Review
Medicine, General & Internal
Xiao-Fang Tan, Li Xu, Ting-Ting Li, Yan-Ting Wu, Wei-Wei Ma, Jia-Yi Ding, Hong-Li Dong
Summary: A meta-analysis of published studies found no negative effects of positive antiphospholipid antibodies on clinical pregnancy rate, live birth rate, and miscarriage risk in patients undergoing in vitro fertilization-embryo transfer (IVF-ET).
Article
Biochemistry & Molecular Biology
Katja Perdan-Pirkmajer, Polona Zigon, Anja Boc, Eva Podovsovnik, Sasa Cucnik, Alenka Mavri, Ziga Rotar, Ales Ambrozic
Summary: This study suggests that negative aCL and/or anti-beta 2GPI at the time of acute DVT may not require further aPL testing, while LA should be checked after discontinuation of anticoagulant therapy. Positive aCL and/or anti-beta 2GPI at the time of acute DVT have a strong positive predictive value for APS and may impact therapeutic decisions.
Article
Biochemistry & Molecular Biology
Tatiana Reshetnyak, Fariza Cheldieva, Maria Cherkasova, Alexander Lila, Evgeny Nasonov
Summary: This study investigates the role of IgA antibodies to cardiolipin (aCL) and IgA antibodies to beta-2 glycoprotein 1 (anti-beta(2)-GP1) in the development of vascular complications in patients with antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE). The results show that the levels of IgA aCL and IgA anti-beta(2)-GP1 are significantly higher in APS patients compared to SLE patients and the control group. These antibodies are closely associated with thrombosis in APS, demonstrating high specificity but low sensitivity for the diagnosis of APS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Marc Emmenegger, Sreedhar Saseendran F. Kumar, Vishalini J. Emmenegger, Tomas J. Malinauskas, Thomas Buettner, Laura Rose, Peter Schierack, Martin B. Sprinzl, Clemens Sommer, Karl B. Lackner, Adriano Aguzzi, Dirk B. Roggenbuck, Katrin B. M. Frauenknecht
Summary: SARS-CoV-2 infection can lead to diverse symptoms, with some patients developing hypercoagulation and autoantibody responses. Research has shown that infection with SARS-CoV-2 can result in the production of autoantibodies, particularly IgM antibodies targeting coagulation proteins. Further investigation is needed to explore the relationship between SARS-CoV-2 infection, autoantibody production, and disease severity.
Article
Biochemistry & Molecular Biology
Francisco Javier Gil-Etayo, Sara Garcinuno, Antonio Lalueza, Raquel Diaz-Simon, Ana Garcia-Reyne, Daniel Enrique Pleguezuelo, Oscar Cabrera-Marante, Edgard Alfonso Rodriguez-Frias, Alfredo Perez-Rivilla, Manuel Serrano, Antonio Serrano
Summary: The presence of aPL in COVID-19 patients is significantly associated with thrombosis, with potential mechanisms including early immune dysregulation and delayed aPL-mediated thrombosis. Additionally, aPL found in COVID-19 patients may preexist before the infection.
Article
Immunology
Xiangjun Liu, Lei Zhu, Hongjiang Liu, Qingmeng Cai, Zelin Yun, Feng Sun, Yuan Jia, Jianping Guo, Chun Li
Summary: Non-criteria antiphospholipid antibodies have a high prevalence in patients with antiphospholipid syndrome, and their inclusion can improve the diagnostic accuracy of APS. APhL IgG, aPS/PT, and aPS IgG may serve as potential biomarkers for predicting thrombotic risk in APS patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medical Laboratory Technology
Sarra Melayah, Mariem Ghozzi, Amani Mankai, Fatma Mechi, Ibtissem Ghedira
Summary: This study found that the frequencies of CCP-Ab and RF are high in patients with IgA isotype of anti-beta 2 glycoprotein I antibodies, suggesting that these patients are susceptible to developing RA.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Medicine, General & Internal
Daniele Roselli, Maria Addolorata Bonifacio, Giovanna Barbuti, Maria Rosaria Rossiello, Prudenza Ranieri, Maria Addolorata Mariggio
Summary: This real life study aimed to explore the connections between laboratory criteria and the prevalence of non-criteria antiphospholipid antibodies (aPL) in antiphospholipid syndrome (APS). The study found a significant association between aPS and aCL as well as aβ(2)GPI, while the association with LA was less significant. Therefore, measuring aPT and aA5 autoantibodies may be useful, particularly in aCL/aβ(2)GPI-negative patients or in cases of isolated LA positivity.
