Journal
CURRENT RHEUMATOLOGY REPORTS
Volume 15, Issue 9, Pages -Publisher
SPRINGER
DOI: 10.1007/s11926-013-0356-9
Keywords
Axial spondyloarthritis; Remission; TNF-blocker; NSAIDs; Optimizing treatment strategies; Non-TNF-blocker biologics; Radiographic progression; Treatment; Treatment challenges; Seronegative arthritis
Categories
Funding
- AbbVie
- Merck Co.
- Pfizer
- Janssen Pharmaceutica
- Merck-Serono
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Major progress has been made in recent years in the management of axial spondyloarthritis (axSpA), including ankylosing spondylitis (AS) and non-radiographic axSpA (nr-axSpA). Most predictors of response have been defined for TNF-blocker therapy, and new treatment strategies are being discussed about how to best reach remission and how to maintain remission. Other biologics besides TNF-blockers have been tested in AS but have so far failed. The IL-17/IL-23 cytokines currently seem to be the most interesting targets. Short-term TNF-blocker therapy does not inhibit radiographic progression but long-term might do so. NSAIDs have been proven to inhibit such progression, even after 2 years of treatment. The effect of a combined therapy of NSAIDs with TNF-blockers on the inhibition of new bone formation in AS patients is currently unknown.
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