Article
Medicine, General & Internal
Ji-Won Kim, Wook-Young Baek, Ju-Yang Jung, Hyoun-Ah Kim, Cheong In Yang, Seung-Ju Kim, Chang-Hee Suh
Summary: This study found that seasonal vitamin D levels are correlated with clinical manifestations and disease activity in lupus patients. Adequate vitamin D levels are important for achieving a low disease activity state in both winter and summer.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Immunology
Jiaqi Zou, Clare Thornton, Emma S. Chambers, Elizabeth C. Rosser, Coziana Ciurtin
Summary: Vitamin D plays a crucial role in modulating the immune system, particularly in patients with autoimmune rheumatic diseases, including arthritis and lupus. Further research is needed to clarify the impact of vitamin D supplementation on disease outcomes and health in this patient population.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
James Greenan-Barrett, Georgia Doolan, Devina Shah, Simrun Virdee, George A. Robinson, Varvara Choida, Nataliya Gak, Nina de Gruijter, Elizabeth Rosser, Muthana Al-Obaidi, Maria Leandro, Michael S. Zandi, Ruth J. Pepper, Alan Salama, Elizabeth C. Jury, Coziana Ciurtin
Summary: Juvenile systemic lupus erythematosus (JSLE) is a form of lupus that occurs before 18 years of age and is associated with more severe disease phenotype, increased morbidity, and mortality compared to adult-onset SLE. Identifying biomarkers specific to JSLE clinical phenotype can lead to better patient management and outcomes. Research into various traditional and novel biomarkers is important for predicting organ involvement and improving treatment strategies for JSLE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Rheumatology
Christine Chew, John A. Reynolds, Apinya Lertratanakul, Peggy Wu, Murray Urowitz, Dafna D. Gladman, Paul R. Fortin, Sang-Cheol Bae, Caroline Gordon, Ann E. Clarke, Sasha Bernatsky, John G. Hanly, David Isenberg, Anisur Rahman, Jorge Sanchez-Guerrero, Juanita Romero-Diaz, Joan Merrill, Daniel Wallace, Ellen Ginzler, Munther Khamashta, Ola Nived, Andreas Jonsen, Kristjan Steinsson, Susan Manzi, Ken Kalunian, Mary Anne Dooley, Michelle Petri, Cynthia Aranow, Ronald van Vollenhoven, Thomas Stoll, Graciela S. Alarcon, S. Sam Lim, Guillermo Ruiz-Irastorza, Christine A. Peschken, Anca D. Askanase, Diane L. Kamen, Murat Inanc, Rosalind Ramsey-Goldman, Ian N. Bruce
Summary: Vitamin D deficiency and MetS may increase cardiovascular risk in SLE patients. Lower 25(OH)D levels were associated with a higher likelihood of MetS and insulin resistance, as well as components of MetS such as hypertension, hypertriglyceridemia, and decreased HDL levels.
Review
Virology
Ancuta Lupu, Ingrith Crenguta Miron, Cristina Gavrilovici, Anca Adam Raileanu, Iuliana Magdalena Starcea, Ileana Ioniuc, Alice Azoicai, Adriana Mocanu, Lacramioara Ionela Butnariu, Felicia Dragan, Vasile Valeriu Lupu
Summary: Pediatric systemic lupus erythematosus is a chronic autoimmune disorder with a highly variable course and prognosis. The use of immunosuppressive therapies and underlying comorbidities increase the risk of severe COVID-19 and poor outcomes in pediatric SLE patients. This review analyzes newly diagnosed cases of pediatric SLE following COVID-19 and examines the impact of COVID-19 on patients with existing pediatric SLE.
Article
Immunology
Lauren A. Vanderlinden, Elizabeth A. Bemis, Jennifer Seifert, Joel M. Guthridge, Kendra A. Young, Mary Kristen Demoruelle, Marie Feser, Wade DeJager, Susan Macwana, Ted R. Mikuls, James R. O'Dell, Michael H. Weisman, Jane Buckner, Richard M. Keating, Patrick M. Gaffney, Jennifer A. Kelly, Carl D. Langefeld, Kevin D. Deane, Judith A. James, Vernon Michael Holers, Jill M. Norris
Summary: Genes associated with vitamin D levels may have a protective role in the development of autoantibodies in first-degree relatives of rheumatoid arthritis patients, but not in systemic lupus erythematosus patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Lambros Athanassiou, Ifigenia Kostoglou-Athanassiou, Pavlos Tsakiridis, Eirini Devetzi, Maria Mavroudi, Pantelis Fytas, Michael Koutsilieris, Panagiotis Athanassiou
Summary: This study examined the levels of vitamin D in patients with systemic lupus erythematosus (SLE) and its relationship with disease activity. The findings showed that SLE patients had lower levels of vitamin D and it was inversely related to disease activity. Therefore, routine screening for vitamin D levels is recommended in SLE patients.