Article
Hematology
Arne Vandevelde, Walid Chayoua, Bas de Laat, Gary W. Moore, Jacek Musial, Stephane Zuily, Denis Wahl, Katrien M. J. Devreese
Summary: The presence of antiphosphatidylserine/prothrombin antibodies (aPS/PT), especially with high antibody titer, is associated with the diagnosis of thrombotic antiphospholipid syndrome (TAPS).
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Rheumatology
Marwa Elkhalifa, Ana-Maria Orbai, Laurence S. Magder, Michelle Petri, Graciela S. Alarcon, Caroline Gordon, Joan Merrill, Paul R. Fortin, Ian N. Bruce, David Isenberg, Daniel Wallace, Ola Nived, Rosalind Ramsey-Goldman, Sang-Cheol Bae, John G. Hanly, Jorge Sanchez-Guerrero, Ann E. Clarke, Cynthia Aranow, Susan Manzi, Murray Urowitz, Dafna D. Gladman, Ken Kalunian, Victoria P. Werth, Asad Zoma, Sasha Bernatsky, Munther Khamashta, Soren Jacobsen, Jill P. Buyon, Mary Anne Dooley, Ronald van Vollenhoven, Ellen Ginzler, Thomas Stoll, Christine Peschken, Joseph L. Jorizzo, Jeffery P. Callen, Sam Lim, Murat Inanc, Diane L. Kamen, Anisur Rahman, Kristjan Steinsson, Andrew G. Franks
Summary: The study assessed the prevalence of anti-beta 2 glycoprotein I IgA in SLE compared to other rheumatic diseases and its association with disease manifestations. Results showed that anti-beta 2 glycoprotein I IgA is more common in patients with SLE, particularly in those of African descent.
Article
Immunology
Savino Sciascia, Rory Bloch, Tyler O'Malley, Anja Kammesheidt, Roberta Vezza Alexander
Summary: High titers of aPL often remain positive, allowing for earlier diagnosis and risk assessment at the initial screening. Low titers may require retesting. There is a high correlation between aCL and aB2GP1 measured using two different technologies. The correlation between PC4d and aPL is low to moderate, suggesting a possible additional value in evaluating the association with thrombosis in autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Chaojun Hu, Siting Li, Zhijuan Xie, Hanxiao You, Hui Jiang, Yu Shi, Wanting Qi, Jiuliang Zhao, Qian Wang, Xinping Tian, Mengtao Li, Yan Zhao, Xiaofeng Zeng
Summary: This study found that detecting aCL IgA, aβ2GPI IgA, aAnxV IgG/M, and aPS/PT IgG/M as biomarkers provides additive value in APS diagnosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Hematology
Michael Pham, Giovanni Orsolini, Cynthia Crowson, Melissa Snyder, Rajiv Pruthi, Kevin Moder
Summary: This study aimed to validate the relationship between anti-phosphatidylserine prothrombin antibodies (aPSPT) and lupus anticoagulant (LAC), and determine their sensitivity and specificity in an all-comer population. The results showed that aPSPT had high specificity but lower sensitivity to LAC. These findings further support the potential of aPSPT as a clinical marker for LAC.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Immunology
Karolina Piekarska, Marta Dratwa, Pawel Radwan, Michal Radwan, Katarzyna Bogunia-Kubik, Izabela Nowak
Summary: Embryo implantation is a critical process in pregnancy, and abnormalities in immune factors can lead to implantation failure and pregnancy loss. This study examines the levels of certain pro- and anti-inflammatory factors in the blood plasma of IVF patients and women who achieved natural pregnancy. The results indicate that IVF patients receiving steroid treatment show differences in IFN-γ and IL-10 levels, and overall, IVF patients have different secretion patterns compared to fertile controls.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Caroline Gronwall, Lisa Liljefors, Holger Bang, Aase H. Hensvold, Monika Hansson, Linda Mathsson-Alm, Lena Israelsson, Vijay Joshua, Anna Svard, Ragnhild Stalesen, Philip J. Titcombe, Johanna Steen, Luca Piccoli, Natalia Sherina, Cyril Clavel, Elisabet Svenungsson, Iva Gunnarsson, Saedis Saevarsdottir, Alf Kastbom, Guy Serre, Lars Alfredsson, Vivianne Malmstrom, Johan Ronnelid, Anca I. Catrina, Karin Lundberg, Lars Klareskog
Summary: The study identified different autoantibody reactivities in patients with rheumatoid arthritis, including various modified protein autoantibodies. Reactivities to carbamylated and acetylated proteins were primarily seen in patients positive for citrullinated protein reactivity, while anti-acetylated histone reactivity was specific to RA. Anti-malondialdehyde acetaldehyde antibodies were associated with disease activity and were not significantly increased in individuals at risk of RA.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Robin Arcani, Daniel Bertin, Nathalie Bardin, Karin Mazodier, Rodolphe Jean, Pierre Suchon, Geoffroy Venton, Aurelie Daumas, Estelle Jean, Patrick Villani, Gilles Kaplanski, Pierre-Andre Jarrot
Summary: The study shows that anti-NuMA antibodies are mainly associated with pSS and SLE, and patients with these antibodies have less severe clinical profiles and require less treatment. Anti-NuMA antibodies may be a useful diagnostic marker when other auto-antibodies are negative and could indicate a good prognosis in autoimmune diseases.
