Article
Chemistry, Multidisciplinary
Corentin Gauthier, Julie Mariot, Morgane Daurat, Christine Dhommee, Khaled El Cheikh, Elodie Morere, Geoffrey Depaepe, Magali Gary-Bobo, Alain Morere, Marcel Garcia, Ilaria Basile, Valerie Gouilleux-Gruart, Marie Maynadier
Summary: The grafting of AMFA on therapeutic proteins improves enzyme delivery by increasing cellular uptake via the M6PR receptor. In this study, the impact of AMFA grafting on the cell uptake and recycling of a monoclonal antibody was investigated. AMFA grafting increased drug release in cells and had no effect on antibody recycling mediated by the FcRn receptor. AMFA grafting did not impair the pharmacokinetics and showed high stability.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Multidisciplinary Sciences
B. Y. H. Lam, A. Williamson, S. Finer, F. R. Day, J. A. Tadross, A. Goncalves Soares, K. Wade, P. Sweeney, M. N. Bedenbaugh, D. T. Porter, A. Melvin, K. L. J. Ellacott, R. N. Lippert, S. Buller, J. Rosmaninho-Salgado, G. K. C. Dowsett, K. E. Ridley, Z. Xu, I. Cimino, D. Rimmington, K. Rainbow, K. Duckett, S. Holmqvist, A. Khan, X. Dai, E. G. Bochukova, R. C. Trembath, H. C. Martin, A. P. Coll, D. H. Rowitch, N. J. Wareham, D. A. van Heel, N. Timpson, R. B. Simerly, K. K. Ong, R. D. Cone, C. Langenberg, J. R. B. Perry, G. S. Yeo, S. O'Rahilly
Summary: MC3R regulates the timing of sexual maturation, linear growth rate, and accrual of lean mass, while MC4R controls appetite, food intake, and energy expenditure. Loss of MC3R leads to delayed puberty, reduced linear growth, and decreased lean mass, while loss of MC4R results in delayed sexual maturation and insensitivity of reproductive cycle length to nutritional perturbation.
Article
Endocrinology & Metabolism
Marinna C. Okawa, Rebecca M. Tuska, Marissa Lightbourne, Brent S. Abel, Mary Walter, Yuhai Dai, Elaine Cochran, Rebecca J. Brown
Summary: Insulin receptor signaling plays a role in growth. Patients with hyperinsulinemia and impaired insulin receptor function show impaired growth and lower bone mineral density, while elevated insulin receptor signaling leads to accelerated growth and higher bone mineral density. This suggests that insulin receptor influences growth through direct metabolic effects in bone and indirect effects via the growth hormone-IGF-1 axis.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Ecology
Xantha Karp
Summary: Diapause is a developmental arrest state adopted in response to unfavorable environmental conditions, characterized by enhanced stress resistance and increased longevity, and regulated by hormonal signaling pathways.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2021)
Review
Endocrinology & Metabolism
Concetta Mastromauro, Cosimo Giannini, Francesco Chiarelli
Summary: Linear growth during childhood is the result of various factors, with the growth hormone-insulin-like growth factor axis playing a crucial role. Growth hormone insensitivity (GHI) is a significant disorder characterized by low IGF-1 levels, normal or elevated GH levels, and lack of IGF-1 response after GH administration. Recombinant IGF-1 preparations can be used for treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Eric T. Sletten, Jose Danglad-Flores, Sabrina Leichnitz, A. Abragam Joseph, Peter H. Seeberger
Summary: The toolbox for the functionalization of glycans assembled on solid-phase is currently limited. This study presents automated and manual phosphorylation protocols for the solid-phase synthesis of oligosaccharides containing up to two mannose-6-phosphates. Automated glycan assembly allows fast access to substrates and facilitates the screening of experimental conditions.
CARBOHYDRATE RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Tomoko Okuyama, Mayu Kyohara, Yasuo Terauchi, Jun Shirakawa
Summary: IGFs mainly mediate long-term actions in cell fates, while insulin predominantly exerts its role on metabolic activities. The interactions between insulin receptor signaling and IGF-I receptor signaling in metabolism and cell fates are complicated, and the function of IGF-I in respective tissues remains insufficiently understood. Clarifying the precise roles of IGF-I signaling on metabolism separate from those of insulin signaling is necessary.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Jingran Cao, Douglas Yee
Summary: The IGF system plays a crucial role in regulating malignancies, but blocking this system has not shown significant benefits in clinical trials. Targeting Type I IGF receptor alone may not be sufficient to disrupt this pathway, as the insulin receptor may also play a relevant role as a cancer target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Marc Tatar
Summary: Mutations of the insulin-like receptor in Drosophila can extend lifespan through two modes of operation, one slowing reproduction and growth, and the other prolonging lifespan without impairing growth and reproduction. The structure of the insulin receptor can modulate aging by influencing the balance between reproduction and survival in fruit flies.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Mirela-Diana Ilie, Antoine Tabarin, Alexandre Vasiljevic, Jean-Francois Bonneville, Lucile Moreau-Grange, Franck Schillo, Brigitte Delemer, Anne Barlier, Dominique Figarella-Branger, Segolene Bisot-Locard, Alexandre Santos, Philippe Chanson, Gerald Raverot
Summary: This study aimed to explore the factors related to SRLs in the treatment of acromegaly and confirmed that SST2A and adenoma granularity are good predictors of response to octreotide. In addition, the optimization of MRI sequences is important for using T2WSI as a predictor of treatment response.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Mengyang Li
Summary: The GH/IGF system plays a role in growth regulation in the body. By studying the basal chordate amphioxus, it was discovered that most members of the GH/IGF system are present in amphioxus, providing strong evidence for the origin of this system in amphioxus.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Editorial Material
Endocrinology & Metabolism
Gudmundur Johannsson, John J. Kopchick
Summary: This thematic review provides short reviews on growth hormone deficiency and insensitivity in children and adults, covering from basic science to clinical significance.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Editorial Material
Nutrition & Dietetics
Nikolay Mironov, Mainul Haque, Azeddine Atfi, Mohammed S. Razzaque
Summary: Phosphorus is an abundant mineral in the human body, playing a crucial role in glucose metabolism and bone health. High phosphate burden has been linked to increased risk of metabolic syndrome and cardiometabolic disorders, highlighting the importance of further research on phosphate toxicity.
