Molecular and Cellular Basis of Autosomal Recessive Primary Microcephaly

The Cell Biology of Neurogenesis: Toward an Understanding of the Development and Evolution of the Neocortex

(2014) Elena Taverna et al.   Annual Review of Cell and Developmental Biology

Emerging roles of MCPH1: Expedition from primary microcephaly to cancer

(2014) Thejaswini Venkatesh et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Importance of the CEP215-Pericentrin Interaction for Centrosome Maturation during Mitosis

(2014) Seongjae Kim et al.   PLoS One

Deregulation of Microcephalin and ASPM Expression Are Correlated with Epithelial Ovarian Cancer Progression

(2014) Rawiah Alsiary et al.   PLoS One

Microcephaly disease gene Wdr62 regulates mitotic progression of embryonic neural stem cells and brain size

(2014) Jian-Fu Chen et al.   Nature Communications

Microcephaly-Associated Protein WDR62 Regulates Neurogenesis through JNK1 in the Developing Neocortex

(2014) Dan Xu et al.   Cell Reports

Investigating microcephaly

(2013) C. G. Woods et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Disruption of Aspm causes microcephaly with abnormal neuronal differentiation

(2013) Akira Fujimori et al.   BRAIN & DEVELOPMENT

CEP120 and SPICE1 Cooperate with CPAP in Centriole Elongation

(2013) David Comartin et al.   CURRENT BIOLOGY

Selective Chemical Crosslinking Reveals a Cep57-Cep63-Cep152 Centrosomal Complex

(2013) Gražvydas Lukinavičius et al.   CURRENT BIOLOGY

Direct Binding of SAS-6 to ZYG-1 Recruits SAS-6 to the Mother Centriole for Cartwheel Assembly

(2013) Molly M. Lettman et al.   DEVELOPMENTAL CELL

Meier–Gorlin syndrome and Wolf–Hirschhorn syndrome: Two developmental disorders highlighting the importance of efficient DNA replication for normal development and neurogenesis

(2013) Claudia Kerzendorfer et al.   DNA REPAIR

DNA damage response in microcephaly development of MCPH1 mouse model

(2013) Zhong-Wei Zhou et al.   DNA REPAIR

Human microcephaly protein CEP135 binds to hSAS-6 and CPAP, and is required for centriole assembly

(2013) Yu-Chih Lin et al.   EMBO JOURNAL

Mutation in PHC1 implicates chromatin remodeling in primary microcephaly pathogenesis

(2013) Salma Awad et al.   HUMAN MOLECULAR GENETICS

CDK6 associates with the centrosome during mitosis and is mutated in a large Pakistani family with primary microcephaly

(2013) Muhammad S. Hussain et al.   HUMAN MOLECULAR GENETICS

CEP120 interacts with CPAP and positively regulates centriole elongation

(2013) Yi-Nan Lin et al.   JOURNAL OF CELL BIOLOGY

The KMN protein network - chief conductors of the kinetochore orchestra

(2013) D. Varma et al.   JOURNAL OF CELL SCIENCE

Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication

(2013) K. F. Sonnen et al.   JOURNAL OF CELL SCIENCE

Human-Specific Hypomethylation of CENPJ, a Key Brain Size Regulator

(2013) Lei Shi et al.   MOLECULAR BIOLOGY AND EVOLUTION

Abnormal centrosomal structure and duplication in Cep135-deficient vertebrate cells

(2013) Burcu Inanç et al.   MOLECULAR BIOLOGY OF THE CELL

Centrosome amplification causes microcephaly

(2013) Véronique Marthiens et al.   NATURE CELL BIOLOGY

Control of cell cycle transcription during G1 and S phases

(2013) Cosetta Bertoli et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pax6 Exerts Regional Control of Cortical Progenitor Proliferation via Direct Repression of Cdk6 and Hypophosphorylation of pRb

(2013) Da Mi et al.   NEURON

Abnormal centrosome and spindle morphology in a patient with autosomal recessive primary microcephaly type 2 due to compound heterozygous WDR62 gene mutation

(2013) Heba Farag et al.   Orphanet Journal of Rare Diseases

Cep63 and Cep152 Cooperate to Ensure Centriole Duplication

(2013) Nicola J. Brown et al.   PLoS One

Hierarchical recruitment of Plk4 and regulation of centriole biogenesis by two centrosomal scaffolds, Cep192 and Cep152

(2013) T.-S. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CEP proteins: the knights of centrosome dynasty

(2013) Ambuj Kumar et al.   PROTOPLASMA

Microcephaly models in the developing zebrafish retinal neuroepithelium point to an underlying defect in metaphase progression

(2013) C. Novorol et al.   Open Biology

A Truncating Mutation of CEP135 Causes Primary Microcephaly and Disturbed Centrosomal Function

(2012) Muhammad Sajid Hussain et al.   AMERICAN JOURNAL OF HUMAN GENETICS

WDR62 missense mutation in a consanguineous family with primary microcephaly

(2012) Carlos A. Bacino et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Microcephaly Gene Links Trithorax and REST/NRSF to Control Neural Stem Cell Proliferation and Differentiation

(2012) Yawei J. Yang et al.   CELL

Show me your license, please: deregulation of centriole duplication mechanisms that promote amplification

(2012) Christopher W. Brownlee et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

CDK5RAP2 Expression During Murine and Human Brain Development Correlates with Pathology in Primary Autosomal Recessive Microcephaly

(2012) Lina Issa et al.   CEREBRAL CORTEX

Building a centriole

(2012) Tomer Avidor-Reiss et al.   CURRENT OPINION IN CELL BIOLOGY

An oblique view on the role of spindle orientation in vertebrate neurogenesis

(2012) Elise Peyre et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

BLD10/CEP135 Is a Microtubule-Associated Protein that Controls the Formation of the Flagellum Central Microtubule Pair

(2012) Zita Carvalho-Santos et al.   DEVELOPMENTAL CELL

SAS-6 coiled-coil structure and interaction with SAS-5 suggest a regulatory mechanism inC. eleganscentriole assembly

(2012) Renping Qiao et al.   EMBO JOURNAL

Kinetochore KMN network gene CASC5 mutated in primary microcephaly

(2012) A. Genin et al.   HUMAN MOLECULAR GENETICS

Structural analysis reveals features of the spindle checkpoint kinase Bub1–kinetochore subunit Knl1 interaction

(2012) Veronica Krenn et al.   JOURNAL OF CELL BIOLOGY

Drosophila Cep135/Bld10 maintains proper centriole structure but is dispensable for cartwheel formation

(2012) H. Roque et al.   JOURNAL OF CELL SCIENCE

WD40-repeat protein 62 is a JNK-phosphorylated spindle pole protein required for spindle maintenance and timely mitotic progression

(2012) M. A. Bogoyevitch et al.   JOURNAL OF CELL SCIENCE

Cell-cycle-regulated expression of STIL controls centriole number in human cells

(2012) C. Arquint et al.   JOURNAL OF CELL SCIENCE

STIL is required for centriole duplication in human cells

(2012) J. Vulprecht et al.   JOURNAL OF CELL SCIENCE

Bld10/Cep135 stabilizes basal bodies to resist cilia-generated forces

(2012) Brian A. Bayless et al.   MOLECULAR BIOLOGY OF THE CELL

Tubulin nucleotide status controls Sas-4-dependent pericentriolar material recruitment

(2012) Jayachandran Gopalakrishnan et al.   NATURE CELL BIOLOGY

Towards a molecular architecture of centriole assembly

(2012) Pierre Gönczy   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Microtubule-Associated Protein ASPM Regulates Spindle Assembly and Meiotic Progression in Mouse Oocytes

(2012) Xiao-Ling Xu et al.   PLoS One

The Centrosome in Cells and Organisms

(2012) M. Bornens   SCIENCE

Disruption of Mouse Cenpj, a Regulator of Centriole Biogenesis, Phenocopies Seckel Syndrome

(2012) Rebecca E. McIntyre et al.   PLoS Genetics

Structural Basis of the 9-Fold Symmetry of Centrioles

(2011) Daiju Kitagawa et al.   CELL

BRIT1/MCPH1 is a multifunctional DNA damage responsive protein mediating DNA repair-associated chromatin remodeling

(2011) Guang Peng et al.   CELL CYCLE

Step to CEP152: uncovering a new mutation implicated in Seckel syndrome

(2011) S Ladha   CLINICAL GENETICS

The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation

(2011) Chieh-Ju C Tang et al.   EMBO JOURNAL

Mechanisms and pathways of growth failure in primordial dwarfism

(2011) A. Klingseisen et al.   GENES & DEVELOPMENT

PLK1 phosphorylation of pericentrin initiates centrosome maturation at the onset of mitosis

(2011) Kwanwoo Lee et al.   JOURNAL OF CELL BIOLOGY

Spindle positioning in human cells relies on proper centriole formation and on the microcephaly proteins CPAP and STIL

