Article
Chemistry, Multidisciplinary
Nailin Yang, Fei Gong, Liang Cheng
Summary: Gas therapy using upconversion nanoparticles (UCNPs) for controlled gas release has shown great promise in various medical applications, such as cancer therapy and bacterial therapy. The unique upconversion luminescence (UCL) ability of UCNPs enables the conversion of long wavelength light to ultraviolet/visible (UV/Vis) light for precise gas release. Further research and development in this area are needed to explore the full potential of UCNP-based nanocomposites in gas therapy.
Review
Biochemistry & Molecular Biology
Daniil Spector, Kirill Pavlov, Elena Beloglazkina, Olga Krasnovskaya
Summary: Pt(IV) prodrugs with a light-controlled mode of activation show high antiproliferative activity when irradiated, but are non-toxic in the absence of light. This review discusses recent advances in photoabsorber-mediated photocontrollable activation of Pt(IV) prodrugs, focusing on the photocatalytic strategy based on flavin derivatives and the conjugation of photoactive molecules with Pt(II) drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Medicinal
Naoyuki Otani, Takashi Tomoe, Atsuhiko Kawabe, Takushi Sugiyama, Yasuto Horie, Hiroyuki Sugimura, Takanori Yasu, Takaaki Nakamoto
Summary: Pulmonary arterial hypertension (PAH) is a disease that leads to right-sided heart failure and death. Basic research has identified the decrease in levels of endogenous vasodilators and increase in levels of endogenous vasoconstrictors in PAH patients, leading to the development of therapeutic agents. Current treatments target specific pathways to improve prognosis.
Review
Chemistry, Applied
Haiting Xu, Wenbiao Nie, Linxin Dai, Ruifeng Luo, Dasheng Lin, Minyue Zhang, Jinming Zhang, Fei Gao
Summary: This article reviews the recent progress of polysaccharides in the field of cancer phototherapy, including the advantages of polysaccharides as nanocarrier materials to deliver phototherapeutic agents (PAs), the main mechanism for the preparation of PAs-loaded polysaccharides nanoformulation, and the construction of polysaccharides-based nano-drug delivery systems (NDDS) for delivery of PAs and its functional modification strategy, aiming to improve the therapeutic effect of phototherapy against cancer.
CARBOHYDRATE POLYMERS
(2023)
Review
Biotechnology & Applied Microbiology
Yi Tan, Haider Mohammed Khan, Bilal Ahmed Sheikh, Huan Sun, Hui Zhang, Jie Chen, Dingming Huang, Xinmei Chen, Changchun Zhou, Jianxun Sun
Summary: Phototherapy, a non-invasive, selective, and low side-effect treatment, has become a promising alternative to traditional clinical treatments. This review summarizes the current developments in phototherapy platforms based on 2D materials, focusing on innovative approaches of photothermal therapy (PTT) and photodynamic therapy (PDT). The efficacy, existing difficulties, and future prospects of 2D materials for phototherapy are also discussed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Adrian Saura-Sanmartin, Laura Andreu-Ardil
Summary: Scents, highly used in various manufactured items, have been the focus of research to improve their longevity and stability. Different controlled release systems, such as polymers and metal-organic frameworks, have been developed to control the release rate of scents. This review highlights the preparation of different scaffolds for slow scent release and provides a critical perspective on the state of the art in this research field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Multidisciplinary
Mengyu Chang, Zhiyao Hou, Man Wang, Chunxia Li, Jun Lin
Summary: Hyperthermia therapy has emerged as a strategy against malignant tumors, particularly when combined with nanomaterial-based photothermal therapy or magnetic hyperthermia. While these treatments alone may not completely cure cancer, when combined with cancer immunotherapy, they have shown potential for enhanced therapeutic outcomes against both primary tumors and metastatic lesions, as well as preventing cancer recurrence and prolonging survival period.
ADVANCED MATERIALS
(2021)
Review
Pharmacology & Pharmacy
Sergio R. S. Veloso, Raquel G. D. Andrade, Elisabete M. S. Castanheira
Summary: Magnetoliposomes have gained attention as delivery systems for on-demand drug release and real-time monitoring of therapy. Various structures have been reported to ensure efficient drug transport and delivery, while improving magnetic properties. However, there is a lack of assessment on formulations and complementary techniques for optimizing thermotherapy efficiency in current literature.
EXPERT OPINION ON DRUG DELIVERY
(2021)
Review
Biotechnology & Applied Microbiology
Shuya Liang, Chao Wang, Yingchun Shao, Yanhong Wang, Dongming Xing, Zhongmin Geng
Summary: Cancer is a leading cause of death worldwide, and conventional therapies often fail to completely eliminate cancer cells due to the unique characteristics of the tumor microenvironment. Bacteria have emerged as a promising platform for cancer therapy, offering specific tumor-targeting ability and serving as carriers for genes or drugs. Engineered bacteria and the use of nanomaterials have shown potential in improving the efficacy of cancer treatments.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Junlei Yang, Hui Wang, Jinyao Liu, Mengkui Ding, Xianjin Xie, Xiaoyu Yang, Yaru Peng, Shuang Zhou, Ruizhuo Ouyang, Yuqing Miao
Summary: Metal organic-frameworks (MOFs) are novel materials with unique advantages such as small particle size, porous framework structure, and high specific surface area, attracting increasing attention. Nano-MOFs, as carriers of biotherapy drugs with adjustable size, exhibit metal ion catalytic activity and organic group functional characteristics for biological treatments. Hybridizing nano-MOFs with other materials to form composites can broaden their applications in drug delivery and tumor therapy.
Review
Pharmacology & Pharmacy
Kehan Liu, Yao Yao, Shujuan Xue, Mengyao Zhang, Dazhao Li, Tao Xu, Feng Zhi, Yang Liu, Dawei Ding
Summary: This review introduces the advantages of combining photothermal therapy (PTT) with photodynamic therapy (PDT) and summarizes recent important progress in combined phototherapies using smart nanomedicines. The challenges and future developments of nanomedicine-mediated combined phototherapies are also discussed.
Review
Chemistry, Inorganic & Nuclear
Sandeep Kaler, Matthew D. Jones
Summary: Switchable catalysis is a powerful tool allowing precise control over polymer architectures. While still a relatively young area of research for ring opening polymerisation reactions, the field is advancing rapidly. Exciting developments in utilizing external stimuli for switchable catalysis are shaping the future of polymer chemistry.
DALTON TRANSACTIONS
(2022)
Review
Chemistry, Multidisciplinary
Kubra Bilici, Sultan Cetin, Eda Aydindogan, Havva Yagci Acar, Safacan Kolemen
Summary: Phototherapies, including photodynamic therapy (PDT) and photothermal therapy (PTT), show promise in cancer treatment by providing localization and a turn-on mechanism for toxicity. Combining PDT and PTT may overcome limitations of each method and improve efficacy. Cyanine dyes have shown potential in serving as both PDT and PTT agents, making them popular choices for phototherapy.
FRONTIERS IN CHEMISTRY
(2021)
Review
Polymer Science
Carlos B. P. Oliveira, Valeria Gomes, Paula M. T. Ferreira, Jose A. Martins, Peter J. Jervis
Summary: This review highlights the latest developments in supramolecular peptide-based hydrogels for drug delivery, focusing on peptide self-assembly, drug release, mechanical properties, functionalization, bioadhesive properties, and drug delivery enhancement strategies.
Article
Engineering, Environmental
Baoling Li, Shaojing Zhao, Li Huang, Qing Wang, Jiafu Xiao, Minhuan Lan
Summary: Carbon dots, as a novel zero-dimensional carbonaceous nanomaterial, have shown great potential in phototherapy as effective photosensitizers or photothermal agents for cancer treatment, and are expected to play an important role in phototheranostics.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Yan-Ting Su, Jian Zhang
Summary: This study aimed to improve the water solubility and stability of cannabidiol (CBD) using micelle technology. CBD-loaded mixed micelles (CBD-M) composed of Poloxamer 407 (P407) and rubusoside (RUB) were successfully prepared and showed significant improvement in solubility and encapsulation efficiency. The CBD-M solution remained stable and maintained the antioxidant activity of CBD after dilution and centrifugation. These findings suggest that CBD-M could serve as a promising formulation for enhanced CBD delivery.
CURRENT DRUG DELIVERY
(2024)