Article
Hematology
L. Talon, V. Fourneyron, S. Senectaire, M. Tardieu, M. Tillier, A. Trapani, A. Trayaud, A. Vaissade, A. F. Sapin, A. Lebreton, T. Sinegre
Summary: A study was conducted to investigate and compare the results and interpretations of lupus anticoagulant (LA) testing following the ISTH-SSC guidelines or available alternatives. The use of in-house cut-off values and pooled normal plasma (PNP) for ratio normalization, as well as ratio interpretation using the index of circulating anticoagulant, showed comparable testing outcomes. Understanding the characteristics of the mixing test is crucial for maximizing its diagnostic potential.
THROMBOSIS RESEARCH
(2023)
Review
Medicine, General & Internal
Angelo Claudio Molinari, Tiziano Martini, Laura Banov, Antonella Ierardi, Marzia Leotta, Alessandra Strangio, Rita Carlotta Santoro
Summary: Diagnosis of antiphospholipid syndrome requires clinical criteria and the presence of antiphospholipid antibodies. Lupus anticoagulant is one of the laboratory parameters used to define this condition. Currently, there are various methods available for detecting antiphospholipid antibodies, but detecting lupus anticoagulant is more challenging.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Armando Tripodi
Summary: Lupus anticoagulant (LA) is a crucial laboratory parameter for the diagnosis and management of antiphospholipid syndrome (APS). Proper detection of LA is essential for long-term treatment of patients with thrombotic events, requiring adherence to guidelines and participation in quality assessment schemes.
Review
Hematology
James C. Fredenburgh, Jeffrey I. Weitz
Summary: Oral anticoagulants are widely used for preventing and treating thrombosis. Direct oral anticoagulants (DOACs) such as dabigatran and apixaban have replaced traditional anticoagulants. New DOACs like asundexian and milvexian, targeting FXIa, offer potential advantages over existing ones.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Hematology
Emmanuel J. Favaloro, Brandon Michael Henry, Giuseppe Lippi
Summary: The presence of lupus anticoagulant (LA) in COVID-19 patients is potentially related to the severity of infection, but the relationship between LA and COVID-19-associated coagulopathy needs to be further investigated. Many confounders, such as anticoagulant therapy and elevated CRP levels, may affect the identification of LA. Larger and better studies are needed to clarify the role of LA in COVID-19 pathology.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2022)
Review
Medicine, General & Internal
Arne Vandevelde, Katrien M. J. Devreese
Summary: The diagnosis and risk stratification of antiphospholipid syndrome (APS) are complex and require various laboratory tests. Efforts to standardize and optimize these tests are ongoing to improve diagnostic accuracy and repeatability. There are challenges in laboratory testing, such as interference by anticoagulation therapy for LAC detection and high variability due to different reagents and detection techniques.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Hematology
Dongmei Yin, Philip G. de Groot, Marisa Ninivaggi, Katrien M. J. Devreese, Bas de Laat
Summary: Isolated lupus anticoagulant (LAC) positivity was highly associated with vascular thrombosis, even better than triple-positive samples. The levels of anti-phosphatidylserine/prothrombin antibodies (anti-PS/PT) were significantly lower in samples with isolated LAC positivity, and isolated LAC showed weaker LAC activity compared with triple-positive patients.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Rheumatology
Amaia Ugarte, Alazne Garcia de Bustos, Ioana Ruiz-Arruza, Adriana Soto-Peleteiro, Daniel Martin-Iglesias, Cristina Gonzalez-Echavarri, Guillermo Ruiz-Irastorza
Summary: This study compared the influence of aPLs on global and cardiovascular damage in patients with SLE diagnosed before and after the year 2000. The results showed that the effects of aPL on damage accrual in SLE patients have been reduced over recent years, possibly due to the widespread use of HCQ and improved thromboprophylaxis.
Article
Hematology
Zeyu Guan, Roxanna Wang, Rawaa H. Hussain, James C. Fredenburgh, Iqbal H. Jaffer, Jeffrey I. Weitz
Summary: This study compared the effects of apixaban, rivaroxaban, and enoxaparin on the prevention of catheter-induced clotting in vitro. The results showed that apixaban and rivaroxaban were significantly less potent than enoxaparin in preventing catheter-induced clotting and thrombin generation. Clinical trials are needed to compare the efficacy of low-molecular-weight heparin with that of direct oral anticoagulants for both prevention and treatment of catheter thrombosis.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Multidisciplinary Sciences
Fan-Yu Chen, Chun-Fan Chen, Ann Charis Tan, Chia-Hao Chan, Fu-An Chen, Wen-Sheng Liu, Tz-Heng Chen, Shuo-Ming Ou, Szu-Yuan Li, Ming-Tsun Tsai, Yung-Tai Chen, Chih-Ching Lin
Summary: Patients with systemic lupus erythematosus (SLE) have a higher incidence of arteriovenous fistula or graft (AVF/AVG) dysfunction during long-term follow-up, necessitating regular monitoring to improve vascular access function.
SCIENTIFIC REPORTS
(2021)
Article
Rheumatology
Selcan Demir, Jessica Li, Laurence S. Magder, Michelle Petri
Summary: The study showed that LA remained the best predictor of thrombosis in SLE patients, and adding additional aPL did not increase the risk except for anti-beta(2)-glycoprotein I IgA.
Article
Immunology
Savino Sciascia, Massimo Radin, Mario Bazzan, Barbara Montaruli, Domenico Cosseddu, Claudio Norbiato, Maria Tiziana Bertero, Renato Carignola, Beatrice Bacco, Silvia Gallo Cassarino, Dario Roccatello
Summary: The presence of antiphospholipid antibodies in COVID-19 patients may contribute to a pro-coagulant state, but differs from patients with overt APS. Therefore, caution is needed in interpreting and generalizing the role of aPL in the management of COVID-19 patients. Additional well-designed clinical studies are necessary before introducing aPL testing as routine in COVID-19 patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Surgery
Nicole E. Speck, Peter Hellstern, Jian Farhadi
Summary: Advancements in surgery and technology have made microsurgical breast reconstruction widely adopted. However, the perioperative management of patients with hemostatic disorders remains uncertain. This study combined literature review and retrospective chart review to identify various disorders associated with thrombotic and hemorrhagic complications in patients undergoing microsurgical breast reconstruction. A standardized risk assessment and management strategy was developed in cooperation with a hematologist.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Abdul Burhan Khan, Urfi Siddiqui, Sana Fatima, Ahmed Abdur Rehman, Mohamad Aman Jairajpuri
Summary: Current antithrombotic drugs have drawbacks, prompting the search for new and cheaper alternatives. This study found that naringin has high binding affinity for PDI, altering its conformation and activity, and thereby affecting blood coagulation rates.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biology
Antonio Cordoba-Fernandez, Francisco Marmol-Garcia, Victoria Eugenia Cordoba-Jimenez
Summary: This study emphasizes the importance of considering the possibility of antiphospholipid syndrome (APS) in podiatric patients with normal foot pulses and coagulation test results. APS is an autoimmune disease that causes inflammatory blood clotting and obstetric complications. This case report discusses a 46-year-old woman who experienced partial ischemic necrosis of the hallux and was eventually diagnosed with APS, leading to successful treatment and prevention of toe amputation.