Review
Cardiac & Cardiovascular Systems
Alexander Akhmedov, Tatsuya Sawamura, Chu-Huang Chen, Simon Kraler, Daria Vdovenko, Thomas F. Luscher
Summary: LOX-1, as a scavenger receptor, plays a crucial role in the development of atherosclerosis, with implications in various cell types, making it a promising diagnostic and therapeutic target for certain cardiovascular diseases.
EUROPEAN HEART JOURNAL
(2021)
Review
Cardiac & Cardiovascular Systems
Alexander Akhmedov, Tatsuya Sawamura, Chu-Huang Chen, Simon Kraler, Daria Vdovenko, Thomas F. Luescher
Summary: LOX-1, a scavenger receptor that promotes atherosclerotic plaque formation, plays a critical role in the development of cardiovascular diseases. Its expression in various cell types underscores its significance in disease progression, highlighting the potential for LOX-1 as a novel therapeutic target in CVDs prevention and treatment.
EUROPEAN HEART JOURNAL
(2021)
Article
Surgery
Halit Eren Taskin, Ahmet Kocael, Pinar Kocael, Kagan Zengin, Muzaffer Al, Volkan Sozer, J. N. Buchwald, T. W. McGlennon, Hafize Uzun
Summary: The study found that weight loss induced by sleeve gastrectomy (SG) can improve the cardiovascular conditions of patients with morbid obesity. After 12 months of SG, metabolic and inflammatory biomarkers significantly decreased and approached the levels of the control group. Baseline albumin level as well as the reduction in oxLDL and cholesterol retention fraction (CRF) were correlated with the reduction in sLOX-1.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Food Science & Technology
Qing Li, Xiuping Liu, Xu Zhang, Yushi Du, Guanyu Chen, Panyin Xiang, Wenhua Ling, Dongliang Wang
Summary: Sustained inflammation promotes macrophage foam cell formation by promoting cholesterol influx and impairing cholesterol efflux. Lactucopicrin at physiologically reachable concentrations inhibits oxLDL-induced foam cell formation in inflammatory mouse macrophages. The mechanism involves reducing LOX-1 distribution in lipid rafts, which contributes to its atheroprotective effect.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Hitomi Ohinata, Takashi Obama, Tomohiko Makiyama, Yuichi Watanabe, Hiroyuki Itabe
Summary: This study found that high-density lipoproteins (HDL) partially decreased neutrophil extracellular trap (NET) formation induced by copper-oxidized low-density lipoprotein (oxLDL). It was also discovered that oxidized phosphatidylcholines and lysophosphatidylcholine in oxLDL promoted NET formation, which could be completely blocked by native HDL. Furthermore, an electronegative subfraction of LDL, LDL(-), was found to promote NET formation. These findings suggest that plasma lipoproteins and their oxidative modifications play multiple roles in promoting NET formation, and HDL acts as a suppressor of this response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Sandeep Kumar, Wahid Ali, Sridhar Mishra, Akshyaya Pradhan, Rishi Sethi, Rashmi Kushwaha, Uma Shankar Singh, Marco Alfonso Perrone
Summary: The study revealed that sLOX-1 can serve as a biomarker for stable CAD and ACS, with potential in predicting the risk of future recurrence of coronary artery disease.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yamei Li, Xueya Zhao, Biwei He, Weibin Wu, Huijuan Zhang, Xingyu Yang, Weiwei Cheng
Summary: Autophagy plays a crucial role in maintaining the function of trophoblast cells, with its activation under hypoxia enhancing angiogenesis and protecting against apoptosis, potentially offering a preventive approach for early-onset preeclampsia.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Sara E. Stinson, Anna E. Jonsson, Mette K. Andersen, Morten A. V. Lund, Louise Aas Holm, Cilius E. Fonvig, Yun Huang, Evelina Stankevic, Helene Baek Juel, Lars aengquist, Thorkild I. A. Sorensen, Emily L. Ongstad, Ranjitha Gaddipati, Joseph Grimsby, Christopher J. Rhodes, Oluf Pedersen, Michael Christiansen, Jens-Christian Holm, Torben Hansen
Summary: This study found that sLOX-1 levels were elevated during and after puberty in children and adolescents with overweight/obesity, and were associated with inflammatory markers and worsened cardiometabolic risk profiles. sLOX-1 may serve as an early marker of cardiometabolic risk and inflammation in pediatric overweight/obesity.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Biochemistry & Molecular Biology
Katharine A. Kott, Elijah Genetzakis, Michael P. Gray, Peter Hansen, Helen M. Mcguire, Jean Y. Yang, Stuart M. Grieve, Stephen T. Vernon, Gemma A. Figtree
Summary: Researchers found that serum sLOX-1 is associated with the severity and incidence of CAD, especially in the population without standard modifiable cardiovascular risk factors (SMuRFs), suggesting that sLOX-1 can be a useful biomarker for risk prediction.
