Article
Chemistry, Multidisciplinary
Wenjie Duan, Shan Qiao, Mingjing Zhuo, Jiaxing Sun, Menglei Guo, Fei Xu, Jinjin Liu, Ting Wang, Xiuxiu Guo, Yan Zhang, Jia Gao, Yueyun Huang, Zhenjie Zhang, Peng Cheng, Shengqian Ma, Yao Chen
Summary: The study developed a systemic assay package to seek suitable MOFs for cutaneous applications, which have high porosity, easy modification, and multifunctionality. Versatile platforms based on MOFs were built with functions such as sebum adsorbability and antimicrobial activity, providing high-performance matrixes for skin applications and paving the way for the reformation of cosmetic and biomedical materials.
Review
Engineering, Biomedical
Yanling Hu, Shengke Li, Heng Dong, Lixing Weng, Lihui Yuwen, Yannan Xie, Jun Yang, Jinjun Shao, Xuejiao Song, Dongliang Yang, Lianhui Wang
Summary: The application of medical implants has greatly improved patients' survival rate and life quality. However, there is an increasing number of cases of implant dysfunction or failure due to bacterial infections in recent years. Conventional antibiotics have low efficacy in treating implant-related infections, thus innovative treatment strategies are urgently needed.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Oncology
Francesca Comito, Rachele Pagani, Giada Grilli, Francesca Sperandi, Andrea Ardizzoni, Barbara Melotti
Summary: This review summarizes the current research areas for the treatment of metastatic or unresectable advanced cutaneous melanoma, including immune checkpoint inhibitors, cell therapy, vaccines, targeted therapy, and combination strategies. While preliminary efficacy data from early phase trials are available in some areas, confirmation in larger patient cohorts is needed. Understanding the biological effects of the molecules and identifying predictive biomarkers remain crucial for selecting patient populations most likely to benefit from novel emerging treatment strategies.
Article
Chemistry, Medicinal
Ajay Gupta, Aryan Gautam, Pijus K. Sasmal
Summary: Photoactivatable or photoremovable protecting groups (PPGs) have gained great interest in the field of biomedical applications for their noninvasive and controlled release of biological effectors by light irradiation. o-hydroxycinnamate (oHC)-based PPGs have received considerable attention for the release of molecules of interest. This miniperspective summarizes the development and future perspectives of oHC PPGs for bioimaging and controlled release of therapeutics and other payloads with real-time monitoring.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Chemistry, Physical
Tongyu Tong, Yupeng Guan, Yuanji Gao, Chengyuan Xing, Shiqiang Zhang, Donggen Jiang, Xiangwei Yang, Yang Kang, Jun Pang
Summary: Although surgical transurethral resection is beneficial for bladder cancer patients, some malignant lesions may be missed or incompletely resected. Nanotechnology-based smart therapeutic platforms, especially stimulus-responsive nanocarriers, have the potential to address the limitations of current adjuvant treatments and improve bladder cancer therapy.
Review
Chemistry, Multidisciplinary
Seok Ki Choi
Summary: Emerging nanotechnologies and multifunctional nanomaterials show significant potential in advancing detection methods and treatment modalities for organophosphates. Nanomaterial-based sensors can detect and quantitatively analyze organophosphates, while nanotherapeutic platforms provide potential remedies through drug delivery and decontamination.
Review
Biochemistry & Molecular Biology
Shijie Jin, Yanping Sun, Xiao Liang, Xinyu Gu, Jiangtao Ning, Yingchun Xu, Shuqing Chen, Liqiang Pan
Summary: This review article introduces the potential of monoclonal antibodies as targeted anticancer agents and their applications in cancer therapy. It also discusses various types of antibodies, clinical study advances, and the rationale and mechanisms of different antibody formats. Well-designed novel antibodies are paving the way for successful treatments of various cancers in the clinic.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Review
Chemistry, Multidisciplinary
Adam Truskewycz, Hong Yin, Nils Halberg, Daniel T. H. Lai, Andrew S. Ball, Vi Khanh Truong, Agata Marta Rybicka, Ivan Cole
Summary: This article discusses the therapeutic potential of carbon quantum dots (CQDs) in biomedical applications. CQDs have shown biocompatibility and have been used for drug solubility, targeting, and facilitating drug delivery. They can also be triggered by environmental conditions or external stimuli, and their fluorescence is valuable for diagnostic purposes. The article also examines the toxicity of CQDs and their compatibility with larger nanoparticle carriers. The future of CQDs in theragnostic applications looks promising due to their multifunctional attributes and biocompatibility.
