Article
Engineering, Environmental
Ruiguo Chen, Qian Li, Qi Zhang, Shuai Xu, Jian Han, Peiyan Huang, Zhiwu Yu, Daping Jia, Juanjuan Liu, Huiling Jia, Ming Shen, Bingwen Hu, Howard Wang, Hongbing Zhan, Teng Zhang, Kun Ma, Junfeng Wang
Summary: A novel approach was proposed to produce nano-HCA@BG for soft tissue repair, which improved biocompatibility through a porous structure and surface-coated amorphous HCA layer. The HCA-coated nanoporous architecture significantly promoted cell growth and proliferation, benefiting wound healing in rodent skin defects.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Biotechnology & Applied Microbiology
Jianhang Du, Huifeng Ding, Shengyang Fu, Dejian Li, Bin Yu
Summary: In this study, a bifunctional Bi-BG scaffold for near-infrared (NIR)-activated photothermal ablation of bone tumors and enhanced bone defect regeneration is fabricated. The Bi-BG scaffolds exhibit outstanding photothermal performance under NIR irradiation and effectively inhibit tumor growth while promoting bone regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Nianrou Mei, Yiwen Wu, Binglin Chen, Tian Zhuang, Xinge Yu, Baiyan Sui, Tingting Ding, Xin Liu
Summary: The integration of 3D printed GelMA-based scaffolds with mesoporous bioactive glass nanoparticles improves the structural stability and promotes the regeneration of periodontal tissues.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Irina Atkinson, Ana Maria Seciu-Grama, Simona Petrescu, Daniela Culita, Oana Catalina Mocioiu, Mariana Voicescu, Raul-Augustin Mitran, Daniel Lincu, Ana-Maria Prelipcean, Oana Craciunescu
Summary: A cerium-containing MBG-derived biomaterial scaffold was synthesized and characterized using various techniques. The results showed that the scaffold had good cytocompatibility and potential applications in bone tissue engineering.
Article
Materials Science, Biomaterials
Sarika Tomar, Rakesh Pandey, Priyanka Surya, Ranjan Verma, Rashi Mathur, Gurudutta Gangenahalli, Sweta Singh
Summary: Effective wound management is challenging due to complexity of wound microenvironment, bacterial infections, impaired angiogenesis, aggravated inflammation, and enduring pain. A multifunctional composite hydrogel was developed to address these challenges, comprised of gelatin, chitosan, polydopamine-coated bioactive glass (BG), and curcumin-capped silver nanoparticles (Cur-AgNPs). The PDA-coated BG provides adhesive, angiogenic, and pain-relieving properties, while Cur-AgNPs offer bactericidal and anti-inflammatory benefits. The composite hydrogel showed excellent wound healing potential by alleviating pain, eliminating microbes, reducing inflammation, promoting angiogenesis, and achieving effective skin regeneration.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Hui Zhu, Mahshid Monavari, Kai Zheng, Thomas Distler, Liliang Ouyang, Susanne Heid, Zhaorui Jin, Jiankang He, Dichen Li, Aldo R. Boccaccini
Summary: Bioprinting has made significant progress in recent years in the fabrication of complex bionic tissues. However, developing cell-laden bioinks with superior physiochemical properties and bio-functionality remains challenging. In this study, a multifunctional nanocomposite bioink was developed using amine-functionalized copper-doped mesoporous bioactive glass nanoparticles and a hydrogel formulation based on dynamic covalent chemistry. This bioink showed favorable rheological properties, improved shape fidelity, and structural stability for extrusion-based bioprinting. The introduction of aminated particles and the reversible dynamic microenvironment enabled rapid spreading and high survival of embedded cells. The bioprinted scaffolds promoted osteogenic differentiation and angiogenesis of cells without additional growth factors in vitro. These nanocomposite bioinks have great potential for bioprinting complex 3D environments in bone tissue engineering.
Article
Materials Science, Multidisciplinary
Aqeel Al-Hamaidah, Mahmood Rezaee Roknabadi, Malek Bagheri Harouni, Bizhan Malaekeh-Nikouei, Asma Mahmoudi, Reza Ghanbari, Alireza Charmforoushan
Summary: We report the synthesis of a mesoporous calcium silicate superparamagnetic nanoparticle with a core-shell structure of ZnMnFe2O4@Fe-CaSiO3. The core-shell nanocomposite exhibits excellent properties including meso-porous structure, superparamagnetism at room temperature, low toxicity, large surface area, tunable pore size, and easy surface manipulation. The addition of different percentages of Fe ions onto the calcium silicate structure further enhances the magnetic properties of the core-shell structure. These mesoporous superparamagnetic nanocomposites have potential applications in drug delivery, magnetic resonance imaging, magnetic hyperthermia, and bone tissue regeneration.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Polymer Science
Ozgur Basal, Ozlem Ozmen, Aylin M. Deliormanli
Summary: In this study, graphene-coated bioactive glass scaffolds were found to enhance bone formation in rat femur defects. The highest amount of bone formation was observed in the group containing 10 wt% graphene.
Review
Chemistry, Multidisciplinary
Smriti Gupta, Shreyasi Majumdar, Sairam Krishnamurthy
Summary: Bioactive glasses (BAGs) have been widely explored as a multifunctional delivery system for various therapeutic molecules, offering controlled release to target tissues and biological activity. Researchers have noted the obstacles hindering the translation of research findings from the lab to clinical settings.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biochemistry & Molecular Biology
Azadeh Saberi, Aliasghar Behnamghader, Behzad Aghabarari, Aliakbar Yousefi, Dorota Majda, Maria Victoria Martinez Huerta, Masoud Mozafari
Summary: This study proposes a three-dimensional composite scaffold made of polylactic acid and spray dried glass-ceramic microparticles. The characterization shows that the scaffold has interconnected porosity and good biomineralization capacity. The scaffold also improves cell adhesion and activity in cell experiments.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Biomedical
Ana Sofia Padua, Ligia Figueiredo, Jorge Carvalho Silva, Joao Paulo Borges
Summary: Bone regeneration is focused on developing composite scaffolds made of chitosan and ceramics like mesoporous bioactive glass (MBG) and mesoporous hydroxyapatite (MHAp). The morphology and properties of the scaffolds were optimized through lyophilization. The composite scaffolds of chitosan with MBG and MHAp showed the best performance in terms of mechanical properties and cell adhesion and proliferation.
PROGRESS IN BIOMATERIALS
(2023)
Article
Materials Science, Ceramics
Aylin M. Deliormanli, Mertcan Ensoylu, Ghada ALMisned, H. O. Tekin
Summary: In this study, polycaprolactone (PCL) and polylactide-co-glycolide (PLGA) coated bioactive glass scaffolds containing molybdenum disulfide (MoS2) nanoparticles were prepared and evaluated for their usability in bone tissue engineering applications. The results showed that the presence of MoS2 nanoparticles in the polymer matrix improved the mechanical properties of the scaffolds and increased the hydroxyapatite-forming ability of the bioactive glass-based composites. Additionally, the composite scaffolds demonstrated high radiation-shielding ability due to the presence of MoS2 nanoparticles.
CERAMICS INTERNATIONAL
(2023)
Article
Nanoscience & Nanotechnology
Joseph Christakiran Moses, Biman B. Mandal
Summary: Successful loading of antibiotics and hormones in mesoporous nanocomposites and fabrication of compatible implant coatings using electrophoretic deposition technique were reported. These coatings exhibited antibacterial efficacy, promoted cell adhesion and osteogenesis, thereby improving implant patency.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
M. Schumacher, P. Habibovic, S. van Rijt
Summary: Mesoporous bioactive glasses have promising properties for regenerative medicine due to their bioactivity and degradability, which are influenced by synthesis parameters and glass stoichiometry. Control of degradation and bioactivity over a broad range can be achieved through glass stoichiometry, allowing targeted material selection for specific regenerative medicine applications.
BIOACTIVE MATERIALS
(2021)
Article
Biochemical Research Methods
Kartikeya Dixit, Archana Raichur, Niraj Sinha
Summary: In this study, carbon nanotube (CNT) reinforced functionally graded bioactive glass scaffolds were successfully fabricated using additive manufacturing technique. The scaffolds showed improved mechanical properties, appropriate pore structure for osteogenesis and angiogenesis, and good bioactivity, making them suitable for bone tissue engineering applications.
IEEE TRANSACTIONS ON NANOBIOSCIENCE
(2022)