Letter
Rheumatology
Antoine Briantais, Benjamin De Sainte Marie, Emmanuelle Campana-Salort, Gilles Kaplanski, Jean-Marc Durand, Daniel Bertin, Nathalie Bardin, Mikael Ebbo, Nicolas Schleinitz
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2022)
Article
Biochemistry & Molecular Biology
Akshita Sharma, Ahmad Joshkon, Aymen Ladjimi, Wael Traboulsi, Richard Bachelier, Stephane Robert, Alexandrine Foucault-Bertaud, Aurelie S. Leroyer, Nathalie Bardin, Indumathi Somasundaram, Marcel Blot-Chabaud
Summary: Over-expression of CD146 leads to increased secretion of sCD146 in TNBC cells, promoting TNBC development and dissemination through up-regulation of EMT and CSC markers. These effects can be blocked using specific anti-sCD146 antibody, M2J-1 mAb. M2J-1 mAb is able to reduce tumor development and dissemination by affecting CSC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Urology & Nephrology
Alice Corthier, Marie Jachiet, Daniel Bertin, Aude Servais, Christelle Barbet, Adrien Bigot, Marie-Sylvie Doutre, Didier Bessis, Ancuta Bouffandeau, Olivier Moranne, Pierre-Andre Jarrot, Nathalie Bardin, Benjamin Terrier, Stephane Burtey, Xavier Puechal, Laurent Daniel, Noemie Jourde-Chiche
Summary: This study describes the kidney involvement of hypocomplementemic urticarial vasculitis (HUV). Patients often present with proteinuria and acute kidney injury. Kidney biopsy shows mostly membrano-proliferative glomerulonephritis or crescentic glomerulonephritis, with frequent C1q deposits. Follow-up results indicate that some patients maintain good renal function, but others develop chronic kidney disease and end-stage kidney disease.
Article
Rheumatology
Marie Nollet, Richard Bachelier, Ahmad Joshkon, Wael Traboulsi, Amandine Mahieux, Anais Moyon, Alexandre Muller, Indumathi Somasundaram, Stephanie Simoncini, Franck Peiretti, Aurelie S. Leroyer, Benjamin Guillet, Brigitte Granel, Francoise Dignat-George, Nathalie Bardin, Alexandrine Foucault-Bertaud, Marcel Blot-Chabaud
Summary: The study identified multiple forms of sCD146 generated by shedding and alternative splicing, with shed sCD146 and I10-sCD146 displaying proangiogenic activity and I5-13-sCD146 showing profibrotic effects. These variants could serve as novel biomarkers and molecular targets for the diagnosis and treatment of SSc and other related disorders.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Medicine, General & Internal
Xavier Heim, Daniel Bertin, Noemie Resseguier, Abdelouahab Beziane, Audrey Metral, Alexandre Brodovitch, Regis Guieu, Jean-Guillaume Steinberg, Marcel Blot-Chabaud, Pierre-Emmanuel Morange, Jean-Louis Mege, Nathalie Bardin
Summary: The detection of aPEs is valuable in exploring thrombosis in cases where conventional markers are negative, especially in cases of deep vein thrombosis. There is a significant association between aPE positivity and systemic ROS production, suggesting a potential mechanism of action of aPEs in thrombosis through signaling related to oxidative stress.
