Article
Orthopedics
Yongheng Ye, Yue Peng, Peiheng He, Qinqin Zhang, Dongliang Xu
Summary: This study identified 13 differentially abundant miRNAs in the urine of patients with idiopathic osteonecrosis of femoral head (ONFH), indicating their diagnostic and prognostic value as biomarkers for ONFH. The noninvasive nature of urinary miRNAs testing makes it potentially useful for the diagnosis and monitoring of ONFH progression.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2021)
Article
Cell & Tissue Engineering
L. Maestro-Paramio, E. Garcia-Rey, F. Bensiamar, L. Saldana
Summary: Idiopathic osteonecrosis of the femoral head (ONFH) is associated with impaired osteoblast activities, characterized by reduced mineralization capacity and increased secretion of pro-resorptive factors.
BONE & JOINT RESEARCH
(2021)
Article
Endocrinology & Metabolism
Yiwei Chen, Yu Miao, Kexin Liu, Bin Zhu, Feng Xue, Junhui Yin, Jian Zou, Guangyi Li, Changqing Zhang, Yong Feng
Summary: This study investigated the differences in bone microarchitecture, bone remodeling activity, and histomorphological characteristics between glucocorticoid-associated osteonecrosis of femoral head (GONFH) and alcohol-associated osteonecrosis of femoral head (AONFH). The results showed that GONFH exhibited a less sclerotic bone microarchitecture and a more active bone metabolic status in both the reactive interface and normal region. These differences might contribute to the development of disease-modifying strategies and treatments for osteonecrosis of femoral head.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Orthopedics
Li-hua Liu, Zi-rong Li, Wei Sun, Yun-ting Wang, Fu-qiang Gao
Summary: This study analyzed the interobserver reliability and intraobserver repeatability of the CJFH typing classification system for nontraumatic ONFH. The results showed that the classification system has substantial inter- and intraobserver reliability.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2022)
Article
Computer Science, Interdisciplinary Applications
Peixu Wang, Xingyu Liu, Jia Xu, Tengqi Li, Wei Sun, Zirong Li, Fuqiang Gao, Lijun Shi, Zhizhuo Li, Xinjie Wu, Xin Xu, Xiaoyu Fan, Chengxin Li, Yiling Zhang, Yicheng An
Summary: A fully automatic deep learning model was developed in this study to detect early-stage ONFH lesions on MRI, showing promising diagnostic performance. The model's AUC was 0.97 with high sensitivity and specificity, and it exhibited good correlation with the ground truth definition. More extensive multicenter studies are needed to further validate and refine the model.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Cell Biology
Jiahe Liu, Chenzhi Li, Fan Yang, Minde Li, Baolin Wu, Haojie Chen, Shaopeng Li, Xiuzhi Zhang, Jiahui Yang, Yan Xia, Mingjian Wu, Yancheng Li, Baoyi Liu, Dewei Zhao
Summary: This study aimed to establish a new mouse model of osteonecrosis using angiotensin II combined with asparaginase and dexamethasone, and to study the effects of this drug combination on femoral head osteonecrosis in mice. The results showed that this drug combination can significantly promote necrosis of the femoral head and disrupt the local blood supply.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Rheumatology
Ahmed Abdelazim A. Hassan, Ahmed A. Khalifa
Summary: The current study aimed to summarize the occurrence and management of femoral head avascular necrosis (FHAVN) following COVID-19 infection. A systematic literature review was conducted, and 14 articles were included. Most of the FHAVN cases were treated with non-surgical methods, including medication and surgical intervention.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Genetics & Heredity
Yongchang Guo, Yuju Cao, Xiaoyan Feng, Dapeng Zhang, Liying Fan, Caihong Shen, Yangang He, Peng Wang, Peihui Wang, Yale Dong, Guofa Sheng, Nini Lv
Summary: The study found that MIR137HG genetic variants are associated with alcohol-induced ONFH susceptibility in Chinese male population, providing scientific evidence for exploring molecular mechanisms of alcohol-induced ONFH.
