Article
Biotechnology & Applied Microbiology
Hong Guo, Jibin Guan, Xian Wu, Yushuang Wei, Jiaqi Zhao, Yan Zhou, Faqian Li, Hong-Bo Pang
Summary: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threatening conditions characterized by excessive lung inflammation. This study developed a peptide-based strategy using a targeting peptide called CRV to deliver glucocorticoids for ALI treatment. The CRV peptide selectively targeted the inflamed lung tissue, reducing side effects in healthy organs. The conjugation of prednisolone (PSL) and CRV using a reactive oxygen species (ROS)-responsive linker allowed for the release of PSL specifically in the inflamed lung tissue, leading to reduced lung injury.
Article
Biochemistry & Molecular Biology
Robert J. Webber, Richard M. Sweet, Douglas S. Webber
Summary: The study found that anti-MV-A iNOS monoclonal antibodies can mitigate the harmful effects of MV-A iNOS and increase the survival rate of mice challenged with sepsis. The efficacy of the treatment is both time- and dose-dependent. Humanized anti-MV-A iNOS mAbs could potentially save tens of thousands of lives annually and improve antibiotic stewardship.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Junjie Gao, Dandan Yang, Zheng Huang, Xueshan Pan, Ruoxue Cao, Chaoqun Lian, Jia Ma, Yuyun Li, Zhiwei Wang, Jun Xia
Summary: Nitric oxide synthase-interacting protein (Nosip) interacts with nitric oxide synthase (NOS) and regulates NO synthesis and release, participating in various physiological and pathological processes. Nosip was found to be elevated in hepatocellular carcinoma (HCC) tissues and cells. Silencing Nosip inhibited HCC cell proliferation and motility, and promoted apoptosis, while overexpression of Nosip had the opposite effects. Quercetin, a natural compound, inhibited the proliferation and motility of HCC cells possibly by repressing Nosip expression. Our findings suggest that Nosip acts as an oncogene in HCC progression and quercetin may be a potential natural compound for treating HCC by targeting Nosip expression.
Review
Biochemistry & Molecular Biology
Han-Yan Zhu, Fen-Fang Hong, Shu-Long Yang
Summary: Vascular dementia is the second most common form of dementia worldwide, caused by cerebrovascular disease. Nitric oxide and nitric oxide synthase play vital roles in the pathogenesis of this disease, with different NOS subtypes having partitioned activities in the brain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Huanyu Jiang, Piyao Ji, Xiaobin Shang, Yan Zhou
Summary: Osteoarthritis (OA) is a disabling joint inflammatory disease characterized by cartilage destruction, bone remodeling, and synovitis. Nitric oxide (NO) plays a key role in this process, functioning as both a normal bone cell-conditioning agent and a mediator of cartilage catabolism and cell apoptosis. The NO/NOS system can act as either an anti-inflammatory or pro-inflammatory agent in OA. This review summarizes the effects of NO on normal and OA joints and explores potential new treatment strategies targeting the NO/NOS system.
Article
Cardiac & Cardiovascular Systems
Hongtu Cui, Yanghui Chen, Ke Li, Rui Zhan, Mingming Zhao, Yangkai Xu, Zhiyong Lin, Yi Fu, Qihua He, Paul C. Tang, Ienglam Lei, Jifeng Zhang, Chenze Li, Yang Sun, Xinhua Zhang, Tiffany Horng, Hong S. Lu, Y. Eugene Chen, Alan Daugherty, Daowen Wang, Lemin Zheng
Summary: Aortic aneurysm and dissection (AAD) are high-risk cardiovascular diseases with no effective cure. The study found that succinate plays an important role in the development of AAD, and plasma succinate concentrations can distinguish patients with AAD from healthy controls. Regulating succinate concentrations through the p38 alpha-CREB-OGDH axis in macrophages may have therapeutic potential for AAD.