Article
Instruments & Instrumentation
Manuela Carvalheiro, Jennifer Vieira, Catarina Faria-Silva, Joana Marto, Sandra Simoes
Summary: Cutaneous leishmaniasis (CL) is a chronic skin disease characterized by skin lesions that may cause permanent scars. This study optimized a deformable lipid vesicle (DLV) for the topical administration of Amphotericin B (AmB) and found it to be effective in reducing parasite viability in skin layers. DLV may represent a cost-effective and safe therapeutic option in CL treatment.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Asma Ghaemi, Masoume Vakili-Azghandi, Khalil Abnous, Seyed Mohammad Taghdisi, Mohammad Ramezani, Mona Alibolandi
Summary: Gene therapy has the potential to prevent or treat various genetic or acquired diseases by regulating gene and protein expression. Effective delivery systems are needed to ensure successful gene therapy, and oral delivery approaches show promise in treating diseases such as inflammatory bowel disease and cancer. This review provides an update on the development of oral gene delivery techniques for gene therapy and vaccination purposes.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Hui Lu, Ting Hong, Yuanying Jiang, Malcolm Whiteway, Shiqun Zhang
Summary: Candidiasis is a fungal infection caused by Candida, most commonly Candida albicans. It can cause various infections on mucous membranes and throughout the body, especially in immunocompromised individuals. However, the immune mechanisms of the host and current antifungal drugs are not fully understood. Therefore, it is important to uncover host immune defenses and develop new antifungal strategies.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Dermatology
Myla Lobo de Souza, Widson Michael dos Santos, Andre Luiz Moreira Domingues de Sousa, Leslie Raphael de Moura Ferraz, Lucas Amadeu Gonzaga da Costa, Emerson Oliveira Silva, Pedro Jose Rolim Neto
Summary: The World Health Organization classifies leishmaniasis as a priority disease for the development of new treatments, with current drugs being ineffective in some cases. The development of an oral drug is seen as a potential solution, with research focusing on new molecules, repositioning drugs, and new formulations. Encouraging prospects have been seen, but further in vivo bioavailability and clinical trials are still needed.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Iman Zare, Daniel M. Chevrier, Anna Cifuentes-Rius, Nasrin Moradi, Yunlei Xianyu, Subhadip Ghosh, Laura Trapiella-Alfonso, Ye Tian, Alireza Shourangiz-Haghighi, Saptarshi Mukherjee, Kelong Fan, Michael R. Hamblin
Summary: The use of protein templates for controlled synthesis of inorganic nanostructures is gaining attention in various fields for their biocompatibility and programmability. Protein-coated metal nanoclusters (MNCs) show potential for applications in nanoprobes, nanodevices, chemosensing, and biosensing. This review discusses the different types of protein templates used, their optoelectronic properties, and various applications, including fluorescence-based imaging, nanotherapeutics, and controlled drug release.
Review
Biochemistry & Molecular Biology
Maria Giovanna Francipane, Bruno Douradinha, Cinzia Maria Chinnici, Giovanna Russelli, Pier Giulio Conaldi, Gioacchin Iannolo
Summary: Glioblastoma (GBM) is an aggressive neurological tumor with no effective long-term treatment options. The discovery of Zika virus (ZIKV) having oncolytic effects against GBM has led to hopes for new therapeutic approaches, but further research on its mechanisms of action is necessary for potential clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Ting Li, Tianyi Ren, Chumei Huang, Yufang Li, Pengfei Yang, Gang Che, Lisi Luo, Yutong Chen, Siqi Peng, Yujing Lin, Linjuan Zeng
Summary: PDAC is a lethal cancer with poor survival rates due to poor treatment response. The study identified S100A16 as a potential therapeutic target for PDAC treatment, showing its correlation with poor prognosis and role in promoting cancer cell metastasis through EMT and TWIST1/STAT3 signaling pathway.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yan-Ting Su, Jian Zhang
Summary: This study aimed to improve the water solubility and stability of cannabidiol (CBD) using micelle technology. CBD-loaded mixed micelles (CBD-M) composed of Poloxamer 407 (P407) and rubusoside (RUB) were successfully prepared and showed significant improvement in solubility and encapsulation efficiency. The CBD-M solution remained stable and maintained the antioxidant activity of CBD after dilution and centrifugation. These findings suggest that CBD-M could serve as a promising formulation for enhanced CBD delivery.
CURRENT DRUG DELIVERY
(2024)