Article
Biochemistry & Molecular Biology
Liang Chen, Bing-Zhang Wang, Jun Xie, Ri-Yan Zhang, Chen Jin, Wei-Kai Chen, Kang-Hao Fang, Chen-Xuan Hong, Tian-Hao Xu, Cheng-Bin Huang, Lei Yang, She-Ji Weng
Summary: The study indicates the important role of SIRT3 in glucocorticoid-induced osteonecrosis of the femoral head. Resveratrol can reduce oxidative stress and mitochondrial damage by activating SIRT3, and promote osteogenic differentiation of BMSCs through the AMPK/PGC-1 alpha/SIRT3 axis. Resveratrol administration can prevent GIONFH, enhance SIRT3 expression, and reduce oxidative levels in affected rats.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Medicine, General & Internal
Quanjun Cui, Woo-Lam Jo, Kyung-Hoi Koo, Edward Y. Cheng, Wolf Drescher, Stuart B. Goodman, Yong-Chan Ha, Phillippe Hernigou, Lynne C. Jones, Shin-Yoon Kim, Kyu Sang Lee, Mel S. Lee, Yun Jong Lee, Michael A. Mont, Nobuhiko Sugano, John Taliaferro, Takuaki Yamamoto, Dewei Zhao
Summary: Osteonecrosis of the femoral head (ONFH) is a devastating disease that mainly affects young and middle-aged adults, with compromised local circulation being a key factor in its pathogenesis. Understanding the pathogenesis is crucial for developing effective treatments for the disease.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Elena Rezus, Bogdan Ionel Tamba, Minerva Codruta Badescu, Diana Popescu, Ioana Bratoiu, Ciprian Rezus
Summary: ONFH is a debilitating disease that affects young adults with complex pathophysiology and unclear etiology. Early diagnosis and treatment are crucial to prevent severe consequences, with hereditary thrombophilia and hypofibrinolysis being associated with ONFH. Anticoagulant treatment can alter disease progression and improve patient quality of life.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Medicine, General & Internal
Hui Wang, Weijian Li, Wenxin Zhang, Peng Wang, Shen Wang, Ruiguo Zhang
Summary: Osteonecrosis of femoral head (ONFH) is a common clinical condition that can be easily diagnosed through imaging examination. However, some rare neoplastic lesions of the femoral head can mimic ONFH, leading to misdiagnosis. We present a case of a 57-year-old male with bone pain in the left hip joint, initially diagnosed as ONFH but later found to be phosphaturic mesenchymal tumor (PMT) through histopathologic analysis. Surgery resulted in significant pain relief, and the patient had an uneventful 1-year follow-up.
Article
Computer Science, Interdisciplinary Applications
DaiZhu Yuan, ZhanYu Wu, Long Yang, Qiang Zou, DaWei Hua, ZiHao Zou, Chuan Ye
Summary: This study investigated the effects of different core decompression drilling locations and diameters on mechanical stability using finite element analysis. It was found that femoral stiffness decreased with increasing drilling diameters, while maximum equivalent stress increased. A safe drilling parameter range suitable for most patients was proposed.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Medicine, General & Internal
Da Song, Cheng-Zhi Ha, Qi Xu, Yan-Hui Hu
Summary: Idiopathic osteonecrosis of the femoral head (INFH) has a significant impact on patients' activities and is a burden to society and patients' families. This study used whole-transcriptome sequencing (WTS) to identify differentially expressed genes in the cancellous bone of the femoral head between INFH and femoral neck fracture (FNF) patients. The downregulation of LRRC17, which plays a role in bone metabolism regulation, may be a key factor in the pathogenesis of INFH.
Article
Genetics & Heredity
Tingting Zhou, Shiqiang Ma, Yunchao Zhao, Donghui Guo, Hengjun Wang, Mingjie Kuang, Xiaoming Li
Summary: We investigated the characteristics and biological functions of extrachromosomal circular DNA (eccDNA) in Alcohol-induced osteonecrosis of the femoral head (AIONFH). Our findings showed that the number of eccDNAs in AIONFH samples was lower than the control samples, and eccDNA formation may be related to transcription or other characteristics of coding genes. EccDNA lengths were mainly distributed between 0.1 kb and 1 kb, with a major peak at 0.358 kb. Significant genes related to bone formation were detected, and pathways such as MAPK and TGF-beta were enriched. EccDNAs in AIONFH may play an important role in regulating bone metabolism.
FRONTIERS IN GENETICS
(2022)
Article
Orthopedics
Shinji Takahashi, Yuta Nonomiya, Hidetomi Terai, Masatoshi Hoshino, Shoichiro Ohyama, Ayumi Shintani, Hiroaki Nakamura
Summary: An AI-based decision system using foot pressure distribution information is effective in screening for locomotive syndrome in elderly individuals. The AI model outperforms the clinical model in identifying locomotive syndrome, and the inclusion of footprint force distribution images significantly improves the prediction algorithm.
