Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei

Chemical–biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target

(2013) Jonathan W Choy et al.   Beilstein Journal of Organic Chemistry

Chemical Proteomic Analysis Reveals the Drugability of the Kinome of Trypanosoma brucei

(2012) Michael D. Urbaniak et al.   ACS Chemical Biology

How Chemoproteomics Can Enable Drug Discovery and Development

(2012) Raymond E. Moellering et al.   CHEMISTRY & BIOLOGY

TOR Signaling Regulates Ribosome and tRNA Synthesis via LAMMER/Clk and GSK-3 Family Kinases

(2012) Jaehoon Lee et al.   MOLECULAR CELL

Pharmacokinetic characterization of a natural product–inspired novel MEK1 inhibitor E6201 in preclinical species

(2011) Vipul Kumar et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

High-Throughput Analysis of an RNAi Library Identifies Novel Kinase Targets in Trypanosoma brucei

(2011) Zachary B. Mackey et al.   Chemical Biology & Drug Design

In Situ Kinase Profiling Reveals Functionally Relevant Properties of Native Kinases

(2011) Matthew P. Patricelli et al.   CHEMISTRY & BIOLOGY

Specific CLK Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing

(2011) Oleg Fedorov et al.   CHEMISTRY & BIOLOGY

LAMMER kinase Kic1 is involved in pre-mRNA processing

(2011) Zhaohua Tang et al.   EXPERIMENTAL CELL RESEARCH

High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome

(2011) S. Alsford et al.   GENOME RESEARCH

Cysteine Mapping in Conformationally Distinct Kinase Nucleotide Binding Sites: Application to the Design of Selective Covalent Inhibitors

(2011) Emeline Leproult et al.   JOURNAL OF MEDICINAL CHEMISTRY

Clk2 and B56β Mediate Insulin-Regulated Assembly of the PP2A Phosphatase Holoenzyme Complex on Akt

(2011) Joseph T. Rodgers et al.   MOLECULAR CELL

Trypanosoma brucei Glycogen Synthase Kinase-3, A Target for Anti-Trypanosomal Drug Development: A Public-Private Partnership to Identify Novel Leads

(2011) Richard O. Oduor et al.   PLoS Neglected Tropical Diseases

2,4-Diaminopyrimidines as Potent Inhibitors of Trypanosoma brucei and Identification of Molecular Targets by a Chemical Proteomics Approach

(2011) Luke Mercer et al.   PLoS Neglected Tropical Diseases

Cdc2-like Kinase 2 Is an Insulin-Regulated Suppressor of Hepatic Gluconeogenesis

(2010) Joseph T. Rodgers et al.   Cell Metabolism

In Vivo Efficacy of Natural Product-Inspired Irreversible Kinase Inhibitors

(2010) Sofia Barluenga et al.   CHEMBIOCHEM

Molecular mechanisms underlying the control of antigenic variation in African trypanosomes

(2010) David Horn et al.   CURRENT OPINION IN MICROBIOLOGY

Polo-Like Kinase Guides Cytokinesis in Trypanosoma brucei through an Indirect Means

(2010) Zhi Li et al.   EUKARYOTIC CELL

Nuclear DBF-2-related Kinases Are Essential Regulators of Cytokinesis in Bloodstream StageTrypanosoma brucei

(2010) Jiangtao Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication

(2010) Alexander Karlas et al.   NATURE

CRK9 contributes to regulation of mitosis and cytokinesis in the procyclic form of Trypanosoma brucei

(2009) Stephane Gourguechon et al.   BMC CELL BIOLOGY

Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial

(2009) Gerardo Priotto et al.   LANCET

The Phosphoproteome of Bloodstream FormTrypanosoma brucei, Causative Agent of African Sleeping Sickness

(2009) Isabelle R. E. Nett et al.   MOLECULAR & CELLULAR PROTEOMICS

Casein kinase 1 isoform 2 is essential for bloodstream form Trypanosoma brucei

(2009) Michael D. Urbaniak   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE

Identifying the proteins to which small-molecule probes and drugs bind in cells

(2009) S.-E. Ong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Burden of Human African Trypanosomiasis

(2009) Eric M. Fèvre et al.   PLoS Neglected Tropical Diseases

Glycogen Synthase Kinase 3 Is a Potential Drug Target for African Trypanosomiasis Therapy

(2008) K. K. Ojo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Phase I Pharmacokinetic and Pharmacodynamic Study of the Oral, Small-Molecule Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor AZD6244 (ARRY-142886) in Patients With Advanced Cancers

(2008) Alex A. Adjei et al.   JOURNAL OF CLINICAL ONCOLOGY

Molecular modeling and crystal structure of ERK2–hypothemycin complexes

(2008) Giulio Rastelli et al.   JOURNAL OF STRUCTURAL BIOLOGY

Eliminating Human African Trypanosomiasis: Where Do We Stand and What Comes Next?

(2008) Pere P Simarro et al.   PLOS MEDICINE