Review
Public, Environmental & Occupational Health
Gabriela K. Khazanov, Rebecca Stewart, Matteo F. Pieri, Candice Huang, Christopher T. Robertson, K. Aleks Schaefer, Hansoo Ko, Jessica Fishman
Summary: This systematic review evaluated the effects of financial incentives on COVID-19 vaccine uptake and intentions, finding that incentives can increase vaccine uptake but their impact on intentions is inconclusive.
PREVENTIVE MEDICINE
(2023)
Article
Computer Science, Theory & Methods
Rong Han, Zheng Yan, Xueqin Liang, Laurence T. Yang
Summary: In a blockchain-based system, designing a feasible incentive mechanism becomes essential to improve system performance by regulating entity behaviors. This study proposes evaluation requirements and taxonomies for incentive mechanisms in blockchain systems. Through a thorough review, the study discusses the advantages and disadvantages of existing incentive mechanisms and identifies unresolved issues and potential directions for future research on the relationship between incentive mechanisms and blockchain.
ACM COMPUTING SURVEYS
(2023)
Article
Neurosciences
Michael I. Demidenko, Edward D. Huntley, Alexander S. Weigard, Daniel P. Keating, Adriene M. Beltz
Summary: This study examines the individual functional connectivity in adolescents and its links to sensation seeking behavior. The findings reveal unique associations between neural motivational processing and sensation seeking behavior, suggesting heterogeneity in the brain-behavior relations in adolescents.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Neurosciences
Debbie M. Yee, Jennifer L. Crawford, Bidhan Lamichhane, Todd S. Braver
Summary: This study investigated the role of human dACC in integrating motivational incentives and found that dACC modulates cognitive control based on the integrated subjective motivational value, affecting task performance.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Psychology, Multidisciplinary
Tara L. White, Meghan A. Gonsalves, Chloe Zimmerman, Hannah Joyce, Ronald A. Cohen, Uraina S. Clark, Lawrence H. Sweet, Carl W. Lejuez, Adam Z. Nitenson
Summary: This study introduces a concept called agentic anger, which is a negatively valenced state that motivates action to achieve risky goals. The neurobehavioral model was evaluated through two proof-of-concept studies, revealing the relationship between agentic anger, reward, and personality traits.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Neurosciences
Yu Chen, Shefali Chaudhary, Chiang-Shan R. Li
Summary: Reward and punishment play a crucial role in motivating decision-making and behavior changes. Through a meta-analysis of studies on the monetary incentive delay task (MIDT), this research identifies the shared and distinct neural responses during win and loss anticipation and outcome. Understanding these neural processes can contribute to empirical research on motivated behaviors and psychopathology.
Article
Behavioral Sciences
Shelley M. Warlow, Kent C. Berridge
Summary: The central nucleus of amygdala (CeA) plays a role in mediating both positively-valenced reward motivation and negatively-valenced fear. Stimulation of CeA circuitry can intensify incentive motivation while not affecting hedonic impact of the reward. CeA can promote either incentive motivation or fearful motivation, potentially leading to different outcomes in neuropsychiatric disorders involving aberrant motivational salience.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Clinical Neurology
Yukiko Ogura, Yumi Wakatsuki, Naoki Hashimoto, Tamaki Miyamoto, Yukiei Nakai, Atsuhito Toyomaki, Yukio Tsuchida, Shin Nakagawa, Takeshi Inoue, Ichiro Kusumi
Summary: The study found a neurobiological foundation for the protective aspect of hyperthymic temperament against depression in the reward system, suggesting that hyperthymic temperament may modulate attentional or motor responses or optimal selection of behavior based on reward, rather than value representation.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Endocrinology & Metabolism
Natalia Chechko, Susanne Stickel, Mikhail Votinov
Summary: Up to 50% of new mothers experience baby blues (BB) within a week of delivery, with affective disturbances being the central symptoms. This study investigates whether incentive processing during the experience of BB can be altered through the monetary incentive delay (MID) task. The results demonstrate that the BB-related time window overlaps with alterations in the brain networks associated with incentive processing.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Behavioral Sciences
Mike J. F. Robinson, Qi Shan A. Bonmariage, Anne-Noel Samaha
Summary: Uncertain and intermittent access to rewards can increase reward-seeking behaviors, which is relevant to human conditions such as gambling, eating disorders, and drug addiction.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Review
Behavioral Sciences
Bowen J. Fung, Elissa Sutlief, Marshall G. Hussain Shuler
Summary: Time perception and reward processing interact through a common dopaminergic mechanism, as supported by both neurobiological and behavioral studies.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Neurosciences
Mariia Kaliuzhna, Matthias Kirschner, Philippe N. Tobler, Stefan Kaiser
Summary: Deficits in neural processing of reward are found in both bipolar disorder (BD) and schizophrenia (SZ), but the underlying mechanisms are unclear. This study shows that adaptive coding is impaired in both BD and SZ patients, but the affected brain regions differ. BD patients show more preserved adaptive coding compared to SZ patients in certain brain regions.
