Article
Multidisciplinary Sciences
C. Pfenninger, S. Grospretre, A. Remontet, T. Lapole
Summary: Comparing different motor simulations in healthy participants showed that visual feedback and unilateral movement with a mirror may provide the greatest effects, suggesting potential optimization in neurorehabilitation.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Sonia Turrini, Francesca Fiori, Emilio Chiappini, Emiliano Santarnecchi, Vincenzo Romei, Alessio Avenanti
Summary: Cortico-cortical paired associative stimulation (ccPAS) is an effective method for inducing associative plasticity in the brain. This study investigated the physiological changes during ccPAS administration and found both facilitatory and inhibitory effects. Monitoring motor-evoked potentials (MEPs) online could provide insights into the effectiveness of the protocol.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Zhengchen Cai, Giovanni Pellegrino, Jean-Marc Lina, Habib Benali, Christophe Grova
Summary: This study investigates the effects of paired associative stimulation on cortical excitability and task-related hemodynamic responses, and finds a positive correlation between them. The findings have important implications for understanding the fundamental properties of cortical function and excitability.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
David A. Rice, Gwyn N. Lewis, Thomas Graven-Nielsen, Rufus Luther, Peter J. McNair
Summary: This study compared the temporal corticomotor excitability changes in the upper and lower limbs in response to acute upper and lower limb pain. The findings indicate a limb-specific corticomotor response to experimental pain that may be related to limb function. This research helps us understand the impact of acute, experimental pain on motor control of both local and distant muscles.
Review
Clinical Neurology
Nahian S. Chowdhury, Wei-Ju Chang, Samantha K. Millard, Patrick Skippen, Katarzyna Bilska, David A. Seminowicz, Siobhan M. Schabrun
Summary: Experimental pain alters corticomotor excitability, with reductions observed in both short and long durations of pain. The magnitude of reduction in corticomotor excitability is associated with pain severity, with greater reductions seen in higher pain severity. In healthy individuals, the suppression of corticomotor excitability may serve as a short-term beneficial strategy but has long-term consequences.
Article
Physiology
Clara Pfenninger, Nathan Grosboillot, Guillaume Digonet, Thomas Lapole
Summary: This study aims to investigate the acute effects of prolonged local vibration on central nervous system excitability. The results suggest that vibration applied to the muscle, whether in a relaxed or contracted state, can decrease motoneuronal excitability and increase cortical excitability.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Clinical Neurology
Vincenzo Rizzo, Carmen Terranova, Giovanni Raffa, Salvatore Massimiliano Cardali, Filippo Flavio Angileri, Giuseppina Marzano, Maria Catena Quattropani, Antonino Germano, Paolo Girlanda, Angelo Quartarone
Summary: Brain tumors can lead to abnormal cortical excitability in affected hemispheres, with decreased SICI, ICF, and SAI. Further research is needed to investigate the relationship between cortical excitability and motor impairment in these patients.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Sangtae Ahn, Flavio Frohlich
Summary: This study provides causal evidence that the early TEP components reflect cortical reactivity to TMS, with the earliest component localized to the left M1, the following components mainly localized to the primary somatosensory cortex, and the later components largely localized to the auditory cortex. Transcranial direct current stimulation selectively modulated cortical and corticospinal excitability by modulating the pre-stimulus mu-rhythm oscillatory power.
Article
Clinical Neurology
Federica Ginanneschi, Luca Valerio Messa, Carla Battisti, Alessandro Rossi
Summary: Altered corticospinal excitability in Parkinson's disease is related to motor signs. After 8 weeks of specialized upper limbs exercise, changes in corticospinal pathway were observed in PD subjects. Clinical improvement may be attributed to restoration of recruitment of large motor units necessary for rapid and strong movements.
NEUROLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Akiyoshi Matsugi, Satoru Nishishita, Kyota Bando, Yutaka Kikuchi, Keigo Tsujimoto, Yuto Tanabe, Naoki Yoshida, Hiroaki Tanaka, Shinya Douchi, Takeru Honda, Masato Odagaki, Hideki Nakano, Yohei Okada, Nobuhiko Mori, Koichi Hosomi
Summary: This study aimed to investigate abnormalities in inhibitory cortical excitability and motor control during ballistic-targeting movements in individuals with degenerative cerebellar ataxia (DCA). The results indicated that individuals with DCA showed longer cortical silent period (cSP), suggesting excessive activity in the inhibitory cortical circuit. However, this increase in inhibitory activity did not contribute to the control of ballistic-targeting movements and did not correlate with the severity of ataxia. These findings contribute to our understanding of motor control abnormalities in people with DCA and provide potential evidence for further research in this area.
