Article
Critical Care Medicine
Yiming Wang, Steven L. Taylor, Jocelyn M. Choo, Lito E. Papanicolas, Rebecca Keating, Kate Hindmarsh, Rachel M. Thomson, Lucy Morgan, Geraint B. Rogers, Lucy D. Burr
Summary: Does long-term macrolide use affect the carriage of resistance within the oropharyngeal microbiota in people with chronic respiratory conditions and the risk of onward transmission to their close contacts?
Review
Pharmacology & Pharmacy
Di Qin, Qing-Feng Tao, Shi-Le Huang, Min Chen, Hui Zheng
Summary: This study compared the efficacy of eluxadoline and antispasmodics in the treatment of irritable bowel syndrome (IBS). The results showed that eluxadoline was as effective as antispasmodics in relieving abdominal pain, but had more reported adverse events. Therefore, antispasmodics remain the first choice for the treatment of IBS.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Kiran Chaudhari, Anil Gohar, Stijn Claerhout, Rakesh Ganorkar
Summary: Controlling isomeric impurities in a key raw material is crucial for obtaining pure isomer-free targeted active pharmaceutical ingredient (API) in downstream processing. This study presents a scalable process for preparing substantially pure clarithromycin 9-(E)-oxime, with less than 1.2% of the (Z)-isomer, without the need for time-consuming purification steps. The pure clarithromycin 9-(E)-oxime can be converted into the pure 9a-lactam scaffold, and other impurities are also identified and controlled. The fine-tuned process allows for large-scale production of potential APIs derived from this scaffold.
Article
Infectious Diseases
Carlos F. Amabile-Cuevas
Summary: Biofilm formation by macrolide-resistant Staphylococcus aureus isolates can be induced by macrolides, especially in the early stages, suggesting that the empirical use of macrolides against infections caused by resistant S. aureus strains could lead to clinical failure or even enhance biofilm formation, making further treatment difficult.
Article
Obstetrics & Gynecology
Rachel D. Seaman, Rachel H. Kopkin, Mark A. Turrentine
Summary: This study suggests that for women with preterm prelabor rupture of membranes, administration of azithromycin is associated with a similar latency period but a lower rate of clinical chorioamnionitis compared to administration of erythromycin.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Physiology
Yun-zhou Shi, Qing-feng Tao, Di Qin, Min Chen, Shu-guang Yu, Hui Zheng
Summary: Acupuncture was found to be more effective than antispasmodics in relieving abdominal pain and improving global IBS symptoms, with lower rates of adverse events. Cimetropium, drotaverine, and acupuncture were all superior over placebo in improving abdominal pain.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Clinical Neurology
Leonard P. Rybak, Vickram Ramkumar, Debashree Mukherjea
Summary: This review summarizes the ototoxicity of non-aminoglycoside antibiotics, discussing antibiotics such as capreomycin, macrolides, and vancomycin that have been associated with hearing loss in animal studies and in patients, especially in neonates. It emphasizes the importance of being aware of the ototoxic potential of these antibiotics, given the extensive focus on the ototoxicity of aminoglycoside antibiotics in the literature.
FRONTIERS IN NEUROLOGY
(2021)
Review
Pharmacology & Pharmacy
Yao-Yao Chen, Xiao-Qian Ye, Tai-Chun Tang, Tian-Wei She, Min Chen, Hui Zheng
Summary: This study conducted an adjusted indirect comparison between CGRPmAbs and BoNT-A, finding similar effectiveness in the preventive treatment of chronic migraine. BoNT-A may be preferentially selected due to its cost-effectiveness. Further studies with direct comparison are needed to confirm these findings.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Reproductive Biology
Elif Keskin-Arslan, Hilal Erol, Nusrel Uysal, Baris Karadas, Tijen Temiz, Yusuf Cem Kaplan
Summary: This study examined the association between gestational use of macrolide antibiotics and the risk of congenital malformations and adverse pregnancy outcomes in infants. The results showed no significant increased risks for major congenital malformations and congenital heart defects following macrolide use during the first trimester, except for an increased risk with azithromycin use. There were also no significant associations between organ specific malformations and macrolide exposures, except for a decreased risk of hypospadias with erythromycin use.
REPRODUCTIVE TOXICOLOGY
(2023)
Review
Medicine, General & Internal
Sadia Janjua, Alexander G. Mathioudakis, Rebecca Fortescue, Ruth A. E. Walker, Sahar Sharif, Christopher J. D. Threapleton, Sofia Dias
Summary: Chronic obstructive pulmonary disease (COPD) is characterized by persistent respiratory symptoms and airflow limitation, with acute exacerbations associated with increased morbidity and mortality. Long-term, prophylactic use of antibiotics may reduce bacterial load, inflammation, and exacerbations in carefully selected COPD patients. However, there is a concern about the development of antimicrobial resistance with prophylactic antibiotic administration.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Environmental Sciences
Ivan Senta, Senka Terzic, Marijan Ahel
Summary: Macrolide antibiotics have been recently added to the EU Watch List of contaminants in the aquatic environment, but a comprehensive assessment of these antibiotics in different environmental compartments is still lacking. In this study, a new method was developed to determine an extended range of macrolide residues in sediment and soil samples, showing that these residues tend to persist in the aquatic environment.
