Article
Food Science & Technology
Mateus Kawata Salgaco, Natalia Partis Perina, Thais Moreno Tome, Elaine Martins Bento Mosquera, Tamara Lazarini, Adilson Sartoratto, Katia Sivieri
Summary: This study evaluated the impact of an infant cereal with probiotics on infants' gut microbiota by simulating human gastrointestinal conditions. The results showed that the cereal can stimulate the growth of beneficial Lactobacillus strains, reduce NH4+ production, and increase the production of short chain fatty acids, especially butyric acid.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Nutrition & Dietetics
Tiantian Li, Chuanqi Chu, Leilei Yu, Qixiao Zhai, Shunhe Wang, Jianxin Zhao, Hao Zhang, Wei Chen, Fengwei Tian
Summary: This study demonstrated that the probiotic Bifidobacterium breve CCFM1067 could modify gut microecology, alleviate neurodegeneration and inflammation in a PD mouse model. This suggests that probiotics may serve as a new approach for PD therapy through the gut-brain axis.
Article
Nutrition & Dietetics
Meng-Meng Niu, Huan-Xin Guo, Jun-Wu Cai, Xiang-Chen Meng
Summary: This study explores the intestinal barrier repair mechanisms of Bifidobacterium breve (B. breve) strains H4-2 and H9-3 with different exopolysaccharide (EPS) production in mice with colitis. The results demonstrate that both strains of B. breve can regulate cytokine levels and repair intestinal damage caused by colitis. H4-2, with higher EPS output, is more effective at repair than H9-3. These findings are important for clinical applications and the development of probiotic products for colitis treatment.
Review
Microbiology
Jiayu Li, Junyu Wang, Meiyu Wang, Li Zheng, Qiuyu Cen, Fangfang Wang, Li Zhu, Rizhao Pang, Anren Zhang
Summary: Depression is a prevalent psychological disease that significantly impacts individuals, families, and society. With the increase in COVID-19 cases, depression rates have further risen globally. Probiotics, especially Bifidobacterium, have been shown to have positive effects in preventing and treating depression, potentially through anti-inflammatory processes and regulation of neurotransmitter synthesis and hormonal balance. This mini-review summarizes the relationship between Bifidobacterium and depression, highlighting the potential future role of Bifidobacterium-based preparations in depression prevention and treatment.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Environmental Sciences
Na Li, Jun Wang, Ping Liu, Jinhua Li, Chundi Xu
Summary: This study established a comprehensive phenotyping and multi-omics analysis method to evaluate the toxicity of nanopolystyrene (PS) on mice. The results showed that PS exposure caused microbial alteration, metabolic disorders, and immune disturbances. Additionally, the probiotic Bifidobacterium breve M-16V was found to have anti-inflammatory and immunomodulatory effects through host-microbiome interactions.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Nutrition & Dietetics
Mona Abdelhamid, Chunyu Zhou, Cha-Gyun Jung, Makoto Michikawa
Summary: Probiotics, specifically Bifidobacterium breve MCC1274, have beneficial effects on brain function by improving memory and cognition through the microbiome-gut-brain axis. This study investigates the potential of B. breve MCC1274 to mitigate Alzheimer's disease-like pathologies in wild-type mice. The results show that oral administration of B. breve MCC1274 reduces A beta 42 levels, inhibits tau phosphorylation, decreases neuroinflammation, and improves synaptic protein levels in the hippocampus. These findings suggest that B. breve MCC1274 may have potential therapeutic effects for Alzheimer's disease.
Article
Microbiology
Alicja M. Nogacka, Silvia Arboleya, Naghmeh Nikpoor, Jeremie Auger, Nuria Salazar, Isabel Cuesta, Jorge R. Alvarez-Buylla, Laura Mantecon, Gonzalo Solis, Miguel Gueimonde, Thomas A. Tompkins, Clara G. de los Reyes-Gavilan
Summary: 2'-Fucosyllactose (2'-FL) is a highly abundant oligosaccharide in human milk that benefits neonatal health. This study evaluated the impact of different probiotic strains or a probiotic formulation on the microbiota and degradation of 2'-FL. Results showed that certain probiotic strains promoted the degradation of 2'-FL in slow-degrading microbiota. Additionally, significant changes in microbiota composition and metabolic activity were observed with specific probiotic strains or the probiotic formulation in slow degraders. Further research is needed to understand the role of host intestinal microbiota in the efficacy of these strains.
