BIOINFORMATICS
(2023)
Review
Physiology
M. H. Hjortshoej, P. Aagaard, C. D. Storgaard, H. Juneja, J. Lundbye-Jensen, S. P. Magnusson, C. Couppe
Summary: This study evaluated the hormonal, immune, and oxidative stress responses in healthy adults following low-load blood-flow restricted resistance exercise (LL-BFRRE) and conventional free-flow resistance exercise (FFRE). The results showed that LL-BFRRE induced higher hormone and immune responses compared to FFRE, and had attenuated oxidative stress responses compared to HL-FFRE.
Article
Neurosciences
Malene Norup, August Lomholt Nielsen, Jonas Rud Bjorndal, Patrick Wiegel, Meaghan Elizabeth Spedden, Jesper Lundbye-Jensen
Summary: In this study, the effects of motor practice on motor performance, accuracy and variability in preadolescent children were investigated. The study also examined changes in corticomuscular coherence following motor practice. Participants performed wrist flexions with specific movement endpoints or force levels. Results showed that position control practice led to greater improvements in movement accuracy compared to force control practice or resting control. There were no significant changes in force task performance or corticomuscular coherence. These findings suggest that preadolescent children improve position control following dynamic accuracy motor practice, but not force control.
HUMAN MOVEMENT SCIENCE
(2023)
Article
Education, Special
Laurits Munk Hojberg, Jesper Lundbye-Jensen, Jacob Wienecke
Summary: This study aimed to investigate how young adults with Down syndrome (DS) learn and retain new motor skills. The results showed that individuals with DS had poorer motor performance compared to typically developed individuals. However, they demonstrated online improvements in performance with practice and showed offline consolidation, leading to significant retention effects.
RESEARCH IN DEVELOPMENTAL DISABILITIES
(2023)
Article
Chemistry, Analytical
Ivana Bardino Novosel, Anina Ritterband-Rosenbaum, Georgios Zampoukis, Jens Bo Nielsen, Jakob Lorentzen
Summary: This study developed and trained an image-based Convolutional Neural Network (CNN) to recognize specific movement classifiers relevant to individuals with cerebral palsy (CP). Monitoring and quantifying movement behavior in CP patients using multiple wearable sensors and CNN is of great value for improving their health outcomes.
Article
Materials Science, Multidisciplinary
Morteza Aghaee, Arun Akkala, Zulfi Alam, Rizwan Ali, Alejandro Alcaraz Ramirez, Mariusz Andrzejczuk, Andrey E. Antipov, Pavel Aseev, Mikhail Astafev, Bela Bauer, Jonathan Becker, Srini Boddapati, Frenk Boekhout, Jouri Bommer, Tom Bosma, Leo Bourdet, Samuel Boutin, Philippe Caroff, Lucas Casparis, Maja Cassidy, Sohail Chatoor, Anna Wulf Christensen, Noah Clay, William S. Cole, Fabiano Corsetti, Ajuan Cui, Paschalis Dalampiras, Anand Dokania, Gijs de Lange, Michiel de Moor, Juan Carlos Estrada Saldana, Saeed Fallahi, Zahra Heidarnia Fathabad, John Gamble, Geoff Gardner, Deshan Govender, Flavio Griggio, Ruben Grigoryan, Sergei Gronin, Jan Gukelberger, Esben Bork Hansen, Sebastian Heedt, Jesus Herranz Zamorano, Samantha Ho, Ulrik Laurens Holgaard, Henrik Ingerslev, Linda Johansson, Jeffrey Jones, Ray Kallaher, Farhad Karimi, Torsten Karzig, Cameron King, Maren Elisabeth Kloster, Christina Knapp, Dariusz Kocon, Jonne Koski, Pasi Kostamo, Peter Krogstrup, Mahesh Kumar, Tom Laeven, Thorvald Larsen, Kongyi Li, Tyler Lindemann, Julie Love, Roman Lutchyn, Morten Hannibal Madsen, Michael Manfra, Signe Markussen, Esteban Martinez, Robert McNeil, Elvedin Memisevic, Trevor Morgan, Andrew Mullally, Chetan Nayak, Jens Nielsen, William Hvidtfelt Padkaer Nielsen, Bas Nijholt, Anne Nurmohamed, Eoin OFarrell, Keita Otani, Sebastian Pauka, Karl Petersson, Luca Petit, Dmitry I. Pikulin, Frank Preiss, Marina Quintero-Perez, Mohana Rajpalke, Katrine Rasmussen, Davydas Razmadze, Outi Reentila, David Reilly, Richard Rouse, Ivan Sadovskyy, Lauri Sainiemi, Sydney Schreppler, Vadim Sidorkin, Amrita Singh, Shilpi Singh, Sarat Sinha, Patrick Sohr, Tomas Stankevic, Lieuwe Stek, Henri Suominen, Judith Suter, Vicky Svidenko, Sam Teicher, Mine Temuerhan, Nivetha Thiyagarajah, Raj Tholapi, Mason Thomas, Emily Toomey, Shivendra Upadhyay, Ivan Urban, Saulius Vaitiekenas, Kevin Van Hoogdalem, David Van Woerkom, Dmitrii V. Viazmitinov, Dominik Vogel, Steven Waddy, John Watson, Joseph Weston, Georg W. Winkler, Chung Kai Yang, Sean Yau, Daniel Yi, Emrah Yucelen, Alex Webster, Ruichen Zhao
Summary: In this study, measurements and simulations of semiconductor-superconductor heterostructure devices were conducted to observe topological superconductivity and Majorana zero modes. The devices were optimized to ensure robustness against nonuniformity and disorder. Experimental results indicate the presence of a topological superconducting phase, which is a prerequisite for experiments involving Majorana zero modes fusion and braiding.
Review
Chemistry, Multidisciplinary
Xinyi Tan, Jens Nielsen
Summary: The dependence on fossil fuels has led to excessive greenhouse gas emissions, causing climate changes and global warming. Biotechnology offers a promising solution for producing high-density liquid transportation fuels that can reduce emissions. Additionally, developing technologies to convert atmospheric CO2 into fossil fuel replacements is urgently needed.
CHEMICAL SOCIETY REVIEWS
(2022)
Review
Biotechnology & Applied Microbiology
Yu Chen, Feiran Li, Jens Nielsen
Summary: Yeast genome-scale metabolic models have a long history and diverse recent applications, including metabolic flux prediction, cell factory design, and multi-yeast comparative analysis. Integrating proteome constraints into the models can improve performance.
FEMS YEAST RESEARCH
(2022)