EUROPEAN HEART JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Amir Asgari, Paul Jurasz
Summary: Megakaryocytes are important members of the hematopoietic system, responsible for regulating vascular homeostasis through platelets. The process of megakaryopoiesis generates mature megakaryocytes which release proplatelets into blood vessels. Nitric oxide (NO) plays a modulatory role in hematopoiesis and hemostasis. This review summarizes the effect of NO and its signaling on megakaryopoiesis and thrombopoiesis under physiological and pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Younes Yassaghi, Sajad Jeddi, Nasibeh Yousefzadeh, Khosrow Kashfi, Asghar Ghasemi
Summary: Long-term nitrate intervention increased the resistance to myocardial ischemia-reperfusion injury (MIRI) in female rats, which was associated with increased heart endothelial nitric oxide synthase (eNOS) expression and circulating progesterone before ischemia and blunting ischemia-induced increased inducible nitric oxide synthase (iNOS) and decreased eNOS after MIRI.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Medicine, Research & Experimental
George J. Dugbartey
Summary: Kidney transplantation is the preferred treatment for patients with kidney failure. However, ischemia-reperfusion injury (IRI) poses a significant challenge to the long-term success of this intervention. Nitric oxide (NO) has emerged as a potential candidate for mitigating IRI and preventing graft rejection in kidney transplantation. This review provides an overview of the sources and protective effects of endogenous and exogenous NO in kidney transplantation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Fabio Arias, Francisco Franco-Montalban, Miguel Romero, Juan Duarte, M. Dora Carrion, M. Encarnacion Camacho
Summary: This paper describes the design, synthesis, and biological evaluation of selective inhibitors of inducible nitric oxide synthase (iNOS). The most potent and selective compound showed inhibitory activity against iNOS without undesirable cardiovascular effects. In silico analysis predicted good drug-likeness properties for promising compounds, which also exhibited adequate cell viability. Docking studies revealed a unique binding mode for one compound and explained its selectivity towards iNOS.
BIOORGANIC CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Slobodan Tepic, Daniel Arens, Tim Buchholz, Dirk Nehrbass, Olivera Cvetkovic, Martin J. Stoddart, R. G. Richards, Stephan Zeiter
Summary: Pneumonia, especially during the COVID-19 pandemic, has become a major public health and economic disaster. This study suggests that lung metabolism in inflammation may have common features regardless of the underlying cause. By comparing mice with bleomycin-induced lung inflammation to control groups, it was found that certain amino acids had significantly lower concentrations in the arterial blood, indicating that arginine replacement therapy may be beneficial in pneumonia.
Review
Biochemistry & Molecular Biology
Almaz Zaki, M. Shadab Ali, Vijay Hadda, Syed Mansoor Ali, Anita Chopra, Tasneem Fatma
Summary: Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) are major causes of ICU death, characterized by severe hypoxemia and inflammation leading to poor lung compliance. Long non-coding RNA (lncRNA) has been shown to be abundantly expressed in ALI and targeting lncRNAs can alleviate ALI. Therefore, lncRNAs hold promise as potential therapeutic targets for ALI.
Editorial Material
Plant Sciences
Francisco J. Corpas, Salvador Gonzalez-Gordo, Jose M. Palma
Summary: Nitric oxide is a crucial signaling molecule in plant physiological processes, but the enzymatic generation of nitric oxide in higher plants is still controversial.
TRENDS IN PLANT SCIENCE
(2022)
Review
Pharmacology & Pharmacy
Sophie L. Maiocchi, Jacqueline Ku, Thuan Thai, Enoch Chan, Martin D. Rees, Shane R. Thomas
Summary: Myeloperoxidase (MPO) is a key oxidative enzyme that impairs endothelial function and is closely associated with the development of cardiovascular disease. MPO promotes vascular inflammation and impairs NO bioactivity through various oxidative reactions.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Marko Ostojic, Ante Zevrnja, Katarina Vukojevic, Violeta Soljic
Summary: Synovitis of the knee synovium is a precursor of knee osteoarthritis, and the expression of inflammatory factors NF-kB, iNOS, and MMP-9 in synovial cells may play a role in the progression of the disease. Macrophages appear to have a leading role in producing inflammatory factors through NF-kB in the intima, while leukocytes may have a dominant role in the subintima of advanced OA. Blocking NF-kB expression in macrophages and leukocytes could be a potential therapeutic target for modifying the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Andrology
Katrine H. Lund, Anne Sofie D. Laursen, Therese K. Gronborg, Gunnar Toft, Bjarke H. Jacobsen, Tanran R. Wang, Amelia K. Wesselink, Elizabeth E. Hatch, Greg J. Sommer, Michael L. Eisenberg, Kenneth J. Rothman, Henrik T. Sorensen, Lauren A. Wise, Ellen M. Mikkelsen
Summary: This study aimed to examine the association between perceived stress and semen quality. The analysis of data from 644 men revealed that perceived stress was not materially associated with semen volume, sperm concentration, or total sperm count.