SCIENTIFIC REPORTS
(2023)
Article
Nutrition & Dietetics
Anjali Sivaramakrishnan, Sangeetha Madhavan
Summary: The combination of aerobic exercise and transcranial direct current stimulation (tDCS) has a significant effect on corticomotor excitability (CME) in stroke survivors for the lower limb. However, no additional priming effects were observed when exercise and tDCS were combined compared to tDCS alone.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2021)
Article
Clinical Neurology
Suet-Ting Chan, Chun-Hwei Tai, Li-Ying Wang, Jer-Junn Luh, Ya-Yun Lee
Summary: This study aimed to investigate whether a single bout of aerobic exercise can facilitate motor sequence learning in people with Parkinson's disease and to explore the associated neurophysiological changes. The results showed that a single session of aerobic exercise could enhance motor sequence learning and induce neuroplastic changes. Clinicians can consider providing aerobic exercise after motor task training for people with Parkinson's disease.
NEUROREHABILITATION AND NEURAL REPAIR
(2023)
Article
Clinical Neurology
Santosh A. Helekar, Jason Thonhoff, Blessy S. John, Lisa Nguyen, David B. Rosenfield, Stanley H. Appel
Summary: This study used a newly developed wearable transcranial rotating permanent magnet stimulator to measure the modulation of spontaneous motor unit potentials in hand muscles of patients with amyotrophic lateral sclerosis. The results showed a correlation between the modulation and the severity of the disease.
JOURNAL OF NEUROLOGY
(2022)
Review
Engineering, Biomedical
Zhongfei Bai, Jiaqi Zhang, Kenneth N. K. Fong
Summary: This study systematically reviewed the effects of different transcranial magnetic stimulation protocols on cortical excitability in stroke patients. The results showed that most protocols were effective in modulating cortical excitability, except for continuous theta burst stimulation. In particular, inhibitory stimulation had positive effects on the affected motor cortex.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2022)
Article
Clinical Neurology
Iuri Santana Neville, Alexandra Gomes dos Santos, Cesar Cimonari Almeida, Cintya Yukie Hayashi, Davi Jorge Fontoura Solla, Ricardo Galhardoni, Daniel Ciampi de Andrade, Andre Russowsky Brunoni, Manoel Jacobsen Teixeira, Wellingson Silva Paiva
Summary: This study utilized nTMS to evaluate cortical excitability in brain hemispheres affected by tumors, finding abnormal CE patterns and distinct features in patients with GBM. Tumor biological behavior may play a role in these changes.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Wei-Peng Teo, Timo Rantalainen, Nathan Nuzum, Leah Valente, Helen Macpherson
Summary: This study found that individuals with Dementia exhibit significant impairments in stride velocity and length during both single- and dual-task gait, as well as increased changes in oxyhaemoglobin levels in the left prefrontal cortex compared to Healthy and SMC individuals. These findings suggest that central changes in cerebral haemodynamic response may precede functional impairments in individuals with subjective memory complaints and Dementia.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Orthopedics
Alvaro Reyes, Danielle M. Bartlett, Timothy J. Rankin, Pauline Zaenker, Kate Turner, Wei-Peng Teo, Shih Ching Fu, Josefa Domingos, Nellie Georgiou-Karistianis, Mel Ziman, Travis M. Cruickshank
Summary: Dual-tasking deficiencies are common in people with premanifest Huntington disease and may be influenced by poor sleep quality. Measures of dual-tasking show acceptable test-retest reliability in this population and should be considered when managing dual-tasking problems.
Article
Neurosciences
Nathan D. Nuzum, Wei-Peng Teo, Helen Macpherson, Amy Loughman, Ewa A. Szymlek-Gay, Ashlee Hendy
Summary: This study investigated the effects of unilateral training on excitatory and inhibitory pathways in the trained and untrained hemispheres across aging, revealing differences in inhibitory changes in untrained hand muscles between older and younger adults, suggesting potential decline in inhibitory capability in older populations.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Review
Sport Sciences
Zi-Siong Chow, Ashleigh T. Moreland, Helen Macpherson, Wei-Peng Teo
Summary: Resistance exercise has been shown to induce neuroplastic changes within the central nervous system and improve cognitive functioning, making it a potential novel adjuvant rehabilitation strategy for populations with neurological impairments. Proper manipulation of exercise parameters is crucial in enhancing cognitive health through resistance training.
Article
Clinical Neurology
Sakshi Dhir, Kaelasha Tyler, Lucy Albertella, Samuel R. Chamberlain, Wei-Peng Teo, Murat Yucel, Rebecca A. Segrave
Summary: This study found differential inhibitory control and self-monitoring profiles across impulsive and compulsive phenotypes in individuals with OCDSs.
Review
Neurosciences
Jessie Siew-Pin Leuk, Kai-En Yow, Clenyce Zi-Xin Tan, Ashlee M. Hendy, Mika Kar-Wing Tan, Tommy Hock-Beng Ng, Wei-Peng Teo
Summary: This study aims to guide future research on the usage of transcranial direct current stimulation (tDCS) in upper limb motor learning by synthesizing available methodologies and results. The meta-analysis of thirty-two studies suggests that different stimulation parameters enhance upper limb motor learning in older adults and Parkinson’s disease (PD) patients.