JOURNAL OF ORTHOPAEDIC SCIENCE
(2023)
Article
Clinical Neurology
Hamidullah Salimi, Hiromitsu Toyoda, Hidetomi Terai, Kentaro Yamada, Masatoshi Hoshino, Akinobu Suzuki, Shinji Takahashi, Koji Tamai, Yusuke Hori, Akito Yabu, Hiroaki Nakamura
Summary: The presence of degenerative spondylolisthesis (DS) or degenerative lumbar scoliosis (DLS) in patients with lumbar spinal stenosis (LSS) does not significantly affect mid-term clinical outcomes after minimally invasive lumbar decompression surgery. Lumbar decompression without fusion can lead to improved lumbar and sagittal spinopelvic alignment in patients with LSS, even with the coexistence of DS or DLS. Minimally invasive surgery can be considered for most patients with LSS.
Article
Medicine, General & Internal
Hidetomi Terai, Shinji Takahashi, Koji Tamai, Yusuke Hori, Masayoshi Iwamae, Masatoshi Hoshino, Shoichiro Ohyama, Akito Yabu, Hiroaki Nakamura
Summary: During the COVID-19 pandemic, patients with spinal disorders experienced a decline in their quality of life and activities of daily living. Age, reduced exercise habits, and female gender were identified as independent factors associated with the decline in activities of daily living.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Rheumatology
Akinobu Suzuki, Kentaro Yamada, Akito Yabu, Koji Tamai, Shinji Takahashi, Kentaro Inui, Tadashi Okano, Tatsuya Koike, Hiroaki Nakamura
Summary: Neck pain is common in patients with rheumatoid arthritis and is associated with lower quality of life. Age, C7 sagittal vertical axis, upper cervical lesion, and endplate erosion are factors associated with neck pain in these patients.
MODERN RHEUMATOLOGY
(2023)
Article
Orthopedics
Hidetomi Terai, Koji Tamai, Shinji Takahashi, Hiroshi Katsuda, Nagakazu Shimada, Yusuke Hori, Yuto Kobayashi, Hiroaki Nakamura
Summary: The prevalence of locomotive syndrome among the elderly population increased after the coronavirus outbreak due to decreased physical activity. A decrease in exercise was identified as a significant risk factor for the onset and progression of locomotive syndrome. Adequate exercise guidelines are urgently needed during the pandemic, especially for the elderly population.
JOURNAL OF ORTHOPAEDIC SCIENCE
(2023)
Article
Clinical Neurology
Shinji Takahashi, Hidetomi Terai, Masatoshi Hoshino, Tadao Tsujio, Minori Kato, Hiromitsu Toyoda, Akinobu Suzuki, Koji Tamai, Akito Yabu, Hiroaki Nakamura
Summary: Machine learning-based algorithms may be more effective than conventional methods for predicting nonunion following osteoporotic vertebral fractures (OVF). This study used ML models to analyze datasets from two prospective cohort studies, involving 505 patients aged over 65 with acute OVFs. The results showed that XGBoost and RF ML algorithms had higher AUC values compared to logistic regression and decision tree models. MRI findings, anterior height ratio, kyphotic angle, BMI, VAS, age, posterior wall injury, fracture level, and smoking habit were identified as important features in the ML algorithms.
EUROPEAN SPINE JOURNAL
(2023)
Article
Clinical Neurology
Yuichi Takeuchi, Shinji Takahashi, Shoichiro Ohyama, Yusuke Hori, Tadao Tsujio, Shiro Kotake, Akito Yabu, Masatoshi Hoshino, Hidetomi Terai, Akio Kobayashi, Hiroaki Nakamura
Summary: The relationship between body mass index (BMI) and spinal pathologies including spinal sagittal balance, back extensor strength (BES), paraspinal muscle mass, prevalent vertebral fracture, disc degeneration, Modic changes, low back pain, and quality of life (QOL) in community-dwelling older adults was investigated. The study found that increased BMI is significantly associated with these spinal pathologies, and suggests that controlling overweight and obesity among older adults can play an important role in their prevention and treatment.
EUROPEAN SPINE JOURNAL
(2023)
Article
Clinical Neurology
Kentaro Yamada, Hiromitsu Toyoda, Takahiko Hyakumachi, Yuichiro Abe, Shinji Takahashi, Akinobu Suzuki, Hidetomi Terai, Hiroaki Nakamura
Summary: This study aimed to compare the long-term risk of reoperation after decompression surgery for lumbar spinal stenosis (LSS) with diffuse idiopathic skeletal hyperostosis (DISH) between less-invasive procedures and conventional decompression techniques. The results showed that less-invasive procedures had a lower risk of reoperation in patients with LSS and L-DISH.