(2011) D. Kitagawa et al.   JOURNAL OF CELL SCIENCE

MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1–Cdc25 pathway

(2011) Ralph Gruber et al.   NATURE CELL BIOLOGY

The centrosome cycle: Centriole biogenesis, duplication and inherent asymmetries

(2011) Erich A. Nigg et al.   NATURE CELL BIOLOGY

A primary microcephaly protein complex forms a ring around parental centrioles

(2011) Joo-Hee Sir et al.   NATURE GENETICS

Autosomal recessive primary microcephaly (MCPH): clinical manifestations, genetic heterogeneity and mutation continuum

(2011) Saqib Mahmood et al.   Orphanet Journal of Rare Diseases

Structures of SAS-6 Suggest Its Organization in Centrioles

(2011) M. van Breugel et al.   SCIENCE

Cdk6-Dependent Regulation of G1 Length Controls Adult Neurogenesis

(2011) Pierre Beukelaers et al.   STEM CELLS

Structure of a Blinkin-BUBR1 Complex Reveals an Interaction Crucial for Kinetochore-Mitotic Checkpoint Regulation via an Unanticipated Binding Site

(2011) Victor M. Bolanos-Garcia et al.   STRUCTURE

Cdk5rap2 exposes the centrosomal root of microcephaly syndromes

(2011) Timothy L. Megraw et al.   TRENDS IN CELL BIOLOGY

Sas-4 provides a scaffold for cytoplasmic complexes and tethers them in a centrosome

(2011) Jayachandran Gopalakrishnan et al.   Nature Communications

Mutations in Centrosomal Protein CEP152 in Primary Microcephaly Families Linked to MCPH4

(2010) Duane L. Guernsey et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Human ASPM participates in spindle organisation, spindle orientation and cytokinesis

(2010) Julie Higgins et al.   BMC CELL BIOLOGY

Distinct subcellular distribution of cyclin dependent kinase 6

(2010) Dawn Kohrt et al.   CELL CYCLE

CDK5RAP2 is required for spindle checkpoint function

(2010) Xiaoying Zhang et al.   CELL CYCLE

Centrioles: active players or passengers during mitosis?

(2010) Alain Debec et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Basal body duplication in Paramecium: The key role of Bld10 in assembly and stability of the cartwheel

(2010) Maria Jerka-Dziadosz et al.   Cytoskeleton

Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors

(2010) S. B. Lizarraga et al.   DEVELOPMENT

CDK5RAP2 Regulates Centriole Engagement and Cohesion in Mice

(2010) Jose A. Barrera et al.   DEVELOPMENTAL CELL

Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome

(2010) Onur Cizmecioglu et al.   JOURNAL OF CELL BIOLOGY

Cep152 interacts with Plk4 and is required for centriole duplication

(2010) Emily M. Hatch et al.   JOURNAL OF CELL BIOLOGY

CDK5RAP2 stimulates microtubule nucleation by the γ-tubulin ring complex

(2010) Yuk-Kwan Choi et al.   JOURNAL OF CELL BIOLOGY

A clinical and molecular genetic study of 112 Iranian families with primary microcephaly

(2010) H. Darvish et al.   JOURNAL OF MEDICAL GENETICS

Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations

(2010) Kaya Bilgüvar et al.   NATURE

Asterless is a scaffold for the onset of centriole assembly

(2010) Nikola S. Dzhindzhev et al.   NATURE

CEP152 is a genome maintenance protein disrupted in Seckel syndrome

(2010) Ersan Kalay et al.   NATURE GENETICS

Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal cortical architecture

(2010) Timothy W Yu et al.   NATURE GENETICS

WDR62 is associated with the spindle pole and is mutated in human microcephaly

(2010) Adeline K Nicholas et al.   NATURE GENETICS

Cdk5rap2 Interacts with Pericentrin to Maintain the Neural Progenitor Pool in the Developing Neocortex

(2010) Joshua J. Buchman et al.   NEURON

Establishment of a Mouse Model with Misregulated Chromosome Condensation due to Defective Mcph1 Function

(2010) Marc Trimborn et al.   PLoS One

Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline

(2010) J. N. Pulvers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Centrosomal protein of 192 kDa (Cep192) promotes centrosome-driven spindle assembly by engaging in organelle-specific Aurora A activation

(2010) V. Joukov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BRIT1/MCPH1 Is Essential for Mitotic and Meiotic Recombination DNA Repair and Maintaining Genomic Stability in Mice

(2010) Yulong Liang et al.   PLoS Genetics

Mutations in STIL, Encoding a Pericentriolar and Centrosomal Protein, Cause Primary Microcephaly