Article
Endocrinology & Metabolism
Eun Ran Kim, Ji Ho Yun, Hyo-Jin Kim, Hyeon Young Park, Yoonseok Heo, Young Suk Park, Do Joong Park, Soo Kyung Koo
Summary: This study investigated the differences in serum hormone and inflammatory cytokine levels before and after surgery in Korean patients with obesity. The results showed that weight loss after surgery led to improvements in clinical parameters and reductions in inflammatory cytokines and hormones. These findings help us understand the mechanism of how bariatric surgery improves glucose metabolism.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Yusuke Moritoh, Shin-ichi Abe, Hiroki Akiyama, Akihiro Kobayashi, Ryokichi Koyama, Ryoma Hara, Shizuo Kasai, Masanori Watanabe
Summary: The enzymatic activity of IP6K is crucial for regulating phosphate levels in mammals, with its inhibition reducing cellular phosphate export and increasing intracellular ATP levels. Inhibition of IP6K lowers plasma phosphate levels and improves kidney functions in chronic kidney disease rats.
NATURE COMMUNICATIONS
(2021)
Editorial Material
Multidisciplinary Sciences
Deborah J. Marsh, Kirsty Foster, Carolyn D. Scott
Article
Oncology
Tiffany Scully, Carolyn D. Scott, Sue M. Firth, Lisa M. Sedger, John E. Pintar, Stephen M. Twigg, Robert C. Baxter
ENDOCRINE-RELATED CANCER
(2018)
Article
Oncology
Nicole J. Caixeiro, Janet L. Martin, Carolyn D. Scott
INTERNATIONAL JOURNAL OF CANCER
(2013)
Article
Oncology
Janet L. Martin, Hasanthi C. de Silva, Mike Z. Lin, Carolyn D. Scott, Robert C. Baxter
MOLECULAR CANCER THERAPEUTICS
(2014)
Article
Geriatrics & Gerontology
A. Amritraj, C. Hawkes, A. L. Phinney, H. T. Mount, C. D. Scott, D. Westaway, S. Kar
NEUROBIOLOGY OF AGING
(2009)
Article
Pathology
Viola A. Heinzelmann-Schwarz, Richard A. Scolyer, James P. Scurry, Alison N. Smith, Margaret Gardiner-Garden, Andrew V. Biankin, Sally Baron-Hay, Carolyn Scott, Robyn L. Ward, Daniel Fink, Neville F. Hacker, Robert L. Sutherland, Philippa M. O'Brien
JOURNAL OF CLINICAL PATHOLOGY
(2007)
Article
Oncology
VA Heinzelmann-Schwarz, M Gardiner-Garden, SM Henshall, JP Scurry, RA Scolyer, AN Smith, A Bali, P Vanden Bergh, S Baron-Hay, C Scott, D Fink, NF Hacker, RL Sutherland, PM O'Brien
BRITISH JOURNAL OF CANCER
(2006)
Article
Cell Biology
CJ Petry, KK Ong, DL Wingate, J Brown, CD Scott, EY Jones, ME Pembrey, DB Dunger
GROWTH HORMONE & IGF RESEARCH
(2005)
Review
Endocrinology & Metabolism
CD Scott, SM Firth
HORMONE AND METABOLIC RESEARCH
(2004)
Article
Oncology
S Baron-Hay, F Boyle, A Ferrier, C Scott
CLINICAL CANCER RESEARCH
(2004)
Article
Oncology
JS Lee, J Weiss, JL Martin, CD Scott
INTERNATIONAL JOURNAL OF CANCER
(2003)
Article
Endocrinology & Metabolism
DB O'Gorman, J Weiss, A Hettiaratchi, SM Firth, CD Scott
Article
Genetics & Heredity
C Gicquel, J Weiss, J Amiel, V Gaston, Y Le Bouc, CD Scott
JOURNAL OF MEDICAL GENETICS
(2004)
Article
Pediatrics
S Cianfarani, C Geremia, CD Scott, D Germani
PEDIATRIC RESEARCH
(2002)