Article
Medicine, General & Internal
Menglan Zhang, Leiwen Peng, Wensheng Li, Yifei Duan, Xiaoqin Liu, Shasha Chen, Jiamin Deng, Xinle Liu
Summary: This study found that IL12B polymorphisms are associated with the susceptibility of JIA and JSLE in Chinese children. The rs3212227 genotype is significantly associated with an increased risk of JSLE, while the rs6887695 genotype is significantly associated with an increased risk of JIA. Additionally, the IL12B haplotype GC is significantly associated with an increased risk of JIA. However, there is no significant difference in the IL17 gene polymorphisms between JIA and JSLE susceptibility.
Review
Immunology
Bo Zhang, Ming Zhao, Qianjin Lu
Summary: Extracellular vesicles (EVs) have attracted wide interest in basic and clinical research in the past two decades. They are small membrane vesicles released by almost all cells and play important roles in immunomodulation and the pathogenesis of autoimmune diseases, showing great potential in the diagnosis and treatment of autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Fulvia Ceccarelli, Marcello Govoni, Matteo Piga, Giulia Cassone, Francesco Paolo Cantatore, Giulio Olivieri, Alberto Cauli, Ennio Giulio Favalli, Fabiola Atzeni, Elisa Gremese, Florenzo Iannone, Roberto Caporali, Marco Sebastiani, Gian Franco Ferraccioli, Giovanni Lapadula, Fabrizio Conti
Summary: Musculoskeletal involvement is a common manifestation of SLE that affects patients' quality of life and prognosis. Understanding the pathogenetic mechanisms is crucial for developing effective therapeutic approaches.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Wenyuan Jin, Xinghui Yang, Meiping Lu
Summary: This case study presents a 13.3-year-old female SLE patient with multifocal ON of the knee joint, the youngest reported in literature. The patient showed significant improvement with high-dose methylprednisolone and intravenous cyclophosphamide pulse therapies, along with oral calcitriol and dipyridamole administration.
Review
Nutrition & Dietetics
Chao-Yi Wu, Huang-Yu Yang, Shue-Fen Luo, Jing-Long Huang, Jenn-Haung Lai
Summary: Vitamin D plays an important role in bone health and immune regulation. Juvenile idiopathic arthritis is a chronic inflammatory joint disease, and vitamin D may have potential effects on its manifestations and outcomes.
Article
Pediatrics
Pondtip Jongvilaikasem, Pornpimol Rianthavorn
Summary: Patients with childhood-onset systemic lupus erythematosus are at risk of becoming short adults, with independent risk factors including male sex, short stature at diagnosis, low body weight at final height, and cumulative corticosteroid dose. Adequate nutrition and corticosteroid minimization should be emphasized in patients at high risk for short final height.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Review
Nutrition & Dietetics
Alessia Alunno, Francesco Carubbi, Elena Bartoloni, Davide Grassi, Claudio Ferri, Roberto Gerli
Summary: In recent years, there has been increasing interest in the influence of diet on rheumatic and musculoskeletal diseases (RMDs). Diet may play a role in the development and progression of these conditions through pro-inflammatory properties and effects on insulin resistance, obesity, and other co-morbidities. Research has been more extensive in rheumatoid arthritis (RA) compared to systemic lupus erythematosus (SLE), with most SLE studies conducted on experimental models.
Article
Immunology
Mathilde Labouret, Stefania Costi, Vincent Bondet, Vincent Trebossen, Enora Le Roux, Alexandra Ntorkou, Sophie Bartoli, Stephane Auvin, Brigitte Bader-Meunier, Veronique Baudouin, Olivier Corseri, Glory Dingulu, Camille Ducrocq, Cecile Dumaine, Monique Elmaleh, Nicole Fabien, Albert Faye, Isabelle Hau, Veronique Hentgen, Theresa Kwon, Ulrich Meinzer, Naim Ouldali, Cyrielle Parmentier, Marie Pouletty, Florence Renaldo, Isabelle Savioz, Flore Rozenberg, Marie-Louise Fremond, Alice Lepelley, Gillian I. Rice, Luis Seabra, Jean-Francois Benoist, Darragh Duffy, Yanick J. Crow, Pierre Ellul, Isabelle Melki
Summary: This study aimed to identify central nervous system (CNS) disease biomarkers of juvenile neuropsychiatric SLE (j-NPSLE). The results showed that cerebrospinal fluid (CSF) levels of neopterin and interferon-alpha (IFN-alpha) protein were significantly higher in active j-NPSLE cases with CNS involvement compared to j-SLE alone. These biomarkers could potentially be useful in the diagnosis and monitoring of j-NPSLE activity.
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)