Review
Medicine, General & Internal
Mrinalini Dey, Ioannis Parodis, Elena Nikiphorou
Summary: Fatigue is a common feature in systemic lupus erythematosus and rheumatoid arthritis, but the two diseases differ in their clinical manifestations and treatment approaches. Addressing fatigue in a holistic manner, along with pain, depression, and anxiety, is crucial for improving quality of life in these patients. Further research is needed to better understand and manage fatigue in these conditions.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Nutrition & Dietetics
Alessia Alunno, Francesco Carubbi, Elena Bartoloni, Davide Grassi, Claudio Ferri, Roberto Gerli
Summary: In recent years, there has been increasing interest in the influence of diet on rheumatic and musculoskeletal diseases (RMDs). Diet may play a role in the development and progression of these conditions through pro-inflammatory properties and effects on insulin resistance, obesity, and other co-morbidities. Research has been more extensive in rheumatoid arthritis (RA) compared to systemic lupus erythematosus (SLE), with most SLE studies conducted on experimental models.
Review
Immunology
Yao-Chin Wang, Muh-Shi Lin, Abel Po-Hao Huang, Chieh-Chen Wu, Woon-Man Kung
Summary: This systematic review and meta-analysis demonstrate an increased risk of dementia among participants with systemic rheumatic diseases (SRDs), except for rheumatoid arthritis (RA).
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Peter Pietschmann, Maria Butylina, Katharina Kerschan-Schindl, Wolfgang Sipos
Summary: Patients with RA are at increased risk of developing osteoporosis, potentially due to autoimmune inflammatory processes leading to systemic inflammation and osteoporosis. Specific treatment for osteoporosis should be considered in RA patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Bo Zhang, Ming Zhao, Qianjin Lu
Summary: Extracellular vesicles (EVs) have attracted wide interest in basic and clinical research in the past two decades. They are small membrane vesicles released by almost all cells and play important roles in immunomodulation and the pathogenesis of autoimmune diseases, showing great potential in the diagnosis and treatment of autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Marcio Luis Acencio, Marek Ostaszewski, Alexander Mazein, Philip Rosenstiel, Konrad Aden, Neha Mishra, Vibeke Andersen, Prodromos Sidiropoulos, Aggelos Banos, Anastasia Filia, Souad Rahmouni, Axel Finckh, Wei Gu, Reinhard Schneider, Venkata Satagopam
Summary: Chronic inflammatory diseases involve complex molecular mechanisms and pose challenges for effective treatments. Using a systemic network model can help understand the interaction of key pathways. The SYSCID map is an interactive causal interaction network that aids in understanding the molecular mechanisms of inflammatory bowel disease, rheumatoid arthritis, and systemic lupus erythematosus, as well as the complexity of omics data.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Health Care Sciences & Services
Yeohan Song, Gabriel Kirsch, Wael Jarjour
Summary: Musculoskeletal ultrasound (US) can effectively detect inflammatory arthritis and guide targeted intra-articular steroid injection to alleviate joint pain in SLE patients with or without fibromyalgia (FM).
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Immunology
Han Wu, Shuxian Chen, Aifen Li, Kangyuan Shen, Shuting Wang, Sijie Wang, Ping Wu, Wenying Luo, Qingjun Pan
Summary: Long non-coding RNAs (lncRNAs) have emerged as potential novel biomarkers and therapeutic targets in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), playing key roles in the pathogenesis of these autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Kuanysh Dossybayeva, Yergali Bexeitov, Zaure Mukusheva, Zhaina Almukhamedova, Maykesh Assylbekova, Diyora Abdukhakimova, Marzhan Rakhimzhanova, Dimitri Poddighe
Summary: This study aimed to assess circulating basophils in children with pediatric SLE. The results showed a significant reduction in peripherally circulating basophils in children with pSLE compared to the other two groups of patients.
Review
Immunology
Michele Fresneda Alarcon, Zoe McLaren, Helen Louise Wright
Summary: Dysregulated neutrophil activation plays a significant role in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus, contributing to inflammation and autoantibody production in both autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Vasiliki-Kalliopi Bournia, George E. Fragoulis, Panagiota Mitrou, Konstantinos Mathioudakis, Anastasios Tsolakidis, George Konstantonis, Georgia Vourli, Dimitrios Paraskevis, Maria G. Tektonidou, Petros P. Sfikakis
Summary: The survival rates over 5 years in inflammatory arthritis under treatment are improving, but all-cause mortality is significantly higher in SLE and SSc, especially for male and younger patients.
Review
Health Care Sciences & Services
Mariangela Manfredi, Lieve Van Hoovels, Maurizio Benucci, Riccardo De Luca, Carmela Coccia, Pamela Bernardini, Edda Russo, Amedeo Amedei, Serena Guiducci, Valentina Grossi, Xavier Bossuyt, Carlo Perricone, Maria Infantino
Summary: uPAR is a membrane-bound glycoprotein, and its bioactive form, suPAR, is primarily expressed on the surface of immunologically active cells. Higher levels of suPAR have been associated with disease severity, relapse, and mortality in various inflammatory diseases. This review summarizes the current literature on the potential role of suPAR as a biomarker in autoimmune rheumatic and non-rheumatic diseases.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Immunology
Chloe Bost, Marina I. Arleevskaya, Wesley H. Brooks, Samuel Plaza, Jean-Charles Guery, Yves Renaudineau
Summary: Growing evidence suggests that the long non-coding RNA Xist expressed in female cells plays a significant role in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Xist controls transcription and sequesters miRNAs, leading to alterations in key inflammatory and proliferative pathways.
CLINICAL IMMUNOLOGY
(2022)
Review
Rheumatology
Mitsuhiro Akiyama, Waleed Alshehri, Keiko Yoshimoto, Yuko Kaneko
Summary: Recent technological progress has advanced our understanding of human immunology through the discovery of T follicular helper (Tfh) and T peripheral helper (Tph) cells. These cells play critical roles in B cell differentiation and maturation, with differences in their functional properties. In various rheumatic and musculoskeletal diseases, the contribution of Tfh and Tph cells varies, with Tph cells predominating in peripheral inflammatory lesions and Tfh cells predominating in affected lesions of IgG4-related disease. This review provides an overview of these novel T cell subsets and their involvement in these diseases.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Pharmacology & Pharmacy
Merel A. A. Opdam, Sophie Benoy, Lise M. Verhoef, Sandra Van Bijnen, Femke Lamers-Karnebeek, Rene A. M. Traksel, Petra Vos, Alfons A. den Broeder, Jasper Broen
Summary: Patients with inflammatory rheumatic diseases do not have an increased risk for COVID-19 compared to the general population. Older age and obesity are major risk factors for hospitalization for COVID-19 in patients with IRD, while the use of methotrexate may have a protective effect in reducing the risk of hospitalization.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)