REVIEWS IN THE NEUROSCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Pui Wah Kong, Tommy Yew Weng Kan, Roslan Abdul Ghani Bin Mohamed Jamil, Wei Peng Teo, Jing Wen Pan, Md Noor Hafiz Abd Halim, Hasan Kuddoos Abu Bakar Maricar, David Hostler
Summary: This study compared two training programs for emergency responders and found that both functional and conventional strength training are effective in improving back muscle characteristics.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Neurosciences
Onno van der Groen, Christopher Latella, Kazunori Nosaka, Dylan Edwards, Wei-Peng Teo, Janet L. Taylor
Summary: Cross-education is the phenomenon of neuromuscular adaptations in the untrained limb after training the opposite limb. This study compared the effects of eccentric and concentric exercise on motor cortex responses using transcranial magnetic stimulation (TMS). The results showed that both eccentric and concentric exercise decreased maximal voluntary isometric contraction (MVIC) torque in the exercised arm. However, the non-exercised biceps brachii showed decreased resting motor threshold (RMT) after concentric exercise and decreased intracortical facilitation (ICF) after eccentric exercise. The findings suggest that unilateral eccentric and concentric exercise have different effects on excitability in the non-exercised hemisphere.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Keller Xin-Yu Chai, Alicia Marie Goodwill, Jessie Siew-Pin Leuk, Wei-Peng Teo
Summary: This study compared brain activation patterns between overground and treadmill walking during dual-task gait. The results showed that gait speed decreased during dual-task gait on overground walking but not on treadmill walking. Cognitive performance remained unchanged during dual-task gait on both overground and treadmill walking. Reduction of oxyhaemoglobin (O2Hb) was observed in the frontopolar cortex (FPC) during dual-task gait compared to cognitive task only, and on the treadmill compared to overground walking. Increased activation was seen in the left and right dorsolateral prefrontal cortices (DLPFC) during dual-task gait but did not differ between treadmill and overground walking. These findings suggest different neural strategies underlying treadmill and overground walking.
Article
Geriatrics & Gerontology
Yichi Zhang, Edmund W. J. Lee, Wei -Peng Teo
Summary: Understanding older people's health-seeking behavior and the use of technology is important for developing appropriate policies and practices to address their health needs. This study investigated the patterns of behaviors and technology use among older adults, and proposed implications for improving health services and policies.
Review
Geriatrics & Gerontology
Yichi Zhang, Jessie Siew-Pin Leuk, Wei -Peng Teo
Summary: Aging population faces inadequate access to appropriate health care, but telehealth can bridge the gap by removing geographical and time barriers. The effectiveness, cost benefits, and acceptability of telehealth in aging care are still unclear.
Article
Engineering, Industrial
Pui W. Kong, Tommy Y. W. Kan, Roslan Abdul Ghani Bin Mohamed Jamil, Wei P. Teo, Jing W. Pan, Noor Hafiz Abd Halim, Hasan Kuddoos Abu Bakar Maricar, David Hostler
Summary: This study found that approximately 50% of the firefighters experienced low back pain in the past year, but most of them were still able to work. Biomechanically, there were no differences in back muscle characteristics between firefighters with and without back pain history. Back disabilities were not related to any biomechanical or demographic measures. Overall, these frontline firefighters are highly functional and did not show diminished physical or neuromuscular responses despite experiencing some back pain.
Article
Sport Sciences
Wei-Peng Teo, Clara Xinru Tan, Alicia M. Goodwill, Saqif Mohammad, Yi-Xuan Ang, Christopher Latella
Summary: This study used near-infrared spectroscopy to measure changes in oxyhemoglobin in different brain regions during muscle contractions. The results showed that high-intensity contractions resulted in increased brain activation in the primary motor cortex and dorsolateral prefrontal cortices.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Review
Environmental Sciences
Shi Min Mah, Alicia M. Goodwill, Hui Chueng Seow, Wei-Peng Teo
Summary: This systematic review examined the effects of high-intensity exercise on lower limb function in acute and subacute stroke patients. The results showed that high-intensity exercise can improve lower limb function, including walking ability and gait speed. This study provides evidence for the implementation of high-intensity exercise in stroke patients during their acute and subacute rehabilitation stages, with no significant adverse events reported.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Education, Special
E. Mazzoli, J. Salmon, C. Pesce, W. -P. Teo, N. Rinehart, T. May, L. M. Barnett
Summary: A 5-week active breaks intervention was found to improve working memory in children with intellectual disability, while other cognitive functions and on-task behavior did not show significant effects. However, stepping time and bouts of sitting were positively affected by the intervention. Further research is needed to clarify the effects on cognition and explore other potential benefits in this population.
JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
(2021)