Article
Oncology
Cathrine F. F. Hjorth, Per Damkier, Tore B. B. Stage, Soren Feddersen, Stephen Hamilton-Dutoit, Bent Ejlertsen, Timothy L. L. Lash, Henrik Boggild, Henrik T. T. Sorensen, Deirdre Cronin-Fenton
Summary: This study found that single nucleotide polymorphisms may influence return-to-work and stable labor market attachment after breast cancer treatment, but overall, the SNPs examined did not have a significant impact on these outcomes in premenopausal women with breast cancer.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Martin Bodtker Mortensen, Omar Dzaye, Hans Erik Botker, Jesper Moller Jensen, Michael Maeng, Jacob Fog Bentzon, Helle Kanstrup, Henrik Toft Sorensen, Jonathon Leipsic, Ron Blankstein, Khurram Nasir, Michael J. Blaha, Bjarne Linde Norgaard
Summary: Low-density lipoprotein cholesterol (LDL-C) is associated with atherosclerotic cardiovascular disease (ASCVD), but its association with ASCVD risk is modified by the presence of coronary artery calcification (CAC). This study found that LDL-C is only associated with ASCVD events in patients with CAC, and not in those without CAC. This information is valuable for individualized risk assessment among middle-aged people with or without coronary atherosclerosis.
Article
Endocrinology & Metabolism
Anton Pottegard, Jacob H. Andersen, Jens Sondergaard, Reimar W. Thomsen, Tina Vilsboll
Summary: This study investigates the changes in drug usage patterns for treating type 2 diabetes in Denmark from 2005 to 2021. The results show an increase in new users of non-insulin, glucose-lowering drugs, with a peak in 2011 and a significant increase in 2020-2021. The prevalence of drug use also steadily increased over the years. General practitioners prescribed the majority of glucose-lowering drugs, and there was a notable shift in the type of drugs prescribed.
DIABETES OBESITY & METABOLISM
(2023)
Article
Psychiatry
Meghan L. Smith, Vijaya Seegulam, Peter Szentkuti, Erzsebet Horvath-Puho, Sandro Galea, Timothy L. Lash, Anthony J. Rosellini, Paula P. Schnurr, Henrik Toft Sorensen, Jaimie L. Gradus
Summary: This study examined the differences in posttraumatic psychopathology between immigrants and native-born persons in Denmark. The findings suggest that immigrants are at a higher risk of developing posttraumatic stress disorder (PTSD) following non-interpersonal trauma, possibly due to adverse experiences during migration.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Article
Obstetrics & Gynecology
Lorena Suarez-Idueta, Hannah Blencowe, Yemisrach B. Okwaraji, Judith Yargawa, Ellen Bradley, Adrienne Gordon, Vicki S. Flenady, Enny L. Paixao, Mauricio Barreto, Sarka Lisonkova, Qi Wen, Petr Velebil, Jitka Jirova, Erzsebet Horvath-Puho, Henrik Toft Sorensen, Luule Sakkeus, Liili A. Abuladze, Khalid Yunis, Ayah Al Bizri, Arturo Barranco, Lisa Broeders, Aimee E. van Dijk, Fawziya O. Alyafei, Tawa Olukade, Neda Razaz, Jonas K. Soderling, Lucy S. Smith, Elizabeth Draper, Estelle Lowry, Neil Rowland, Rachael Wood, Kirsten Monteath, Isabel Pereyra, Gabriella O. Pravia, Eric E. Ohuma, Joy Lawn
Summary: A study compared neonatal mortality rates in 125.5 million live births across 15 countries from 2000 to 2020. The findings showed that preterm newborns with small size for gestational age had the highest mortality rates. At the population level, preterm newborns with appropriate size for gestational age contributed the most to neonatal deaths.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Gastroenterology & Hepatology
Frederikke Schonfeldt Troelsen, Henrik Toft Sorensen, Lars Pedersen, Lone Dragnes Brix, Louise Bang Grode, Evelien Dekker, Rune Erichsen
Summary: This study investigated the plausible explanations for post-colonoscopy colorectal cancer (PCCRC) in a Danish Region using the World Endoscopy Organization algorithm, finding that most PCCRCs originate from possible missed lesions and incompletely resected lesions. These findings underscore the importance of quality assurance of colonoscopy procedures and polypectomy techniques.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Ola Olen, Karin E. Smedby, Rune Erichsen, Lars Pedersen, Jonas Halfvarson, Asa Hallqvist-Everhov, Johan SWIBREG Study Grp, Johan Askling, Anders Ekbom, Michael C. Sachs, Henrik Toft Sorensen, Jonas F. Ludvigsson
