New Enlightenment of Skin Cancer Chemoprevention through Phytochemicals:In VitroandIn VivoStudies and the Underlying Mechanisms

Bioactive Grape Proanthocyanidins Enhance Immune Reactivity in UV-Irradiated Skin through Functional Activation of Dendritic Cells in Mice

(2013) M. Vaid et al.   Cancer Prevention Research

Sunlight UV-Induced Skin Cancer Relies upon Activation of the p38  Signaling Pathway

(2013) K. Liu et al.   CANCER RESEARCH

Nicotinamide enhances repair of ultraviolet radiation-induced DNA damage in human keratinocytes and ex vivo skin

(2013) Devita Surjana et al.   CARCINOGENESIS

The inhibition of resveratrol to human skin squamous cell carcinoma A431 xenografts in nude mice

(2013) Yuqin Hao et al.   FITOTERAPIA

Occupational exposure to arsenic and risk of nonmelanoma skin cancer in a multinational European study

(2013) Simona Surdu et al.   INTERNATIONAL JOURNAL OF CANCER

p53-mediated autophagy adjustment is involved in the protection of silibinin against murine dermal inflammation and epidermal apoptosis induced by UVB irradiation

(2013) Qiong Wang et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Non-melanoma skin cancer: carcinogenesis and chemoprevention

(2013) Andrew C. Chen et al.   PATHOLOGY

Tea and human health: The dark shadows

(2013) Aditi Jain et al.   TOXICOLOGY LETTERS

Src kinase is a direct target of apigenin against UVB-induced skin inflammation

(2012) Sanguine Byun et al.   CARCINOGENESIS

Polymeric black tea polyphenols modulate the localization and activity of 12-O-tetradecanoylphorbol-13-acetate-mediated kinases in mouse skin: Mechanisms of their anti-tumor-promoting action

(2012) Gaurav Kumar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dual effects of silibinin treatment on autophagy-regulated dermal apoptosis retardation and epidermal apoptosis up-regulation in UVB-induced skin inflammation

(2012) Qiong Wang et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Retinoids in the chemoprevention of non-melanoma skin cancers: why, when and how

(2012) Vincenzo Bettoli et al.   JOURNAL OF DERMATOLOGICAL TREATMENT

PKM2 inhibitor shikonin suppresses TPA-induced mitochondrial malfunction and proliferation of skin epidermal JB6 cells

(2012) Wenjuan Li et al.   MOLECULAR CARCINOGENESIS

Grape seed proanthocyanidins reactivate silenced tumor suppressor genes in human skin cancer cells by targeting epigenetic regulators

(2012) Mudit Vaid et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Pterostilbene, a natural analogue of resveratrol, potently inhibits 7,12-dimethylbenz[a]anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse skin carcinogenesis

(2012) Mei-Ling Tsai et al.   Food & Function

Cyclooxygenase-dependent signaling is causally linked to non-melanoma skin carcinogenesis: pharmacological, genetic, and clinical evidence

(2011) Karin Müller-Decker   CANCER AND METASTASIS REVIEWS

Norathyriol Suppresses Skin Cancers Induced by Solar Ultraviolet Radiation by Targeting ERK Kinases

(2011) J. Li et al.   CANCER RESEARCH

Silibinin prevents ultraviolet B radiation-induced epidermal damages in JB6 cells and mouse skin in a p53-GADD45α-dependent manner

(2011) Srirupa Roy et al.   CARCINOGENESIS

(-)-Epigallocatechin-3-gallate and DZNep reduce polycomb protein level via a proteasome-dependent mechanism in skin cancer cells

(2011) S. R. Choudhury et al.   CARCINOGENESIS

Ferulic acid, a phenolic phytochemical, inhibits UVB-induced matrix metalloproteinases in mouse skin via posttranslational mechanisms

(2011) Vanisree Staniforth et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

p38 MAP kinase plays a functional role in UVB-Induced mouse skin carcinogenesis

(2011) Sally E. Dickinson et al.   MOLECULAR CARCINOGENESIS

Silibinin Is a Potent Sensitizer of UVA Radiation-induced Oxidative Stress and Apoptosis in Human Keratinocyte HaCaT Cells†

(2011) Sreekanth Narayanapillai et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Pomegranate Fruit Extract Inhibits UVB-induced Inflammation and Proliferation by Modulating NF-κB and MAPK Signaling Pathways in Mouse Skin†

(2011) Naghma Khan et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Topical Grape Seed Proanthocyandin Extract Reduces Sunburn Cells and Mutant p53 Positive Epidermal Cell Formation, and Prevents Depletion of Langerhans Cells in an Acute Sunburn Model

(2011) Xiao-Ying Yuan et al.   PHOTOMEDICINE AND LASER SURGERY

Grape Seed Proanthocyanidins Inhibit Melanoma Cell Invasiveness by Reduction of PGE2 Synthesis and Reversal of Epithelial-to-Mesenchymal Transition

(2011) Mudit Vaid et al.   PLoS One

Induction of apoptosis by lupeol in human epidermoid carcinoma A431 cells through regulation of mitochondrial, Akt/PKB and NF-kappaB signaling pathways

(2010) Sahdeo Prasad et al.   CANCER BIOLOGY & THERAPY

Synergistic Effects of Combined Phytochemicals and Skin Cancer Prevention in SENCAR Mice

(2010) M. C. Kowalczyk et al.   Cancer Prevention Research

Green Tea Polyphenols Prevent UV-Induced Immunosuppression by Rapid Repair of DNA Damage and Enhancement of Nucleotide Excision Repair Genes