ENVIRONMENTAL POLLUTION
(2021)
Review
Pediatrics
Guihua Song, Yan Zhang, Suping Yu, Mengmeng Sun, Bingxue Zhang, Minghao Peng, Weigang Lv, Hongyun Zhou
Summary: This study summarized the available randomized controlled trials (RCTs) to assess the efficacy and safety of macrolides on pathogens, lung function, laboratory parameters, and safety in children with bronchiectasis. The analysis of 7 RCTs showed that long-term use of macrolides reduced the risk of Moraxella catarrhalis but had no significant effect on other pathogens. Macrolides did not increase the risk of adverse events (AEs) or serious AEs and had no impact on forced expiratory volume in one second (FEV1%) predicted.
PEDIATRIC RESEARCH
(2023)
Review
Infectious Diseases
Lauri Ivaska, Alex-Mikael Barkoff, Jussi Mertsola, Qiushui He
Summary: This review summarizes the current understanding of the epidemiology, resistance mechanisms, and clinical implications of macrolide resistance in Bordetella pertussis. China has seen a high prevalence of macrolide-resistant B. pertussis, while sporadic cases have been reported in other parts of the world.
Article
Medicine, General & Internal
Giorgia Sulis, Brice Batomen, Anita Kotwani, Madhukar Pai, Sumanth Gandra
Summary: The study indicates a significant increase in antibiotic sales, particularly azithromycin, during the peak phase of the first COVID-19 epidemic wave in India, highlighting the urgent need for antibiotic stewardship measures.
Article
Microbiology
Lucy D. Burr, Steven L. Taylor, Alyson Richard, Veronika Schreiber, Stevie Lingman, Megan Martin, Lito E. Papanicolas, Jocelyn M. Choo, Geraint B. Rogers
Summary: This study investigated the effects of long-term macrolide therapy on oropharyngeal microbiota and macrolide resistance, as well as the potential transmission of resistance to close contacts. The results showed that macrolide therapy did not significantly alter the oropharyngeal microbiota, but there was an increase in macrolide resistance in streptococci. However, there was no evidence of onward transmission of resistance to close contacts.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Review
Allergy
Wen Li, Zhong Qin, Jie Gao, Zhibin Jiang, Yihui Chai, Liancheng Guan, Yuhong Ge, Yunzhi Chen
Review
Respiratory System
Li Wen, Wang Zhong, Yihui Chai, Qin Zhong, Jie Gao, Liancheng Guan, Zhang Mengzhi, Liu Huaiquan, Yu Haiyang, Wang Qingxue, Yang Changfu, Chen Yunzhi
CANADIAN RESPIRATORY JOURNAL
(2020)
Review
Integrative & Complementary Medicine
Yihui Chai, Yunzhi Chen, Wen Li, Zhong Qin, Jie Gao, Zhibin Jiang, Yuhong Ge, Liancheng Guan, Mengzhi Zhang, Huaiquan Liu, Haiyang Yu, Qingxue Wang, Changfu Yang
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2020)
Article
Pharmacology & Pharmacy
Xiaoduo Huang, Wenchao Tang, Chang Lin, Zongge Sa, Mengdan Xu, Jieying Liu, Lina Wang, Wen Li, Yunzhi Chen, Changfu Yang
Summary: The study demonstrated the protective effect of Astragalus polysaccharides against CTD-induced liver injury by regulating metabolic pathways.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2021)
Article
Integrative & Complementary Medicine
Huaiquan Liu, Hong Yang, Zhong Qin, Yunzhi Chen, Haiyang Yu, Wen Li, Xing Zhu, Jingwen Cai, Jing Chen, Mengzhi Zhang
Summary: The study explored the molecular mechanism of Danggui Buxue Decoction (DBD) in intervening premature ovarian failure (POF). The results showed that DBD could treat POF by regulating the balance of ESR and AR in the TP53-AKT signaling pathway, with the core compounds quercetin and kaempferol, and critical targets TP53, IL6, ESR1, AKT1, and AR playing important roles.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Multidisciplinary Sciences
Xiaozheng Wu, Wen Li, Zhenliang Luo, Yunzhi Chen
Summary: The study found that the MUC5B promoter rs35705950 T/G gene polymorphism is associated with the risk of IPF, with varying effects among different populations. The meta-analysis results showed significant associations between various genetic models and IPF risk in Caucasian, Asian, and mixed populations. The strength of association with the minor T allele and all T genetic model was more significant in the Caucasian population compared to the Asian population.
SCIENTIFIC REPORTS
(2021)
Article
Integrative & Complementary Medicine
Xiaozheng Wu, Wen Li, Zhenliang Luo, Yunzhi Chen
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2020)