Article
Neurosciences
Anxin Wang, Xue Tian, Jie Xu, Hao Li, Qin Xu, Pan Chen, Xia Meng, Yongjun Wang
Summary: This study found a positive association between sLOX-1 and the risk of recurrent stroke, and the addition of sLOX-1 to conventional risk models improved the predictive value for recurrent stroke. Furthermore, the association between higher sLOX-1 and recurrent stroke was more pronounced in patients with a history of stroke.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Lina Wirestam, Frida Jonsson, Helena Enocsson, Christina Svensson, Maria Weiner, Jonas Wettero, Helene Zachrisson, Per Eriksson, Christopher Sjowall
Summary: A study examined the association between anti-oxidized low-density lipoprotein (anti-oxLDL) antibodies and subclinical atherosclerosis in patients with different systemic lupus erythematosus (SLE) phenotypes. Anti-oxLDL levels were measured in SLE patients, healthy controls, and subjects with anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV). The results showed no significant difference in anti-oxLDL levels between SLE patients and healthy controls, but levels were significantly higher in AAV subjects. There was also a significant decrease in anti-oxLDL levels in the SLE group over a 3-year period. The study did not find strong associations between anti-oxLDL antibodies and vascular affection in SLE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Hui-Lin Hu, Hui-Xiu Zheng, Na Yuan, Chang-Lin Zhai, Hao Chen, Hai-Hua Pan, Gang Qian
Summary: circUSP9X promotes the proliferation and migration of oxidized low-density lipoprotein-treated vascular smooth muscle cells by regulating the expression of miR-599 and STIM1.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Peripheral Vascular Disease
Roberto Villalobos-Labra, Ricky Liu, Floor Spaans, Tamara Saez, Tamara Semeria Maitret, Anita Quon, Tatsuya Sawamura, Christy-Lynn M. Cooke, Sandra T. Davidge
Summary: The study demonstrates that LOX-1 mediates the endothelial dysfunction induced by preeclampsia-STBEVs. This finding expands on the mechanisms that may lead to adverse outcomes in preeclampsia and proposes LOX-1 as a potential target for future interventions.
Article
Biochemistry & Molecular Biology
Sivanan Sivasinprasasn, Naruemon Wikan, Jiraporn Tocharus, Waraluck Chaichompoo, Apichart Suksamrarn, Chainarong Tocharus
Summary: The study revealed that the combined application of PAVA and RSV can inhibit ox-LDL-induced inflammatory responses, decrease activation of NF-KB/NLRP3 pathway, reduce recruitment of monocytes, and ameliorate impairment of cell-cell junctions, offering a novel mechanism for the treatment of cardiovascular diseases.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Medicine, General & Internal
Ting Hung, Jin-You Jhan, Jian-Hong Lin, Kun-Ta Yang, Bang-Gee Hsu, Jui-Chih Chang
Summary: This study aimed to evaluate the relationship between serum MDA-oxLDL levels and CAVI in patients with triple-vessel coronary artery disease who underwent CABG surgery. The results showed a positive correlation between MDA-oxLDL levels and CAVI levels.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dermatology
Theodosios Bisdas, Nikolaos Patelis, Georgia Argyrakopoulou, Dimitrios Tsiachris, Aristotelis Kurtis, Panagiotis Gargalianos-Kakoliris, Christodoulos Stefanadis
Summary: The complexity of critical limb ischemia (CLI) requires a dedicated multidisciplinary team for treatment. This study aimed to assess the effectiveness of referring CLI patients scheduled for major amputation elsewhere to a dedicated CLI center. The analysis showed that patients in severe stages of CLI who received a second opinion from a dedicated multidisciplinary team had high limb salvage and survival rates after major amputation.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2022)
Article
Biochemistry & Molecular Biology
Valeska Ormazabal, Estefania Nova-Lampeti, Daniela Rojas, Felipe A. Zuniga, Carlos Escudero, Paola Lagos, Alexa Moreno, Yanara Pavez, Camila Reyes, Milly Yanez, Mabel Vidal, Guillermo Cabrera-Vives, Katherine Oporto, Claudio Aguayo
Summary: Tissue regeneration is impaired in patients with metabolic disorders. The study found that the secretome of human endothelial cell-differentiated mesenchymal stem cells (hMSC-EC) and a combination of specific proteins enriched in hMSC-EC secretome can enhance wound healing in a hyperglycemic condition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Camila Reyes, Estefania Nova-Lamperti, Daniel Duran-Sandoval, Daniela Rojas, Jorge Gajardo, Enrique Guzman-Gutierrez, Camila Bustos-Ruiz, Valeska Ormazabal, Felipe A. Zuniga, Carlos Escudero, Claudio Aguayo
Summary: This study demonstrates the anti-inflammatory effect and tissue damage reduction of LOXIN. Overexpression of LOXIN blocks Lox-1-mediated uptake of ox-LDL, resulting in decreased Lox-1 expression in endothelial cells and reduced fatty streak lesions in the aorta, as well as inflammation and fibrosis in the liver.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Gonzalo Labarca, Mario Henriquez-Beltran, Liliana Lamperti, Estefania Nova-Lamperti, Sergio Sanhueza, Camilo Cabrera, Romina Quiroga, Barbara Antilef, Valeska Ormazabal, Felipe Zuniga, Daniela Castillo, Gloria Horta, Daniel Enos, Jaime Lastra, Jessica Gonzalez, Adriano Targa, Ferran Barbe
Summary: The study found an association between Obstructive Sleep Apnea (OSA) and long-term symptoms and inflammatory cytokines after COVID-19 infection. At 1 year after infection, OSA patients still showed abnormal lung function, and those with OSA who developed ARDS had a risk of neurocognitive impairment.
FRONTIERS IN MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Valeska Ormazabal, Soumyalekshmi Nair, Flavio Carrion, H. David Mcintyre, Carlos Salomon
Summary: Extracellular vesicles play a critical role in cell communication and can alter the metabolic phenotype in recipient cells through molecular signaling. Gestational diabetes mellitus can reprogram the fetal genome and increase the risk of obesity, metabolic disorders, and cardiovascular disease. Understanding the impact of extracellular vesicle signaling in this process is important for implementing preventive strategies.
CARDIOVASCULAR DIABETOLOGY
(2022)
Review
Cell Biology
Javad Sharifi-Rad, Veronique Seidel, Michalak Izabela, Margalida Monserrat-Mequida, Antoni Sureda, Valeska Ormazabal, Felipe A. Zuniga, Shivaprasad Shetty Mangalpady, Raffaele Pezzani, Alibek Ydyrys, Gulmira Tussupbekova, Miquel Martorell, Daniela Calina, William C. Cho
Summary: Cancer is a leading cause of death worldwide, and its development is linked to oxidative stress. The transcription factor Nrf2 plays a vital role in protecting cells against oxidative stress in cancer growth, progression, and therapy resistance. Therefore, innovative inhibitors targeting Nrf2 are being investigated. This comprehensive review explores the potential of phenolic compounds, found in traditional plant-based remedies, as effective anticancer agents by inhibiting Nrf2. The clinical applications of naturally-occurring bioactive compounds as Nrf2 inhibitors, specifically polyphenols, are also discussed.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Polymer Science
Katherina Fernandez, Aylen Llanquileo, Monserrat Bustos, Valentina Aedo, Isleidy Ruiz, Sebastian Carrasco, Mauricio Tapia, Miguel Pereira, Manuel F. Melendrez, Claudio Aguayo, Leonard I. Atanase
Summary: A conductive composite material for wound dressing was developed using graphene oxide (GO), nanocellulose (CNF), and tannins (TA) reduced with polydopamine (PDA). The composite material was characterized using SEM, FTIR, XRD, XPS, and TGA, and its conductivity, mechanical properties, cytotoxicity, and in vitro wound healing were evaluated. Successful physical interaction between CNF, TA, and GO was achieved. Increasing CNF amount improved the strength, cytotoxicity, and wound healing performance, while reducing thermal properties, surface charge, and conductivity. Slight reduction in cell viability and migration was observed with TA incorporation, possibly due to dosage and chemical composition. However, the in vitro results demonstrated the potential of these composite materials for wound healing.
Article
Biochemistry & Molecular Biology
Marlin Solorzano, Gislaine Granfeldt, Natalia Ulloa, Guillermo Molina-Recio, Rafael Molina-Luque, Claudio Aguayo, Fanny Petermann-Rocha, Miquel Martorell
Summary: The criteria for diagnosing metabolic syndrome in pediatric population vary, leading to inconsistent prevalence rates. This study aimed to establish diagnostic models using non-invasive (anthropometric) and invasive (serum biomarkers) variables for early detection of metabolic syndrome in Chilean children. The results showed that lipid biomarkers (HDL-c and TG) and their ratio (TG/HDL-c) had higher diagnostic capacity, followed by body mass index (BMI) and waist-to-height ratio (WHtR). Detecting metabolic syndrome was possible through both invasive and non-invasive methods in overweight and obese children.
Review
Biology
Hector Valdebenito-Navarrete, Victor Fuentes-Barrera, Carlos T. Smith, Alexis Salas-Burgos, Felipe A. Zuniga, Leonardo A. Gomez, Apolinaria Garcia-Cancino
Summary: Infection with SARS-CoV-2 virus causes COVID-19, which has rapidly spread globally and become a pandemic. The current treatment for COVID-19 includes antivirals, antibiotics for secondary bacterial infections, and drugs targeting symptoms. Additionally, probiotics, particularly immunobiotics, have been proposed as new alternatives for treating COVID-19 by beneficially stimulating intestinal and pulmonary immunity.
Article
Pediatrics
Carolina Ochoa-Rosales, Lorena Mardones, Marcelo Villagran, Claudio Aguayo, Miquel Martorell, Carlos Celis-Morales, Natalia Ulloa
Summary: Children carrying the 'A' allele at the FTO gene have higher obesity prevalence. A cross-sectional study was conducted on 323 children aged 6-11 years to examine the relationship between FTO rs9939609 polymorphism and plasma adiponectin, and the mediating role of body adiposity. Linear regressions and mediation analysis were used to analyze the data. The study found that body adiposity may mediate up to 29.8% of the association between FTO and adiponectin.
Article
Nanoscience & Nanotechnology
Hector Contreras, Pedro Alarcon-Zapata, Estefania Nova-Lamperti, Valeska Ormazabal, Manuel Varas-Godoy, Carlos Salomon, Felipe A. Zuniga
Summary: Extracellular vesicles (EVs) are involved in the transport of biomolecules between cells. This study presents an optimized method for isolating small EVs from biological fluids using SEC columns. Results show that G200/40 column offers a more homogeneous enrichment of small EVs compared to G200/120.
FRONTIERS IN NANOTECHNOLOGY
(2023)
Article
Medicine, Research & Experimental
Pedro Alarcon-Zapata, Andy J. Perez, Karin Toledo-Onate, Hector Contreras, Valeska Ormazabal, Estefania Nova-Lamperti, Claudio A. Aguayo, Carlos Salomon, Felipe A. Zuniga
Summary: This study provides a comprehensive metabolomic analysis of ovarian cancer cell lines, revealing distinct metabolic profiles between sensitive and resistant cell lines. The difference in glutathione metabolism was significant, and depletion of glutathione led to a change in drug sensitivity. The findings offer potential targets for overcoming drug resistance and suggest enhancing chemotherapy efficacy through targeting the glutathione pathway.
Article
Peripheral Vascular Disease
Katherine Oporto, Claudia Radojkovic, Edwin A. Mellisho, Felipe Zuniga, Valeska Ormazabal, Enrique Guzman-Gutierrez, Estefania Nova-Lamperti, Lleretny Rodriguez-Alvarez, Mario Aranda, Carlos Escudero, Claudio Aguayo
Summary: Endothelial progenitor cells (EPCs) are stem cells derived from bone marrow that migrate to damaged tissues for repair and regeneration. This study investigated the effects of adenosine receptor (AR) activation on the release of small extracellular vesicles (sEVs) from early EPCs (eEPCs). The results showed that AR activation increased the release of sEVs from eEPCs and these sEVs promoted angiogenesis in recipient endothelial cells. This study provides the first evidence that adenosine enhances the release of sEVs from eEPCs, which have pro-angiogenic effects on recipient endothelial cells.
MICROVASCULAR RESEARCH
(2023)
Review
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Ioannis Doundoulakis, Panagiota Manolakou, Demetrios Sougiannis, Athanasios Kordalis, Konstantinos A. Gatzoulis, Gian-Battista Chierchia, Carlo de Asmundis, Christodoulos Stefanadis, Konstantinos Tsioufis
Summary: Nowadays, cryoballoon (CB) has become an established alternative to radio frequency (RF) ablation for pulmonary vein isolation (PVI), with the ability to isolate PVs in a single application. In a study on over 1000 consecutive patients, our center optimized the CB PVI procedure. It is expected that future guidelines will recommend CB as the first-line PVI for patients with paroxysmal AF and a class I indication. In a long-term follow-up of the EARLY-AF trial, CB showed a lower incidence of persistent atrial fibrillation compared to anti-arrhythmic drugs.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