HUMAN BRAIN MAPPING
(2023)
Article
Psychiatry
Tim Van Timmeren, Ruth J. Van Holst, Anna E. Goudriaan
Summary: This study compared the activation of the striatum during reward anticipation between patients with alcohol use disorder (AUD) and gambling disorder (GD) using functional MRI. The results showed hypoactivation of the reward system in AUD patients compared to healthy controls. However, the study did not support the hypothesis that addiction-related cues explain striatal dysfunction.
JOURNAL OF BEHAVIORAL ADDICTIONS
(2023)
Article
Behavioral Sciences
Kathrin Weidacker, Seung-Goo Kim, Camilla L. Nord, Catarina Rua, Christopher T. Rodgers, Valerie Voon
Summary: Studies suggest that habenula neurons are activated in anticipation of non-rewarding outcomes and suppressed in anticipation of rewarding outcomes, a function disrupted in depression. This study used ultra-high field fMRI to investigate habenular activity during loss avoidance, monetary loss, and neutral events in healthy individuals. The findings demonstrate substantial neural differences between different outcomes and enhanced functional connectivity between the habenula, hippocampus, and subcallosal cingulate in anticipation of potential losses.
Article
Neurosciences
Oliver Grimm, Magdalena Nagele, Lea Kupper-Tetzel, Moritz de Greck, Michael Plichta, Andreas Reif
Summary: The study found that the dopamine agonist L-DOPA and antagonist amisulpride did not have a significant impact on the reward system as expected, challenging the sensitivity of reward anticipation contrast in healthy volunteers for assessing dopamine-specific changes through pharmacological fMRI.
PSYCHOPHARMACOLOGY
(2021)
Article
Psychology, Clinical
Zuzana Forejtova, Tereza Serranova, Tomas Sieger, Matej Slovak, Lucia Novakova, Gabriela Vechetova, Evzen Ruzicka, Mark J. Edwards
Summary: The study explored the relationships between various symptoms in FND patients and found significant correlations between self-reported and objective measures of motor and non-motor symptoms, as well as HRQoL. Despite attempting to identify subgroups within the cohort, cluster analysis showed a homogenous patient sample, supporting the idea of a unified pathophysiology for these symptoms.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Clinical Neurology
Francesca Magrinelli, Kailash P. Bhatia, Mehran Beiraghi Toosi, Fatemeh Arab, Ehsan Ghayoor Karimiani, Sahar Sedighzadeh, Behnaz Ansari, Maedeh Neshatdoust, Clarissa Rocca, Henry Houlden, Reza Maroofian
Summary: This article reports a new phenotype of childhood-onset choreo-dystonia in four patients from two unrelated Iranian pedigrees, who harbor a novel pathogenic variant in the HPCA gene. A systematic review of the literature reveals that HPCA-related dystonia can present as an isolated condition or in combination with various symptoms. Most cases show a poor or no response to common antidystonic medications.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Review
Clinical Neurology
Ishani Rajapakshe, Eoin Mulroy, Francesca Magrinelli, Chulika Makawita, Kailash P. Bhatia, Bimsara Senanayake
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Esther Cubo, Sheng Luo, Pablo Martinez-Martin, Glenn T. Stebbins, Jeffrey Lin, Dongrak Choi, Alvaro Garcia-Bustillo, Pablo Mir, Diego Santos-Garcia, Marcos Serrano-Duenas, Mayela Rodriguez-Violante, Carlos Singer
Summary: This article summarizes the formal process of completing the MDS-NMS program and presents data on the first non-English version (Spanish). The results show that the Spanish version of MDS-NMS met the criteria to be designated as an official translation and is now available on the MDS website.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Editorial Material
Clinical Neurology
Marcelo Merello, Kailash Bhatia
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Editorial Material
Clinical Neurology
Michelangelo Mancuso, Holm Graessner, Marianne de Visser, Anita Arsovska, Kailash Bhatia
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Alberto Albanese, Kailash P. Bhatia, Francisco Cardoso, Cynthia Comella, Giovanni Defazio, Victor S. C. Fung, Mark Hallett, Joseph Jankovic, Hyder A. Jinnah, Ryuji Kaji, Joachim K. Krauss, Anthony Lang, Eng King Tan, Marina A. J. Tijssen, Marie Vidailhet
Summary: This document provides a consensus on the diagnosis and classification of isolated cervical dystonia (iCD) and proposes diagnostic criteria and classification. It aims to systematize terminology and the diagnostic process for reproducibility and applicability. The criteria include motor abnormalities and nonmotor manifestations, and three iCD presentations are described. The relationship between iCD and isolated head tremor is also discussed. Continuous revision of the criteria is necessary as knowledge of iCD expands.