(2010) S. K. Katiyar et al.   Cancer Prevention Research

Chemoprevention of Intestinal Tumorigenesis in APCmin/+ Mice by Silibinin

(2010) S. Rajamanickam et al.   CANCER RESEARCH

Honokiol, a phytochemical from the Magnolia plant, inhibits photocarcinogenesis by targeting UVB-induced inflammatory mediators and cell cycle regulators: development of topical formulation

(2010) M. Vaid et al.   CARCINOGENESIS

Curcumin targeted signaling pathways: basis for anti-photoaging and anti-carcinogenic therapy

(2010) Madalene C.Y. Heng   INTERNATIONAL JOURNAL OF DERMATOLOGY

Extract ofPunica granatuminhibits skin photoaging induced by UVB irradiation

(2010) Hye Min Park et al.   INTERNATIONAL JOURNAL OF DERMATOLOGY

Resveratrol Targets Transforming Growth Factor-β2 Signaling to Block UV-Induced Tumor Progression

(2010) Kwang Ho Kim et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Myricetin Inhibits Akt Survival Signaling and Induces Bad-mediated Apoptosis in a Low Dose Ultraviolet (UV)-B-irradiated HaCaT Human Immortalized Keratinocytes

(2010) Wanyeon KIM et al.   JOURNAL OF RADIATION RESEARCH

3,3′-diindolylmethane suppresses 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and tumor promotion in mouse skin via the downregulation of inflammatory mediators

(2010) Eun Ji Kim et al.   MOLECULAR CARCINOGENESIS

Dietary Grape Seed Proanthocyanidins Inhibit UVB-Induced Cyclooxygenase-2 Expression and Other Inflammatory Mediators in UVB-Exposed Skin and Skin Tumors of SKH-1 Hairless Mice

(2010) Som D. Sharma et al.   PHARMACEUTICAL RESEARCH

Oral Feeding of Pomegranate Fruit Extract Inhibits Early Biomarkers of UVB Radiation-induced Carcinogenesis in SKH-1 Hairless Mouse Epidermis

(2010) Farrukh Afaq et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Protective Action of Resveratrol in Human Skin: Possible Involvement of Specific Receptor Binding Sites

(2010) Stéphane Bastianetto et al.   PLoS One

Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms

(2009) Joi A. Nichols et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Lupeol induces p53 and cyclin-B-mediated G2/M arrest and targets apoptosis through activation of caspase in mouse skin

(2009) Nidhi Nigam et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Switching Akt: from survival signaling to deadly response

(2009) Marek Los et al.   BIOESSAYS

Dietary grape seed proanthocyanidins inhibit 12-O-tetradecanoyl phorbol-13-acetate-caused skin tumor promotion in 7,12-dimethylbenz[a]anthracene-initiated mouse skin, which is associated with the inhibition of inflammatory responses

(2009) S. M. Meeran et al.   CARCINOGENESIS

The Bmi-1 polycomb protein antagonizes the (-)-epigallocatechin-3-gallate-dependent suppression of skin cancer cell survival

(2009) S. Balasubramanian et al.   CARCINOGENESIS

Protective effect of pomegranate-derived products on UVB-mediated damage in human reconstituted skin

(2009) Farrukh Afaq et al.   EXPERIMENTAL DERMATOLOGY

Resveratrol enhances cell-mediated immune response to DMBA through TLR4 and prevents DMBA induced cutaneous carcinogenesis

(2009) Nabiha Yusuf et al.   MOLECULAR CARCINOGENESIS

Resveratrol bioavailability and toxicity in humans

(2009) Charles-Henry Cottart et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Involvement of HIF-1α in UVB-induced epidermal hyperplasia

(2009) Young-Suk Cho et al.   MOLECULES AND CELLS

Cancer Chemoprevention by Pomegranate: Laboratory and Clinical Evidence

(2009) Vaqar Mustafa Adhami et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Multi-targeted prevention and therapy of cancer by proanthocyanidins

(2008) Vijayalakshmi Nandakumar et al.   CANCER LETTERS

Myricetin Suppresses UVB-Induced Skin Cancer by Targeting Fyn

(2008) S. K. Jung et al.   CANCER RESEARCH

Guggulsterone modulates MAPK and NF- B pathways and inhibits skin tumorigenesis in SENCAR mice

(2008) S. Sarfaraz et al.   CARCINOGENESIS

Caffeic acid, a phenolic phytochemical in coffee, directly inhibits Fyn kinase activity and UVB-induced COX-2 expression

(2008) N. J. Kang et al.   CARCINOGENESIS

Polymeric black tea polyphenols inhibit mouse skin chemical carcinogenesis by decreasing cell proliferation

(2008) R. Patel et al.   CELL PROLIFERATION

Protective Effects of Standardized Pomegranate (Punica granatumL.) Polyphenolic Extract in Ultraviolet-Irradiated Human Skin Fibroblasts

(2008) Lisbeth A. Pacheco-Palencia et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Inhibition of UVB-Induced Skin Tumor Development by Drinking Green Tea Polyphenols Is Mediated Through DNA Repair and Subsequent Inhibition of Inflammation

(2008) Syed M. Meeran et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Chemopreventive Potential of Resveratrol in Mouse Skin Tumors Through Regulation of Mitochondrial and PI3K/AKT Signaling Pathways

(2008) Preeti Roy et al.   PHARMACEUTICAL RESEARCH

Silymarin, a Flavonoid from Milk Thistle (Silybum marianum L.), Inhibits UV-induced Oxidative Stress Through Targeting Infiltrating CD11b+Cells in Mouse Skin

(2008) Santosh K. Katiyar et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Resveratrol induces apoptosis involving mitochondrial pathways in mouse skin tumorigenesis

(2007) Neetu Kalra et al.   LIFE SCIENCES