EUROPEAN SPINE JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Akito Yabu, Akinobu Suzuki, Kazunori Hayashi, Yusuke Hori, Hidetomi Terai, Kumi Orita, Hasibullah Habibi, Hamidullah Salimi, Hiroshi Kono, Hiromitsu Toyoda, Takafumi Maeno, Shinji Takahashi, Koji Tamai, Tomonori Ozaki, Masayoshi Iwamae, Shoichiro Ohyama, Yuuki Imai, Hiroaki Nakamura
Summary: Ligamentum flavum (LF) hypertrophy, a major cause of lumbar spinal canal stenosis, is influenced by mechanical stress. This study used RNA-seq to analyze changes in gene expression in a rabbit LF hypertrophy model and identified periostin as a molecule that fluctuates in response to mechanical stress. Further investigation using human LF tissues and primary LF cell cultures confirmed periostin's role in LF hypertrophy and its correlation with thickness. Mechanical stress upregulated periostin expression and promoted inflammation through upregulation of IL-6 expression, leading to LF degeneration and hypertrophy. Periostin may be a promising therapeutic target for lumbar spinal stenosis.
Article
Clinical Neurology
Hiroyuki Inose, Tsuyoshi Kato, Shoichi Ichimura, Hiroaki Nakamura, Masatoshi Hoshino, Shinji Takahashi, Daisuke Togawa, Toru Hirano, Yasuaki Tokuhashi, Tetsuro Ohba, Hirotaka Haro, Takashi Tsuji, Kimiaki Sato, Yutaka Sasao, Masahiko Takahata, Koji Otani, Suketaka Momoshima, Takashi Hirai, Toshitaka Yoshii, Kunihiko Takahashi, Atsushi Okawa
Summary: This study found that nonunion, subsequent vertebral fracture, and lower sacral slope were closely associated with poorer quality of life in patients with thoracolumbar osteoporotic vertebral fractures managed conservatively with a brace in the chronic phase. Therefore, improving or preventing these factors may improve the quality of life of affected patients.
Article
Clinical Neurology
Hiromitsu Toyoda, Hidetomi Terai, Kentaro Yamada, Minori Kato, Akinobu Suzuki, Shinji Takahashi, Koji Tamai, Akito Yabu, Masayoshi Iwamae, Yuta Sawada, Hiroaki Nakamura
Summary: A clinical prediction rule using a decision tree model was developed to predict clinical outcomes in patients undergoing minimally invasive lumbar decompression surgery for lumbar spinal stenosis.
Article
Medicine, General & Internal
Yoichi Ohta, Ryo Sugama, Yukihide Minoda, Shigekazu Mizokawa, Shinji Takahashi, Mitsuhiko Ikebuchi, Tamotsu Nakatsuchi, Hiroaki Nakamura
Summary: A retrospective study compared the early postoperative outcomes of minimally invasive total hip arthroplasty between anterolateral and posterolateral approaches. The surgical time was longer in the posterolateral group, and the C-reactive protein level was higher in the posterolateral group only on postoperative day 3. There was no significant difference in the recovery rate of muscle strength between the two approaches.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Koji Tamai, Hidetomi Terai, Masatoshi Hoshino, Hitoshi Tabuchi, Minori Kato, Hiromitsu Toyoda, Akinobu Suzuki, Shinji Takahashi, Akito Yabu, Yuta Sawada, Masayoshi Iwamae, Makoto Oka, Kazunori Nakaniwa, Mitsuhiro Okada, Hiroaki Nakamura
Summary: This study aimed to validate the diagnostic accuracy of a deep-learning algorithm for cervical cord compression. The results showed that the algorithm had higher diagnostic accuracy than spine physicians.
Article
Medicine, General & Internal
Makoto Oka, Akinobu Suzuki, Hidetomi Terai, Minori Kato, Hiromitsu Toyoda, Shinji Takahashi, Koji Tamai, Hiroaki Nakamura
Summary: This study aimed to determine the factors associated with the final diagnosis in cases requiring spinal biopsy. Results showed that a history of malignant tumors and the presence of pedicle lesions and/or extravertebral lesions were related factors for both tumors or malignancy in the final diagnosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Clinical Neurology
Shinji Takahashi, Hiroyuki Inose, Koji Tamai, Masayoshi Iwamae, Hidetomi Terai, Hiroaki Nakamura
Summary: Osteoporotic vertebral fractures (OVFs) can be treated with vertebral augmentation, but there are risks of complications and revision surgery. The risks for revision surgery include age, gender, and diabetes. Current evidence lacks substantial guidance for treatment strategies, and alternative surgeries and conservative treatments should be considered for high-risk patients.