(2009) Arun Kumar et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Compound heterozygous ASPM mutations in Pakistani MCPH families

(2009) Farooq Muhammad et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Centrioles, Centrosomes, and Cilia in Health and Disease

(2009) Erich A. Nigg et al.   CELL

Control of Centriole Length by CPAP and CP110

(2009) Thorsten I. Schmidt et al.   CURRENT BIOLOGY

Overly Long Centrioles and Defective Cell Division upon Excess of the SAS-4-Related Protein CPAP

(2009) Gregor Kohlmaier et al.   CURRENT BIOLOGY

Compound heterozygous ASPM mutations associated with microcephaly and simplified cortical gyration in a consanguineous Algerian family

(2009) Abdelkrim Saadi et al.   European Journal of Medical Genetics

Identification and Characterization of a Novel Nuclear Protein Complex Involved in Nuclear Hormone Receptor-mediated Gene Regulation

(2009) Shivani Garapaty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microcephalin and pericentrin regulate mitotic entry via centrosome-associated Chk1

(2009) Alexandra Tibelius et al.   JOURNAL OF CELL BIOLOGY

Mutation Analysis of the ASPM Gene in 18 Pakistani Families With Autosomal Recessive Primary Microcephaly

(2009) Rizwana Kousar et al.   JOURNAL OF CHILD NEUROLOGY

Drosophila Bld10 Is a Centriolar Protein That Regulates Centriole, Basal Body, and Motile Cilium Assembly

(2009) Violaine Mottier-Pavie et al.   MOLECULAR BIOLOGY OF THE CELL

BRIT1/MCPH1 links chromatin remodelling to DNA damage response

(2009) Guang Peng et al.   NATURE CELL BIOLOGY

CPAP is a cell-cycle regulated protein that controls centriole length

(2009) Chieh-Ju C. Tang et al.   NATURE CELL BIOLOGY

Expanding the clinical and neuroradiologic phenotype of primary microcephaly due to ASPM mutations

(2009) S. Passemard et al.   NEUROLOGY

Many roads lead to primary autosomal recessive microcephaly

(2009) Angela M. Kaindl et al.   PROGRESS IN NEUROBIOLOGY

Primary microcephaly: do all roads lead to Rome?

(2009) Gemma K. Thornton et al.   TRENDS IN GENETICS

Primary microcephaly with ASPM mutation shows simplified cortical gyration with antero-posterior gradient pre- and post-natally

(2008) Julie Desir et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

The centrosome is a polyfunctional multiprotein cell complex

(2008) I. B. Alieva et al.   BIOCHEMISTRY-MOSCOW

Geminin is partially localized to the centrosome and plays a role in proper centrosome duplication

(2008) Fei Lu et al.   BIOLOGY OF THE CELL

ASPM Is a Novel Marker for Vascular Invasion, Early Recurrence, and Poor Prognosis of Hepatocellular Carcinoma

(2008) S.-Y. Lin et al.   CLINICAL CANCER RESEARCH

MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis

(2008) Shan-Zhong Yang et al.   EMBO REPORTS

Functional characterization of the microtubule-binding and -destabilizing domains of CPAP and d-SAS-4

(2008) Wen-Bin Hsu et al.   EXPERIMENTAL CELL RESEARCH

A novel function of CEP135 as a platform protein of C-NAP1 for its centriolar localization

(2008) Kyeongmi Kim et al.   EXPERIMENTAL CELL RESEARCH

Microcephalin/MCPH1 Associates with the Condensin II Complex to Function in Homologous Recombination Repair

(2008) Jamie L. Wood et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Making bigger brains-the evolution of neural-progenitor-cell division

(2008) J. L. Fish et al.   JOURNAL OF CELL SCIENCE

The molecular landscape of ASPM mutations in primary microcephaly

(2008) A K Nicholas et al.   JOURNAL OF MEDICAL GENETICS

Mutations in the Pericentrin (PCNT) Gene Cause Primordial Dwarfism

(2008) A. Rauch et al.   SCIENCE

KNL1 and the CENP-H/I/K Complex Coordinately Direct Kinetochore Assembly in Vertebrates

(2007) Iain M. Cheeseman et al.   MOLECULAR BIOLOGY OF THE CELL

CDK5RAP2 Is a Pericentriolar Protein That Functions in Centrosomal Attachment of the γ-Tubulin Ring Complex

(2007) Ka-Wing Fong et al.   MOLECULAR BIOLOGY OF THE CELL