Article
Veterinary Sciences
Susan Ciaravolo, Lina Maria Martinez-Lopez, Richard J. N. Allcock, Andrew P. Woodward, Caroline Mansfield
Summary: This longitudinal microbiome study found that a commercially available veterinary synbiotic product did not significantly impact the microbial diversity of healthy dogs' fecal microbiome, but did result in transient increases in certain probiotic species, with the microbiota partially reverting to its baseline state after discontinuation of the product.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Oncology
Qingxiang Li, Yuke Li, Yifei Wang, Le Xu, Yuxing Guo, Yixiang Wang, Lin Wang, Chuanbin Guo
Summary: The intestinal microbiota, particularly through the probiotic B. breve, can enhance the efficacy of cancer immunotherapy, promoting tumor cell apoptosis; the mechanism of B. breve may involve the regulation of DC-related chemokines and the promotion of IL-12 secretion; the study suggests that exogenous B. breve can alter the intestinal microbiota and enhance its antitumor effect.
Article
Microbiology
Francois Bernier, Tatsuya Kuhara, Jinzhong Xiao
Summary: Consuming Bifidobacterium breve MCC1274 has beneficial effects on memory improvement and prevention of brain atrophy in individuals with mild cognitive impairment (MCI). Preclinical studies using Alzheimer's disease (AD) models have shown that this probiotic can protect against brain inflammation. This study found that extracts of B. breve MCC1274 cells reduced the expression of perilipin 4 (PLIN4), a lipid droplet docking protein that is increased during inflammation. Niacin, a component of MCC1274 cell extracts, increased PLIN4 expression but MCC1274 extracts and niacin blocked PLIN4 induction caused by oxidative stress, reduced lipid droplet formation, and prevented IL-6 cytokine production.
Article
Food Science & Technology
Meng-Meng Niu, Huan-Xin Guo, Jun-Wu Cai, Bo-Fan Duan, Yu-Han Chen, Xiang-Chen Meng
Summary: This study found that an exopolysaccharide (BBE) from Bifidobacterium breve could restore intestinal injury caused by colitis by increasing the survival ability of intestinal epithelial cells. BBE also inhibited oxidative protein expression, restored abnormal inflammatory factor production, and replenished short-chain fatty acids. Moreover, BBE regulated the imbalance of intestinal flora. Therefore, BBE has the potential to be used as an anti-inflammatory substance.
Article
Chemistry, Medicinal
Chaiyavat Chaiyasut, Bhagavathi Sundaram Sivamaruthi, Narissara Lailerd, Sasithorn Sirilun, Subramanian Thangaleela, Suchanat Khongtan, Muruganantham Bharathi, Periyanaina Kesika, Manee Saelee, Thiwanya Choeisoongnern, Pranom Fukngoen, Sartjin Peerajan, Phakkharawat Sittiprapaporn
Summary: Type 2 diabetes is a prevalent metabolic disorder with various health threats. This study investigated the effects of Bifidobacterium breve supplementation on glycemic control, lipid profile, and microbiome in subjects with type 2 diabetes.
Article
Nutrition & Dietetics
Akari Hiraku, Setsuko Nakata, Mai Murata, Chendong Xu, Natsumi Mutoh, Satoshi Arai, Toshitaka Odamaki, Noriyuki Iwabuchi, Miyuki Tanaka, Takahisa Tsuno, Masahiko Nakamura
Summary: Supplementation with Bifidobacterium longum subsp. infantis (B. infantis) M-63 in healthy term infants leads to an increase in beneficial bacteria, a decrease in stool pH, and an increase in acetic acid and IgA levels. It also reduces the frequency of defecation and watery stools. This study highlights the importance of early supplementation with B. infantis M-63 in the development of gut microbiota in infants.
Article
Agriculture, Multidisciplinary
Bowen Li, Mengfan Ding, Xiaoming Liu, Jianxin Zhao, R. Paul Ross, Catherine Stanton, Bo Yang, Wei Chen
Summary: This study found that Bifidobacterium breve CCFM1078 can alleviate joint inflammation by adjusting the profile of gut microbiota and enhancing the intestinal barrier, as well as reducing the release of inflammatory cytokines.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Nutrition & Dietetics
Xinqi Chen, Yang Chen, Catherine Stanton, Reynolds Paul Ross, Jianxin Zhao, Wei Chen, Bo Yang
Summary: This study aimed to investigate the dose-response effect of Bifidobacterium breve CCFM683 on relieving psoriasis and its underlying patterns. Specifically, the expression of keratin 16, keratin 17, and involucrin were substantially decreased by specific doses of the probiotic. Moreover, the gut microbiota in mice treated with the probiotic was rebalanced and the concentrations of colonic bile acids were positively correlated with the effectiveness of the strain in relieving psoriasis.