JOURNAL OF CLINICAL MEDICINE
(2022)
Letter
Dermatology
Didier Bessis, Sophie Trouillet-Assant, Leo-Paul Secco, Nathalie Bardin, Brigitte Blanc, Veronique Blatiere, Christine Chable-Bessia, Christophe Delfour, Celine Girard, Jean-Christophe Richard, Nathalie Gros, Vincent Le Moing, Nicolas Molinari, Valerie Pallure, Amandine Pisoni, Nadia Raison-Peyron, Elisa Reynaud, Emilie Schwob, Remi Pescarmona, Quentin Samaran, Marjolaine Willems, Thierry Vincent, Mircea T. Sofonea, Alexandre Belot, Edouard Tuaillon
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Dermatology
Xavier Heim, Julien Bermudez, Ahmad Joshkon, Elise Kaspi, Richard Bachelier, Marie Nollet, Melanie Velier, Laetitia Dou, Alexandre Brodovitch, Alexandrine Foucault-Bertaud, Aurelie S. Leroyer, Audrey Benyamine, Aurelie Daumas, Brigitte Granel, Florence Sabatier, Francoise Dignat-George, Marcel Blot-Chabaud, Nathalie Bardin
Summary: This study reveals the involvement of CD146 in the regulation of Wnt/ROS signaling in skin fibrosis of systemic sclerosis. The absence of CD146 leads to procanonical Wnt signaling, increased ROS content, and DNA oxidative damage. Furthermore, CD146 and its ligand are upregulated in fibroblasts from patients with systemic sclerosis. These findings highlight the importance of CD146 in the pathogenesis of systemic sclerosis and provide insights for innovative therapeutic strategies.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Multidisciplinary Sciences
Daniel Bertin, Alexandre Brodovitch, Alexandre Lopez, Robin Arcani, Grace M. Thomas, Abdou Beziane, Samuel Weber, Benjamin Babacci, Xavier Heim, Louise Rey, Marc Leone, Jean Louis Mege, Nathalie Bardin
Summary: The detection of antiphospholipid autoantibodies (aPL), particularly aCL IgG, in COVID-19 patients is significantly associated with disease severity. Additionally, severe cases exhibit higher levels of circulating exDNA, which may exacerbate the thrombo-inflammatory state related to disease severity.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Ahmad Joshkon, Emeline Tabouret, Wael Traboulsi, Richard Bachelier, Stephanie Simoncini, Sandrine Roffino, Carine Jiguet-Jiglaire, Bassam Badran, Benjamin Guillet, Alexandrine Foucault-Bertaud, Aurelie S. Leroyer, Francoise Dignat-George, Olivier Chinot, Hussein Fayyad-Kazan, Nathalie Bardin, Marcel Blot-Chabaud
Summary: In this study, it was found that an increase in sCD146 concentration in the sera of GBM patients after the first cycle of bevacizumab treatment was significantly associated with poor progression-free survival and shorter overall survival. This suggests that sCD146 may be an early biomarker to predict and prevent bevacizumab resistance in patients with glioblastoma.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Alexandrine Bertaud, Ahmad Joshkon, Xavier Heim, Richard Bachelier, Nathalie Bardin, Aurelie S. Leroyer, Marcel Blot-Chabaud
Summary: Cardiac fibrosis is a condition characterized by irreversible necrosis of the heart muscle, caused by various acute or chronic diseases, genetic alterations, or aging. Currently, there is no curative treatment available to prevent or attenuate cardiac fibrosis, which leads to progressive cardiac dysfunction and life-threatening outcomes. This review summarizes different targets and new strategies proposed to fight cardiac fibrosis, as well as discussing future directions, such as the use of exosomes or nanoparticles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Hematology
Robin Arcani, Raphael Cauchois, Pierre Suchon, Samuel Weber, Rodolphe Jean, Pierre-Andre Jarrot, Louise Rey, Geoffroy Venton, Marie Koubi, Romain Muller, Daniel Bertin, Jean-Louis Mege, Gilles Kaplanski, Nathalie Bardin
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2023)
Review
Rheumatology
Eya Toumi, Soraya Mezouar, Anne Plauzolles, Laurent Chiche, Nathalie Bardin, Philippe Halfon, Jean Louis Mege
Summary: SLE is a complex autoimmune disease influenced by genetics and environmental factors. Mouse models provide valuable insights into the pathogenesis of SLE and serve as testing platforms for new therapies. Recent studies suggest that targeting gut microbiota may offer promising therapeutic approaches for SLE. However, the underlying mechanisms of gut microbiota dysbiosis in SLE are still unclear. This review aims to explore the relationship between gut microbiota dysbiosis and SLE, and identify potential biomarkers and therapy targets.
LUPUS SCIENCE & MEDICINE
(2023)
Article
Rheumatology
Robin Arcani, Louise Rey, Alice Mazziotto, Daniel Bertin, Gilles Kaplanski, Pierre-Andre Jarrot, Pierre Lafforgue, Geoffroy Venton, Xavier Heim, Patrick Villani, Jean-Louis Mege, Alexandre Brodovitch, Nathalie Bardin
Summary: The concentration and fluctuations of anti-Jo-1 autoantibodies may serve as predictive markers for the severity and evolution of antisynthetase syndrome (ASS), and their quantification could be a valuable tool for disease monitoring and improving therapeutic management of ASS patients.
ARTHRITIS RESEARCH & THERAPY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
C. Dubrou, M. Blin, K. Fallague, R. Bachelier, C. Chareyre, S. Robert, A. Bertaud, R. Lacroix, F. Dignat-George, N. Bardin, M. Blot-Chabaud, A. Leroyer