Summary: Earlier studies on lymphoma risk in patients with inflammatory bowel disease (IBD) have provided varying estimates, but have been limited by detection biases, misclassification, and small sample sizes. Our binational cohort study found that the risk of lymphoma has increased in Crohn's disease (CD) patients over the past 20 years, but not in ulcerative colitis (UC) patients. The increase in risk was mainly driven by T-cell lymphomas and aggressive B-cell lymphomas.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Endocrinology & Metabolism
N. R. Gadgaard, C. Varnum, R. G. H. H. Nelissen, C. Vandenbroucke-Grauls, H. T. Sorensen, A. B. Pedersen
Summary: The impact of comorbidity on infection risk among hip fracture patients is not clear, but a high incidence of infection was found. Comorbidity was identified as an important risk factor for infection up to 1 year after surgery. The results indicate a need for increased investment and support for patients with high comorbidity in pre- and postoperative programs.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Public, Environmental & Occupational Health
Soren Hauge Okholm, David Nagy, Dora Koermendine Farkas, Cecilia Hvitfeldt Fuglsang, Frederikke Schonfeldt Troelsen, Victor Henderson, Henrik Toft Sorensen
Summary: This cohort study examined the association between non-traumatic subdural hematoma and cancer risk. The results showed that the risk of a new cancer diagnosis was clearly increased in patients with non-traumatic subdural hematoma during the first year of follow-up. However, the absolute risk was low, thus limiting the clinical relevance of early cancer detection in these patients.
CLINICAL EPIDEMIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Morten Schmidt, Lars Arendt-Nielsen, Ellen-Margrethe Hauge, Henrik Toft Sorensen, Lars Pedersen
Summary: This study investigated the dose dependency of diclofenac's cardiovascular risks by using Danish health registries and a target trial emulation design. The results showed that both high-dose and low-dose diclofenac users had a similar increased risk of cardiovascular events compared to non-users. This finding challenges the assumption that low-dose diclofenac is risk-neutral.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Psychiatry
Mette Kielsholm Thomsen, Marie Dahl Jorgensen, Lars Pedersen, Rune Erichsen, Henrik Toft Sorensen, Ellen M. Mikkelsen
Summary: Despite having a similar incidence to the general population, people with mental disorders show increased mortality due to colorectal cancer. A population-based cohort study in Denmark evaluated the participation of people with mental disorders in organised colorectal cancer screening. Results showed that individuals with mild or moderate mental disorders had lower participation rates, more positive screening results, and lower adherence to and completeness of follow-up colonoscopy compared to those without mental disorders. Encouragement and support from healthcare professionals are important for improving cancer screening participation among patients with mental disorders.
Article
Hematology
Maria A. de Winter, Alicia Uijl, Harry R. Buller, Marc Carrier, Alexander T. Cohen, John-Bjarne Hansen, Karin H. A. H. Kaasjager, Ajay K. Kakkar, Saskia Middeldorp, Gary E. Raskob, Henrik Toft Sorensen, Philip S. Wells, Mathilde Nijkeuter, Jannick A. N. Dorresteijn
Summary: By categorizing VTE patients without cancer, 5 distinct clinical subtypes were identified, which were associated with anticoagulant treatment and clinical outcomes. This suggests that the heterogeneity of VTE cases extends beyond the distinction between provoked and unprovoked VTE.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Correction
Public, Environmental & Occupational Health
Dagrun Slettebo Daltveit, Kari Klungsoyr, Anders Engeland, Anders Ekbom, Mika Gissler, Ingrid Glimelius, Tom Grotmol, Laura Madanat-Harjuoja, Anne Gulbech Ording, Henrik Toft Sorensen, Rebecca Troisi, Tone Bjorge
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Oncology
Jazmine Abril, Britton Trabert, Rebecca Troisi, Tom Grotmol, Anders Ekbom, Anders Engeland, Mika Gissler, Ingrid Glimelius, Laura Madanat-Harjuoja, Anne Gulbech Ording, Henrik Toft Sorensen, Steinar Tretli, Tone Bjorge
Summary: This study examines the risk factors for uterine sarcoma and compares them with MMMTs and type I endometrial carcinomas. The results show that risk factors vary substantially between uterine sarcoma and MMMTs.
CANCER CAUSES & CONTROL
(2023)
