Biomedical Properties of a Natural Dietary Plant Metabolite, Zerumbone, in Cancer Therapy and Chemoprevention Trials

Toxicological evaluation of zerumbone on antitumor effects in mice

(2014) Bae Jin   African Journal of Pharmacy and Pharmacology

In vivo and In vitro Genotoxic Effects of Zerumbone

(2014) Adel S. Al-Zubairi et al.   CARYOLOGIA

Lipid-lowering effects of zerumbone, a natural cyclic sesquiterpene of Zingiber zerumbet Smith, in high-fat diet-induced hyperlipidemic hamsters

(2014) Thing-Fong Tzeng et al.   FOOD AND CHEMICAL TOXICOLOGY

Zerumbone Inhibits Angiogenesis by Blocking NF-κB Activity in Pancreatic Cancer

(2014) Tomoya Shamoto et al.   PANCREAS

Inclusion Complex of Zerumbone with Hydroxypropyl-β-Cyclodextrin Induces Apoptosis in Liver Hepatocellular HepG2 Cells via Caspase 8/BID Cleavage Switch and Modulating Bcl2/Bax Ratio

(2013) Nabilah Muhammad Nadzri et al.   Evidence-based Complementary and Alternative Medicine

Zerumbone, a Natural Cyclic Sesquiterpene ofZingiber zerumbetSmith, Attenuates Nonalcoholic Fatty Liver Disease in Hamsters Fed on High-Fat Diet

(2013) Thing-Fong Tzeng et al.   Evidence-based Complementary and Alternative Medicine

The Ethanol Extract ofZingiber zerumbetAttenuates Streptozotocin-Induced Diabetic Nephropathy in Rats

(2013) Thing-Fong Tzeng et al.   Evidence-based Complementary and Alternative Medicine

Antibacterial and antimutagenic activities of novel zerumbone analogues

(2013) S.C. Santosh Kumar et al.   FOOD CHEMISTRY

Zerumbone-loaded nanostructured lipid carriers: preparation, characterization, and antileukemic effect

(2013) Heshu Rahman et al.   International Journal of Nanomedicine

6-Gingerol prevents adipogenesis and the accumulation of cytoplasmic lipid droplets in 3T3-L1 cells

(2013) Thing-Fong Tzeng et al.   PHYTOMEDICINE

Non-Specific Protein Modifications by a Phytochemical Induce Heat Shock Response for Self-Defense

(2013) Kohta Ohnishi et al.   PLoS One

Antimalarial activity and cytotoxicity of zerumbone derivatives

(2013) Uraiwan Sriphana et al.   SCIENCEASIA

Zerumbone, an electrophilic sesquiterpene, induces cellular proteo-stress leading to activation of ubiquitin–proteasome system and autophagy

(2012) Kohta Ohnishi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Key cell signaling pathways modulated by zerumbone: Role in the prevention and treatment of cancer

(2012) Remya Prasannan et al.   BIOCHEMICAL PHARMACOLOGY

Zerumbone causes Bax- and Bak-mediated apoptosis in human breast cancer cells and inhibits orthotopic xenograft growth in vivo

(2012) Anuradha Sehrawat et al.   BREAST CANCER RESEARCH AND TREATMENT

Absence of Genotoxic and Mutagenic Effects ofZingiber zerumbet(L.) Smith (Zingiberaceae) Extract

(2012) Chia Ju Chang et al.   Evidence-based Complementary and Alternative Medicine

Zerumbone, a Southeast Asian Ginger Sesquiterpene, Induced Apoptosis of Pancreatic Carcinoma Cells through p53 Signaling Pathway

(2012) Songyan Zhang et al.   Evidence-based Complementary and Alternative Medicine

Zerumbone inhibits interleukin-6 and induces apoptosis and cell cycle arrest in ovarian and cervical cancer cells

(2012) Siddig Ibrahim Abdelwahab et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Antiulcer principle from Zingiber montanum

(2012) Mohammad Al-Amin et al.   JOURNAL OF ETHNOPHARMACOLOGY

The rapidly emerging role of zerumbone in attenuating tumor growth in systemic malignancies

(2012) Shailendra Kapoor   MOLECULAR NUTRITION & FOOD RESEARCH

Zerumbone protects HEK 293 cells from irradiation-induced DNA damage via activating Keap1/Nrf2/ARE pathway

(2011) Cuiyan Tang   African Journal of Pharmacy and Pharmacology

Zerumbone Induces Heme Oxygenase-1 Expression in Mouse Skin and Cultured Murine Epidermal Cells through Activation of Nrf2

(2011) J.-W. Shin et al.   Cancer Prevention Research

Ginger and its Health Claims: Molecular Aspects

(2011) Masood Sadiq Butt et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Zingiber zerumbet(L.) Smith: A Review of Its Ethnomedicinal, Chemical, and Pharmacological Uses

(2011) N. J. Yob et al.   Evidence-based Complementary and Alternative Medicine

Anticancer Activity of the Bioreductive and Non-Bioreductive Zerumbone Derivatives

