Review
Geosciences, Multidisciplinary
Kent C. Condie, Sergei A. Pisarevsky, Stephen J. Puetz
Summary: Research suggests that over the past 2.3 billion years, the formation, assembly, and breakup of supercontinents are related to zircon ages, large igneous province (LIP) activity, and orogen frequency. Each phase is influenced by mantle events such as mantle plumes and subduction activities, which may directly or indirectly lead to occurrences of LIP events and crustal movements.
Review
Immunology
Tejpal Gill, James T. Rosenbaum
Summary: Spondyloarthritis (SpA) is a group of immune mediated inflammatory diseases strongly associated with the MHC class I molecule, HLA-B27. Although various hypotheses have been proposed to explain the HLA-B27 and disease association, the exact mechanisms underlying disease pathogenesis remain unclear. Evidence suggests that diseases related to HLA-B27 may have a microbial pathogenesis, and the influence of microbes on disease development is significant.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Denis Wakefield, Daniel Clarke, Peter McCluskey
Summary: Over the past 5 years, there has been steady progress in understanding the pathogenesis, clinical features, and treatment of acute anterior uveitis (AU). Large gene wide association studies have confirmed AU as a polygenic disease with overlaps with other conditions. Recent research has shown the importance of the microbiome in AU, with evidence suggesting that HLA B27 may influence gut microbiome composition. Clinical investigations have confirmed the typical features of AU and the value of immunosuppressive treatments.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Neurosciences
Nii A. Addy
Summary: The research by Nguyen and colleagues reveals topographically distinct and pathway-specific effects of nicotine on VTA dopamine neurons, which likely mediate reward and anxiety, respectively.
Article
Biology
Maren Kasper, Michael Heming, David Schafflick, Xiaolin Li, Tobias Lautwein, Melissa Meyer zu Horste, Dirk Bauer, Karoline Walscheid, Heinz Wiendl, Karin Loser, Arnd Heiligenhaus, Gerd Meyer zu Hoerste
Summary: Uveitis is a group of inflammatory eye diseases characterized by infiltration of leukocytes into the uveal tissues. HLA-B27-positive uveitis displays a unique pattern of ocular leukocyte infiltration with a prominent presence of plasmacytoid and classical dendritic cells. These cells play a central role in predicted local cell-cell communication within the eye, suggesting their importance in HLA-B27-associated inflammation.
Article
Immunology
Nan Sheng, Yingying Gao, Hui Li, Wenwen Wang, Linyu Geng, Bo Zhang, Qiang Huang, Xueqin Wang, Lingyun Sun
Summary: This study explored the associations between several single nucleotide polymorphisms (SNPs) in the coding gene of tumor necrosis factor alpha (TNFa) and ankylosing spondylitis (AS) risk. The results showed that the T allele of rs1799724 was associated with increased AS risk, while the A allele of rs361525 was associated with decreased AS risk. Moreover, the contributions of rs1799724 and rs361525 to AS risk were dependent on HLA-B27 status.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Amit Kumar Thakur, Manni Luthra-Guptasarma
Summary: Ankylosing spondylitis (AS) is a type of spondyloarthropathy strongly associated with the genetic marker HLA-B27. This study investigates the differential disease association of two HLA-B27 subtypes, B*2704 and B*2709, and finds distinct protein clearance mechanisms involved in their degradation. These findings provide insights into the different pathogenic outcomes of these HLA-B27 subtypes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Yimei Ding, Luan Xue
Summary: This study compared the clinical manifestations, imaging features, and laboratory inspection between HLA-B27 negative and HLA-B27 positive patients with Reactive arthritis (ReA). It found no significant difference in imaging features or laboratory inspection between the two groups, but there was a difference in the joints involved.
