Refractory asthma – beyond step 5, the role of new and emerging adjuvant therapies

Randomized, Double-Blind, Placebo-controlled Study of Brodalumab, a Human Anti–IL-17 Receptor Monoclonal Antibody, in Moderate to Severe Asthma

(2013) William W. Busse et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Safety of bronchial thermoplasty in patients with severe refractory asthma

(2013) Ian D. Pavord et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Obesity-Associated Severe Asthma Represents a Distinct Clinical Phenotype

(2013) David Gibeon et al.   CHEST

Dose-ranging study of lebrikizumab in asthmatic patients not receiving inhaled steroids

(2013) Michael Noonan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Bronchial thermoplasty: Long-term safety and effectiveness in patients with severe persistent asthma

(2013) Michael E. Wechsler et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis

(2013) Wendy C. Moore et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Effectiveness of Omalizumab in Severe Allergic Asthma: A Retrospective UK Real-World Study

(2013) Neil Barnes et al.   JOURNAL OF ASTHMA

Efficacy and safety of once-daily GW870086 a novel selective glucocorticoid in mild-moderate asthmatics: a randomised, two-way crossover, controlled clinical trial

(2013) Philippe Bareille et al.   JOURNAL OF ASTHMA

Dupilumab in Persistent Asthma with Elevated Eosinophil Levels

(2013) Sally Wenzel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Azithromycin for prevention of exacerbations in severe asthma (AZISAST): a multicentre randomised double-blind placebo-controlled trial

(2013) Guy G Brusselle et al.   THORAX

Once-daily fluticasone furoate (FF)/vilanterol reduces risk of severe exacerbations in asthma versus FF alone

(2013) Eric D Bateman et al.   THORAX

NICE guidance on omalizumab for severe asthma

(2013) Richard A Diaz et al.   Lancet Respiratory Medicine

Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials

(2013) Lui G Franciosi et al.   Lancet Respiratory Medicine

Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo-controlled clinical trial

(2012) P. Nair et al.   CLINICAL AND EXPERIMENTAL ALLERGY

An update on bronchodilators in Phase I and II clinical trials

(2012) Mario Cazzola et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Tiotropium in Asthma Poorly Controlled with Standard Combination Therapy

(2012) Huib A.M. Kerstjens et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical management and outcome of refractory asthma in the UK from the British Thoracic Society Difficult Asthma Registry: Table 1

(2012) Joan Sweeney et al.   THORAX

Reslizumab for Poorly Controlled, Eosinophilic Asthma

(2011) Mario Castro et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Roflumilast with long-acting  2-agonists for COPD: influence of exacerbation history

(2011) E. D. Bateman et al.   EUROPEAN RESPIRATORY JOURNAL

Lebrikizumab Treatment in Adults with Asthma

(2011) Jonathan Corren et al.   NEW ENGLAND JOURNAL OF MEDICINE

Glucocorticosteroids: current and future directions

(2010) Peter J Barnes   BRITISH JOURNAL OF PHARMACOLOGY

Efficacy and safety of etanercept in moderate-to-severe asthma: a randomised, controlled trial

(2010) S. T. Holgate et al.   EUROPEAN RESPIRATORY JOURNAL

Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes

(2010) Annette T. Hastie et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Tiotropium Bromide Step-Up Therapy for Adults with Uncontrolled Asthma

(2010) Stephen P. Peters et al.   NEW ENGLAND JOURNAL OF MEDICINE

Beneficial effect of inhaled mannitol and cough in asthmatics with mucociliary dysfunction

(2010) Evangelia Daviskas et al.   RESPIRATORY MEDICINE

P20 The eligibility of patients with difficult asthma for omalizumab since the change to the treatment criteria

(2010) A. Burton et al.   THORAX

A Randomized, Double-blind, Placebo-controlled Study of Tumor Necrosis Factor-α Blockade in Severe Persistent Asthma

(2009) Sally E. Wenzel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effectiveness and Safety of Bronchial Thermoplasty in the Treatment of Severe Asthma

(2009) Mario Castro et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Identification of Asthma Phenotypes Using Cluster Analysis in the Severe Asthma Research Program

(2009) Wendy C. Moore et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma

(2009) Pranabashis Haldar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mepolizumab for Prednisone-Dependent Asthma with Sputum Eosinophilia

(2009) Parameswaran Nair et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cluster Analysis and Clinical Asthma Phenotypes

(2008) Pranab Haldar et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Randomized Controlled Trial of Oral Antifungal Treatment for Severe Asthma with Fungal Sensitization

(2008) David W. Denning et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A new perspective on concepts of asthma severity and control

(2008) D. R. Taylor et al.   EUROPEAN RESPIRATORY JOURNAL

Targeting the NF-κB pathway in asthma and chronic obstructive pulmonary disease

(2008) Michael R. Edwards et al.   PHARMACOLOGY & THERAPEUTICS

The role of a soluble TNF  receptor fusion protein (etanercept) in corticosteroid refractory asthma: a double blind, randomised, placebo controlled trial

(2008) J B Morjaria et al.   THORAX

British Guideline on the Management of Asthma

(2008)   THORAX

Clarithromycin Targets Neutrophilic Airway Inflammation in Refractory Asthma

(2007) Jodie L. Simpson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE