Complex Network-Driven View of Genomic Mechanisms Underlying Parkinson’s Disease: Analyses in Dorsal Motor Vagal Nucleus, Locus Coeruleus, and Substantia Nigra

Astrocyte glycogenolysis is triggered by store-operated calcium entry and provides metabolic energy for cellular calcium homeostasis

(2014) Margit S. Müller et al.   GLIA

The histone deacetylase HDAC3 is essential for Purkinje cell function, potentially complicating the use of HDAC inhibitors in SCA1

(2014) Anand Venkatraman et al.   HUMAN MOLECULAR GENETICS

Autosomal recessive phosphoglucomutase 3 (PGM3) mutations link glycosylation defects to atopy, immune deficiency, autoimmunity, and neurocognitive impairment

(2014) Yu Zhang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The evaluation of polyglutamine repeats in autosomal dominant Parkinson's disease

(2014) Chikara Yamashita et al.   NEUROBIOLOGY OF AGING

SIRT1 in Neurodevelopment and Brain Senescence

(2014) A. Zara Herskovits et al.   NEURON

Neuroprotective effects of metabotropic glutamate receptor group II and III activators against MPP(+)-induced cell death in human neuroblastoma SH-SY5Y cells: The impact of cell differentiation state

(2014) D. Jantas et al.   NEUROPHARMACOLOGY

Association of GRM3 polymorphism with white matter integrity in schizophrenia

(2014) Joanna Mounce et al.   SCHIZOPHRENIA RESEARCH

Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases

(2014) S. A. Purro et al.   Journal of Molecular Cell Biology

Targeting Wnt signaling at the neuroimmune interface for dopaminergic neuroprotection/repair in Parkinson's disease

(2014) Francesca L'Episcopo et al.   Journal of Molecular Cell Biology

Selenium homeostasis and antioxidant selenoproteins in brain: Implications for disorders in the central nervous system

(2013) Holger Steinbrenner et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Dissecting the role of sortilin receptor signaling in neurodegeneration induced by NGF deprivation

(2013) Simona Capsoni et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reactive nucleolar and Cajal body responses to proteasome inhibition in sensory ganglion neurons

(2013) Ana Palanca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

CHOP regulates the p53–MDM2 axis and is required for neuronal survival after seizures

(2013) Tobias Engel et al.   BRAIN

Altered Ribostasis: RNA-Protein Granules in Degenerative Disorders

(2013) Mani Ramaswami et al.   CELL

The G protein-coupled receptor GPRC5B contributes to neurogenesis in the developing mouse neocortex

(2013) N. Kurabayashi et al.   DEVELOPMENT

Over-expression of the miRNA cluster at chromosome 14q32 in the alcoholic brain correlates with suppression of predicted target mRNA required for oligodendrocyte proliferation

(2013) A.M. Manzardo et al.   GENE

Beyond modules and hubs: the potential of gene coexpression networks for investigating molecular mechanisms of complex brain disorders

(2013) C. Gaiteri et al.   GENES BRAIN AND BEHAVIOR

Role of Stress Granules and RNA-Binding Proteins in Neurodegeneration: A Mini-Review

(2013) Tara Vanderweyde et al.   GERONTOLOGY

Linear ubiquitination-mediated NF- B regulation and its related disorders

(2013) F. Tokunaga   JOURNAL OF BIOCHEMISTRY

Gas7b (Growth Arrest Specific Protein 7b) Regulates Neuronal Cell Morphology by Enhancing Microtubule and Actin Filament Assembly

(2013) Aina Gotoh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of full-length and truncated trkB in human striatum and substantia nigra neurons: implications for Parkinson’s disease

(2013) Mark E. Fenner et al.   JOURNAL OF MOLECULAR HISTOLOGY

Arborization of Dendrites by Developing Neocortical Neurons Is Dependent on Primary Cilia and Type 3 Adenylyl Cyclase

(2013) S. M. Guadiana et al.   JOURNAL OF NEUROSCIENCE

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(2013) Mihai Moldovan et al.   MOLECULAR MEDICINE

Dlx1&2-Dependent Expression of Zfhx1b (Sip1, Zeb2) Regulates the Fate Switch between Cortical and Striatal Interneurons

(2013) Gabriel L. McKinsey et al.   NEURON

Genetics of Parkinson's disease – state of the art, 2013

(2013) Vincenzo Bonifati   PARKINSONISM & RELATED DISORDERS

Epigenetic targeting of histone deacetylase: Therapeutic potential in Parkinson's disease?

(2013) Ian F. Harrison et al.   PHARMACOLOGY & THERAPEUTICS

Complex Network Analysis of CA3 Transcriptome Reveals Pathogenic and Compensatory Pathways in Refractory Temporal Lobe Epilepsy

(2013) Silvia Yumi Bando et al.   PLoS One

Genomics and Bioinformatics of Parkinson's Disease

(2013) S. W. Scholz et al.   Cold Spring Harbor Perspectives in Medicine

The Transcription Factors Sox10 and Myrf Define an Essential Regulatory Network Module in Differentiating Oligodendrocytes

(2013) Julia Hornig et al.   PLoS Genetics

SNCA (α-synuclein)-induced toxicity in yeast cells is dependent on Sir2-mediated mitophagy

(2012) Belém Sampaio-Marques et al.   Autophagy

Efficient statistical significance approximation for local similarity analysis of high-throughput time series data

(2012) Li C. Xia et al.   BIOINFORMATICS

Structural Analysis of SHARPIN, a Subunit of a Large Multi-protein E3 Ubiquitin Ligase, Reveals a Novel Dimerization Function for the Pleckstrin Homology Superfold

(2012) Benjamin Stieglitz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SHARPIN is a key regulator of immune and inflammatory responses

(2012) Zhe Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Evidence Providing New Insights into TOB-Promoted Deadenylation and Supporting a Link between TOB's Deadenylation-Enhancing and Antiproliferative Activities

(2012) N. Ezzeddine et al.   MOLECULAR AND CELLULAR BIOLOGY

Differential network biology

(2012) Trey Ideker et al.   Molecular Systems Biology

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

(2012) Huai-Xiang Hao et al.   NATURE

A role for primary cilia in glutamatergic synaptic integration of adult-born neurons

(2012) Natsuko Kumamoto et al.   NATURE NEUROSCIENCE

Dual-Mode Modulation of Smad Signaling by Smad-Interacting Protein Sip1 Is Required for Myelination in the Central Nervous System

(2012) Qinjie Weng et al.   NEURON

Differential expression of ADAM15 and ADAM17 metalloproteases in the rat brain after severe hypobaric hypoxia and hypoxic preconditioning

(2012) Elena Rybnikova et al.   NEUROSCIENCE RESEARCH

Gas7-Deficient Mouse Reveals Roles in Motor Function and Muscle Fiber Composition during Aging

(2012) Bo-Tsang Huang et al.   PLoS One

Beyond α-synuclein transfer: pathology propagation in Parkinson's disease

(2012) Christian Hansen et al.   TRENDS IN MOLECULAR MEDICINE

Sortilin: a receptor to regulate neuronal viability and function

(2012) Anders Nykjaer et al.   TRENDS IN NEUROSCIENCES

Alpha-synuclein: from secretion to dysfunction and death

(2012) O Marques et al.   Cell Death & Disease

The metastasis-promoting S100A4 protein confers neuroprotection in brain injury

(2012) Oksana Dmytriyeva et al.   Nature Communications

Peptide-binding GRP78 protects neurons from hypoxia-induced apoptosis

(2011) Nitza Goldenberg-Cohen et al.   APOPTOSIS

Phospholipase A2, reactive oxygen species, and lipid peroxidation in CNS pathologies

(2011) Rao Muralikrishna Adibhatla et al.   BMB Reports

Longitudinal evolution of compensatory changes in striatal dopamine processing in Parkinson's disease

(2011) Ramachandiran Nandhagopal et al.   BRAIN

Gene expression in the Parkinson's disease brain

(2011) Patrick A. Lewis et al.   BRAIN RESEARCH BULLETIN

Experimental modeling of preclinical and clinical stages of Parkinson’s disease

(2011) V. G. Khaindrava et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson’s disease

(2011) Giuseppa Mudò et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cell death pathways and autophagy in the central nervous system and its involvement in neurodegeneration, immunity and central nervous system infection: to die or not to die - that is the question

(2011) A. Rosello et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The MPTP neurotoxic lesion model of Parkinson's disease activates the apolipoprotein E cascade in the mouse brain

(2011) D. Domenger et al.   EXPERIMENTAL NEUROLOGY

Apolipoprotein D mediates autocrine protection of astrocytes and controls their reactivity level, contributing to the functional maintenance of paraquat-challenged dopaminergic systems

(2011) Raquel Bajo-Grañeras et al.   GLIA

Sumoylation inhibits α-synuclein aggregation and toxicity

(2011) Petranka Krumova et al.   JOURNAL OF CELL BIOLOGY

Apolipoprotein D alters the early transcriptional response to oxidative stress in the adult cerebellum

(2011) Raquel Bajo-Grañeras et al.   JOURNAL OF NEUROCHEMISTRY

Etiology and pathogenesis of Parkinson's disease

(2011) Anthony H. Schapira et al.   MOVEMENT DISORDERS

Ars2 maintains neural stem-cell identity through direct transcriptional activation of Sox2

(2011) Celia Andreu-Agullo et al.   NATURE

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

(2011) Fumiyo Ikeda et al.   NATURE

Cilia in the CNS: The Quiet Organelle Claims Center Stage

(2011) Angeliki Louvi et al.   NEURON

What Genetics Tells us About the Causes and Mechanisms of Parkinson's Disease

(2011) Olga Corti et al.   PHYSIOLOGICAL REVIEWS

Identifying Consensus Disease Pathways in Parkinson's Disease Using an Integrative Systems Biology Approach

(2011) Yvonne J. K. Edwards et al.   PLoS One

Gene Expression Profiling of Embryonic Human Neural Stem Cells and Dopaminergic Neurons from Adult Human Substantia Nigra

(2011) Hany E. S. Marei et al.   PLoS One

Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet

(2011) P. Krebs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Can Parkinson's disease pathology be propagated from one neuron to another?

(2011) Christopher J.R. Dunning et al.   PROGRESS IN NEUROBIOLOGY

Cavitation-Enhanced Extravasation for Drug Delivery

(2011) Costas D. Arvanitis et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

Functional genomics of the brain: uncovering networks in the CNS using a systems approach

(2011) Genevieve Konopka   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

ShcD interacts with TrkB via its PTB and SH2 domains and regulates BDNF-induced MAPK activation

(2010) Yuangang You et al.   BMB Reports

Impact of RNA degradation on gene expression profiling

(2010) Lennart Opitz et al.   BMC Medical Genomics

Network properties of human disease genes with pleiotropic effects

(2010) Sreenivas Chavali et al.   BMC Systems Biology

A Family of Protein-Deglutamylating Enzymes Associated with Neurodegeneration

(2010) Krzysztof Rogowski et al.   CELL

Phantom, a New Subclass of Mutator DNA Transposons Found in Insect Viruses and Widely Distributed in Animals

(2010) C. P. Marquez et al.   GENETICS

Broker Genes in Human Disease

(2010) James J. Cai et al.   Genome Biology and Evolution

Neuropathology of sporadic Parkinson disease before the appearance of parkinsonism: preclinical Parkinson disease

(2010) Isidre Ferrer et al.   JOURNAL OF NEURAL TRANSMISSION

Brain stem pathology in Parkinson's disease: An evaluation of the Braak staging model

(2010) Ann E. Kingsbury et al.   MOVEMENT DISORDERS

Missing pieces in the Parkinson's disease puzzle

(2010) Jose A Obeso et al.   NATURE MEDICINE

Network medicine: a network-based approach to human disease

(2010) Albert-László Barabási et al.   NATURE REVIEWS GENETICS

Current status and future directions of gene expression profiling in Parkinson's disease

(2010) James G. Greene   NEUROBIOLOGY OF DISEASE

A Glial Signal Consisting of Gliomedin and NrCAM Clusters Axonal Na+ Channels during the Formation of Nodes of Ranvier

(2010) Konstantin Feinberg et al.   NEURON

GNL3L depletion destabilizes MDM2 and induces p53-dependent G2/M arrest

(2010) L Meng et al.   ONCOGENE

The serine/arginine-rich protein SF2/ASF regulates protein sumoylation

(2010) F. Pelisch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ossifying Dermatofibroma With Osteoclast-Like Giant Cells: Report of a Case and Literature Review

(2009) John A Papalas et al.   AMERICAN JOURNAL OF DERMATOPATHOLOGY

Regulation of apoAI processing by procollagen C-proteinase enhancer-2 and bone morphogenetic protein-1

(2009) Jian Zhu et al.   JOURNAL OF LIPID RESEARCH

Mesenchymal stem cell transplantation attenuates blood brain barrier damage and neuroinflammation and protects dopaminergic neurons against MPTP toxicity in the substantia nigra in a model of Parkinson's disease

(2009) Yin Xia Chao et al.   JOURNAL OF NEUROIMMUNOLOGY

Analysis of the expression and function of BRINP family genes during neuronal differentiation in mouse embryonic stem cell-derived neural stem cells

(2009) Michiyo Terashima et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Cytotoxic effects of oxysterols associated with human diseases: Induction of cell death (apoptosis and/or oncosis), oxidative and inflammatory activities, and phospholipidosis

(2009) Anne Vejux et al.   MOLECULAR ASPECTS OF MEDICINE

Structural Studies of a Four-MBT Repeat Protein MBTD1

(2009) Jitka Eryilmaz et al.   PLoS One

MBT domain proteins in development and disease

(2009) Roberto Bonasio et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Applicability of current staging/categorization of α-synuclein pathology and their clinical relevance

(2008) Laura Parkkinen et al.   ACTA NEUROPATHOLOGICA

Human apolipoprotein A–I binds amyloid-β and prevents Aβ-induced neurotoxicity

(2008) Andréa C. Paula-Lima et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Protein phosphatase 4 catalytic subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylation

(2008) Kazuhito Toyo-oka et al.   JOURNAL OF CELL BIOLOGY

Review: The group II metabotropic glutamate receptor 3 (mGluR3, mGlu3, GRM3): expression, function and involvement in schizophrenia

(2008) PJ Harrison et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Generation and Characterization of rgs5 Mutant Mice

(2008) M. H. Nisancioglu et al.   MOLECULAR AND CELLULAR BIOLOGY

Runx transcription factors in neuronal development

(2008) Ken-ichi Inoue et al.   Neural Development

SIRT1 negatively regulates HDAC1-dependent transcriptional repression by the RBP1 family of proteins

(2008) O Binda et al.   ONCOGENE

Neurobiology and treatment of Parkinson's disease

(2008) Anthony H.V. Schapira   TRENDS IN PHARMACOLOGICAL SCIENCES