Article
Microbiology
Chiara Braglia, Daniele Alberoni, Martin Pablo Porrini, Paula Melisa Garrido, Loredana Baffoni, Diana Di Gioia
Summary: This study explores the potential of using compounds such as organic acids or biological agents, including waste products from the circular economy like wine waste, to improve honeybee health. Some ingredients like acetic acid at high concentration, p-coumaric acid, and Saccharomyces sp. strain KIA1 were found to be effective in controlling nosemosis, while wine acetic acid increased the amount of N. ceranae. New solutions are needed to manage nosemosis, especially natural methods that do not harm honey bees or the environment.
Article
Microbiology
Eliana Musmeci, Francesco Candeliere, Alberto Amaretti, Maddalena Rossi, Stefano Raimondi
Summary: The draft genome sequence of Clostridium tertium WC0709, a gut bacterium capable of utilizing mucin as the sole carbon and nitrogen source, has been presented. This genome sequence will serve as a valuable reference for comparative genome analysis and for investigating the relationship with the host.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2021)
Article
Behavioral Sciences
Laura Turriziani, Arianna Ricciardello, Francesca Cucinotta, Fabiana Bellomo, Giada Turturo, Maria Boncoddo, Silvestro Mirabelli, Maria Luisa Scattoni, Maddalena Rossi, Antonio M. Persico
Summary: The study shows that gut mobilization significantly reduces symptoms such as hyperactivity, anxiety, irritability, and repetitive behaviors in chronically constipated autistic children. While urinary p-cresol levels varied, they were not significantly correlated with changes in behavioral parameters.
Article
Nutrition & Dietetics
Fabiola De Marchi, Alessandro Collo, Ada Scognamiglio, Maria Cavaletto, Nicole Bozzi Cionci, Giampaolo Biroli, Diana Di Gioia, Sergio Riso, Letizia Mazzini
Summary: This study aims to evaluate the safety and feasibility of a normocaloric ketogenic diet (KD) in people with amyotrophic lateral sclerosis (ALS) and to limit disease progression by reducing hyperexcitability levels and modulating neuroinflammation. The study will monitor clinical outcomes, blood parameters, and gut microbiota analyses of the participants, with the hope of developing a patient-centered diet program with positive results.
Article
Materials Science, Composites
Laura Sisti, Grazia Totaro, Antonella Rosato, Nicole Bozzi Cionci, Diana Di Gioia, Luisa Barbieri, Andrea Saccani
Summary: Particulate composites based on PLA and PBS have been developed by incorporating milled silver skin waste. The addition of silver skin enhances mechanical properties and provides protection against UV degradation, showing potential for waste-based composites with added value.
POLYMER COMPOSITES
(2022)
Article
Infectious Diseases
Nicole Bozzi Cionci, Laura Lucaccioni, Elisa Pietrella, Monica Ficara, Caterina Spada, Paola Torelli, Luca Bedetti, Licia Lugli, Diana Di Gioia, Alberto Berardi
Summary: Premature infants receiving antibiotic treatments have increased levels of targeted intestinal bacteria, especially Bifidobacterium spp., as they grow older. Prolonged exposure to antibiotics affects Clostridium and B. fragilis levels in the first weeks of life, but these changes are no longer observed at 90 days of age. The variation in bacterial counts is associated with the length of hospital stay, feeding, and mechanical ventilation.
Article
Microbiology
Francesco Candeliere, Stefano Raimondi, Raffaella Ranieri, Eliana Musmeci, Alfonso Zambon, Alberto Amaretti, Maddalena Rossi
Summary: GUS enzymes produced by intestinal bacteria can affect the metabolism of drugs and xenobiotics by removing glucuronic acid from glucuronides. The number and structural categories of GUS enzymes vary in the gut microbiomes of different geographical populations, but they do not have significant correlations with drug response. L1 and mL1 are the most important categories of GUS enzymes involved in the hydrolysis of small molecules, with Bacteroides being a major contributor. Interindividual variations in GUS profiles, particularly in the L1 and mL1 categories, likely play a major role in the variability of pharmacomicrobiomics, which can influence drug response and toxicity.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Gloria Spampinato, Francesco Candeliere, Alberto Amaretti, Fabio Licciardello, Maddalena Rossi, Stefano Raimondi
Summary: Sliced cooked ham packaged in a modified atmosphere is prone to microbial contamination, which can affect its sensorial properties and safety. In this study, the microbial load and chemical-physical features of cooked ham were monitored during the secondary shelf life. Lactic acid bacteria played a protective role in preventing contamination by other bacteria, and the production and packaging stages were crucial in managing the safety risk associated with the product.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Stefano Raimondi, Francesco Candeliere, Alberto Amaretti, Stefania Costa, Silvia Vertuani, Gloria Spampinato, Maddalena Rossi
Summary: This study analyzed the genome sequences of Leuconostoc and used ANI and core genome to check the species classification and infer the evolutionary lineage. The results showed that the minimum evolution ANI tree had the most similar topology with the core genome tree, while single gene trees were less adherent. Based on an ANI threshold of 95%, the organization of the genus Leuconostoc could be amended, and new species and subspecies were identified.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Stefano Raimondi, Giorgia Foca, Alessandro Ulrici, Lorenza Destro, Alan Leonardi, Raissa Buzzi, Francesco Candeliere, Maddalena Rossi, Alberto Amaretti
Summary: The yeast Wickerhamomyces anomalus WC 1501 has been shown to be an excellent producer of D-arabitol, with high conversion yield and productivity, using glycerol as a substrate.