MOVEMENT DISORDERS
(2023)
Review
Clinical Neurology
Anwesan De, Kailash P. Bhatia, Jens Volkmann, Robert Peach, Sebastian R. Schreglmann
Summary: Tremor is a common movement disorder that is diagnosed based on clinical assessment, but achieving accurate diagnosis is not always straightforward. Recent advancements in clinical diagnostic criteria and device-based qualitative analysis have improved diagnostic accuracy. Machine-learning (ML) studies utilizing accelerometric assessments have shown potential for less-biased classification and quantification of tremor disorders. However, caution must be exercised to avoid spurious or nongeneralizable results. This work summarizes recent developments in ML tools for tremor research, highlighting the opportunities and limitations of these approaches.
MOVEMENT DISORDERS
(2023)
Article
Medicine, General & Internal
Konstantin G. Heimrich, Aline Schoenenberg, Diego Santos-Garcia, Pablo Mir, Tino Prell
Summary: Nonmotor symptoms have a negative impact on health-related quality of life in patients with Parkinson's disease. This study aimed to understand the network structure of nonmotor symptoms and their impact on quality of life, particularly focusing on the most influential symptoms.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Louise Marston, Marie Le Novere, Federico Ricciardi, Irwin Nazareth, Alan Carson, Mark Edwards, Laura H. Goldstein, Jonathan Marsden, Hayley Noble, Markus Reuber, Jon Stone, Rachael M. Hunter, Glenn Nielsen
Summary: Functional motor disorder (FMD) is a common neurological condition that causes symptoms such as weakness and tremor. The Physio4FMD trial aims to evaluate the effectiveness and cost effectiveness of specialist physiotherapy for FMD. The trial was impacted by the COVID-19 pandemic, leading to disruptions in the treatment of participants. The analysis plans have been adjusted to account for these disruptions and maintain the integrity of the trial while providing meaningful results.
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2023)
Article
Clinical Neurology
Anna Sadnicka, Mark John Edwards
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Sara A. Finkelstein, Alan Carson, Mark J. Edwards, Kasia Kozlowska, Sarah C. Lidstone, David L. Perez, Ginger Polich, Jon Stone, Selma Aybek
NEUROLOGIC CLINICS
(2023)
Article
Medicine, General & Internal
Konstantin Heimrich, Sarah Mendorf, Aline Schoenenberg, Diego Santos-Garcia, Pablo Mir, Tino COPPADIS Study Group, Tino Prell
Summary: The clinical presentation of Parkinson's disease is often characterized by depressive symptoms, which significantly affect the patients' quality of life. Through network analysis, this study identified the depressive symptoms of loss of energy, past failure, and tiredness or fatigue as having the greatest impact on overall quality of life.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Ray Jen Neo, Arpan R. Mehta, Mikail Weston, Francesca Magrinelli, Andrea Quattrone, Sonia Gandhi, Eileen M. Joyce, Kailash P. Bhatia
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Review
Clinical Neurology
Anwesan De, Kailash P. Bhatia, Jens Volkmann, Robert Peach, Sebastian R. Schreglmann
Summary: Tremor, the most frequent human movement disorder, can be challenging to diagnose accurately. Machine learning models applied to accelerometric recordings have the potential to provide unbiased classification and quantification of tremor disorders. However, proper implementation is crucial to avoid misleading conclusions. This article summarizes recent developments in machine learning tools for tremor research, highlights opportunities and limitations, and encourages the movement disorder community to actively engage in applying these analytical technologies.
MOVEMENT DISORDERS
(2023)