(2011) Siripit Pitchuanchom et al.   Letters in Drug Design & Discovery

Potential efficacy of ginger as a natural supplement for nonalcoholic fatty liver disease

(2011) Amirhossein Sahebkar   WORLD JOURNAL OF GASTROENTEROLOGY

Zerumbone-Induced Antinociception: Involvement of the l-Arginine-Nitric Oxide-cGMP -PKC-K+ATP Channel Pathways

(2010) Enoch Kumar Perimal et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Characterization of the inclusion complex of zerumbone with hydroxypropyl-β-cyclodextrin

(2010) Eltayeb E.M. Eid et al.   CARBOHYDRATE POLYMERS

Potential chemoprevention of diethylnitrosamine-initiated and 2-acetylaminofluorene-promoted hepatocarcinogenesis by zerumbone from the rhizomes of the subtropical ginger (Zingiber zerumbet)

(2010) Manal Mohamed Elhassan Taha et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Cytotoxicity against cholangiocarcinoma cell lines of zerumbone derivatives

(2010) Uraiwan Songsiang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice

(2010) M.R. Sulaiman et al.   FITOTERAPIA

Combination of Zerumbone and Cisplatin to Treat Cervical Intraepithelial Neoplasia in Female BALB/c Mice

(2010) Ahmad Bustamam Abdul et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Ethnomedical uses of Zingiberaceous plants of Northeast India

(2010) Tushar et al.   JOURNAL OF ETHNOPHARMACOLOGY

Zerumbone induces apoptosis in T-acute lymphoblastic leukemia cells

(2010) Siddig Ibrahim Abdelwahab et al.   LEUKEMIA RESEARCH

Antiinflammatory and Antinociceptive Activities of Zingiber zerumbet Methanol Extract in Experimental Model Systems

(2010) Z.A. Zakaria et al.   MEDICAL PRINCIPLES AND PRACTICE

Evaluation of the genotoxicity of zerumbone in cultured human peripheral blood lymphocytes

(2010) Adel S. Al-Zubairi et al.   TOXICOLOGY IN VITRO

Development and validation of an HPTLC method for analysis of zerumbone, the anticancer marker fromZingiber zerumbet

(2009) K. K. Rout et al.   ACTA CHROMATOGRAPHICA

Chemical investigation of the leaf and rhizome essential oils of Zingiber zerumbet (L.) Smith from Bangladesh

(2009) Mohammad Nazrul Islam Bhuiyan et al.   Bangladesh Journal of Pharmacology

Zerumbone Abolishes RANKL-Induced NF-κB Activation, Inhibits Osteoclastogenesis, and Suppresses Human Breast Cancer–Induced Bone Loss in Athymic Nude Mice

(2009) Bokyung Sung et al.   CANCER RESEARCH

Zerumbone Enhances TRAIL-Induced Apoptosis through the Induction of Death Receptors in Human Colon Cancer Cells: Evidence for an Essential Role of Reactive Oxygen Species

(2009) S. Yodkeeree et al.   CANCER RESEARCH

Chemoprotective Mechanism of the Natural Compounds, Epigallocatechin- 3-O-Gallate, Quercetin and Curcumin Against Cancer and Cardiovascular Diseases

(2009) Smita Jagtap et al.   CURRENT MEDICINAL CHEMISTRY

Regression of cervical intraepithelial neoplasia by zerumbone in female Balb/c mice prenatally exposed to diethylstilboestrol: Involvement of mitochondria-regulated apoptosis

(2009) Siddig Ibrahim Abdelwahab et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Preliminary analysis of the antinociceptive activity of zerumbone

(2009) M.R. Sulaiman et al.   FITOTERAPIA

High content of zerumbone in volatile oils ofZingiber zerumbetfrom southern India and Malaysia

(2009) Sabulal Baby et al.   FLAVOUR AND FRAGRANCE JOURNAL

Protective effect of ginger extract against bromobenzene-induced hepatotoxicity in male rats

(2009) A.S. El-Sharaky et al.   FOOD AND CHEMICAL TOXICOLOGY

Anticancer and Antimicrobial Activities of Zerumbone from the Rhizomes of Zingiber zerumbut

(2009) Ahmad B. Abdul et al.   International Journal of Pharmacology

Antinociceptive Activity of the Essential Oil ofZingiber zerumbet

(2009) Mohd Sulaiman et al.   PLANTA MEDICA

Zerumbone Down-regulates Chemokine Receptor CXCR4 Expression Leading to Inhibition of CXCL12-Induced Invasion of Breast and Pancreatic Tumor Cells

(2008) Bokyung Sung et al.   CANCER RESEARCH

Zerumbone, a tropical ginger sesquiterpene, inhibits colon and lung carcinogenesis in mice

(2008) Mihye Kim et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibitory effect of compounds from Zingiberaceae species on human platelet aggregation

(2007) I. Jantan et al.   PHYTOMEDICINE