MICROBIAL CELL FACTORIES
(2022)
Article
Plant Sciences
Sara Bosi, Lorenzo Negri, Mattia Accorsi, Loredana Baffoni, Francesca Gaggia, Diana Di Gioia, Giovanni Dinelli, Ilaria Marotti
Summary: This study investigated the effectiveness of three biostimulant products on a golf green. The results showed that ExpB was the most effective in improving turfgrass characteristics and reducing negative environmental impacts.
Article
Food Science & Technology
Ivana Nikodinoska, Giulia Tabanelli, Loredana Baffoni, Fausto Gardini, Francesca Gaggia, Federica Barbieri, Diana Di Gioia
Summary: This study aimed to select new lactic acid bacteria (LAB) strains from spontaneously fermented sausages produced in different areas of Italy, which can be used as starter cultures and bioprotective agents in fermented salami. New autochthonous Lat. sakei strains were obtained, lacking antibiotic resistance, possessing antimicrobial activity against major meat pathogens, and with high growth performance under osmotic pressure. These strains have the potential to improve the safety of fermented meats, even without the use of chemical preservatives. Moreover, studying autochthonous cultures is crucial for preserving the specific characteristics of traditional products, which represent important cultural heritage.
Article
Food Science & Technology
Diletta Balli, Lorenzo Cecchi, Giuseppe Pieraccini, Manuel Venturi, Viola Galli, Marta Reggio, Diana Di Gioia, Sandra Furlanetto, Serena Orlandini, Marzia Innocenti, Nadia Mulinacci
Summary: In this study, fermentation was applied to improve the nutritional properties of millet, and three microorganism combinations were tested. The fermentation processes led to an increase in minerals, such as calcium and iron, and richer total phenols compared to the unfermented sample. Different oligopeptides were obtained depending on the microorganisms used, and FPM2 showed the highest resistant starch content and prebiotic activity. Millet fermented with Saccharomyces cerevisiae plus Campanilactobacillus paralimentarius can be proposed as a new food with improved nutritional properties.
Article
Engineering, Biomedical
Francesca Fraulini, Stefano Raimondi, Francesco Candeliere, Raffaella Ranieri, Alfonso Zambon, Gigliola Lusvardi
Summary: Mesoporous bioactive glasses (MBGs) have been widely used in tissue engineering for hard tissue regeneration. In order to develop biomaterials with antibiotic properties, cerium-doped MBGs were investigated as controlled drug delivery systems (DDSs) for gentamicin (Gen), a wide spectrum antibiotic commonly used against postoperative infections. The results showed that the optimized Gen-loaded cerium-doped MBGs retained significant bioactivity, antioxidant properties, and exhibited antibacterial efficacy for up to 10 days of controlled release. These findings make Gen-loaded cerium-doped MBGs promising candidates for simultaneous hard tissue regeneration and in situ antibiotic release.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Microbiology
Chiara Nasuti, Jennifer Ruffini, Laura Sola, Mario Di Bacco, Stefano Raimondi, Francesco Candeliere, Lisa Solieri
Summary: Craft beer is driving the search for novel ale yeast cultures, and the aging of sour beer in wooden barrels is found to be a source of suitable craft ale yeast candidates. During the aging process, different biotypes of yeast dominate the mycobiota, including Saccharomyces cerevisiae, Pichia membranifaciens, Brettanomyces bruxellensis, Brettanomyces anomalus, and S. cerevisiae x S. uvarum hybrids. The identified strains have relevant brewing properties and produce volatile organic compounds (VOCs), such as phenylethyl alcohol, that contribute to unique sensorial attributes in craft beer.