Article
Ophthalmology
Douglas A. Jabs, Nisha R. Acharya, Soon-Phaik Chee, Debra Goldstein, Peter McCluskey, Philip Murray, Neal Oden, Alan G. Palestine, James T. Rosenbaum, Jennifer E. Thorne, Brett E. Trusko
Summary: This study aimed to establish classification criteria for spondyloarthritis/HLA-B27-associated anterior uveitis using machine learning, achieving high accuracy in both training and validation sets. Key criteria for this condition were identified, with a low misclassification rate, indicating their potential utility in clinical and translational research.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Immunology
Melissa N. van Tok, Mohamed Mandour, Joseph Wahle, Mark E. Labadia, Marleen G. H. van de Sande, Gerald Nabozny, Dominique L. Baeten, Leonie M. van Duivenvoorde
Summary: Although RORC inhibitor treatment significantly suppresses the IL-17 axis, it accelerates and aggravates experimental SpA in the HLA-B27 tg rat model.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
James T. Rosenbaum, Michael H. Weisman, Hedley Hamilton, Cassie Shafer, Elin Aslanyan, Richard A. Howard, Kimberly Ogle, John D. Reveille, Kevin L. Winthrop, Dongseok Choi
Summary: HLA-B27 positive patients with axial spondyloarthritis (AxSpA) tend to have lower disease activity compared to HLA-B27 negative patients, as indicated by higher BASDAI scores. HLA-B27 positive patients with mild back pain are more likely to be diagnosed with AxSpA, suggesting a cognitive bias introduced by the HLA-B27 test.
SCIENTIFIC REPORTS
(2021)
Article
Ophthalmology
Haya H. Al-Ani, Joanne L. Sims, Rachael L. Niederer
Summary: This study aimed to evaluate the long term complications and vision loss in HLA-B27 uveitis. The results showed that despite the relatively common occurrence of complications, the majority of patients had good visual prognosis.
Article
Immunology
Izabela Lenart, Linh-Huyen Truong, Dinh Dung Nguyen, Olga Rasiukiene, Edward Tsao, Jonathan Armstrong, Pankaj Kumar, Kirsty McHugh, Branca I. Pereira, Balraj S. Maan, Malgorzata A. Garstka, Paul Bowness, Neil Blake, Simon J. Powis, Keith Gould, Darren Nesbeth, Antony N. Antoniou
Summary: Peptide-loaded Major Histocompatibility Complex (pMHC) class I molecules can be expressed in a single chain trimeric (SCT) format. Certain MHC class I molecules, including HLA-B27 HC, tend to form aggregates. The folding and dimerization of the single chain complex are determined by specific regions of the HLA-B27 HC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pediatrics
Matthew L. Stoll, Kimberly DeQuattro, Zhixiu Li, Henna Sawhney, Pamela F. Weiss, Peter A. Nigrovic, Tracey B. Wright, Kenneth Schikler, Barbara Edelheit, Casey D. Morrow, John D. Reveille, Matthew A. Brown, Lianne S. Gensler
Summary: Multiple studies have shown an abnormal microbiota in patients with spondyloarthritis (SpA). This study investigated the genetic contributions of these microbiota abnormalities. The findings suggest that there is an association between HLA-B27 status and microbiota composition, but HLA-B27 may not be involved in microbiota alterations associated with SpA. Additionally, B. fragilis and F. prausnitzii were found to be associated with juvenile SpA.
Article
Medicine, Research & Experimental
Chun-Chi Lu, Guo-Shu Huang, Tony Szu-Hsien Lee, En Chao, Hsiang-Cheng Chen, Yong-Si Guo, Shi-Jye Chu, Feng-Cheng Liu, San-Yuan Kao, Tsung-Yun Hou, Chen-Hung Chen, Deh-Ming Chang, Sin-Yi Lyu
Summary: Structural damage to the sacroiliac joints on MRI, including sclerosis, erosions, and focal joint space widening, may be present in nr-axSpA patients without detectable inflammation. Focal joint space widening is significantly correlated with the severity of inflammation seen on MRI, contributing to the accurate diagnosis of nr-axSpA, especially in populations with less common BME, HLA-B27-negative individuals, Asian patients without BME, or patients with normal inflammatory biomarkers.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)