In SilicoInvestigation of Traditional Chinese Medicine Compounds to Inhibit Human Histone Deacetylase 2 for Patients with Alzheimer’s Disease

Decrease of the Immunophilin FKBP52 Accumulation in Human Brains of Alzheimer's Disease and FTDP-17

(2018) Julien Giustiniani et al.   JOURNAL OF ALZHEIMERS DISEASE

Investigation of the Novel Lead of Melanocortin 1 Receptor for Pigmentary Disorders

(2014) Hsin-Chieh Tang et al.   Evidence-based Complementary and Alternative Medicine

Pharmacological Chaperone Design for Reducing Risk Factor of Parkinson’s Disease from Traditional Chinese Medicine

(2014) Hung-Jin Huang et al.   Evidence-based Complementary and Alternative Medicine

Editorial (Recent Developments and Future Directions at Current Computer Aided Drug Design)

(2013) Subhash C. Basak   Current Computer-Aided Drug Design

A Novel Integrated Framework and Improved Methodology of Computer-Aided Drug Design

(2013) Calvin Yu-Chian Chen   CURRENT TOPICS IN MEDICINAL CHEMISTRY

How to design a drug for the disordered proteins?

(2013) Calvin Yu-Chian Chen et al.   DRUG DISCOVERY TODAY

Discovery of novel insomnia leads from screening traditional Chinese medicine database

(2013) Hsin-Yi Chen et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Voxel-based classification of FDG PET in dementia using inter-scanner normalization

(2013) Frank Thiele et al.   NEUROIMAGE

Drug Design for Neuropathic Pain Regulation from Traditional Chinese Medicine

(2013) Weng Ieong Tou et al.   Scientific Reports

A novel series of l-2-benzyloxycarbonylamino-8-(2-pyridyl)-disulfidyloctanoic acid derivatives as histone deacetylase inhibitors: Design, synthesis and molecular modeling study

(2012) Dawei Huang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Mercaptoacetamide-based class II HDAC inhibitor lowers Aβ levels and improves learning and memory in a mouse model of Alzheimer's disease

(2012) You Me Sung et al.   EXPERIMENTAL NEUROLOGY

Weighted Equation and Rules—A Novel Concept for Evaluating Protein-Ligand Interaction

(2012) Calvin Yu-Chian Chen   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Ligand-Based Dual Target Drug Design for H1N1: Swine Flu- A Preliminary First Study

(2012) Chien-Yu Chen et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Structure-Based and Ligand-Based Drug Design for HER 2 Receptor

(2012) Hung-Jin Huang et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

iSMART: An Integrated Cloud Computing Web Server for Traditional Chinese Medicine for Online Virtual Screening,de novoEvolution and Drug Design

(2012) Kai-Wei Chang et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Potent Inhibitor Design Against H1N1 Swine Influenza: Structure-based and Molecular Dynamics Analysis for M2 Inhibitors from Traditional Chinese Medicine Database

(2012) Chia-Hui Lin et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Traditional Chinese medicine application in HIV: anin silicostudy

(2012) Hung-Jin Huang et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

An epigenetic blockade of cognitive functions in the neurodegenerating brain

(2012) Johannes Gräff et al.   NATURE

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

CAVER 3.0: A Tool for the Analysis of Transport Pathways in Dynamic Protein Structures

(2012) Eva Chovancova et al.   PLoS Computational Biology

LIBSVM

(2012) Chih-Chung Chang et al.   ACM Transactions on Intelligent Systems and Technology

Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, protects dopaminergic neurons from neurotoxin-induced damage

(2011) SH Chen et al.   BRITISH JOURNAL OF PHARMACOLOGY

LigPlot+: Multiple Ligand–Protein Interaction Diagrams for Drug Discovery

(2011) Roman A. Laskowski et al.   Journal of Chemical Information and Modeling

SwissParam: A fast force field generation tool for small organic molecules

(2011) Vincent Zoete et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

iScreen: world’s first cloud-computing web server for virtual screening and de novo drug design based on TCM database@Taiwan

(2011) Tsung-Ying Tsai et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

High performance screening, structural and molecular dynamics analysis to identify H1 inhibitors from TCM Database@Taiwan

(2011) Su-Sen Chang et al.   Molecular BioSystems

Treat Alzheimer's disease by traditional Chinese medicine?

(2011) Mao-Feng Sun et al.   MOLECULAR SIMULATION

TCM Database@Taiwan: The World's Largest Traditional Chinese Medicine Database for Drug Screening In Silico

(2011) Calvin Yu-Chian Chen   PLoS One

SAHA Decreases HDAC 2 and 4 Levels In Vivo and Improves Molecular Phenotypes in the R6/2 Mouse Model of Huntington's Disease

(2011) Michal Mielcarek et al.   PLoS One

Stroke prevention by traditional Chinese medicine? A genetic algorithm, support vector machine and molecular dynamics approach

(2011) Kuan-Chung Chen et al.   Soft Matter

Two Birds with One Stone? Possible Dual-Targeting H1N1 Inhibitors from Traditional Chinese Medicine

(2011) Su-Sen Chang et al.   PLoS Computational Biology

PONDR-FIT: A meta-predictor of intrinsically disordered amino acids

(2010) Bin Xue et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides

(2010) Jerome C. Bressi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Benzimidazole and imidazole inhibitors of histone deacetylases: Synthesis and biological activity

(2010) Jerome C. Bressi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Insights into designing the dual-targeted HER2/HSP90 inhibitors

(2010) Chien-Yu Chen et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Histone Methylation Regulates Memory Formation

(2010) S. Gupta et al.   JOURNAL OF NEUROSCIENCE

Current developments of computer-aided drug design

(2010) Hung-Jin Huang et al.   Journal of the Taiwan Institute of Chemical Engineers

Valproic acid stimulates clusterin expression in human astrocytes: Implications for Alzheimer's disease

(2010) Tapio Nuutinen et al.   NEUROSCIENCE LETTERS

Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice

(2010) S. Peleg et al.   SCIENCE

CHARMM: The biomolecular simulation program

(2009) B. R. Brooks et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

HDAC2 negatively regulates memory formation and synaptic plasticity

(2009) Ji-Song Guan et al.   NATURE

HDAC2 is the one

(2009) Leonie Welberg   NATURE REVIEWS NEUROSCIENCE

Inhibitors of Class 1 Histone Deacetylases Reverse Contextual Memory Deficits in a Mouse Model of Alzheimer's Disease

(2009) Mark Kilgore et al.   NEUROPSYCHOPHARMACOLOGY

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation