Article
Infectious Diseases
Paola Cerini, Francesca Rita Meduri, Flaminia Tomassetti, Isabella Polidori, Marta Brugneti, Eleonora Nicolai, Sergio Bernardini, Massimo Pieri, Francesco Broccolo
Summary: The World Health Organization has identified three categories of pathogens based on the need for new antibiotics: critical, high, and medium priority. The prevalence of antibiotic resistant bacteria, such as CPO, MRSA, and VRE, has increased from 2019 to 2022 in both nosocomial and community patients. This highlights the importance of implementing preventive and control measures to reduce the spread of multidrug-resistant pathogens.
Article
Immunology
Zhengtu Li, Yongming Li, Shaoqiang Li, Zhun Li, Ying Mai, Jing Cheng, Danhong Su, Yangqing Zhan, Nanshan Zhong, Feng Ye
Summary: A previously unknown Nocardia species (GZ2020(T)) was isolated from a patient with bronchiectasis and recurrent pneumonia. It is resistant to multiple drugs but susceptible to linezolid and moxifloxacin, posing a health threat to patients.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Public, Environmental & Occupational Health
Tingting Le, Ling Wang, Chaoying Zeng, Leiwen Fu, Zhihua Liu, Jing Hu
Summary: Nosocomial and healthcare-associated K. pneumoniae infections displayed similar clinical features and antimicrobial resistance, differing from community-acquired infections. CRKP and ESBL-producing strains were mainly found in HCA and nosocomial groups, showing clonal diversity. Cross transmission of CRKP existed among HCA and nosocomial patients, suggesting the need for consistent empirical therapy and resistance surveillance for these infections.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2021)
Article
Critical Care Medicine
Edwige Peju, Jean-Francois Llitjos, Julien Charpentier, Anne Francois, Nathalie Marin, Alain Cariou, Jean-Daniel Chiche, Jean-Paul Mira, Jerome Lambert, Matthieu Jamme, Frederic Pene
Summary: This study investigated the impact of blood product transfusions on the susceptibility to ICU-acquired infections in high-risk patients with septic shock, and found that transfusions of platelets and fresh frozen plasma were independently associated with the further occurrence of ICU-acquired infections.
CRITICAL CARE MEDICINE
(2021)
Article
Infectious Diseases
Yossef Levi, Debby Ben-David, Inna Estrin, Hodaya Saadon, Maya Krocker, Lili Goldstein, Dan Klafter, Shani Zilberman-Itskovich, Dror Marchaim
Summary: The study found significant differences in the diagnosis of hospital-acquired urinary tract infections between the Israeli Ministry of Health and the U.S. Centers for Disease Control and Prevention, with a high level of agreement for catheter-associated infections but lower agreement for all HAUTI. The major error rate in diagnosing HAUTI based on IMOH criteria but not CDC criteria was 31%.
Article
Infectious Diseases
Dadasaheb G. Maindad, Suresh Shenoy, Suchitra Shenoy, Sandeep Gopal, Bailuru Vishwanath Tantry
Summary: This study analyzed the resistance pattern of organisms isolated from hospital-acquired infections in cirrhotic patients and determined appropriate antibiotics treatment protocols. The results showed a high prevalence of multi-drug resistance and extensive drug resistance in HA infections of cirrhosis patients. Cephalosporins and quinolones were found to be inappropriate empirical antibiotics, and a tigecycline with carbapenem like meropenem and vancomycin based protocol was suggested for treatment.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Health Care Sciences & Services
Michele Treglia, Margherita Pallocci, Pierluigi Passalacqua, Giuseppe Sabatelli, Lucilla De Luca, Claudia Zanovello, Agostino Messineo, Giuseppe Quintavalle, Alberto Michele Cisterna, Luigi Tonino Marsella
Summary: This study examines the phenomenon of professional liability related to healthcare-associated infections (HAIs) and highlights its economic, juridical, and clinical-managerial aspects. The findings suggest that analyzing the legal and medico-legal aspects of HAIs can be a useful tool for assessing healthcare performance and implementing patient safety measures.
Article
Multidisciplinary Sciences
Michelangelo Bartolo, Chiara Zucchella, Hend Aabid, Beatrice Valoriani, Massimiliano Copetti, Andrea Fontana, Domenico Intiso, Mauro Mancuso
Summary: This multicenter observational study reveals the impact of healthcare-associated infections on functional outcomes in inpatient neuro-rehabilitation. Infected patients showed significantly lower improvements in Glasgow Coma Scale, Disability Rating Scale, and modified Barthel Index compared to non-infected patients, and had a higher mortality rate.
SCIENTIFIC REPORTS
(2022)
Review
Infectious Diseases
ZhiHong Jiang, YiFan Ren, ChuanXin Zhang, Yu Yin, ChaoHui Li
Summary: Community-acquired S. maltophilia infection in children with normal immunity is rare but possible. Prompt treatment and medication adjustment are necessary to ensure the child's recovery and minimize medication side effects.
INFECTION AND DRUG RESISTANCE
(2022)
Review
Multidisciplinary Sciences
Molly Kukua Abban, Eunice Ampadubea Ayerakwa, Lydia Mosi, Abiola Isawumi
Summary: The burden of Hospital care-associated infections (HCAIs) is a growing global concern, especially in Intensive care units (ICUs) housing high-risk and immunocompromised patients. This review discusses the contributions of antimicrobial resistance (AMR) pathogens to the increasing burden of HCAIs, with a focus on last-resort antibiotics such as polymyxins. The review explores the impact of structural modifications and cationic interactions on AMR and severity of HCAIs. Bacterial survival mechanisms and plasmid-mediated resistance are also discussed, highlighting the challenges in mitigating AMR within ICUs.
Review
Public, Environmental & Occupational Health
J. A. Suaya, M. A. Fletcher, L. Georgalis, A. G. Arguedas, J. M. McLaughlin, G. Ferreira, C. Theilacker, B. D. Gessner, T. Verstraeten
Summary: Hospital-acquired pneumonia (HAP) is more severe than community-acquired pneumonia (CAP). The prevalence of Streptococcus pneumoniae in HAP episodes was summarized in this study. S. pneumoniae was identified in 5.1% of HAP episodes, with higher rates in the intensive care unit.
JOURNAL OF HOSPITAL INFECTION
(2021)
Article
Microbiology
Mohadeseh Ostovari Deilamani, Farhad Nikkhahi, Mehdi Bakht, Safar Ali Alizadeh, Fatemeh Fardsanei, Amir Javadi, Seyed Mahmoud Amin Marashi, Masoumeh Aslanimehr, Amir Peymani
Summary: The study found that EDTA significantly increased the effectiveness of ethanol and had a synergistic effect. All XDR isolates tested carried biofilm-producing genes and showed reduced expression of these genes after exposure to ethanol and EDTA at different concentrations. Future research should include more diverse microbial communities and explore the effects of additional disinfectants.
Article
Food Science & Technology
Urszula Zarzecka, Arkadiusz Jozef Zakrzewski, Wioleta Chajecka-Wierzchowska, Anna Zadernowska
Summary: This study aimed to define the genetic mechanisms of linezolid resistance in enterococci isolated from animal origin foods. The results showed that 26.9% of isolates displayed linezolid resistance, with the most common acquired resistance gene being poxtA. The presence of mobile genetic elements encoding this resistance poses a rapid transmission risk.
Article
Microbiology
Marta Gomez, Arancha Valverde, Rosa del Campo, Juan Miguel Rodriguez, Antonio Maldonado-Barragan
Summary: The human microbiota may serve as a potential reservoir for infection, with commensal Klebsiella strains exhibiting virulence traits comparable to infective isolates. A commensal K. pneumoniae strain showed inhibitory activity against multidrug-resistant Klebsiella isolates.
Article
Microbiology
Fernanda Morcatti Coura, Vitoria Marra de Souza Savini, Rafael Gariglio Clark Xavier, Carolina Pantuzza Ramos, Rodrigo Otavio Silveira Silva, Marcos Bryan Heinemann, Andrea Micke Moreno, Terezinha Knobl, Elaine Maria Seles Dorneles, Dirceia Aparecida da Costa Custodio, Carine Rodrigues Pereira, Pedro Felipe Rodrigues e Oliveira, Amanda Bruno Pulinelli
Summary: This study found that Escherichia coli was the main pathogen causing UTIs, showing a high frequency of multidrug-resistance and virulence factors. The research revealed that many E. coli strains were resistant to multiple antibiotics, with strains resistant to ampicillin, sulfamethoxazole/trimethoprim, or tetracycline more likely to be multidrug-resistant.
CURRENT MICROBIOLOGY
(2021)
Article
Optics
Daniella dos Santos Courrol, Carla Regina Borges Lopes, Thiago da Silva Cordeiro, Marcia Regina Franzolin, Nilson Dias Vieira Junior, Ricardo Elgul Samad, Lilia Coronato Courrol
OPTICS AND LASER TECHNOLOGY
(2018)
Article
Genetics & Heredity
Hebert F. Culler, Samuel C. F. Couto, Juliana S. Higa, Renato M. Ruiz, Min J. Yang, Vanessa Bueris, Marcia R. Franzolin, Marcelo P. Sircili
Article
Multidisciplinary Sciences
Carlos Alberto Moreira-Filho, Silvia Yumi Bando, Fernanda Bernardi Bertonha, Leandro Rodrigues Ferreira, Christiana de Freitas Vinhas, Lucila Habib Bourguignon Oliveira, Maria Claudia Nogueira Zerbini, Glaucio Furlanetto, Paulo Chaccur, Magda Carneiro-Sampaio
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
Sandra E. Vieira, Silvia Y. Bando, Milena de Paulis, Danielle B. L. Oliveira, Luciano M. Thomazelli, Edison L. Durigon, Marina B. Martinez, Carlos Alberto Moreira-Filho
Article
Microbiology
Silvia Y. Bando, Priscila Iamashita, Filipi N. Silva, Luciano da F. Costa, Cecilia M. Abe, Fernanda B. Bertonha, Beatriz E. C. Guth, Andre Fujita, Carlos A. Moreira-Filho
Article
Virology
Luiz Gustavo Bentim Goes, Rodrigo Melim Zerbinati, Adriana Fumie Tateno, Andrea Vieira de Souza, Fabian Ebach, Victor M. Corman, Carlos Alberto Moreira-Filho, Edison Luiz Durigon, Luiz Vicente Ribeiro Ferreira da Silva Filho, Jan Felix Drexler
JOURNAL OF MEDICAL VIROLOGY
(2020)
Article
Multidisciplinary Sciences
Fernanda Bernardi Bertonha, Silvia Yumi Bando, Leandro Rodrigues Ferreira, Paulo Chaccur, Christiana Vinhas, Maria Claudia Nogueira Zerbini, Magda Maria Carneiro-Sampaio, Carlos Alberto Moreira-Filho
Review
Pediatrics
Magda Carneiro-Sampaio, Carlos Alberto Moreira-Filho, Silvia Yumi Bando, Jocelyne Demengeot, Antonio Coutinho
FRONTIERS IN PEDIATRICS
(2020)
Article
Microbiology
Marta de Oliveira Domingos, Silvio Marciano da Silva Junior, Wagner Milanello, Shirley Sizue Nakamura Nakano, Marcia Regina Franzolin, Luis Fernando dos Santos, Kamila Oliveira Nunes, Vaniky Duarte Marques, Waldir P. Elias, Herbert Guimaraes de Sousa Silva, Bruna De Lucca Caetano, Roxane Maria Fontes Piazza
Summary: This study found that the role of uropathogenic Escherichia coli (UPEC) in colonization and infection is related to the anatomical and functional abnormalities of the urinary system in female patients. Cystitis in female patients with normal urinary tract is associated with ExPEC, while cystitis in female patients with abnormal urinary tract is associated with pathogenic intestinal E. coli strains that have acquired the ability to colonize the bladder.
Article
Microbiology
Marcia Regina Franzolin, Daniella dos Santos Courrol, Susana de Souza Barreto, Lilia Coronato Courrol
Summary: Eugenia uniflora, also known as Brazilian cherry, is used to synthesize silver and gold nanoparticles with antimicrobial activity. The nanoparticles showed inhibition of bacterial and fungal growth, indicating the importance of functional groups in their antimicrobial effects.
Article
Microbiology
Herbert Guimaraes de Sousa Silva, Marcia Regina Franzolin, Geovana Ferreira dos Anjos, Angela Silva Barbosa, Luis Fernando dos Santos, Kaique Ferrari Miranda, Ronaldo Maciel Marques, Matilde Costa Lima de Souza, Roxane Maria Fontes Piazza, Marta de Oliveira Domingos
Summary: This study found that anti-O55 antibodies can enhance the innate immune system's ability to eliminate capsulated aEPEC and STEC, and also inhibit their adhesion and killing.
Article
Multidisciplinary Sciences
Silvia Y. Bando, Fernanda B. Bertonha, Pedro H. N. Menezes, Andre K. Takahara, Nathalia A. Khaled, Paula Santos, Mara S. Junqueira, Roberto M. Cesar, Carlos A. Moreira-Filho
Summary: Febrile seizures in early childhood pose a risk for developing epilepsy of the mesial temporal lobe, however, the underlying molecular mechanisms remain poorly understood. Therefore, rat models of hyperthermia-induced seizures have been used to investigate these mechanisms.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Daniella dos Santos Courrol, Carla Regina Borges Lopes, Camila Bueno Pacheco Pereira, Marcia Regina Franzoli, Flavia Rodrigues de Oliveira Silva, Lilia Coronato Courrol
INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH
(2019)
Meeting Abstract
Immunology
Silvia Y. Bando, Fernanda B. Bertonha, Lucila H. B. Oliveira, Carlos Alberto Moreira-Filho, Magda Carneiro-Sampaio
JOURNAL OF CLINICAL IMMUNOLOGY
(2019)
Article
Cell Biology
Hatylas Azevedo, Nathalia Amato Khaled, Paula Santos, Fernanda Bernardi Bertonha, Carlos Alberto Moreira-Filho
DISEASE MODELS & MECHANISMS
(2018)